A Study on the Association of Interleukin-1 Cluster with Genetic Risk in Bipolar I Disorder in Iranian Patients: A Case-control Study.
Abstract The pathogenesis of Bipolar I Disorder (BP-I) involves immune-mediated mechanisms, especially an imbalance in pro-inflammatory/anti-inflammatory cytokines in plasma or cerebrospinal fluid. Interleukin-1 (IL-1) gene cluster, coding some of these pro-inflammatory cytokines, might play a role in various neuropathologies related to neuron inflammation. The aim of the present study was to investigate the possible role of IL-1 gene cluster polymorphisms in determining the susceptibility to BP-I in Iranian population. 48 patients with BP-I in Mashhad (in north-eastern Iran), diagnosed by two psychiatrists using ...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 1, 2016 Category: Allergy & Immunology Authors: Talaei A, Tavakkol Afshari J, Fayyazi Bordbar MR, Pouryousof H, Faridhosseini F, Saghebi A, Rezaei Ardani A, Talaei A, Tehrani M Tags: Iran J Allergy Asthma Immunol Source Type: research

Mindfulness-based Stress Reduction (MBSR) and Its Effects on Psychoimmunological Factors of Chemically Pulmonary Injured Veterans.
Abstract Mindfulness-based Stress Reduction (MBSR) is a treatment program for relieving stress and coping with chronic illnesses. In recent three decades, studies have shown that MBSR has a positive effect on physical and psychological dimensions of chronic illnesses. Chemically pulmonary injured veterans have chronic pulmonary and psychological problems due to mustard gas exposure and complications of Iran-Iraq war. These stresses have negative effects on their general health and immune system. To the best of our knowledge, this is the first study conducted on psychoneuroimmunology and MBSR in these patients. For...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 1, 2016 Category: Allergy & Immunology Authors: Arefnasab Z, Babamahmoodi A, Babamahmoodi F, Noorbala AA, Alipour A, Panahi Y, Shams J, Riazi Rad F, Khaze V, Ghanei M Tags: Iran J Allergy Asthma Immunol Source Type: research

Effects of Quercetin Treatment on Epithelium-derived Cytokines and Epithelial Cell Apoptosis in Allergic Airway Inflammation Mice Model.
This study aimed to evaluate the influence of quercetin on histopathological aspects and airway epithelium in  allergic airway  inflammation mice model. Twenty-eight BALB/c mice were randomly divided into four groups: Group I (control), Group II (untreated mice with allergic airway inflammation), Group III (allergic airway inflammation quercetin-treated [16mg/kg/day]), Group IV (allergic airway inflammation dexamethasone-treated [1mg/kg/day]). Ovalbumin was administered intraperitoneally and via inhalation to achieve allergic airway inflammation mice model and treatments were also given intraperitoneally. Epithel...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 1, 2016 Category: Allergy & Immunology Authors: Caglayan Sozmen S, Karaman M, Cilaker Micili S, Isik S, Bagriyanik A, Arikan Ayyildiz Z, Uzuner N, Anal O, Karaman O Tags: Iran J Allergy Asthma Immunol Source Type: research

Metformin Alleviates Lipopolysaccharide-induced Acute Lung Injury through Suppressing Toll-like Receptor 4 Signaling.
In this study we investigated whether activation of AMPK by metformin could protect the lung from lipopolysaccharide (LPS)-induced acute injury by inhibitingng TLR4 pathway. Male Wistar rats were randomly divided into 3 groups (n=6): control group received normal saline (0.5 mL), LPS group received LPS (0.5 mg/kg), and metformin-treated group received LPS and metformin (100 mg/kg). Nine hours later nuclear factor-κB (NF-κB), phosphorylated, and non-phosphorylated AMPK using western blot, and the rate of TLR4 mRNA expression using real-time PCR were assessed in the lung tissue. To evaluate neutrophil infiltratio...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 1, 2016 Category: Allergy & Immunology Authors: Vaez H, Najafi M, Toutounchi NS, Barar J, Barzegari A, Garjani A Tags: Iran J Allergy Asthma Immunol Source Type: research

Functional and Key Gene Expression Analyses of Chicken Monocyte-derived Dendritic Cells with Recombinant Interleukin 4.
In this study full length of chicken IL-4 (cIL-4) cDNA was cloned, characterized and expressed in Escherichia coli. Subsequently, the expressed IL-4 was used to induce monocytes- derived DCs (MDDC). Typical features of DCs such as long membrane protrusions, apparently was dominant only four days after cytokine induction. Analyses of selected key genes' expression also confirmed that most of the monocytes shifted to DCs. The findings of the present study strongly suggest that the cloning and expression of cIL-4 in the bacterial host without any codon optimization or other modifications could produce mature MDDC in...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 1, 2016 Category: Allergy & Immunology Authors: Khajeh H, Bahari A, Lagzian M, Sabbagh SK Tags: Iran J Allergy Asthma Immunol Source Type: research

The Effect of Artemisia fragrans Willd: Essential Oil on Inducible Nitric Oxide Synthase Gene Expression and Nitric Oxide Production in Lipopolysaccharide-stimulated Murine Macrophage Cell Line.
Abstract The genus Artemisia is estimated to comprise over 800 species with anti-cancer, anti-fungal, anti-oxidant and anti-inflammatory properties. Artemisia fragrans (A. fragrans), a species that belongs to genus Artemisia, is rich in monoterpenes and sesquiterpenes derivatives. Due to anti-inflammatory properties of monoterpenes and sesquiterpenes, we aimed to investigate the effect of A. fragrans essential oil on mRNA expression of inducible nitric oxide synthase (iNOS) gene and nitric oxide (NO) production in Lipopolysaccharide (LPS) -stimulated RAW264.7 cell line. NO, which is synthesized by iNOS, is the mai...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 1, 2016 Category: Allergy & Immunology Authors: Farghadan M, Ghafoori H, Vakhshiteh F, Shahzadeh Fazeli SA, Farzaneh P, Kokhaei P Tags: Iran J Allergy Asthma Immunol Source Type: research

