Immunopathology of sarcoidosis.
Abstract The immunopathology of sarcoidosis remains elusive despite years of research into this multiorgan disease.However, recent studies have provided new insights into the genetics and immune components involved in the clinical manifestation of the disease. Granulomatous inflammation is due to the host immune response to a persistent poorly degradable unknown antigen.Mycobacterium tuberculosis (MTB) is the major disease driver in many patients. The immune mechanisms that cause this disease start with the antigenic stimulus, followed by T-cell, macrophage and dendritic cell activation via a classic MHC II-mediat...
Source: Iranian Journal of Allergy, Asthma and Immunology - August 31, 2014 Category: Allergy & Immunology Authors: Mortaz E, Masjedi MR, Tabarsi P, Pourabdollah M, Adcock IM Tags: Iran J Allergy Asthma Immunol Source Type: research

Evaluation of the adjuvant activity of propranolol, a Beta-adrenergic receptor antagonist, on efficacy of a malaria vaccine model in BALB/c mice.
In this study PRP was used as an adjuvant in combination with Plasmodium berghei (P. berghei) whole blood stage (PWBS) antigens. BALB/c mice were immunized three times with a 2-week interval, either PWBS vaccine alone or in combination with the adjuvant alum or propranolol. The control group received phosphate buffered saline. Evaluation of the cellular and humoral immunity was performed by measurement of interferon (IFN)-γ, tumor necrosis factor (TNF)-α, lymphocyte proliferation, total IgG and IgG2a in the control and immunized groups. Furthermore, Clinical evaluations were carried out by analyze survival rate...
Source: Iranian Journal of Allergy, Asthma and Immunology - August 31, 2014 Category: Allergy & Immunology Authors: Shahabi S, Mohammadzadeh Hajipirloo H, Keramati A, Hazrati Tappeh K, Bozorgomid A Tags: Iran J Allergy Asthma Immunol Source Type: research

Effects of inhaled L-arginine administration in a murine model of acute asthma.
Abstract Increased arginase activity in the airways decreases L-arginine and causes deficiency of bronchodilating and anti-inflammatory nitric oxide (NO) in asthma. As, it is suggested that L-arginine may have therapeutic potential in asthma treatment, we aimed to investigate the effects of inhaled L-arginine on oxygen saturation (SaO2) and airway histology in a murine model of acute asthma. Twenty eight BALB/c mice were divided into four groups; I, II, III and IV (control). All groups except the control were sensitized and challenged with ovalbumin. After establishement of acute asthma attack by metacholine admin...
Source: Iranian Journal of Allergy, Asthma and Immunology - August 31, 2014 Category: Allergy & Immunology Authors: Arikan-Ayyildiz Z, Karaman M, Firinci F, Kiray M, Bagriyanik A, Yilmaz O, Uzuner N, Karaman O Tags: Iran J Allergy Asthma Immunol Source Type: research

Effect of Dexamethasone and Nigella sativa on Inducible Nitric Oxide Synthase in the Lungs of a Murine Model of Allergic Asthma.
Abstract The aim of this study was to investigate the effects of Nigella sativa (NS) fixed oil in comparison to dexamethasone (Dex) on inducible nitric oxide synthase (iNOS), peripheral blood eosinophils (PBE), allergen specific serum IgG1 and interleukins and airway inflammation in a murine model of allergic asthma. Thirty-one mice were divided into four groups. Group I (n = 6) served as the control group. Group II (n = 10) mice were sensitized intraperitoneally and challenged intratracheally with cone albumin with no treatment. Group III(n = 6) mice were sensitized, challenged, and treated with Dex for 17 days s...
Source: Iranian Journal of Allergy, Asthma and Immunology - August 31, 2014 Category: Allergy & Immunology Authors: Abdel-Aziz M, Abass A, Zalata K, Abd Al-Galel T, Allam U, Karrouf G Tags: Iran J Allergy Asthma Immunol Source Type: research

Comparison of Essential Fatty Acid Intakes and Serum Levels of Inflammatory Factors between Asthmatic and Healthy Adults: A Case- Control Study.
This study was conducted to compare dietary intakes of essential fatty acids and serum levels of inflammatory factors in asthmatic and healthy adults, and to examine the potential relationship between inflammatory markers and dietary fatty acids. In this case-control study, 47 asthmatic patients (26 males and 21 females) were compared with 47 controls (24 males and 23 females). Blood samples were taken from case and control groups and tumor necrosis factor-α (TNF-α), high sensitive C-reactive protein (hs-CRP), leptin and adiponectin were determined. Dietary intakes were assessed by semi-quantitative food freque...
Source: Iranian Journal of Allergy, Asthma and Immunology - August 31, 2014 Category: Allergy & Immunology Authors: Haidari F, Mohammadshahi M, Borsi SH, Haghighizadeh MH, Malgard S Tags: Iran J Allergy Asthma Immunol Source Type: research

