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The SARS-Cov-2 Proliferation Blocked by a Novel and Potent Main Protease Inhibitor via ...
In conclusion, we suggest that ZINC31157475can potentially treat COVID-19 by inhibition of the 3CLp. However, in-vitro and in-vivo study is essential for approval of this suggestion. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research

Self-emulsifying Drug Delivery System for Improved Dissolution and Oral Absorption of ...
In this study, we focused on quetiapine fumarate (QTF), a class II BCS drug. QTF is an atypical antipsychotic used in the treatment of schizophrenia and bipolar disorders. Our objective was to develop a new QTF-loaded self-emulsifying drug delivery system (SEDDS) to improve the dissolution and absorption of the drug. An experimental design approach was used to develop and optimize QTF-loaded SEDDS. The optimized formulation was characterized for droplets size, zeta potential, PDI, and stability. It was then evaluated using an in-vitro combined test for dissolution and Everted gut sac technique. Mathematical modeling and Tr...
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research

Investigation and Comparison of the Effect of TGF- β3, kartogenin and Avocado/Soybean ...
Due to the lack of suitable therapeutic approaches to cartilage defect, the objective of this study was to determine the effect of Transforming growth factor-β3 (TGF-β3), avocado/soybean (ASU) and Kartogenin (KGN) on chondrogenic differentiation in human adipose-derived stem cells (hADSCs) on fibrin scaffold. hADSCs seeded in fibrin scaffold and cultured in chondrogenic media. These cells were divided into 4 groups (control, TGF-β3, ASU and KGN). Cell viability was estimated by MTT assay. Differentiated cells were evaluated by histological and immunohistochemical (IHC) techniques. Expression genes [sex deter...
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research

Promising Hybrids Derived from S-Allylcysteine and NSAIDs Fragments against Colorectal Cancer: ...
We synthesized twelve hybrids, S-allyl Cysteine methyl, ethyl and propyl ester-based non-steroidal anti-inflammatory drugs and their structures were elucidated by spectroscopic analysis. The chemopreventive potential of all compounds was evaluated against SW480 human colon adenocarcinoma cells and the non-malignant CHO-K1 cell line. Among the tested compounds, hybrids 10b-c, 11b and 12b displayed the best anticancer activity with IC50 values between 0.131-0.183 mM and selectivity indices higher than 1 after 48 h of treatment. Selectivity indices were comparable to those reported for the reference drug, 5-fluorouracil (SI&g...
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research

The Feasibility Study of Plasma-activated Water as Physical Therapy to Induce Apoptosis in ...
In this study, a Helium (He) plasma jet operating in 0.75 W dissipated power and 15 kHz frequency was used as cold atmospheric plasma source. The electrical, thermal, and optical properties of the (He) plasma jet, as well as the pH, conductivity, and temperature of the PAW samples, Low-temperature plasma (LTP) has demonstrated great potential in biomedicine, especially in cancer therapy in-vivo and in-vitro. Plasma activated water (PAW) as an indirect plasma therapy is a significant source of reactive oxygen and nitrogen species (RONS) which play an important role in apoptosis induction in cancer cells. In this study, Heli...
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research

Histone Deacetylase Inhibitors, Intrinsic and Extrinsic Apoptotic Pathways, and Epigenetic ...
In conclusion, because histone deacetylation is a potentially reversible change, epigenetic histone modification represents new opportunities for cancer management by reactivation of gene silencing. The inhibition of HDACs by GDACIs can effectively induce apoptosis and suppress cancer cell proliferation. These compounds can engage both intrinsic and extrinsic apoptotic pathways. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research

Effect of Zebularine in Comparison to Trichostatin A on the Intrinsic and Extrinsic Apoptotic ...
Aberrant histone modifications or promoter region hypermethylation of tumor suppressor genes (TSGs) have been recognized as the important epigenetic molecular mechanism in cancer induction. The potential anticancer activities of histone deacetylase inhibitors (HDACIs) and DNA methyltransferase inhibitors (DNMTIs) have been investigated in recent years. The current study was assigned to investigate the effect of trichostatin A (HDACI) in comparison to zebularine (DNMTI) on the intrinsic pro-apoptotic (Bax, Bim, and Bak) and anti-apoptotic (Bcl-2, Mcl-1, and Bcl-xL) genes and extrinsic (DR4, DR5, FAS, FAS-L, and TRAIL genes)...
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research