A Safe and Effective Method for Wheat Oral Immunotherapy.
Abstract At present the only available management for food allergy is avoidance; however, abstaining from allergic foods can affect the quality of life. Oral Immunotherapy (OIT) is an efficient method for increasing tolerance towards food allergens. The aim of this study was desensitizing patients above five years of age with wheat allergy and evaluating the safety and efficacy of OIT for children with IgE-mediated wheat allergy. The method of Rush Oral Immunotherapy (ROIT) was performed on 8 anaphylactic wheat allergic patients as well as outpatient method on 5 non-anaphylactic ones. In ROIT, build-up phase was p...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 1, 2016 Category: Allergy & Immunology Authors: Khayatzadeh A, Gharaghozlou M, Ebisawa M, Shokouhi Shoormasti R, Movahedi M Tags: Iran J Allergy Asthma Immunol Source Type: research

A Novel Approach to Discriminate Subgroups in Multiple Sclerosis.
Abstract Multiple sclerosis (MS) is an autoimmune disease of central nervous system. Since different types of immune cells are involved in MS pathogenesis, in this study we aimed to evaluate serum levels of several immunological components including soluble CD4 (sCD4), sCD8, sCD163, and immunoglobulins as markers of activity of T-cells, macrophages, and B-cells in different types of MS. Serum levels of sCD4, sCD8, and sCD163 of patients with relapsing-remitting MS (RRMS, n=61), primary progressive MS (PRMS, n=31), secondary progressive MS (SPMS, n=31), clinical isolated syndrome (CIS, n=31) and neuromyelitis optic...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 1, 2016 Category: Allergy & Immunology Authors: Farrokhi M, Saadatpour Z, Fadaee E, Saadatpour L, Rezaei A, Moeini P, Amani Beni A Tags: Iran J Allergy Asthma Immunol Source Type: research

A Case of Anaphylaxis to Patent Blue in a Patient with Sentinel Lymph Node Excision.
This article supports the necessity of an increased awareness of the possibility of anaphylactic reactions to PBV during SLN surgery, even if the patient never had contact to PBV before. PMID: 28129687 [PubMed - in process] (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - December 1, 2016 Category: Allergy & Immunology Authors: Aurich S, Seitz AT, Tomm J, Simon JC, Treudler R Tags: Iran J Allergy Asthma Immunol Source Type: research

Normothermic Ex Vivo Lung Perfusion in Brain-dead Donors Reduces Inflammatory Cytokines and Toll-like Receptor Expression.
This study investigated how the performance of EVLP on brain-dead (BD) donor lungs affects the production and release of inflammatory cytokines (IL-6, IL-8, and TNF-a), inflammatory cells and toll-like receptors (TLR) -2, 4. This study was conducted with an animal subject for qualification of EVLP team and then EVLP was performed on 4 human cases referred to Masih Daneshvari Hospital (Tehran,Iran), from May 2013 to July 2015. Two of these cases, who had acceptable lung function parameters, were enrolled in this study for immunologic investigations. Bronchoalveolar lavages (BAL) were taken before and after EVLP. Cytokines w...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 1, 2016 Category: Allergy & Immunology Authors: Shafaghi S, Mortaz E, Abbasi Dezfuli A, Godarzi H, Sheikhy K, Ansari Aval Z, Farzanegan B, Emami H, Hosseini-Baharanchi FS, Najafizadeh K Tags: Iran J Allergy Asthma Immunol Source Type: research

Association of Nucleotide-binding Oligomerization Domain Receptors with Peptic Ulcer and Gastric Cancer.
This study aimed to evaluate the effect of the expression level of NOD1 and NOD2 on the susceptibility to gastric cancer as well as peptic ulcer in individuals with H. pylori infection. The gene expression levels of these molecules were compared in three groups of non-ulcer dyspepsia (NUD) as a control group (n=52); peptic ulcer disease (PUD), (n=53); and gastric cancer (GC), (n=39). Relative expression levels of NOD1 in patients with GC were higher than those of NUD and PUD (p
Source: Iranian Journal of Allergy, Asthma and Immunology - October 1, 2016 Category: Allergy & Immunology Authors: Mohammadian Amiri R, Tehrani M, Taghizadeh S, Shokri-Shirvani J, Fakheri H, Ajami A Tags: Iran J Allergy Asthma Immunol Source Type: research

Identification and Characterization of Main Allergic Proteins in Cooked Wolf Herring Fish.
Abstract Our aim in this study was to identify and characterize allergic proteins in cooked wolf herring fish. We heated the crude extract alternatively at 50, 60, 70, 80, 90, and 100°C for one hour and results were compared by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). Also, proteins were immunoblotted with fish-sensitive patients' sera. The major allergenic proteins were identified via mass spectrometry. These allergenic proteins were then purified by anion exchange chromatography and the IgE-immunoreactivity of the fractions was compared with the crude extracts via disk enzyme-lin...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 1, 2016 Category: Allergy & Immunology Authors: Mohamadi M, Falak R, Mokhtarian K, Khoramizadeh MR, Sadroddiny E, Kardar GA Tags: Iran J Allergy Asthma Immunol Source Type: research

