Immune Profiling of SARS-CoV-2; What We Know and What We Don't Know
Iran J Allergy Asthma Immunol. 2023 Jun 16;22(3):217-232. doi: 10.18502/ijaai.v22i3.13050.ABSTRACTCoronavirus disease 2019 (COVID-19), described as World War 3, is the current worldwide health challenge and nearly all countries have so far faced this disaster. There is still no cure because of the complicated pathogenesis, however, there are several studies on track investigating different aspects of the immune response to the virus. In this review, we will provide an overview of recent investigations that have analyzed immune cells in patients with COVID-19. We will then discuss the differences in immune profiles between ...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Mahshid Zohouri Atri Ghods Mina Roshan Zamir Fazel Shokri Abbas Ghaderi Source Type: research

Exosomes from Adipose Tissue-derived Mesenchymal Stem Cells Induce Regulatory T Cells in COVID-19 Patients
This study aimed to assess the effect of MSC-derived exosomes (MSC-Exo) on the differentiation of peripheral blood mononuclear cells (PBMCs) into Tregs from patients with COVID-19. Exosomes were isolated from adipose tissue-derived MSCs. PBMCs were separated from the whole blood of COVID-19 patients (n=20). Treg frequency was assessed before and 48 hours after treatment of PBMCs with MSC-Exo using flow cytometry. Expression of FOXP3 and cytokine genes, and the concentration of cytokines associated with Tregs, were assessed before and after treatment with MSC-Exo. The frequency of CD4+CD25+CD127- Tregs was significantly hig...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Morteza Motallebnezhad Ali Hazrati Hadi Esmaeili Gouvarchin Ghaleh Nematollah Jonaidi-Jafari Sanaz Abbaspour-Aghdam Kosar Malekpour Mehdi Yousefi Hossein Samadi Kafil Farhad Jadidi-Niaragh Leila Roshangar Hamed Valizadeh Morteza Izadi Majid Ahmadi Source Type: research

Health Status and Inconveniences of Asthmatic Children During the First Year of the COVID-19 Pandemic
Iran J Allergy Asthma Immunol. 2023 Jun 16;22(3):245-253. doi: 10.18502/ijaai.v22i3.13052.ABSTRACTThe Coronavirus Disease 2019 (COVID-19) pandemic has been the most significant health concern in recent years, with respiratory symptoms being the most prominent. In children, asthma is the most prevalent chronic disease. Due to the similarities between the symptoms of these two conditions, we sought to assess the general health status of pediatric patients with asthma and their COVID-19-related difficulties during the first year of the pandemic in Iran. We collected data for this study by administering a questionnaire to the ...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Saber Gharagozlou Negin Rostamzadeh Mohammad Gharagozlou Source Type: research

Effect of Vitamin D on the HMGB1/RAGE Pathway and Adipokines Levels in Obese Asthmatic Mice
In this study, we, therefore, induced obesity and established an obese asthma mouse model using ovalbumin (OVA) stimulation and applied treatment with Vit D (100 ng/kg). Accordingly, thirty mice were randomly divided into 5 equal groups of normal control, asthma, obese asthma, asthma+Vit D, and obese asthma+ Vit D. The levels of inflammatory factors and adipokines were measured by the ELISA assay; then the quantitative reverse transcription PCR (qRT-PCR) method was used to evaluate the expression of high mobility group box 1(HMGB1) and receptor for advanced glycation end products [RAGE] genes.T he results showed that OVA s...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Yijia Fan Junguo Chen Xiaofeng Zhu Source Type: research

Formulation and Evaluation of the Anti-inflammatory, Anti-oxidative, and Anti-remodelling Effects of the Niosomal Myrtenol on the Lungs of Asthmatic Rats
Iran J Allergy Asthma Immunol. 2023 Jun 16;22(3):265-280. doi: 10.18502/ijaai.v22i3.13054.ABSTRACTAsthma is a common chronic allergic disease that affects a significant percentage of the world's population. Niosomes are nanoparticles consisting of non-ionic surfactants that can be used for drug delivery. This research was designed to investigate the impacts of inhalation of simple and niosomal forms of myrtenol against adverse consequences of asthma in rats. Asthma induction was performed via injection of ovalbumin, followed by its inhalation. Niosomes were created by a heating protocol, and their physicochemical features ...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Mohammad Amin Rajizadeh Mohammad Hadi Nematollahi Elham Jafari Mohammad Abbas Bejeshk Mehrnaz Mehrabani Farzaneh Rostamzadeh Mitra Samareh Fekri Hamid Najafipour Source Type: research

