Iranian Journal of Allergy, Asthma and Immunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Impaired CD4+ Cytotoxic T Lymphocyte Activity in Polyomavirus BK Infected Kidney Transplant Recipients
Iran J Allergy Asthma Immunol. 2023 Sep 3;22(4):379-389. doi: 10.18502/ijaai.v22i4.13610.ABSTRACTThe reactivation of polyomavirus BK (BKPyV) contributes to increased morbidity and mortality rates of transplant patients, especially kidney transplant recipients (KTRs). CD4+ T cells are important immune cells active during BKPyV infection in KTRs. This research tried to examine the phenotype of CD4+ T cells in the stage of BKPyV activation in KTRs.The re cipients were separated into 2 groups of BKPyV-active and nonactive KTRs (10 patients in each group) and were compared with 10 healthy control subjects. The viral load was ev...
Source: Iranian Journal of Allergy, Asthma and Immunology - September 28, 2023 Category: Allergy & Immunology Authors: Nasrin Noshadi Ramin Yaghoubi Afsoon Afshari Mohsen Forouzanfar Saeede Soleimanian Source Type: research

Prognostic Value of Admission Neutrophil Count in Asthma Patients with COVID-19: A Comparative Analysis with other Systemic Inflammation Indices for In-Hospital Mortality Prediction
In conclusion, while numerous inflammatory indices were associated with mortality in COVID-19 patients without asthma, neutrophil counts could independently predict mortality risk in asthma COVID-19 patients.PMID:37767681 | DOI:10.18502/ijaai.v22i4.13611 (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - September 28, 2023 Category: Allergy & Immunology Authors: Hassan Ghobadi Jafar Mohammadshahi Aylin Tarighi Seyed Amir Hossein Hosseini Kara Garjani Mohammad Reza Aslani Source Type: research

The Radiological Manifestations of Phagocytic Primary Immunodeficiencies in Children
Iran J Allergy Asthma Immunol. 2023 Sep 3;22(4):398-404. doi: 10.18502/ijaai.v22i4.13612.ABSTRACTPrimary immunodeficiencies are a diverse group of rare genetic disorders, among which phagocytic dysfunction impairs neutrophil function in a wide range of inherited disorders. Due to the heterogeneity of the disorders a multidisciplinary approach is often required for early diagnosis and initiation of appropriate treatments. The aim of this study was to evaluate the imaging findings in children admitted with phagocytic primary immunodeficiencies. Thirty-five children who fulfilled the inclusion criteria for phagocytic dysfunct...
Source: Iranian Journal of Allergy, Asthma and Immunology - September 28, 2023 Category: Allergy & Immunology Authors: Mitra Khalili Zahra Chavoshzadeh Sepideh Darougar Mahboubeh Mansouri Narges Eslami Delara Babaie Mehrnaz Mesdaghi Abdollah Karimi Shahnaz Armin Alireza Fahimzad Roxana Mansour Ghanaei Sedigheh Rafiee Tabatabaie Fatemeh Akrami Source Type: research

A Rare Autoimmune Disease Detected in the Differential Diagnosis of Immunodeficiency: Histiocytosis-lymphadenopathy Plus Syndrome
We present a 7-year-old Syrian patient with pericardial effusion whose acute phase reactants did not decrease despite treatment. In order to emphasize the variety and raise awareness of H syndrome in the hopes of achieving an early diagnosis and appropriate treatment, molecular investigation of SLC29A3-related disorders is crucial. H syndrome is an uncommon genetic condition with a broad spectrum of phenotypes. Therefore, early genetic testing is essential for the accurate diagnosis of patients. Doctors should be aware of this condition and its symptoms and consider autoimmune diseases as a possible alternative diagnosis i...
Source: Iranian Journal of Allergy, Asthma and Immunology - September 28, 2023 Category: Allergy & Immunology Authors: Elif Arik Ozlem Keskin Ercan Kucukosmanoglu Mahmut Cesur Source Type: research

Case of Polyethylene Glycol Allergy Confirmed with Basophil Activation Test and Oral Challenge Successfully Immunized with SARS-CoV-2 Vaccine
We report a Caucasian 32-year-old woman with referred anaphylaxis almost instantly after oral intake of a macrogol-containing laxative. Despite an anaphylactic reaction, the patient showed negative results for both the skin test and specific IgE to monomer, while the basophil activation test and oral challenge were positive. The patient was later successfully vaccinated with a polysorbate 80-containing SARS-CoV-2 vaccine following an additional work-up. As a result, the inactive form of PEG cannot be fully diagnosed, and it is considered a "hidden" allergen. Allergens like polysorbates need special consideration due to the...
Source: Iranian Journal of Allergy, Asthma and Immunology - September 28, 2023 Category: Allergy & Immunology Authors: Maria Pasali Styliani Taka Caterina Chliva Alexandros Katoulis Michael Makris Source Type: research