Impact of IgE-mediated Food Allergy on Parental Quality of Life in Iranian Patients.
Abstract Food allergy is a common disorder especially in the first years of life. Strict avoidance of the responsible food is the most effective therapeutic measure so far. But this continuous vigilance could be stressful for the patient and family and decreases their quality of life (QOL). This survey was designed to evaluate the impact of IgE-mediated food allergy on parental QOL in Iranian patients and to develop a valid Persian version of "Food Allergy Quality Of Life- Parental Burden (FAQL-PB) questionnaire". 90 patients (28 females, 62 males) and their parents who were referred to the clinic of All...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 1, 2016 Category: Allergy & Immunology Authors: Fathi SM, Tavakol M, Rezaei N, Movahedi M, Aghamohammadi A, Shariat M, Sadeghi B, Behniafard N, Darabi B, Hajikhani A, Abdollahpour I, Gharagozlou M Tags: Iran J Allergy Asthma Immunol Source Type: research

Relationships between High-mobility Group Protein B1 and Triggering Receptor Expressed on Myeloid Cells Concentrations in Gingival Crevicular Fluid and Chronic Periodontitis.
Abstract One of the inflammatory mediators which is secreted by inflammatory cells is high-mobility group protein B1 (HMGB1). Interaction of HMGB1 and toll-like receptors (TLRs) leads to increased production of inflammatory cytokines. On the other hand, it was shown that triggering receptor expressed on myeloid cells (TREM-1) also can be activated by TLRs, and its soluble form (sTREM-1) can be formed by cleaving of membrane-bound form of TREM-1 proteinases. Since there is not enough knowledge about the precise role of HMGB1 and sTREM-1 in periodontal diseases, the aim of this study was to evaluate the concentratio...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 1, 2016 Category: Allergy & Immunology Authors: Paknejad M, Sattari M, Roozbahani Z, Ershadi M, Mehrfard A Tags: Iran J Allergy Asthma Immunol Source Type: research

T-helper Cell Type-1 Transcription Factor T-Bet Is Down-regulated in Type 1 Diabetes.
Abstract T cells have been identified as key players in the pathogenesis of type 1 diabetes. However, the exact role of T-cell subpopulations in this pathway is presently unknown. The purpose of this study was to assess the expression pattern of two lineage-specifying transcription factors GATA-3 and T-bet, which are important in T helper type 1 (Th1) and Th2 cell development, respectively. Gene expression analysis of peripheral blood mononuclear cells (PBMCs) was performed using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Plasma levels of IFN-γ and IL-4 were also determined by EL...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 1, 2016 Category: Allergy & Immunology Authors: Vaseghi H, Sanati MH, Jadali Z Tags: Iran J Allergy Asthma Immunol Source Type: research

Association of New Putative Epitopes of Myelin Proteolipid Protein (58-74) with Pathogenesis of Multiple Sclerosis.
This study is conducted to evaluate the activatory effects of PLP58-74 on T lymphocytes and humoral immunity. PLP58-74 was considered as an immunodominant epitope candidate of PLP using bioinformatics tools. Patients and healthy individuals' peripheral blood mononuclear cells (PBMCs) were treated with PLP58-74 and its proliferative effects were evaluated through assessing proliferating cell nuclear antigen (PCNA) gene expression changes by real time PCR and immunocytochemistry assay. Finally, the rate of CD4+ and CD8+ T cells were assessed by flowcytometry. ELISA was also performed to measure anti PLP58-74 antibody in pati...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 1, 2016 Category: Allergy & Immunology Authors: Zamanzadeh Z, Ahangari G, Ataei M, Pouragahi S, Nabavi SM, Sadeghi M, Sanati MH Tags: Iran J Allergy Asthma Immunol Source Type: research

Enhanced Immune Responses against HIV-1 with Adenovector (Gag and Tat) Prime/Protein Boost Regimen and GM-CSF Injection.
In this study, we evaluated the rAd5 prime/protein boost strategy in a murine model. We used rAd5 harboring single HIV-1 genes. These genes, including gag (p24) and exon1 of tat, were amplified from HIV-1 (clade A) RNA using nested PCR. Recombinant vectors were constructed, purified and then injected at 1012 viral particles into four groups, each comprising five mice. The groups were each assigned to receive one of rAd5 prime/protein boost Gag, Tat with and without recombinant granulocyte-macrophage colony-stimulating factor (rGM-CSF), and rAd5 with and without genes. The humoral responses were evaluated using ELISA and ce...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 1, 2016 Category: Allergy & Immunology Authors: Hosseini Rouzbahani N, Bayanolhagh S, Gholami M, Esmaeilzadeh A, Bayat Jozani Z, Mohraz M, Pourfathollah AA Tags: Iran J Allergy Asthma Immunol Source Type: research

Association between PTPN22/CTLA-4 Gene Polymorphism and Allergic Rhinitis with Asthma in Children.
This study reveals a significant association between SNPs in PTPN22, CTLA-4 gene and AR with asthma in Chinese Han children, which might be susceptibility factors for AR and asthma. PMID: 27917628 [PubMed - in process] (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - October 1, 2016 Category: Allergy & Immunology Authors: Song SH, Wang XQ, Shen Y, Hong SL, Ke X Tags: Iran J Allergy Asthma Immunol Source Type: research

Identification of HLA Class I Misreads/Dropouts Using Serological Typing, in Comparison with DNA-based Typing.
Abstract Serology and DNA techniques are employed for Human Leukocyte Antigen (HLA) typing in different transplant centers. Results may not always correlate well and may need retyping with different technique. All the patients (with aplastic anemia, thalassemia, and immunodeficiency) and their donors, requiring HLA typing for bone marrow transplant were enrolled in the study. Serological HLA typing was done by complement-dependent lymphocytotoxicity while DNA-based typing was done with sequence specific primers (SSP). Serology identified 167 HLA A and 165 HLA B antigens while SSP in same samples identified 181 HLA...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 1, 2016 Category: Allergy & Immunology Authors: Tipu HN, Bashir MM, Noman M Tags: Iran J Allergy Asthma Immunol Source Type: research