Anti-inflammatory Effects of Ziziphus Jujube Mill on LPS-induced Acute Lung Injury in Mice
Iran J Allergy Asthma Immunol. 2023 Jun 16;22(3):281-289. doi: 10.18502/ijaai.v22i3.13056.ABSTRACTZiziphus Jujuba Mill (Z.J) is a well-known ethnomedical source of biologically active compounds with anti-inflammatory effects. However, its significance in acute lung injury (ALI) has never been studied. The present study aimed to explore whether Z.J could attenuate lipopolysaccharide (LPS)-induced inflammatory responses in an experimental model of ALI. Male BALB/c mice received an intratracheal administration of LPS (n=32) or phosphate buffer saline (PBS) (control, n=8). Within 1, 11, and 23 h post-LPS injection, mice were r...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Parastoo Shaban Niloofar Honari Nafiseh Erfanian Mehran Hosseini Hossein Safarpour Saeed Nasseri Source Type: research

Clinical Characteristics and Economic Burden of Asthma in China: A Multicenter Retrospective Study
Iran J Allergy Asthma Immunol. 2023 Jun 16;22(3):290-298. doi: 10.18502/ijaai.v22i3.13057.ABSTRACTAsthma is a common chronic airway inflammation that produces a healthcare burden on the economy. We aim to obtain a better understanding of the clinical status and disease burden of patients with asthma in China. A retrospective study was carried out based on the computerized medical records in the Jinan Health Medical Big Data Platform between 2011 and 2019 (available data from 38 hospitals). The asthma severity of each patient was assessed retrospectively and categorized as mild, moderate, or severe according to Global Initi...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Bin Shang Xiangguo Li Yu Xu Wenxin Ren Junren Wang Chunyan Xing Shujuan Jiang Jian Sun Source Type: research

IL-25 Impact on Malignant B Cells Survival and T Cells Activation in Chronic Lymphocytic Leukemia
Iran J Allergy Asthma Immunol. 2023 Jun 16;22(3):299-311. doi: 10.18502/ijaai.v22i3.13058.ABSTRACTT cell dysregulation and shift to T helper 2 responses, boosting tumor microenvironment support, contributes to the survival of leukemic B cells in Chronic Lymphocytic Leukemia. Interleukin (IL)-25 is involved in the initiation of T helper 2 cell responses. Signal transduction of IL-25 begins with the heterodimer receptor (IL-17RA/IL-17RB). The presence of IL-25 in the tumor microenvironment may affect the supportive effects of T cells in the surrounding tumor cell environment. The purpose of this study was to evaluate the rol...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Mehrnoosh Pashei Farahnaz Ghahremanfard Ehsan Manouchehri Doulabi Maral Hemmati Fatemeh Pak Parviz Kokhaei Source Type: research

Serologic Biomarkers in Pemphigus Monitoring: C-reactive Protein, Macrophage Migration Inhibitory Factor, and Prolactin Levels Versus Autoantibody Assays
In conclusion, anti-Dsg1, anti-Dsg3, and IIF autoantibody titers remain standard biomarkers for assessing disease activity, severity, and PV monitoring. The trend of CRP was similar to that of anti-Dsg1, anti-Dsg3, and IIF. Thus, CRP may be used for PV monitoring.PMID:37524667 | DOI:10.18502/ijaai.v22i3.13059 (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Hossein Mortazavi Vahide Saeidi Kamran Balighi Nafiseh Esmaeili Amir Teimourpour Maryam Daneshpazhooh Shahin Hamzelou Zahra Saffarian Jafar Taghizadeh Fazli Source Type: research

Association of Interleukin-2 Gene Polymorphism with Henoch-sch ├Ânlein Purpura Nephritis
Iran J Allergy Asthma Immunol. 2023 Jun 16;22(3):319-326. doi: 10.18502/ijaai.v22i3.13060.ABSTRACTHenoch-Sch├Ânlein purpura nephritis (HSPN) is a common vasculitis that mostly affects children, and previous studies have indicated that genetic factors may influence disease susceptibility. The aim of this study was to evaluate a possible association of three interleukin-2 (IL-2) gene polymorphisms (rs3136534, rs2069776, and rs2069762) with HSPN in the Chinese population. A total of 81 patients with HSPN and 200 healthy children were enrolled. The distribution of genotypes, allelic frequencies, and haplotype frequencies among...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Jiajia Cao Junfeng Zhang Hui Xu Wei Li Jianrong Shi Qing Ye Source Type: research