Effect of age and eosinophil number on fractional exhaled nitric oxide level in non-asthmatic children in shanghai.
This study aimed to identify the relationship between fractional exhaled nitric oxide (FeNO) level and potential factors in non-asthmatic children from Shanghai, China. From March to April 2012, the school-aged children fulfilling the inclusion criteria were recruited. The FeNO levels of non-asthmatic children were detected by the Nano Coulomb nitric oxide analyzer. Questionnaires were recorded, including personal data, family illness history and daily habits. In addition, not only the number of leukocytes and eosinophils but also the level of hemoglobin in peripheral blood, were measured via the automated blood cell analy...
Source: Iranian Journal of Allergy, Asthma and Immunology - August 31, 2014 Category: Allergy & Immunology Authors: Liu W, Chu J, Sun L, Shen Z, Liu Y, Peng Q, Gao X Tags: Iran J Allergy Asthma Immunol Source Type: research

Prevalence and Risk Factors of Asthma and Allergic Diseases in Primary Schoolchildren Living in Bushehr, Iran: Phase I, III ISAAC Protocol.
Abstract Asthma and allergic diseases present a major health burden. Information on the prevalence of these diseases indicates that these diseases are increasing in various parts of the world. It was hoped that this study would be helpful to health system policy-makers in planning allergy prevention programs in the region.The prevalence of asthma and allergic diseases and relation between the various risk factors involved were assessed among schoolchildren in the city of Bushehr, Iran. The ISAAC Phase I and III questionnaires were completed by parents of 1280 children aged 6-7 years and self-completed by 1115 stud...
Source: Iranian Journal of Allergy, Asthma and Immunology - August 31, 2014 Category: Allergy & Immunology Authors: Farrokhi S, Gheybi MK, Movahhed A, Dehdari R, Gooya M, Keshvari S, Gholampour H, Mansourian Z, Khosravi Y, Ghahramani F, Zandi S, Etemadan R, Tahmasebi R, Reaisi A, Keshmiri S, Fadaizadeh L, Masjedi MR Tags: Iran J Allergy Asthma Immunol Source Type: research

The ITGAV-rs3911238 Polymorphism Is Associated with Disease Activity in Rheumatoid Arthritis.
This study investigated association of four single nucleotide polymorphisms (SNPs) in ITGAV with disease activity score (DAS28), serum levels of C-reactive protein (CRP), and anti-cyclic citrullinated peptide(anti-CCP) antibody in 419 RA patients and 398 healthy individuals. Four SNPs in ITGAV gene (rs3911238, rs3738919, rs10174098 and rs3768777) were analyzed. Serum concentrations of anti-CCP antibody and CRP were measured by ELISA. We used the EULAR activity criteria to calculate DAS28-CRP. Among these SNPs, the ITGAV-rs3911238-G/C polymorphism was associated with RA disease activity [remission-to-low and moderate-to-hig...
Source: Iranian Journal of Allergy, Asthma and Immunology - August 31, 2014 Category: Allergy & Immunology Authors: Shakiba E, Tavilani H, Goodarzi MT, Kiani A, Pourmotabbed T, Vaisi-Raygani A Tags: Iran J Allergy Asthma Immunol Source Type: research

The HLA-G 14bp insertion/deletion polymorphism in Women with Recurrent Spontaneous Abortion.
Abstract HLA-G is a non-classical HLA class Ib molecule with limited protein variability generated by alternative splicing. HLA-G displays immunotolerant properties and hence plays important roles in the maintenance of a successful pregnancy and maternal tolerance of the semiallogenic fetus. Polymorphism of the HLA-G gene may potentially affect the biological properties of the protein, and a 14-bp insertion/deletion polymorphism in exon 8 of the 3' untranslated region (3' UTR) of the HLA-G gene is thought to influence HLA-G expression. To study the association of the 14-bp insertion/deletion (INDEL) polymorphism w...
Source: Iranian Journal of Allergy, Asthma and Immunology - August 31, 2014 Category: Allergy & Immunology Authors: Afkhami F, Shekari Khaniani M, Farzadi L, Paknejad Z, Mansoori Derakhshan S Tags: Iran J Allergy Asthma Immunol Source Type: research

Allergic and nonallergic asthma in children: are they distinct phenotypes?
Abstract The aim of current study is to describe clinical similarities and differences between atopic and non-atopic asthma in children. In a cross-sectional study, 95 asthmatic children (75 allergics and 20 nonallergics) were included in the study. Demographic, clinical, and familial history were compared between two groups. There was no significant differences between variables like sex, age of onset (p=0.75), severity (p=0.70), and family history among the two groups (p=0.42). Patients with allergic asthma were significantly older than those with non- allergic asthma (11.28±3.19 and 9.75±2.35 year...
Source: Iranian Journal of Allergy, Asthma and Immunology - August 31, 2014 Category: Allergy & Immunology Authors: Mahdaviani SA, Mohajerani SA, Fakhri M, Ebrahimi M, Bashardoost B, Razavi SJ, Toolabi M, Tajik A, Khalilzadeh S, Masjedi MR Tags: Iran J Allergy Asthma Immunol Source Type: research

Progesterone Skin Test in Severe Attacks of Angioedema during Menstrual Cycle.
We present a case of 24-year-old woman showing severe angioedema attacks occurring from the first day of her menstruation and continuing for 4-5 days and having positive progesterone intradermal test (IDT). To our knowledge, there is no case in the literature which is coupled with PH isolated angioedema attacks. In this case report we will discuss diagnostic value of progesterone IDT. PMID: 25150080 [PubMed - in process] (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - August 31, 2014 Category: Allergy & Immunology Authors: Yerebasmaz N, Kutlu A, Aydin E, Karabacak E, Ozturk S, Gun I Tags: Iran J Allergy Asthma Immunol Source Type: research