A Novel CYBB Mutation in Chronic Granulomatous Disease in Iran.
Abstract Chronic granulomatous disease (CGD) is a rare primary immunodeficiency disorder due to a genetic defect in one of the components of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. This complex is composed of membrane-bound gp91-phox and p22-phox subunits, and cytosolic subunits consisting of p47-phox, p67-phox, and p40-phox. A mutation in CYBB gene encoding gp91-phox located on chromosome Xp21.1, leads to X-linked CGD. Herein, we report a 4-year-old Iranian boy presented with episodes of recurrent fever, cervical lymphadenopathy, and abdominal abscesses. Mutation analysis of the CYBB ...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 1, 2016 Category: Allergy & Immunology Authors: Tajik S, Badalzadeh M, Fazlollahi MR, Houshmand M, Zandieh F, Khandan S, Pourpak Z Tags: Iran J Allergy Asthma Immunol Source Type: research

Lung Altered Expression of IL-1 β mRNA and Its Signaling Pathway Molecules in Obese-asthmatic Male Wistar Rats.
Lung Altered Expression of IL-1β mRNA and Its Signaling Pathway Molecules in Obese-asthmatic Male Wistar Rats. Iran J Allergy Asthma Immunol. 2016 Jun;15(3):183-97 Authors: Aslani MR, Keyhanmanesh R, Khamaneh AM, Ebrahimi Saadatlou MA, Mesgari Abbasi M, Alipour MR Abstract Epidemiological and clinical studies indicate a close relationship between obesity and asthma. Here, we determined the impact of diet-induced obesity on the expression levels of IL-1β, IRAK-1 and TRAF-6 mRNA as well as IL-1β protein level and pathological changes in male Wistar rat's lung after sensitization with oval...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 1, 2016 Category: Allergy & Immunology Authors: Aslani MR, Keyhanmanesh R, Khamaneh AM, Ebrahimi Saadatlou MA, Mesgari Abbasi M, Alipour MR Tags: Iran J Allergy Asthma Immunol Source Type: research

Lack of Association between Interleukin-8 Gene +781 C/T Polymorphism and Henoch-Sch önlein Purpura in Childhood.
In this study, we aimed to investigate whether IL-8 gene +781 C/T (rs2227306) polymorphism has an influence on susceptibility and clinical manifestations of patients to HSP. This hospital-based case-control study comprised 192 patients with HSP and 202 healthy controls. The genotypes of IL-8 gene +781 C/T polymorphism were identified using PCR-TaqMan method. All genotype frequencies of both groups (patients and controls) conformed to the Hardy-Weinberg equilibrium. No significant differences in allele or genotype frequencies of IL-8 gene +781 C/T polymorphism were observed between patients with HSP and controls (p=0.98, &c...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 1, 2016 Category: Allergy & Immunology Authors: Xu H, Pan YX, Zhang J, Liu Y, Mao JH, Li W Tags: Iran J Allergy Asthma Immunol Source Type: research

Association of Promoter Polymorphisms of Interleukin-10 and Interferon-Gamma Genes with Tuberculosis in Azeri Population of Iran.
In this study, we investigated a possible association between interleukin-10 (IL-10) -1082A⁄G (rs1800896) and interferon (IFN)-gamma +874T/A (rs2430561) promoter polymorphisms and tuberculosis (TB) in the Azeri population of Iran. IL-10 -1082G/A and IFN-gamma +874T/A single nucleotide polymorphisms (SNPs) were genotyped by amplification refractory mutation system (ARMS)-PCR in 200 healthy controls and 124 tuberculosis patients. IL-10 -1082 A allele was more frequent in the control group than in the patient group (p=0.001, odds ratio [OR]=2.183). On the other hand, the AA genotype was significantly more frequent in th...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 1, 2016 Category: Allergy & Immunology Authors: Asgharzadeh M, Ghorghanlu S, Rashedi J, Mahdavi Poor B, Khaki-Khatibi F, Moaddab SR, Samadi-Kafil H, Pourostadi M Tags: Iran J Allergy Asthma Immunol Source Type: research

Reduced Phagocytic Capacity of Blood Monocyte/Macrophages in Tuberculosis Patients Is Further Reduced by Smoking.
Abstract Tuberculosis (TB) and tobacco use are two major alarming global health issues posing immense threats to human populations. Mycobacterium tuberculosis (MTB) by activation of macrophages could induce the sequences of cells activation and releases of inflammatory cytokines such as CXCL-8, Il-12 and TNF-α which in turn induces the immune system network. However no information is available on other activity of cells by MTB and smoking. In the current study we aimed to investigate the serum levels TNF-a, CXCL-8 and phagocytosis capacity in tuberculosis patients with and without smoking. 103 subjects enter...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 1, 2016 Category: Allergy & Immunology Authors: Aryanpur M, Mortaz E, Masjedi MR, Tabarsi P, Garssen J, Adcock IM, Mozafarian A, Sharifi H Tags: Iran J Allergy Asthma Immunol Source Type: research

Lung Altered Expression of IL-1β mRNA and Its Signaling Pathway Molecules in Obese-asthmatic Male Wistar Rats.
Lung Altered Expression of IL-1β mRNA and Its Signaling Pathway Molecules in Obese-asthmatic Male Wistar Rats. Iran J Allergy Asthma Immunol. 2016 Jun;15(3):183-97 Authors: Aslani MR, Keyhanmanesh R, Khamaneh AM, Ebrahimi Saadatlou MA, Mesgari Abbasi M, Alipour MR Abstract Epidemiological and clinical studies indicate a close relationship between obesity and asthma. Here, we determined the impact of diet-induced obesity on the expression levels of IL-1β, IRAK-1 and TRAF-6 mRNA as well as IL-1β protein level and pathological changes in male Wistar rat's lung after sensitization with oval...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 1, 2016 Category: Allergy & Immunology Authors: Aslani MR, Keyhanmanesh R, Khamaneh AM, Ebrahimi Saadatlou MA, Mesgari Abbasi M, Alipour MR Tags: Iran J Allergy Asthma Immunol Source Type: research

