Iranian Journal of Pharmaceutical Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Occurrence of Aflatoxins in Commercial Cereal-based Baby Foods in Iran: A Probabilistic Risk ...
The aim of this study was to assess the occurrence of Aflatoxins (AFs) including B1, B2, G1 and G2 in commercial cereal-based baby foods by HPLC-FLD method in Iran and related risk assessment in three baby age groups (6-12, 12-18, and 18-24 months) using Monte Carlo simulation approach. Results showed an occurrence ranging from 20% to 60% for B1, B2, and G2 aflatoxins, while AFG1 was not detected in any assessed samples. Exposure and risk assessment was estimated to be two groups (aflatoxin B1 and total aflatoxins). The highest estimated dietary exposure to both AFB1 and total AFs was estimated for 6-12 months aged babies,...
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research

Trust-building in the Pharmacist-patient Relationship: A Qualitative Study
This study aimed to identify the factors that can enhance and improve trust between pharmacists and patients. This study was a qualitative study consisting of an in-depth semi-structured interview followed by a focus group discussion. In the first phase of the study, a semi-structured open-ended interview was conducted with patients, pharmacists, and pharmacy technicians. The interview phase was followed by transcribing verbatim and content analysis and a focus group discussion. Finally, 49 items of trust-building factors between the patient and the pharmacists were obtained. A questionnaire was designed and distributed am...
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research

Rapid Detection of Adulteration in Dendrobium Huoshanense with Dendrobium Henanense by ATR-FTIR ...
In this study, the Attenuated Total Re flectance Fourier transform Infrared Spectroscopy (ATR-FTIR) combined with chemometric methods was established to detect fraudulent addition in DHS with DHN. The partial least squares (PLS) models based on the ATR-FTIR files of DHS mixed with different proportions of DHN were built under cross vali dation and tested with different independent data sets. To reduce the variables' lack of information and increase the accuracy of the model, different wavelength selection methods including Moving Window Partial Least Squares (MW-PLS), Monte Carlo-uninformative variable elimination (MC-UV...
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research

Design, Synthesis, Docking Study and Biological Evaluation of ...
A novel series of benzothiazine-3-carboxamide 1,1-dioxide derivatives by modifying the piroxicam scaffold was designed, synthesized, and evaluated as anti-HIV agents. The 1,2-benzothiazine-3-carboxamide 1,1-dioxide scaffold consists of hydroxy and carboxamide groups as a chelating motif to form an interaction with Mg2+ ions within the integrase active site as a target. Most of the compounds displayed encouraging anti-HIV activity in a cell-based assay. Among them, compounds 13d, 13l and 13m were the most potent with EC50 values ranging from 20-25 mM and SI> 26. Docking study of compounds in integrase active site propose...
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research

Exogenous surfactant versus placebo in the treatment of moderate and severe ARDS in COVID-19: ...
Conclusions: Surfactant significantly alleviates the respiratory status in moderate to severe COVID-19 ARDS with two consecutive 100 mg doses of surfactant (with 6 hours’ interval); though previous studies have been controversial, regarding the effect of surfactant in general forms of ARDS. Higher doses might have better effects, mandating more trials. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - July 7, 2021 Category: Drugs & Pharmacology Source Type: research

Effects of wound fluid on breast cancer-derived spheroids in a 3D culture system: a case series ...
Surgery is the standard treatment for breast malignancies, although local and distant relapses might occur. Previous studies have shown that surgery-induced wound fluid (WF) contains tumor-initiating and progressing factors; however, these experiments have only been performed on breast cancer cell lines. Since a cancerous tumor includes various components like malignant cells, recruited non-malignant cells and extracellular matrix, those investigations that only focused on cancer cell lines themselves are not adequate to establish WF's effects. We conducted a 3D model study where we mimicked the in vivo tumor microenvironm...
Source: Iranian Journal of Pharmaceutical Research - July 7, 2021 Category: Drugs & Pharmacology Source Type: research

Development and Optimization of Lipid-polymer Hybrid Nanoparticles Containing Melphalan Using ...
This study aimed to develop and optimize the production of hybrid lipid-polymer nanoparticles (HLPNPs) for the targeted delivery of melphalan anticancer drugs. Response surface methodology (RSM) and central composite design (CCD) were used to evaluate and optimize the effects of three independent variables including lipid, polymer, and polyvinyl alcohol (PVA) ratios on the nanoparticles (NPs) size and drug entrapment efficiency (EE%). Hybrid NPs were prepared using the nanoprecipitation method. The results demonstrated that spherical NPs were synthesized, and the rate of EE% went up by increasing the polymer as well as dec...
Source: Iranian Journal of Pharmaceutical Research - June 7, 2021 Category: Drugs & Pharmacology Source Type: research

Semi-Synthesis of New 1,2,3-Triazole Derivatives of 9-Bromonoscapine and their Anticancer Activities
Novel 1,2,3-triazole-tethered 9-bromonoscapine derivatives were synthesized by the propargylation of N-nornoscapine followed by Huisgen’s 1,3-dipolar cycloaddition of the terminal alkynes with different azides. Cytotoxicity of the products was studied by MTT assay against the MCF-7 breast cancer cell line. Most of the compounds revealed a better cytotoxicity than N-nornoscapine and 9-bromonornoscapine as the parent compounds. Among the synthesized compounds, those with a hydroxylated aliphatic side chain (5p, 5q, and 5r) showed the highest activities (IC50s: 47.2, 37.9, and 32.3μg/mL, respectively). Molecular dock...
Source: Iranian Journal of Pharmaceutical Research - May 31, 2021 Category: Drugs & Pharmacology Source Type: research