Anti-cyclic citrullinated Peptide antibody and rheumatoid factor isotypes in Iranian patients with rheumatoid arthritis: evaluation of clinical value and association with disease activity.
In this study we determined the frequency, sensitivity and specificity of anti cyclic citrullinated peptides (anti-CCP) IgG antibody, total rheumatoid factor (RF-T), and RF isotypes in Iranian patients with rheumatoid arthritis (RA) and their association with age, clinical and serological parameters. Anti-CCP and RF-T and RF isotypes level were measured in 418 patients and 399 healthy controls by enzyme-linked immunosurbant assay (ELISA). Additionally, serum C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), visual analog scale (VAS) and disease activity score (DAS28) were evaluated in RA patients. The anti-CC...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 29, 2014 Category: Allergy & Immunology Authors: Shakiba Y, Koopah S, Jamshidi AR, Amirzargar AA, Massoud A, Kiani A, Nicknam MH, Nazari B, Nikbin B Tags: Iran J Allergy Asthma Immunol Source Type: research

Altered Pattern of Naïve and Memory B cells and B1 Cells in Patients with Chronic Granulomatous Disease.
Altered Pattern of Naïve and Memory B cells and B1 Cells in Patients with Chronic Granulomatous Disease. Iran J Allergy Asthma Immunol. 2014 Jun;13(3):157-65 Authors: Mohsenzadegan M, Fattahi F, Fattahi F, Mirshafiey A, Fazlollahi MR, Naderi Beni F, Movahedi M, Pourpak Z Abstract Chronic granulomatous disease (CGD) is a rare primary immunodeficiency disorder characterized by a greatly increased susceptibility to severe fungal and bacterial infections caused by defects in NADPH oxidase of phagocytic cells. We aimed to investigate immunophenotype alterations of naïve and memory B cells and B1a cell...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 29, 2014 Category: Allergy & Immunology Authors: Mohsenzadegan M, Fattahi F, Fattahi F, Mirshafiey A, Fazlollahi MR, Naderi Beni F, Movahedi M, Pourpak Z Tags: Iran J Allergy Asthma Immunol Source Type: research

Otological findings in pediatric patients with hypogammaglobulinemia.
This study was designed to investigate clinical and paraclinical otological complications in major types of PAD. A cross sectional study was conducted on 55 PAD patients with diagnosis of selective IgA deficiency, common variable immunodeficiency (CVID), X-linked agammaglobulinemia (XLA), and hyper IgM syndrome. All patients underwent otological examinations, audiometry, and auditory brain stem response. Otological complications were detected in 54.5% of PAD patients. Conductive hearing loss was the main finding amongst PID patients (73.3%) followed by sensorineural hearing loss which was present in 8 cases. Otitis media w...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 29, 2014 Category: Allergy & Immunology Authors: Tavakol M, Kouhi A, Abolhassani H, Ghajar A, Afarideh M, Shahinpour S, Aghamohammadi A Tags: Iran J Allergy Asthma Immunol Source Type: research

The Effect of Conventional Immunosuppressive Therapy on Cytokine Serum levels in Pemphigus Vulgaris Patients.
In conclusion, IL-1β and IL-6 could be involved in the pathogenesis of pemphigus vulgaris. The positive trend of IL-22 is a new finding and should be confirmed by further studies. PMID: 24659121 [PubMed - in process] (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - March 29, 2014 Category: Allergy & Immunology Authors: Mortazavi H, Esmaili N, Khezri S, Khamesipour A, Vasheghani Farahani I, Daneshpazhooh M, Rezaei N Tags: Iran J Allergy Asthma Immunol Source Type: research

Interferon-gamma gene polymorphism +874 (a/t) in chinese children with henoch-schönlein purpura.
Interferon-gamma gene polymorphism +874 (a/t) in chinese children with henoch-schönlein purpura. Iran J Allergy Asthma Immunol. 2014 Jun;13(3):184-9 Authors: Xu H, Li W, Fu H, Jiang G Abstract The aim of this study was to investigate the possible influence of Interferon-gamma (IFN-γ) gene polymorphism +874 (A/T) (rs2430561) in the susceptibility and renal complications of patients with Henoch-Schonlein purpura (HSP). We also studied the effects of IFN-γ allelic variation on serum levels of pro-and anti-inflammatory cytokines in HSP patients. The study population comprised 97 patients suffe...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 29, 2014 Category: Allergy & Immunology Authors: Xu H, Li W, Fu H, Jiang G Tags: Iran J Allergy Asthma Immunol Source Type: research

Evaluation of The Correlation and Reproducibility between Histamine, IL-4, and IL-13 Release from Human Basophils.
Abstract Human basophils play a key role in allergic diseases such as asthma and in a variety of immunological disorders. The generation of IL-4 and IL-13 can be induced from basophil by IgE-mediated and non-IgE-mediated mechanisms. Time and stimulus-dependent differences in the regulation of these cytokines could have relevance to their biological effects. The aim of the present study was activation of basophils in order to evaluate the extent of histamine, IL-4, and IL-13 generations. Basophil-enriched suspensions were prepared by Percoll gradients. The release of histamine and cytokines was assessed after activ...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 29, 2014 Category: Allergy & Immunology Authors: Eskandari N, Bastan R, Ahmadi M, Peachell PT Tags: Iran J Allergy Asthma Immunol Source Type: research