Sensitization to Food Additives in Patients with Allergy: A Study Based on Skin Test and Open Oral Challenge.
Abstract There has been a great increase in the consumption of various food additives in recent years. The purpose of this study was to identify the incidence of sensitization to food additives by using skin prick test in patients with allergy and to determine the concordance rate between positive skin tests and oral challenge in hypersensitivity to additives. This cross-sectional study included 125 (female 71, male 54) patients aged 2-76 years with allergy and 100 healthy individuals. Skin tests were performed in both patient and control groups with 25 fresh food additives. Among patients with allergy, 22.4% show...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 1, 2016 Category: Allergy & Immunology Authors: Moghtaderi M, Hejrati Z, Dehghani Z, Dehghani F, Kolahi N Tags: Iran J Allergy Asthma Immunol Source Type: research

The Association between Vascular Endothelial Growth Factor-related Factors with Severity of Multiple Sclerosis.
Abstract Previous studies have demonstrated that vascular endothelial growth factor (VEGF) can trigger angiogenesis as well as inflammation through binding to its membranous receptor-1 on endothelial and inflammatory cells. We aimed to correlate the circulatory number of cells expressing such receptor as well as the serum level of VEGF and the soluble form of its receptor-1 (sVEGFR1) to the severity of multiple sclerosis (MS). This case-control study was done on 102 cases of MS lacking any other inflammatory or pathologic conditions and 75 healthy volunteer subjects. The severity of MS was examined by expanded dis...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 1, 2016 Category: Allergy & Immunology Authors: Kouchaki E, Otroshi Shahreza B, Faraji S, Nikoueinejad H, Sehat M Tags: Iran J Allergy Asthma Immunol Source Type: research

Effects of Intermittent Fasting on Experimental Autoimune Encephalomyelitis in C57BL/6 Mice.
Abstract Several religions recommend periods of fasting. One of the most frequently asked questions of MS patients before the holy month of Ramadan is weather fasting might have an unfavorable effect on their disease course. This debate became more challenging after the publication of experimental studies suggesting that calorie restriction prior to disease induction attenuates disease severity. We conducted this study to assess early and late effects of fasting on the animal model of MS, known as autoimmune encephalomyelitis. EAE was induced in the C57BL/6 mice, using Myelin Oligodendrocyte Glycopeptide  (MO...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 1, 2016 Category: Allergy & Immunology Authors: Razeghi Jahromi S, Ghaemi A, Alizadeh A, Sabetghadam F, Moradi Tabriz H, Togha M Tags: Iran J Allergy Asthma Immunol Source Type: research

Cytotoxic T Lymphocyte Antigen-4 Gene Variants in Type 2 Diabetic Patients with or without Neuropathy.
Abstract Many studies have shown that cytotoxic T lymphocyte antigen-4 (CTLA-4) gene variants are associated with several autoimmune diseases particularly type 1 diabetes. Due to the lack of consistent data for this association with type 2 diabetes (T2D), this study explored the possible influence of CTLA-4 gene polymorphisms at -1722 (T/C), -318 (C/T), and +49 (G/A) positions for susceptibility to T2D in relation with neuropathy. One hundred and eleven unrelated patients with T2D [49 patients with diabetic peripheral neuropathy (DPN) and 62 patients without PDN] and 100 healthy ethnic- and gender-matched controls...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 1, 2016 Category: Allergy & Immunology Authors: Kiani J, Khadempar S, Hajilooi M, Rezaei H, Keshavarzi F, Solgi G Tags: Iran J Allergy Asthma Immunol Source Type: research

Evaluation of PBMC Distribution and TLR9 Expression in Patients with Systemic Lupus Erythematosus.
Abstract Systemic lupus erythematosus (SLE) is a chronic autoimmune disease which results in damage to various organs. Some animal studies have revealed that activation of Toll-like receptors (TLRs) is important in the pathogenesis of SLE. In the present study, the percentage of different immune cell subsets in 35 SLE patients and 38 control subjects was analyzed by flow cytometry. We also assessed the expression of TLR9 in the population of peripheral blood mononuclear cells (PBMCs) including T lymphocytes (CD4+ and CD8+), B lymphocytes (CD19+), NK cells (CD56+) and monocytes (CD14+) in SLE patients and healthy c...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 1, 2016 Category: Allergy & Immunology Authors: Mortezagholi S, Babaloo Z, Rahimzadeh P, Ghaedi M, Namdari H, Assar S, Azimi Mohamadabadi M, Salehi E Tags: Iran J Allergy Asthma Immunol Source Type: research

Lack of Association between Interleukin-8 Gene +781 C/T Polymorphism and Henoch-Schönlein Purpura in Childhood.
In this study, we aimed to investigate whether IL-8 gene +781 C/T (rs2227306) polymorphism has an influence on susceptibility and clinical manifestations of patients to HSP. This hospital-based case-control study comprised 192 patients with HSP and 202 healthy controls. The genotypes of IL-8 gene +781 C/T polymorphism were identified using PCR-TaqMan method. All genotype frequencies of both groups (patients and controls) conformed to the Hardy-Weinberg equilibrium. No significant differences in allele or genotype frequencies of IL-8 gene +781 C/T polymorphism were observed between patients with HSP and controls (p=0.98, &c...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 1, 2016 Category: Allergy & Immunology Authors: Xu H, Pan YX, Zhang J, Liu Y, Mao JH, Li W Tags: Iran J Allergy Asthma Immunol Source Type: research