Immune Profiling of SARS-CoV-2; What We Know and What We Don't Know
Iran J Allergy Asthma Immunol. 2023 Jun 16;22(3):217-232. doi: 10.18502/ijaai.v22i3.13050.ABSTRACTCoronavirus disease 2019 (COVID-19), described as World War 3, is the current worldwide health challenge and nearly all countries have so far faced this disaster. There is still no cure because of the complicated pathogenesis, however, there are several studies on track investigating different aspects of the immune response to the virus. In this review, we will provide an overview of recent investigations that have analyzed immune cells in patients with COVID-19. We will then discuss the differences in immune profiles between ...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Mahshid Zohouri Atri Ghods Mina Roshan Zamir Fazel Shokri Abbas Ghaderi Source Type: research

Exosomes from Adipose Tissue-derived Mesenchymal Stem Cells Induce Regulatory T Cells in COVID-19 Patients
This study aimed to assess the effect of MSC-derived exosomes (MSC-Exo) on the differentiation of peripheral blood mononuclear cells (PBMCs) into Tregs from patients with COVID-19. Exosomes were isolated from adipose tissue-derived MSCs. PBMCs were separated from the whole blood of COVID-19 patients (n=20). Treg frequency was assessed before and 48 hours after treatment of PBMCs with MSC-Exo using flow cytometry. Expression of FOXP3 and cytokine genes, and the concentration of cytokines associated with Tregs, were assessed before and after treatment with MSC-Exo. The frequency of CD4+CD25+CD127- Tregs was significantly hig...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Morteza Motallebnezhad Ali Hazrati Hadi Esmaeili Gouvarchin Ghaleh Nematollah Jonaidi-Jafari Sanaz Abbaspour-Aghdam Kosar Malekpour Mehdi Yousefi Hossein Samadi Kafil Farhad Jadidi-Niaragh Leila Roshangar Hamed Valizadeh Morteza Izadi Majid Ahmadi Source Type: research

Health Status and Inconveniences of Asthmatic Children During the First Year of the COVID-19 Pandemic
Iran J Allergy Asthma Immunol. 2023 Jun 16;22(3):245-253. doi: 10.18502/ijaai.v22i3.13052.ABSTRACTThe Coronavirus Disease 2019 (COVID-19) pandemic has been the most significant health concern in recent years, with respiratory symptoms being the most prominent. In children, asthma is the most prevalent chronic disease. Due to the similarities between the symptoms of these two conditions, we sought to assess the general health status of pediatric patients with asthma and their COVID-19-related difficulties during the first year of the pandemic in Iran. We collected data for this study by administering a questionnaire to the ...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Saber Gharagozlou Negin Rostamzadeh Mohammad Gharagozlou Source Type: research

Effect of Vitamin D on the HMGB1/RAGE Pathway and Adipokines Levels in Obese Asthmatic Mice
In this study, we, therefore, induced obesity and established an obese asthma mouse model using ovalbumin (OVA) stimulation and applied treatment with Vit D (100 ng/kg). Accordingly, thirty mice were randomly divided into 5 equal groups of normal control, asthma, obese asthma, asthma+Vit D, and obese asthma+ Vit D. The levels of inflammatory factors and adipokines were measured by the ELISA assay; then the quantitative reverse transcription PCR (qRT-PCR) method was used to evaluate the expression of high mobility group box 1(HMGB1) and receptor for advanced glycation end products [RAGE] genes.T he results showed that OVA s...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Yijia Fan Junguo Chen Xiaofeng Zhu Source Type: research

Formulation and Evaluation of the Anti-inflammatory, Anti-oxidative, and Anti-remodelling Effects of the Niosomal Myrtenol on the Lungs of Asthmatic Rats
Iran J Allergy Asthma Immunol. 2023 Jun 16;22(3):265-280. doi: 10.18502/ijaai.v22i3.13054.ABSTRACTAsthma is a common chronic allergic disease that affects a significant percentage of the world's population. Niosomes are nanoparticles consisting of non-ionic surfactants that can be used for drug delivery. This research was designed to investigate the impacts of inhalation of simple and niosomal forms of myrtenol against adverse consequences of asthma in rats. Asthma induction was performed via injection of ovalbumin, followed by its inhalation. Niosomes were created by a heating protocol, and their physicochemical features ...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Mohammad Amin Rajizadeh Mohammad Hadi Nematollahi Elham Jafari Mohammad Abbas Bejeshk Mehrnaz Mehrabani Farzaneh Rostamzadeh Mitra Samareh Fekri Hamid Najafipour Source Type: research