Effects of Imatinib Mesylate in Mouse Models of Multiple Sclerosis and In vitro Determinants.
Abstract Experimental autoimmune encephalomyelitis (EAE) is a mouse model for multiple sclerosis (MS), This autoimmune disease is mainly mediated by adaptive and innate immune responses that lead to an inflammatory demyelination and axonal damage. Imatinib mesylate is a selective protein tyrosine kinase inhibitor with immunomodulatory properties that abrogates multiple signal transduction pathways in immune cells. In the present research, our aim was to test the therapeutic efficacy of imatinib in experimental model of MS. We performed EAE induction in 23 female C57 mice by myelin oligodendrocyte glycoprotein-35-5...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 29, 2014 Category: Allergy & Immunology Authors: Azizi G, Haidari MR, Khorramizadeh M, Naddafi F, Sadria R, Javanbakht MH, Sedaghat R, Tofighi Zavareh F, Mirshafiey A Tags: Iran J Allergy Asthma Immunol Source Type: research

HLA-G allele and Haplotype Frequencies in a Healthy Population of Iran.
According to this study, the most prevalent alleles in the Iranian population were G*01:01:01:01 (52.5%), G*01:01:02 (16%) and G*01:04:03 (14.5%) and also the lowest alleles regarding the frequency were G*01:01:01:06 (0.5%) and G*01:03 (0.5%). The results of G*01:01:01:01 and G*01:04:01 frequencies showed some similarities with the polish population. Our results were similar to the north Indian population for the frequencies of G*01:06 and G*01:01:02. PMID: 24659125 [PubMed - in process] (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - March 29, 2014 Category: Allergy & Immunology Authors: Kuroshli Z, Gourabi H, Bazrgar M, Sanati MH, Bahraminejad E, Anisi K Tags: Iran J Allergy Asthma Immunol Source Type: research

A patch test confirmed phenobarbital-induced fixed drug eruption in a child.
Abstract A-10-year-old girl was referred to our department for multiple hyperpigmented plaques. One week previously, she had been given one suppository of acetylsalicylic acid - phenobarbital for fever. Twelve hours after the drug intake the child developed pruritic red plaques on the left thigh. Six weeks after resolution of the acute reaction, patch tests were performed separately, with phenobarbital and acetylsalicylic acid. On 48-hour reading, only the phenobarbital patch test on residual pigmented lesion was positive. Because of possible cross-reactions between aromatic anticonvulsants, subsequent patch tests...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 29, 2014 Category: Allergy & Immunology Authors: Chadly Z, Aouam K, Chaabane A, Belhadjali H, Abderrazzak Boughattas N, Zili JE Tags: Iran J Allergy Asthma Immunol Source Type: research

Significance of Immunostaining Data in IgA Nephropathy Patients; Current Knowledge and New Concepts.
Abstract No Abstract. PMID: 24659127 [PubMed - as supplied by publisher] (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - March 29, 2014 Category: Allergy & Immunology Authors: Baradaran A, Nasri H Tags: Iran J Allergy Asthma Immunol Source Type: research

T cell immune responses in psoriasis.
Abstract A central role for T cells and their cytokines in the pathogenesis of psoriasis has been proposed; however, there are controversies over the details of this issue. The goal of this study is to summarise currently available data on the importance of T cells in psoriasis pathogenesis.A systematic review of the English medical literature was conducted by searching PubMed, Embase, ISI Web of Knowledge, and Iranian databases including Iranmedex, and SID for studies on associations between the involvement of T cell subsets and psoriasis.The results of the present study indicate that alterations in the number an...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 29, 2014 Category: Allergy & Immunology Authors: Jadali Z, Eslami MB Tags: Iran J Allergy Asthma Immunol Source Type: research

Effects of enzymatic hydrolysis on the allergenicity of whey protein concentrates.
In this study, WPC were hydrolyzed by trypsin and twenty-four BALB/c mice were divided into three groups and fed with WPC formula and WPC hydrolysates formula, while the control mice received milk-free diet.The results revealed that there was no significant difference between the body weights among all groups. WPC-fed mice produced an elevated spleen lymphocyte proliferation level than WPC hydrolysates-fed mice and also produced higher levels of WPC-specific IgE in intestinal tract and serum in comparison to WPC hydrolysates-fed mice and control group. Significant up-regulation of plasma histamine levels were also observed...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 29, 2014 Category: Allergy & Immunology Authors: Duan C, Yang L, Li A, Zhao R, Huo G Tags: Iran J Allergy Asthma Immunol Source Type: research

Component-Resolved Diagnosis (CRD): Is It Worth It? Frequency and Differentiation in Rhinitis Patients with Mite Reactivity.
Abstract Component-resolved diagnosis (CRD) using microarray technology has recently been introduced with the aim to improve diagnosis of allergy. The aim of this study was to compare performance of this allergen microarray to those of an established extract-based skin prick testing (SPT).45 patients with allergic rhinitis were studied (16 children and 29 adults). SPT to Dermatophagoides pteronyssinus, Dermatophagoides farinae and Blomia tropicalis extracts and allergen microarray ImmunoCAP ISAC were carried out for all patients. Forty out of 45 patients demonstrated positive SPT to all mite extracts tested. These...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 29, 2014 Category: Allergy & Immunology Authors: Mohamad Yadzir ZH, Misnan R, Abdullah N, Bakhtiar F, Leecyous B, Murad S Tags: Iran J Allergy Asthma Immunol Source Type: research