Anti-rubella, Mumps and Measles IgG Antibodies in Medical Students of Tehran University.
In this study, in order to evaluate the protective responses against measles, mumps and rubella, the level and avidity of virus-specific IgG antibodies were measured in 53 medical students of Tehran University, aged between 20-30 years. Except for mumps vaccine, all the students had been vaccinated against measles and rubella according to Iran's nationwide mass vaccination protocol for all persons aged 5-25 in 2003. Our results showed that 96.2% of the volunteers had a protective level (>15 IU/ml) of IgG against rubella, 79.2% had a protective level (>11 IU/ml) of IgG against measles and 64.16% had a protective level...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 1, 2016 Category: Allergy & Immunology Authors: Keshavarz M, Nicknam MH, Tebyanian M, Shahkarami MK, Izad M Tags: Iran J Allergy Asthma Immunol Source Type: research

Mannose-binding Lectin Mediated Complement Pathway in Autoimmune Neurological Disorders.
Abstract Multiple sclerosis (MS) is a complex, demyelinating disease of the central nervous system (CNS) with variable phenotypic presentations, while Guillain-Barre Syndrome (GBS) is the prototypic acute inflammatory disorder that affects the peripheral nervous system. Myasthenia gravis (MG) is a T cell dependent and antibody mediated autoimmune disease. Although it has been shown that complement plays a critical role in the pathogenesis of MS, GBS, and MG, the role of mannose-binding lectin (MBL) as a biomarker of immunopathogensis of these diseases and also its association with the severity of them have been po...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 1, 2016 Category: Allergy & Immunology Authors: Farrokhi M, Dabirzadeh M, Dastravan N, Etemadifar M, Ghadimi K, Saadatpour Z, Rezaei A Tags: Iran J Allergy Asthma Immunol Source Type: research

Prevalence of Asthma, COPD, and Chronic Bronchitis in Iran: A Systematic Review and Meta-analysis.
In this study, we aimed to conduct a meta-analysis on the results of eligible studies to estimate the prevalence of asthma, COPD, and Chronic bronchitis in Iran. International and Iranian databases including PubMed, Scopus, Web of Science, Iranmedex, and scientific information database (SID) were searched for population-based studies that had reported the prevalence of asthma and COPD from 1990 to 2015. We conducted the meta-analysis using metaprop application of Stata statistical software. I-Squared was used for calculating heterogeneity among the studies. To determine causes of heterogeneity, subgroup analysis and meta-r...
Source: Iranian Journal of Allergy, Asthma and Immunology - April 1, 2016 Category: Allergy & Immunology Authors: Varmaghani M, Farzadfar F, Sharifi F, Rashidian A, Moin M, Moradi-Lakeh M, Rahimzadeh S, Saeedi Moghaddam S, Kebriaeezadeh A Tags: Iran J Allergy Asthma Immunol Source Type: research

Is There Any Parameter Helpful for Predicting a Suitable Candidate for Mite Immunotherapy?
İ Abstract Few biomarkers that can predict the clinical response to allergen immunotherapy (AIT) have been identified. The aim of the present study was to investigate parameters that could be used "in predicting the clinical response to AIT" in children with asthma caused by house dust mites. We evaluated 107 children with mild persistent asthma who were sensitised only to mite aeroallergens. The study group included 47 patients who underwent a 4-to-5-year course of subcutaneous immunotherapy with standardised mite allergenic extract. Sixty patients who had not undergone AIT but were allergic to house ...
Source: Iranian Journal of Allergy, Asthma and Immunology - April 1, 2016 Category: Allergy & Immunology Authors: Karaman S, Can D, Erdem SB, Nacaroğlu HT, Karkıner CŞ, Günay İ Tags: Iran J Allergy Asthma Immunol Source Type: research

Efficacy of Sublingual Immunotherapy with Dermatophagoides Pteronyssinus: A Real-life Study.
Abstract Sublingual allergen immunotherapy (SLIT) is considered to be safer and more convenient than subcutaneus immunotherapy. SLIT trials with house dust mites involving patients with allergic rhinitis (AR) and asthma reported discordant results. The aim of the study was to investigate the clinical efficacy and safety of SLIT with Dermatophagoides pteronyssinus (D.pt) extract produced in Serbia and patient's satisfaction through open-label trial. Adult patients with allergic rhinitis were randomized into two groups: one received drugs and SLIT, while other received only drugs. Symptom score (SS), medication scor...
Source: Iranian Journal of Allergy, Asthma and Immunology - April 1, 2016 Category: Allergy & Immunology Authors: Vesna TS, Denisa D, Slavenka J, Lidija B, Aleksandra B, Jasna B, Vojislav D, Aleksandra PP, Aleksandra A, Mirjana B Tags: Iran J Allergy Asthma Immunol Source Type: research

Molecular Cloning and Expression of Pro J 1: A New Allergen of Prosopis Juliflora Pollen.
Abstract Pollen from mesquite (Prosopis juliflora) is one of the important causes of immediate hypersensitivity reactions in the arid and semi-arid regions of the world. The aim of present study is to produce and purify the recombinant form of allergenic Ole e 1-like protein from the pollen of this allergenic tree. Immunological and cross-inhibition assays were performed for the evaluation of IgE-binding capacity of purified recombinant protein. For molecular cloning, the coding sequence of the mesquite Ole e 1-like protein was inserted into pTZ57R/T vector and expressed in Escherichia coli using the vector pET-21...
Source: Iranian Journal of Allergy, Asthma and Immunology - April 1, 2016 Category: Allergy & Immunology Authors: Dousti F, Assarehzadegan MA, Morakabati P, Khosravi GR, Akbari B Tags: Iran J Allergy Asthma Immunol Source Type: research