Synthesis, Antimicrobial Activity, and Molecular Docking Studies of Aminoguanidine Derivatives ...
A series of aminoguanidine derivatives containing an acylhydrazone moiety was designed based on combination principles to find new antibacterial agents with wide spectra and high activities. The synthesized compounds were characterized by spectral methods and screened for their antibacterial activity. The results showed that several compounds provided great antimicrobial activities against Gram-positive bacteria (including the multidrug-resistant clinical isolates). Especially, this series of compounds presented high potency against Staphylococcus aureus, among which the derivative 3f was the most promising one with a MIC ...
Source: Iranian Journal of Pharmaceutical Research - May 31, 2021 Category: Drugs & Pharmacology Source Type: research

Studying the Expression Efficiencies of Human Clotting Factor IX Analogs, Rationally-designed ...
Glyco-engineering has attracted lots of interest in studies dealing with the pharmacokinetics of therapeutic proteins. Based on our previous in-silico studies, two sites were selected in the N-terminal gamma-carboxy glutamic acid-rich (Gla) domain of the human clotting factor IX (hFIX) to add new N-glycosylation sites. Site-directed mutagenesis was employed to conduct K22N and R37N substitutions and introduce new N-glycosylation sites in the mature hFIX. The expression efficiencies of the mutants, in parallel with the wild-type hFIX (hFIXwt), were assessed in suspension adapted Chinese hamster ovary (CHO-s) cells at transc...
Source: Iranian Journal of Pharmaceutical Research - May 31, 2021 Category: Drugs & Pharmacology Source Type: research

Evaluation of the Effect of Dexmedetomidine on Postoperative Cognitive Dysfunction through A β ...
Postoperative cognitive dysfunction is a common postoperative neurological complication in elderly patients, and has some relationship with neuroinflammation. some studies have shown ability of dexmedetomidine to improve cognitive performance in elderly individuals who underwent thoracic surgery. Therefore, our study hypothesized that dexmedetomidine treatment may reduce the incidence of POCD in elderly patients.In addition,this study detected the antineuroinflammatory effects of dexmedetomidine byβ-amyloid aggregation inhibitors and release of cytokines in elderly patients . The results show that dexmedetomidine used...
Source: Iranian Journal of Pharmaceutical Research - May 31, 2021 Category: Drugs & Pharmacology Source Type: research

Quorum Sensing Inhibitors: Curbing Pathogenic Infections through Inhibition of Bacterial ...
Currently, most of the developed and developing countries are facing the problem of infectious diseases. The genius way of an exaggerated application of antibiotics led the infectious agents to respond by bringing a regime of persisters to resist antibiotics attacks prolonging their survival. Persisters have the dexterity to communicate among themself using signal molecules via the process of Quorum Sensing (QS), which regulates virulence gene expression and biofilms formation, making them more vulnerable to antibiotic attack. Our review aims at the different approaches applied in the ordeal to solve the riddle for QS inhi...
Source: Iranian Journal of Pharmaceutical Research - May 31, 2021 Category: Drugs & Pharmacology Source Type: research

Minimum Data Set for a Poisoning Registry: A Systematic Review
Poisoning, as a well-known medical condition, puts everyone at risk. As a data management tool, a registry plays an important role in monitoring the poisoned patients. Having a poisoning minimum data set is a major requirement for creating a poisoning registry. Therefore, the present systematic review was conducted in 2019 to identify the minimum data set for a poisoning registry. Searches were performed in four scientific databases, i.e., PubMed, Scopus, Web of Science, and Embase. The keywords used in the searches included minimum data set,“poison”, and“registry”. Two researchers independently eva...
Source: Iranian Journal of Pharmaceutical Research - May 31, 2021 Category: Drugs & Pharmacology Source Type: research

A Pilot Randomized, Clinical Trial of the Anti-pruritus Effect of Melatonin in Patients with ...
Pruritus is one of the disturbing complications induced by chronic liver disease (CLD), bearing a negative impact on patient quality of life and potentially resulting in early liver transplants. Given the main role of the autotaxin enzyme in pruritus induced by CLD and the suppressive effects of melatonin on the expression of the autotaxin gene, this study was designed to evaluate the antipruritic effect of melatonin in patients with CLD. A double-blind, cross-over, randomized, placebo-controlled pilot trial was conducted on patients with CLD -induced pruritis. Patients were randomly assigned to two groups where they recei...
Source: Iranian Journal of Pharmaceutical Research - May 31, 2021 Category: Drugs & Pharmacology Source Type: research

How Much Iranian Parents Know of and How Well They Practice Regarding Antibiotics?
This study aimed to evaluate ill children’s parents’ knowledge and practice of prescribed antibiotics. Our subjects included only parents with children up to 12 (inclusive) years of age in Tehran, Iran’s capital. A prospective cross-sectional survey was conducted at 203 health care centers in Tehran. Parents’ knowledge was evaluated using a 37-item researcher-made questionnaire, and their practice about antibiotics was measured with a self-stated questionnaire, followed by an observational method to gain a real insight into their practice. SPSS 22 was used to analyze the data.A total of 401 randomly...
Source: Iranian Journal of Pharmaceutical Research - May 31, 2021 Category: Drugs & Pharmacology Source Type: research