The effects of high fat, low carbohydrate and low fat, high carbohydrate diets on tumor necrosis factor superfamily proteins and proinflammatory cytokines in C57BL/6 mice.
In this study, we investigated the effect of dyslipidemia on RANKL and OPG alongside with pro-inflammatory cytokines. Thirty male C57Bl/6 mice (4 weeks old) were randomized to two purified diet groups (15 animals in each group), high fat, low carbohydrate diet (HFLCD) and its matched low fat, high carbohydrate diet (LFHCD). After 12 weeks of feeding in standard situations, the plasma concentration of lipid profile, interleukin (IL)1Beta,, IL-6, tumor necrosis factor-alpha (TNF-α) and RANKL, OPG, and RANKL: OPG ratio were measured.In the present study, although the body weight significantly increased during 12 weeks i...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 29, 2014 Category: Allergy & Immunology Authors: Sirjani M, Taleban FA, Hekmatdoost A, Amiri Z, Pellizzon M, Hedayati M, Bidad K, Shokouhi Shoormasti R, Pourpak Z Tags: Iran J Allergy Asthma Immunol Source Type: research

Alleviation of experimental allergic encephalomyelitis in C57BL/6 mice by soy daidzein.
In conclusion, daidzein reduced the extent of demyelination and disease severity. Chronic oral therapy with low dose of daidzein did not prevent experimental autoimmune encephalomyelitis. However, high doses of daidzein could prohibit disease exacerbation.  PMID: 24659161 [PubMed - in process] (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - March 29, 2014 Category: Allergy & Immunology Authors: Razeghi Jahromi S, Arrefhosseini SR, Ghaemi A, Alizadeh A, Moradi Tabriz H, Togha M Tags: Iran J Allergy Asthma Immunol Source Type: research

Expression of CD11b as an Adhesion Molecule on Neutrophils in Children with Kawasaki Disease.
Abstract Inflammation of blood vessels is a characteristic feature of Kawasaki disease. Neutrophils play a key role in the inflammatory responses where movement of neutrophils toward the site of inflammation depends on CD11b/CD18 expression as adhesion molecules on these cells. The purpose of this study was to investigate CD11b/CD18 expression in patients with Kawasaki disease upon diagnosis and after treatment.The study included 20 children with Kawasaki disease aged from 3 months to 8 years. Mean fluorescence intensity of CD11b levels on diagnosis and at 1-2 and 6 weeks after intravenous immunoglobulin (IVIG) th...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 29, 2014 Category: Allergy & Immunology Authors: Heidari B, Amin R, Kashef S, Alyasin S, Moghtaderi M, Aminshahidi M, Kalani M Tags: Iran J Allergy Asthma Immunol Source Type: research

YKL-40 in Asthma and its Correlation with Different Clinical Parameters.
Abstract It has been suggested that elevated serum level of YKL-40 could be a marker for asthma and its severity. Along with few published studies, we investigated its correlation with asthma and its severity as well as spirometric indices.114 patients with asthma and 114 healthy controls underwent the assessment of serum level of YKL-40 (by ELISA) and spirometric indices. Pearson's coefficient determined the correlation between the variables and multivariate linear regression analysis was used for adjusting the effect of different probable confounding factors.Serum levels of YKL-40 were significantly higher in th...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 29, 2014 Category: Allergy & Immunology Authors: Saba M, Sharif MR, Akbari H, Nikoueinejad H, Ramazani Jolfaii M Tags: Iran J Allergy Asthma Immunol Source Type: research

The persian version of the chronic urticaria quality of life questionnaire: factor analysis, validation, and initial clinical findings.
Abstract Chronic urticaria (CU) also known as chronic idiopathic urticaria results in a lowered quality of life (QoL). Disease specific questionnaires are necessary to assess QoL in CU patients. Chronic Urticaria Quality of Life Questionnaire (CU-Q2oL) is the only available and validated disease specific questionnaire in the assessment of QoL in CU patients originally developed in Italian language. The aim of the current study was to develop the Persian version of the CU-Q2oL with an acceptable reliability and validity.Using the standard methods provided by guidelines, CU-Q2oL was translated into Persian. A total ...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 29, 2014 Category: Allergy & Immunology Authors: Tavakol M, Mohammadinejad P, Baiardini I, Braido F, Gharagozlou M, Aghamohammadi A, Nabavi M, Dabbaghzade A, Tavakol Z, Afarideh M, Rezaei N Tags: Iran J Allergy Asthma Immunol Source Type: research

Papillon Lefevre Syndrome and footsteps of mycobacterium tuberculosis.
Abstract Papillon Lefevre Syndrome ( PLS ) is a very rare genetic syndrome that only less than 500 cases have reported in the world. Patients have a typical cutaneous involvement with hyperkeratosis especially on the soles and palms and early shedding of primary teeth. Internal organs involvement such as liver abscess has been presented as case reports. This is for the first time that a genetically documented PLS with footsteps of mycobacterium tuberculosis in liver and kidney will report. PMID: 24659165 [PubMed - in process] (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - March 29, 2014 Category: Allergy & Immunology Authors: Zandieh F, Mirsaed Ghazi B, Izadi A, Gharegozlu M, Aghajani M, Sheikh M Tags: Iran J Allergy Asthma Immunol Source Type: research