Indoor Dust Allergen Levels in the Homes of Patients with Childhood Asthma: An Experience From Southwestern Iran.
This study was designed to quantify indoor allergens from homes of families that had at least one case of childhood asthma at home in a southwestern city of Iran. The relationship between the indoor allergen levels and home characteristics was also investigated. Dust samples were collected from the bedrooms and the kitchens of 35 homes where children with persistent asthma were living. The levels of indoor allergens were measured by enzyme linked immunosorbent assay (ELISA). Detectable amounts of mite, mouse and cockroach allergens were found in all evaluated places. None of our patients were exposed to a threshold concent...
Source: Iranian Journal of Allergy, Asthma and Immunology - April 1, 2016 Category: Allergy & Immunology Authors: Moghtaderi M, Farjadian S, Fereidouni M, Nasiri M, Nejat A Tags: Iran J Allergy Asthma Immunol Source Type: research

Leptin and Atopic Dermatitis in Korean Elementary School Children.
Abstract The prevalence of atopic dermatitis (AD) and obesity have been increasing considerably in Korean school-children. AD is a chronic pruritic recurrent inflammatory skin disorder. Leptin is secreted by adipocytes which has been suggested to be immunologically active; however, their role in AD has not yet been well understood. A total of 227 subjects out of 2,109 elementary school children were defined as having AD based on the ISAAC questionnaire survey. Ninety subjects with AD, aged between 6 and 12 years, completed scoring of severity of AD (SCORAD), skin prick testing, blood tests for total IgE, eosinophi...
Source: Iranian Journal of Allergy, Asthma and Immunology - April 1, 2016 Category: Allergy & Immunology Authors: Seo S, Yoon WS, Cho Y, Park SH, Choung JT, Yoo Y Tags: Iran J Allergy Asthma Immunol Source Type: research

Immunomodulatory Effect of Chymotrypsin in CNS Is Sex-independent: Evidence of Anti-inflammatory Role for IL-17 in EAE.
Abstract Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are inflammatory autoimmune diseases of the central nervous system. Chymotrypsin is a serine protease with immunomodulatory effect in the peripheral organs. We previously demonstrated the immunomodulatory effect of chymotrypsin in ameliorating the EAE in female Lewis rats. However, there are sex-based differences in the immune system, drug activity, and CNS structure and composition. In addition, female gender is a better prognostic indicator of MS and males are more severely affected by EAE than females. Conseq...
Source: Iranian Journal of Allergy, Asthma and Immunology - April 1, 2016 Category: Allergy & Immunology Authors: Ghaffarinia A, Parvaneh S, Jalili C, Riazi-Rad F, Yaslianifard S, Pakravan N Tags: Iran J Allergy Asthma Immunol Source Type: research

Improved Diagnosis of the Polysensitized Allergic Rhinitis Patients Using Component Resolved Diagnosis Method.
Abstract Allergy diagnosis needs to be improved in polysensitized patients due to the existence of possible confounding factors in this type of patients. Component resolved diagnosis (CRD) is a new concept in the investigation of polysensitized patients. The aim of this study was to evaluate if the utilization of ImmunoCAP ISAC improve the diagnosis of the polysensitized allergic rhinitis patients. Skin prick test (SPT) to 58 crude allergen extracts and CRD (ImmunoCAP ISAC) were carried out for 5 polysensitized allergic rhinitis patients. Two patients had a shellfish allergy and avoidance of shellfish was the only...
Source: Iranian Journal of Allergy, Asthma and Immunology - April 1, 2016 Category: Allergy & Immunology Authors: Mohamad Yadzir ZH, Bakhtiar F, Misnan R, Abdullah N, Leecyous B, Murad S Tags: Iran J Allergy Asthma Immunol Source Type: research

The Most Common Cow's Milk Allergenic Proteins with Respect to Allergic Symptoms in Iranian Patients.
Abstract Cow's milk allergy (CMA) is an immunological response to cow's milk proteins such as casein, α-lactalbumin and β lactoglobulin. The aim of this study was to determine the most common cow's milk allergenic proteins in patients with CMA and identify the most effective proteins in different allergic symptoms. Eighty seven patients (≤18 years) with allergy to cow's milk from 2006 to 2013 entered this study. They had a positive history of allergic reactions to cow's milk and a positive specific IgE test to whole cow's milk. The patients' symptoms were divided into four groups. Serum specific IgEs...
Source: Iranian Journal of Allergy, Asthma and Immunology - April 1, 2016 Category: Allergy & Immunology Authors: Shokouhi Shoormasti R, Fazlollahi MR, Barzegar S, Teymourpour P, Yazdanyar Z, Lebaschi Z, Nourizadeh M, Tazesh B, Movahedi M, Kashani H, Pourpak Z, Moin M Tags: Iran J Allergy Asthma Immunol Source Type: research

Toxocara Canis and Chronic Urticaria.
Abstract No Abstract. PMID: 27090371 [PubMed - as supplied by publisher] (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - April 1, 2016 Category: Allergy & Immunology Authors: Joob B, Wiwanitkit V Tags: Iran J Allergy Asthma Immunol Source Type: research

Role of Proangiogenic Factors in Immunopathogenesis of Multiple Sclerosis.
In this study, the link between proangiogenic factors and multiple sclerosis pathogenesis was examined by conducting a systemic review. Thus we searched the English medical literature via PubMed, ISI web of knowledge, Medline and virtual health library (VHL) databases. In this review, we describe direct and indirect roles of some proangiogenic factors in MS pathogenesis and report the association of these factors with pathological and inflammatory angiogenesis. PMID: 26996106 [PubMed - as supplied by publisher] (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - February 1, 2016 Category: Allergy & Immunology Authors: Hamid KM, Mirshafiey A Tags: Iran J Allergy Asthma Immunol Source Type: research