PMSF Attenuates Morphine Antinociceptive Tolerance and Dependence in Mice: Its Association with ...
In conclusion, it seems that PMSF can suppress morphine tolerance and dependence. However, more studies are needed to clarify its mechanism.  (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research

Different Respiratory Samples for COVID-19 Detection by Standard and Direct Quantitative ...
This study aimed to compare the diagnostic performance of different samples for Coronavirus disease 2019 (COVID-19) detection. It was found that NPS, the reference respiratory specimen for COVID-19 detection, is more sensitive than OPS. However, the application of NPS has many drawbacks, including challenging sampling process and increased risk of transmission to healthcare workers (HCWs). Saliva samples can be collected less invasively and quickly by HCWs with less contact or by own patients, and they can be considered as an alternative to NPS for COVID-19 detection by RT-qPCR. Additionally, sputum, which demonstrates hig...
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research

Development of Novel Adhesive Bilayer Lyophilized Wafer of Moxifloxacin as a Modern Wound Dressing
Wound healing is a complex process and is influenced by different factors. Aimed to enhance the wound healing procedure, the Moxifloxacin bilayer wafer was designed, optimized and evaluated as an advanced wound healing dressing. The wafers were prepared by the lyophilization and casting method. Optimization was done according to the results of bioadhesion force, swelling index, release rate, T40 and T90 (the time to reach 40% and 90% of release). The optimized wafer was evaluated against in-vitro and in-vivo efficacy using the disc diffusion method and histologic evaluation after application on the wound. The optimize...
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research

Application of QSAR Method in the Design of Enhanced Antimalarial Derivatives of ...
The resistance of the P. falciparum strain to some of the antimalarial drugs has been a dominant dilemma facing the treatment of this fetid disease. This necessitates the detection and development of new antimalarial agents targeting the P. falciparum. Azetidine-2-carbonitriles reported for its antimalarial activities, could provide an alternative to the customized antimalarial drugs. Leading to the use of quantitative structure-activity relationship (QSAR) studies, which relates the structures of Azetidine-2-carbonitriles with their activities to generate predictive models. The structures were optimized using density func...
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research

Validation of a Multiclass Method for the Screening of 15 Antibiotic Residues in Milk Using ...
This study showed that the biochip-based technique is valid to identify and quantify antibiotic residues in milk at the studied validation levels. The method was rapid, easy, safe, and able to screen 13 sulphonamide, dapsone and trimethoprim from a single milk sample simultaneously with no sample preparation procedure (or just one-step centrifugation). (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research

Assessment of Cytotoxic and Apoptotic Effects of Salvia syriaca L. ...
This work is aimed to elucidate cytotoxic and apoptotic effects of Salvia syriaca essential oil and its chemical composition by GC-MS. The human colon cancer cells (Caco-2) were treated with different essential oil concentrations for 24 h. Crystal violet test was used to determine cell viability at 630 nm by using an ELISA reader. Apoptotic processes were measured by Annexin V-FITC Apoptosis Assay Kit. Germacrene D (21.77%), trans-β-ocimene (14.66%),β-pinene (9.07%),α-cadinol (8.19%) andα-pinene (6.50%) were the main components of oil determined by GC-MS. Moreover, we observed that the cytotoxic effec...
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research

Private Demand for Covid-19 Vaccine: A Contingent Assessment from a Low-and Middle-income Country
This study aimed to estimate Iranian willingness to pay (WTP) for a hypothetical COVID-19 vaccine and its determinants. A cross-sectional online survey was conducted from May 2nd to 20th, 2020 among the general population of Iran to estimate WTP for hypothetical COVID-19 vaccines. Four scenarios with different levels of efficacy and duration of protection were presented to respondents in the payment card scale of the contingent valuation method (CVM). With the corresponding WTPs under di fferent scenarios, mean, trimmed mean, median WTP values, and vaccine demand was estimated. A semi-log regression model was employe...
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research

Adjunct Hypertonic Saline in Patients with Diffuse Edema Due to Heart Failure: A Randomized ...
In patients with diuretic resistance due to heart failure, higher doses or continuous furosemide infusion and adding hypertonic saline solution (HSS) to diuretics could be effective. The goal of this study was to assess the effectiveness of hypertonic saline solution administration in weight loss of hospitalizedpatients with diuretic-resistant edema due to heart failure. In a randomized double-blinded clinical trial, adult patients with diffuse peripheral edema due to heart failure who were unresponsive to 80 mg of oral furosemide were enrolled. The patients were randomized into two groups. In the intervention and control ...
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research