Oleaceae pollen allergy and its cross-reactivity in the mediterranean area in the context of globalization.
Abstract Opening frontiers has led in the last two decades to a massive migration of Romanians to Spain and Italy, two countries known to have large areas planted with olives. Romania owns large areas planted with ash forests. Because of cross-reactivity between these two trees belonging to the Oleaceae family and the big allergenic potential of olive pollens, after a number of years of residence in these countries, many Romanians will present allergic respiratory symptoms of rhinitis and asthma, both in the season of olive pollination and ash pollination. PMID: 24659166 [PubMed - in process] (Source: Iranian...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 29, 2014 Category: Allergy & Immunology Authors: Berghi NO Tags: Iran J Allergy Asthma Immunol Source Type: research

Esomeprazole: a safe alternative to lansoprazole allergy?
Abstract Proton pump inhibitors (PPIs) are widely prescribed drugs in daily practice. Allergic reactions, even small number of anaphylactic reactions to PPIs have been reported. Omeprazole, lansoprazole, pantoprazole, rapeprazol and esomeprazole are classified in the same group. Despite the similarity of biochemical structures among these drugs, presence of cross-reactivity between PPIs is controversial.1,2 In this letter, we present 3 lansoprazole allergy cases, who were prescribed and took esomeprazole safely after allergic reactions to lansoprazole. PMID: 24659167 [PubMed - in process] (Source: Iranian Jou...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 29, 2014 Category: Allergy & Immunology Authors: Kara M, Tanoglu A, Kutlu A, Sirkeci O, Kekilli M Tags: Iran J Allergy Asthma Immunol Source Type: research

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Iran J Allergy Asthma Immunol. 2014 Aug;13(4):298-299 Authors: Hussain S Abstract No abstract. PMID: 24659168 [PubMed - as supplied by publisher] (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - March 29, 2014 Category: Allergy & Immunology Authors: Hussain S Tags: Iran J Allergy Asthma Immunol Source Type: research

Listeria Monocytogenes Protein Fraction Induces Dendritic Cells Maturation and T helper 1 Immune Responses.
In conclusion, Listeria protein activated-BMDCs can be used as a cell based vaccine to induce anti-tumor immune responses. PMID: 24338222 [PubMed - in process] (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2013 Category: Allergy & Immunology Authors: Saei A, Boghozian R, Mirzaei R, Jamali A, Vaziri B, Hadjati J Tags: Iran J Allergy Asthma Immunol Source Type: research

Rosiglitazone Inhibits HMC-1 Cell Migration and Adhesion Through a Peroxisome Proliferator-Activated Receptor Gamma-Dependent Mechanism.
In conclusion, RG inhibits the migration and adhesion of HMC-1 cells by a PPARγ-dependent mechanism. PMID: 24338223 [PubMed - in process] (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2013 Category: Allergy & Immunology Authors: Zhang G, Yang J, Li P, Cao J, Nie H Tags: Iran J Allergy Asthma Immunol Source Type: research

Lack of Association between Single Nucleotide Polymorphism rs10818488 in TRAF1/C5 Region and Rheumatoid Arthritis in Iranian Population.
Abstract The association of rs10818488 SNP located in TRAF1/C5 region with Rheumatoid Arthritis (RA), has been picked up by genome-wide association studies. Independent studies in different populations revealed inconsistent results. The aim of this study was to investigate the possible association of this SNP with RA in Iranian population.A total of 362 cases and 422 healthy controls were recruited in this study. Genomic DNA was extracted from whole blood and the genotyping was performed by PCR-RFLP (Polymerase Chain Reaction-Restriction Fragment Length Polymorphism). A set of genotypes was confirmed by sequencing...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2013 Category: Allergy & Immunology Authors: Ahmadlou S, Akhiani M, Salimzadeh A, Keramatipour M Tags: Iran J Allergy Asthma Immunol Source Type: research

Comparison of immunomodulating properties of Beta-lactoglobulin and its hydrolysates.
Abstract Cow's milk allergy is one of the most common food allergies in childhood. Beta-lactoglobulin (β- lg) is a dominant allergen in cow's milk. Hydrolysis is known as an effective method to reduce the allergenicity of proteins. Thus, the objective of this study was to compare the allergenicity of β-lg and its hydrolysates using an animal model.Twenty four BALB/c mice were divided into three groups and subcutaneously injected with native bovine β-lg and its hydrolysates on days 0, 7 and 14. During the sensitization period, a number of systemic anaphylactic indicators were observed in mice sensiti...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2013 Category: Allergy & Immunology Authors: Duan CC, Li AL, Yang LJ, Zhao R, Fan WG, Huo GC Tags: Iran J Allergy Asthma Immunol Source Type: research