Teucrium polium Extract Alleviates Pathological Features of Asthma via lL-12 and IFN- γ Modulation in Murine OVA-induced Allergic Asthma
This study showed that the administration of TP extract could improve pathological features, such as airway inflammation, and reduce systemic inflammation.PMID:37767675 | DOI:10.18502/ijaai.v22i4.13605 (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - September 28, 2023 Category: Allergy & Immunology Authors: Shole Daneshvar-Ghahfarokhi Vahid Mohammadi-Shahrokhi Amir Rahnama Reza Nosratabadi Source Type: research

Tumor Necrosis Factor- α (-308G & gt;A) Gene Polymorphism and Its Association with Asthma and Atopy Status
In conclusion, TNF (-308) AA and AG genotypes are associated with asthma susceptibility in Iranian children, although there was no significant difference in polymorphism between atopic and non-atopic asthma and no difference in asthma severity groups.PMID:37767676 | DOI:10.18502/ijaai.v22i4.13606 (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - September 28, 2023 Category: Allergy & Immunology Authors: Anahita Razaghian Nima Parvaneh Ali Akbar Amirzargar Mohammad Gharagozlou Source Type: research

Role of Long Non-coding RNA HSD17B3-AS1 in Trauma for COVID-19
This study analyzed Sequence Read Archive data from COVID-19 patients with acute versus milder symptoms, identifying dysregulated genes and non-coding RNAs. To verify this correlation, the expression of the candidate gene was evaluated with quantitative polymerase chain reaction (qPCR) in mouse models, while immunoglobulin (Ig) G titer was measured using enzyme-linked immunosorbent assay (ELISA) in mouse serum samples. Here we introduced a novel lncRNA called HSD17B3-AS1, suggested as a therapeutic target in COVID-19 patients with acute symptoms. Furthermore, we revealed nanocurcumin is reducing the expression of HSD17B3-A...
Source: Iranian Journal of Allergy, Asthma and Immunology - September 28, 2023 Category: Allergy & Immunology Authors: Amir-Reza Javanmard Hadi Esmaeili Gouvarchinghaleh Ruhollah Dorostkar Mahdi Tat Source Type: research

Comparison of Plasma Levels of MicroRNA-155-5p, MicroRNA-210-3p, and MicroRNA-16-5p in Rheumatoid Arthritis Patients with Healthy Controls in a Case-control Study
The objective of the current study was to evaluate the expression of microRNA (miR)-155-5p, miR-210-3p, and miR-16-5p in the plasma of patients with rheumatoid arthritis in comparison with a healthy control group to attain an expression profile for earlier diagnosis and treatment. To carry out this study, 100 individuals were chosen as two equally sized groups of rheumatoid arthritis patients and healthy controls. Five milliliters of blood were drawn from each individual, and plasma RNA was extracted using Trisol solution. Complementary DNAs were synthesized using the Moloney leukemia virus (MMLV) and deoxynucleoside triph...
Source: Iranian Journal of Allergy, Asthma and Immunology - September 28, 2023 Category: Allergy & Immunology Authors: Nasrin Mohebi Elia Damavandi Abdol-Rahman Rostamian Maliheh Javadi-Arjmand Shafieh Movassaghi Hamid Choobineh Majid Kabuli Mohsen Ghadami Source Type: research

Differential Expression of miR-21-5p, miR-20a-5p, TGF- β1, and TGF-β Receptor 2 in Skin, Serum, and Lung Samples Exposed to Sulfur Mustard
Iran J Allergy Asthma Immunol. 2023 Sep 3;22(4):366-378. doi: 10.18502/ijaai.v22i4.13609.ABSTRACTSulfur mustard (SM) or mustard gas is a blister chemical agent that causes pulmonary damage by triggering inflammation and oxidative injury. Alterations in microRNA (miR) transcript levels are found in pulmonary diseases and even inflammation. Therefore, we evaluated the expression levels of miR-20a-5p, miR-21-5p, and two target transcripts (transforming growth factor-beta [TGF-β1] and TGF-β receptor 2 [TGFR2]) in lung, serum, and skin samples from patients exposed to SM. Total RNA was extracted from lung, serum, and skin sam...
Source: Iranian Journal of Allergy, Asthma and Immunology - September 28, 2023 Category: Allergy & Immunology Authors: Mohadeseh Valizadeh Shiva Irani Mahmood Tavallaei Masoud Soleimani Source Type: research