Iranian Journal of Pharmaceutical Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Inhibition of Different Pain Pathways Attenuates Oxidative Stress in Glial Cells: A Mechanistic ...
This study was aimed to investigate the protective effects of some selected analgesics in neuropathic pain-induced oxidative damage in the isolated glial cells of the rat brain. In this experiment, rats were randomly divided into 5 main groups. Rats in group 1 received no medication, whereas rats in groups 2 to 5 received ASA (aspirin), celecoxib, morphine, and etanercept daily, respectively. Each main group divides into 3 subgroups: normal, sham, and neuropathic pain model rats. The glial cells of the rat brain were isolated at different time points. Our results demonstrate that neuropathic pain induces ROS generation as ...
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research

An Overview on Quantum Dot-based Nanocomposites for Electrochemical Sensing on Pharmaceutical Assay
Quantum dots (QDs) are one of the first nanotechnological materials to be integrated with sensor technologies and have been widely anticipated to eventually find application chances in several commercial pharmaceutical and clinical products. They are one of the most important developments in the rapidly growing world of material science technology. The excellent properties of QDs may allow the design of simple, precise, and inexpensive electrochemical methods for the detection of pharmaceuticals. Electrochemical techniques offer accuracy, high sensitivity, low cost, simplicity, ease of preparation of the samples in a very ...
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research

Efficacy and Safety of 0.25% Timolol Gel in Healing Split-Thickness Skin Graft Site
As a common intervention among burn patients, skin graft has some risks such as infections and delay of wound healing. The aim of this study was to assess the efficacy and safety of topical 0.25% Timolol Gel (TG) in promoting wound healing in split-thickness skin graft donor sites. We conducted a double-blind, randomized clinical trial to assess re-epithelialization time, the level of pain based on the Visual Analog Scale (VAS), and the wound infection incidence. The scar status was also evaluated by the Vancouver Scar Scale (VSS) and the Patient and Observer Scar Assessment Scale (POSAS). Totally, 64 patients were random...
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research

Novel Cytotoxic Phenanthro-triazine-3-thiol Derivatives as Potential DNA Intercalators and ...
 Novel phenanthro-triazine-3-thiol derivatives were designed as potential DNA intercalators and Bcl-2 inhibitors. After being synthesized, the compounds were evaluated for their cytotoxic activity against MOLT-4 (human acute lymphoblastic leukemia) and MCF-7 (human breast adenocarcinoma) cells by MTT assay. P1 (bearing hydrogen substitution) was the most potent derivative against MOLT-4 with an IC50 value of 7.1± 1.1μM, whereas P11 (bearing phenyl substitution) demonstrated considerable cytotoxicity against MCF-7 with an IC50 value of 15.4± 2.9μM. Compounds P7, P8, P14 and P15 exhibited moderate cy...
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research

Ultrasound and Sonogenetics: A New Perspective for Controlling Cells with Sound
An important challenge in neurobiology is to stimulate a single neuron, especially in deep areas of the brain. The optogenetics methods need a surgical operation to convey light sources to targeted cells. Nowadays, non-invasive tools such as sonogenetics with the ability to modulate and visualizing cellular and molecular processes have attracted much attention. The study of the biological functions of living organisms always requires tools for monitoring and imaging dynamically. Current sonogenetic approaches use ultrasound as a non-invasive tool to precisely control cellular function. In general, sonogenetics includes the...
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research

Biological Activities and the Essential Oil Analysis of Cousinia harazensis and C. calocephala
In conclusion, C. harazensis with more phenol and flavonoids content showed better results in terms of biological activities.  (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research

An Observational Study on the Application of the Second-generation Radiopaque Subcutaneous Implant
To analyze the effect, side effects, and satisfaction of the second-generation radiopaque subcutaneous implant, providing healthcare workers a basis for propaganda and guidance. Methods: A total of 214 cases of healthy women with birth control requirements from August 2016 to June 2018 received ray subcutaneous implants. Quantitative surveys were administered 10 days, 3 months, 12 months, and 24 months later. All cases were implanted successfully. The number of effective cases was 211, with 3 cases lost to follow-up. The pregnancy rate of 211 subjects during receiving implant was 0. Changes in bleeding patterns (130 cases,...
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research

The Design, Synthesis and Evaluation of Rho-kinase Inhibitory Activity of 4-aryl-thiazole-2-amines
Rho-associated kinases (ROCK) are a class of serine/threonine kinases that play important roles in various biological processes. ROCK are becoming attractive targets for drug designing. A novel scaffold was designed according to molecular hybridization strategy, then a series of 4-aryl-5-aminomethyl-thiazole-2-amines were synthesized, and their inhibitory activities on ROCK were screened by enzyme-linked immunosorbent assay (ELISA). The results showed that 4-aryl-5-aminomethyl-thiazole-2-amines derivatives displayed certain ROCK II inhibitory activities. The IC50 value of the most potent compound 4v was found to be 20 nM. ...
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research