Significant Changes of 5-Hydroxytriptamine 3A Receptor Gene Expression in Peripheral Blood Mononuclear Cells of Allergic Asthmatic Patients.
Abstract Asthma is a chronic inflammatory disorder of the airways. The stress is a factor for asthma which indicates a disorder in the function of communicational mediators of nervous and immunological systems such as neurotransmitters. A study indicated that blood serotonin concentration increases in asthmatic patients. Other study indicates that one kind of the serotonin receptors, named 5HT3A, on PBMCs causes secretion of series of pro-inflammatory cytokines which play important roles in allergic asthma disease. Thus, we evaluated the ratio expression level of 5HT3A subtype receptors in asthma.The Peripheral Bl...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2013 Category: Allergy & Immunology Authors: Mohammadi Amirabad L, Ahangari G, Derakhshan Deilami G Tags: Iran J Allergy Asthma Immunol Source Type: research

Chronic aspiration of gastric and duodenal contents and their effects on inflammatory cytokine production in respiratory system of rats.
Abstract Gastroesophageal reflux disease (GERD) is defined with clinical symptoms of heart burning and regurgitation. It may be associated with external esophageal symptoms such as chronic cough, asthma, laryngitis, chronic lung disease, sinusitis and pulmonary fibrosis. In the present study, rats with chronic aspiration of gastroduodenal contentswere studied for cellular phenotypes and cytokine concentrations in bronchoalveolar lavage and lung tissue.Thirty-six male Albino N-MRI rats were randomly divided into six groups. After anesthesia and tracheal intubation, the animals received either 0.5ml/kg of normal sal...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2013 Category: Allergy & Immunology Authors: Samareh Fekri M, Poursalehi HR, Najafipour H, Shahouzahi B, Bazargan Harandi N Tags: Iran J Allergy Asthma Immunol Source Type: research

The effect of personality disorders on asthma severity and quality of life.
Abstract Assesment of health related quality of life (HRQL) is increasingly recognized as an important part of the patient care in asthma. We aimed to evaluate the effect of personality disorders (PDs) on HRQL and the severity of disease in asthmatic patients.Ninety seven consecutive patients with asthma and ninety healthy controls were included. All patients completed a Short Form-36 health survey (SF-36) and Structured Clinical Interview Form for DSM-III-R Axis-II Disorders (SCID-II).All SF-36 questionnaire scores of asthmatic patients were significantly lower than the controls. There were statistical difference...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2013 Category: Allergy & Immunology Authors: Yılmaz A, Cumurcu BE, Etikan I, Hasbek E, Doruk S Tags: Iran J Allergy Asthma Immunol Source Type: research

Assessment of the quality of life in patients with bronchial asthma, before and after yoga: a randomised trial.
The objective of this study was to assess the effect of yoga on quality of life in patients with bronchial asthma.120 non-smoking male and female patients of asthma in the age group of 17-50 years were randomized into two groups i.e. Group A (Yoga group) and Group B (control group). All patients remained on their prescribed medication, but Group A patients practiced yoga breathing exercises for 8 weeks.Asthma Quality of Life Questionnaire (AQLQ) and diary record was used to assess quality of life, number and severity of asthmatic attacks, and the dosage of the medication required at baseline and after 8 weeks.Group A subje...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2013 Category: Allergy & Immunology Authors: Sodhi C, Singh S, Bery A Tags: Iran J Allergy Asthma Immunol Source Type: research

Prenatal diagnosis of leukocyte adhesion deficiency type-1 (five cases from iran with two new mutations).
Abstract Leukocyte adhesion deficiency type-1(LAD-1) is one of the immunodeficiency autosomal recessive diseases that results from mutation in integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) ITGB2 gene. The aim of this study was to investigate molecular prenatal diagnosis of LAD-1.Four pregnant women with five fetuses (one pregnancy was twin) with clinical and laboratory diagnosis of LAD-1 in their previous children were studied. The chorionic villus sampling (CVS) was obtained when mothers were in 10-12th weeks of gestation.Mutation analysis of ITGB2 gene for affected children revealed 3 missse...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2013 Category: Allergy & Immunology Authors: Esmaeili B, Ghadami M, Fazlollahi MR, Niroomanesh S, Atarod L, Chavoshzadeh Z, Moradi Z, Alizadeh Z, Pourpak Z Tags: Iran J Allergy Asthma Immunol Source Type: research

Disseminated aspergillosis as the herald manifestation of chronic granulomatous disease in an adult patient.
We report a disseminated aspergillosis as the representative of adult onset chronic granulomatous disease without previous infection, with dramatic response to combination of antifungal and interferon therapy.  PMID: 24338231 [PubMed - in process] (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2013 Category: Allergy & Immunology Authors: Alavi Darazam I, Akhavan Zanjani H, Sanaee D, Tabarsi P, Alavi Moghaddam M, Mansouri D Tags: Iran J Allergy Asthma Immunol Source Type: research

Abortion in Iranian legal system: a review.
Abstract Abortion traditionally means, "to miscarry" and is still known as a problem which societies has been trying to reduce its rate by using legal means. Despite the pregnant women and fetuses have being historically supported; abortion was firstly criminalized in 1926 in Iran, 20 years after establishment of modern legal system. During next 53 years this situation changed dramatically, so in 1979, the time of Islamic Revolution, aborting fetuses before 12 weeks and therapeutic abortion (TA) during all the pregnancy length was legitimate, based on regulations that used medical justification. After 19...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2013 Category: Allergy & Immunology Authors: Abbasi M, Shamsi Gooshki E, Allahbedashti N Tags: Iran J Allergy Asthma Immunol Source Type: research