Effect of Vitamin A Supplementation on fatigue and depression in Multiple Sclerosis patients: A Double-Blind Placebo-Controlled Clinical Trial.
Abstract Decreasing the population and activation of inflammatory T helper cells in multiple sclerosis (MS) patients using vitamin A derivatives (retinoic acids) has been well documented. The present study determined the effect of vitamin A supplementation on psychiatric signs in MS patients. The subjects were 101 relapsing-remitting MS patients enrolled in a placebo-controlled randomized clinical trial. The treatment group was administered 25000 IU/d retinyl palmitate (RP) for 6 months followed by 10000 IU/d RP for another 6 months. The results for baseline characteristics, modified fatigue impact scale and Beck ...
Source: Iranian Journal of Allergy, Asthma and Immunology - February 1, 2016 Category: Allergy & Immunology Authors: Bitarafan S, Saboor-Yaraghi A, Sahraian MA, Soltani D, Nafissi S, Togha M, Beladi Moghadam N, Roostaei T, Mohammadzadeh Honarvar N, Harirchian MH Tags: Iran J Allergy Asthma Immunol Source Type: research

Increase in mRNA Level of Orexin1 and 2 Receptors Following Induction of Experimental Autoimmune Encephalomyelitis in Mice.
In this study, the mRNA expression levels of some hypothalamic peptides were investigated in C57BL/6 female mice with experimental autoimmune encephalomyelitis (EAE). Animals were randomly divided into two control and EAE groups. EAE was induced by administration of myelin oligodendrocyte glycoprotein (MOG) with complete Ferund's adjuvant and pertussis toxin. Twenty-first days following immunization, mice were decapitated to remove the brains. Then, the expression profiles of prepro-orexin, orexin 1 receptors (OX1R) and orexin 2 receptors (OX2R) in hypothalamic region were assessed using real-time PCR method. In this study...
Source: Iranian Journal of Allergy, Asthma and Immunology - February 1, 2016 Category: Allergy & Immunology Authors: Fatemi I, Shamsizadeh A, Roohbakhsh A, Ayoobi F, Sanati MH, Motevalian M Tags: Iran J Allergy Asthma Immunol Source Type: research

Analysis of Killer Cell Immunoglobulin-like Receptor Genes and Their HLA Ligands in Iranian Patients with Ankylosing Spondylitis.
Abstract Ankylosing Spondylitis (AS) is a chronic rheumatic disease which mainly involves the axial skeleton. It seems that non-HLA genes, as well as HLA-B27 gene, are linked to the etiology of the disease. Recently, it has been documented that KIRs and their HLA ligands are contributed to the Ankylosing Spondylitis. The aim of this study was to evaluate the KIR genes and their HLA ligands in Iranian AS patients and healthy individuals. The present study includes 200 AS patient samples and 200 healthy control samples. KIR genotyping was performed using the polymerase chain reaction sequence-specific primer (P...
Source: Iranian Journal of Allergy, Asthma and Immunology - February 1, 2016 Category: Allergy & Immunology Authors: Mahmoudi M, Jamshidi AR, Karami J, Mohseni A, Amirzargar AA, Farhadi E, Ahmadzadeh N, Nicknam MH Tags: Iran J Allergy Asthma Immunol Source Type: research

Expression Levels of Proinflammatory Cytokines and NLRP3 Inflammasome in an Experimental Model of Oxazolone-induced Colitis.
Abstract IL-1β and IL-17A are two cytokines with strong proinflammatory activities and are now known to be involved in a number of chronic inflammatory disorders. High-mobility group box 1 (HMGB1) is a nuclear protein regulating the expression of these proinflammatory cytokines. The NLRP3 inflammasome promotes the maturation of the IL-1β and its activation has been shown as a critical mechanism in the pathogenesis of inflammatory bowel disease (IBD). However, underlying mechanisms to modulate their production in IBD are still unclear. The aim of this study was to investigate the expression levels of mRNA...
Source: Iranian Journal of Allergy, Asthma and Immunology - February 1, 2016 Category: Allergy & Immunology Authors: Zherebiatiev A, Kamyshnyi A Tags: Iran J Allergy Asthma Immunol Source Type: research

Association between TNFAIP3 Gene Polymorphisms and Risk of Allergic Rhinitis in a Chinese Han Population.
Abstract Tumor necrosis factor alpha-inducible protein 3 (TNFAIP3) gene polymorphisms have been reported to be associated with the susceptibility to several immune-related diseases. Here we investigated the effect of TNFAIP3 gene polymorphisms on the risk of allergic rhinitis (AR) in a Chinese Han population. The case-control study included 540 AR patients and 524 healthy controls. Genotyping for TNFAIP3 polymorphisms (rs5029928, rs9494885, rs10499194, rs610604, and rs7753873) were performed using restriction fragment length polymorphism analysis and DNA sequencing. Allele and genotype frequencies were compared be...
Source: Iranian Journal of Allergy, Asthma and Immunology - February 1, 2016 Category: Allergy & Immunology Authors: Ke X, Yang Y, Shen Y, Wang X, Hong S Tags: Iran J Allergy Asthma Immunol Source Type: research

Peanut allergy in Mexican children: what is the effect of age at first consumption?
e;a V Abstract Studies suggest that children who start solid foods early are at risk for developing food allergies. Herein, we evaluated the effects of the introduction of peanuts to the diets of children on emerging peanut allergies. Children with allergic rhinitis and asthma were enrolled in the present study and evaluated in four stages. In the first stage, a clinical history was completed for all participants. In the second stage, skin tests were conducted to detect the sensitization to peanuts. In the third stage, the parents were interviewed about the peanut-eating habits of their children. In the fourth sta...
Source: Iranian Journal of Allergy, Asthma and Immunology - February 1, 2016 Category: Allergy & Immunology Authors: Bedolla Barajas M, Alcala-Padilla G, Morales Romero J, Camacho Fregoso J, Rivera Mejía V Tags: Iran J Allergy Asthma Immunol Source Type: research