Chemical Variation, Antimicrobial, Nitric Oxide Scavenging Activities and Tyrosinase Inhibition ...
Volatile organic compositions of the essential oils (EOs), solid-phase microextraction (SPME) and SPME of n-hexane extracts from the flower and stem-leaf of Filipendula vulgaris (F. vulgaris) were analyzed by GC-FID/MS.  A total of 107 constituents were characterized, flower and stem-leaf parts of the plant were found to contain different volatile organic compounds. Tricosane (29.6%), n-nonanal (20.5%) were identified as the main components in the essential oil of the flower, while phytol (35.2%) was found to be a major constituent in the essential oil of stem-leaf. Benzaldehyde (56.0%) and n-nonanal (31.6%) were...
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research

Benefits and Risks of Melatonin in Hepatic and Pancreatic Disorders; A Review of Clinical Evidences
Melatonin is the " clock factor " produced from the pineal gland dominating regular circadian rhythm in mammalians. It is an indoleamine with potent multifunctional pharmacological effects, both receptor dependent and non-receptor dependent effects, including antioxidant and anti-inflammatory activities. The aim of this review is to summarize clinical evidence related to melatonin's effectiveness in the treatment of liver and pancreas diseases. Databases including PubMed, Scopus, and Cochran Library were searched up to November 2020.Finally, this review has summarized up-to-date clinical evidence to investigate the efficac...
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research

The Impact of Inflation and Its Uncertainty on Pharmaceutical Prices: Evidence from Iran
This study aimed to investigate the effect of inflation and its uncertainty on inflation in pharmaceutical prices in Iran. In this study, the monthly time series of consumer price index from 2001 to 2017 was used to calculate inflation uncertainty based on a generalized autoregressive conditional heteroscedasticity model. Hylleberg-Engle-Granger-Yoo test was performed to determine the stationary of the data. Feasibility tests were also used to explore the application of Autoregressive conditional heteroscedasticity family models to these data. The causal relationship between inflation uncertainty and inflation in the pharm...
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research

Exploration of Inbuilt Novel Properties as Bioretardant Cum Stabilizer of Isolated Biopolymer ...
The research aims to develop bionanosuspension using a biopolymer isolated from Fragaria ananassa fruit that constitutes potential and natural polymeric properties. At first, the biomaterial was isolated from the natural fruit pulp of Fragaria ananassa by an economical method of isolation. The model drug was nanosized by a novel sonication method. The isolated biopolymer was characterized for its polymeric properties, and its potential capabilities were evaluated in the delivery of nanosized phenytoin. The isolated biopolymer was characterized for DSC, FTIR, NMR, mass, and scanning electron microscopy. The isolated biomate...
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research

Psychiatric Adverse Drug Reactions and Potential Anti-COVID-19 Drug Interactions with ...
Coronavirus disease 2019 (COVID-19) management in patients with predisposing psychiatric disorders would be challenging due to potential drug-drug interactions (PDDIs) and precipitation of their disease severity. Furthermore, COVID-19 itself might precipitate or induce unpredicted psychiatry and neuropsychiatry complications in these patients. In this literature review study, the psychological impacts of COVID-19 and major psychiatric adverse drug reactions (ADRs) of COVID-19 treatment options have been discussed. A detailed Table has been provided to assess potential drug-drug interactions of COVID-19 treatment options wi...
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research

Comparison of HPLC and UV Spectrophotometric Methods for Quantification of Favipiravir in ...
There is no currently successful method to treat Covid-19 infection. Nevertheless, previously licensed pharmaceuticals to treat other virus infections are used on an off-label basis either alone or in combination. One of them is favipiravir. Favipiravir, also known as favilavir, is an antiviral drug that is active against many viruses. Spectrophotometric and liquid chromatographic methods have been developed and validated for the quantitative determination of favipiravir in pharmaceutical formulations. Chromatographic method has been performed using reverse-phase technique on a C-18 column with a mobile phas...
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research

Preliminary Study on Hepatoprotective Effect and Mechanism of (-)-Epigallocatechin-3-gallate ...
In this study, in-vitro and in-vivo experiments were carried out to verify the hepatoprotective effect of EGCG against APAP-induced liver injury and explore the potential mechanism. Results indicated that EGCG effectively relieved the liver injury caused by APAP, as well as APAP-induced mitochondrial dysfunction. The protective role of EGCG was not only attributed to its antioxidant capacity; but also might be related to the protective effect on hepatic mitochondrial impairment; based on that, EGCG could improve the membrane potential and activities of the respiratory chain complexes in liver mitochondria. Our study casts ...
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research