Alteration in Frequency and Function of CD4+CD25+FOXP3+ Regulatory T cells in Patients with Immune Thrombocytopenic Purpura.
Abstract Immune thrombocytopenic purpura (ITP) is an autoimmune bleeding disorder characterized by production of auto-antibodies against platelet antigens. It is obvious that regulatory T cells (Tregs) have a major role in controlling immune homeostasis and preventing autoimmunity.To investigate the frequency and functions of Tregs, twenty ITP patients and twenty age- and sex-matched healthy controls were recruited. The peripheral blood mononuclear cells were isolated and the proportion of Tregs was defined by flow cytometry method. The expression of immune-regulatory markers, cytotoxic T-lymphocyte associated ant...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2013 Category: Allergy & Immunology Authors: Arandi N, Mirshafiey A, Jeddi-Tehrani M, Shaghaghi M, Sadeghi B, Abolhassani H, Sharifian RA, Rahiminejad MS, Aghamohammadi A Tags: Iran J Allergy Asthma Immunol Source Type: research

The Effects of Vitamin D on Allergen-Induced Expression of Interleukin-13 and Interleukin-17 in Cord Blood CD4+T Cells.
The objective of our study was to investigate the effects of 1,25-(OH)2D3 on allergen-stimulated expression of asthma related cytokines in cord blood T cells. Cord blood samples were collected from the umblilical vein of 24 term deliveries during labor, CD4+T cells derived from cord blood mononuclear cells (CBMCs), were cultured for 72 hours with ovalbumin (OVA), β-lactoglobulin (β-LG), respectively, in presence or absence of 1,25-(OH)2D3 to detect the levels of interleukin-13 (IL-13) and interleukin-17 (IL-17) in culture supernatants and the mRNA expressions in CD4+T cells. After allergens stimulation, CD4+T cel...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2013 Category: Allergy & Immunology Authors: Zhong H, Zhou XJ, Hong JG Tags: Iran J Allergy Asthma Immunol Source Type: research

Vitamin e supplementation, lung functions and clinical manifestations in children with moderate asthma: a randomized double blind placebo- controlled trial.
Abstract Asthma is the most common chronic inflammatory disorder characterized by cough, wheezing and dyspnea in children. Nutrition is an important factor which influences on induction and exacerbation of asthma. There are controversies to use Vitamin E in asthmatic patients. The aim of this study was to evaluate the effect of vitamin E supplement in children with moderate asthma. This is a randomized double blind placebo-controlled trial performed on children (age 2-17 years old) with moderate asthma (5-17 years old) from March 2010 to March 2012. Case group were treated with fluticasone and vitamin E (50mg/day)...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2013 Category: Allergy & Immunology Authors: Ghaffari J, Farid Hossiani R, Khalilian A, Nahanmoghadam N, Salehifar E, Rafatpanah H Tags: Iran J Allergy Asthma Immunol Source Type: research

Gastroesophagial reflux disease and asthma in pregnant women with dyspnea.
In conclusion, the prevalence of GERD was quite high in pregnant women, irrespective of the fact that they were asthmatic or non-asthmatic. Further studies evaluating women throughout pregnancy will inform us more about this relationship. PMID: 24338255 [PubMed - in process] (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2013 Category: Allergy & Immunology Authors: Bidad K, Heidarnazhad H, Pourpak Z, Shayestefar G, Moayeri H, Zendehdel N Tags: Iran J Allergy Asthma Immunol Source Type: research

Evaluation of immunological parameters in diabetic patients: are these patients immunodeficient?
Abstract It has been widely thought that diabetic patients are prone to infections due to hyperglycemia induced immunodeficiency; the present study was designed to examine this opinion. In diabetic patients and normal control groups T-cell reactivity to hsp-60 molecule, tetanus toxoid recall antigen (TT) and phytohemagglutinin-A (PHA) mitogen were evaluated The number of circulating IFN-γ, IL-10 and IL-13 cytokine producing cells stimulated with above antigens or mitogen as well as the serum levels of Th1/Th2 type cytokines were determined. Total serum immunoglobulins (IgG, IgA, IgM), C3, C4 and CH50 were al...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2013 Category: Allergy & Immunology Authors: Moazezi Z, Hosseinian A, Ahmad Moazam E, Eslami MB, Mosavi E, Akhavan-Niaki H, Bijani A, Schloot N, Mostafazadeh A Tags: Iran J Allergy Asthma Immunol Source Type: research

Mannan-binding lectin serum levels in 593 healthy Iranian children and adults.
Abstract Mannan-binding lectin (MBL) is a vital protein of innate immune system and has two critical functions: complement activation through the lectin pathway and opsonization. MBL deficiency has been classified as the most common inherited immunodeficiency known in humans (about 30% of the population), and is associated with predisposition to infections and high risk of some autoimmune diseases. The purpose of this study was to determine the profile of MBL serum level in Iranian healthy population in association with sex and age groups for the first time. We studied the serum concentration of MBL in 593 Iranian...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2013 Category: Allergy & Immunology Authors: Zahedifard S, Rashidi E, Shams S, Saghafi S, Fazlollahi M, Talebzadeh A, Kazemnejad A, Soltani A, Pourpak Z Tags: Iran J Allergy Asthma Immunol Source Type: research