Anti-inflammatory Effects of Ziziphus Jujube Mill on LPS-induced Acute Lung Injury in Mice
Iran J Allergy Asthma Immunol. 2023 Jun 16;22(3):281-289. doi: 10.18502/ijaai.v22i3.13056.ABSTRACTZiziphus Jujuba Mill (Z.J) is a well-known ethnomedical source of biologically active compounds with anti-inflammatory effects. However, its significance in acute lung injury (ALI) has never been studied. The present study aimed to explore whether Z.J could attenuate lipopolysaccharide (LPS)-induced inflammatory responses in an experimental model of ALI. Male BALB/c mice received an intratracheal administration of LPS (n=32) or phosphate buffer saline (PBS) (control, n=8). Within 1, 11, and 23 h post-LPS injection, mice were r...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Parastoo Shaban Niloofar Honari Nafiseh Erfanian Mehran Hosseini Hossein Safarpour Saeed Nasseri Source Type: research

Clinical Characteristics and Economic Burden of Asthma in China: A Multicenter Retrospective Study
Iran J Allergy Asthma Immunol. 2023 Jun 16;22(3):290-298. doi: 10.18502/ijaai.v22i3.13057.ABSTRACTAsthma is a common chronic airway inflammation that produces a healthcare burden on the economy. We aim to obtain a better understanding of the clinical status and disease burden of patients with asthma in China. A retrospective study was carried out based on the computerized medical records in the Jinan Health Medical Big Data Platform between 2011 and 2019 (available data from 38 hospitals). The asthma severity of each patient was assessed retrospectively and categorized as mild, moderate, or severe according to Global Initi...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Bin Shang Xiangguo Li Yu Xu Wenxin Ren Junren Wang Chunyan Xing Shujuan Jiang Jian Sun Source Type: research

IL-25 Impact on Malignant B Cells Survival and T Cells Activation in Chronic Lymphocytic Leukemia
Iran J Allergy Asthma Immunol. 2023 Jun 16;22(3):299-311. doi: 10.18502/ijaai.v22i3.13058.ABSTRACTT cell dysregulation and shift to T helper 2 responses, boosting tumor microenvironment support, contributes to the survival of leukemic B cells in Chronic Lymphocytic Leukemia. Interleukin (IL)-25 is involved in the initiation of T helper 2 cell responses. Signal transduction of IL-25 begins with the heterodimer receptor (IL-17RA/IL-17RB). The presence of IL-25 in the tumor microenvironment may affect the supportive effects of T cells in the surrounding tumor cell environment. The purpose of this study was to evaluate the rol...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Mehrnoosh Pashei Farahnaz Ghahremanfard Ehsan Manouchehri Doulabi Maral Hemmati Fatemeh Pak Parviz Kokhaei Source Type: research

Serologic Biomarkers in Pemphigus Monitoring: C-reactive Protein, Macrophage Migration Inhibitory Factor, and Prolactin Levels Versus Autoantibody Assays
In conclusion, anti-Dsg1, anti-Dsg3, and IIF autoantibody titers remain standard biomarkers for assessing disease activity, severity, and PV monitoring. The trend of CRP was similar to that of anti-Dsg1, anti-Dsg3, and IIF. Thus, CRP may be used for PV monitoring.PMID:37524667 | DOI:10.18502/ijaai.v22i3.13059 (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Hossein Mortazavi Vahide Saeidi Kamran Balighi Nafiseh Esmaeili Amir Teimourpour Maryam Daneshpazhooh Shahin Hamzelou Zahra Saffarian Jafar Taghizadeh Fazli Source Type: research

Association of Interleukin-2 Gene Polymorphism with Henoch-sch ├Ânlein Purpura Nephritis
Iran J Allergy Asthma Immunol. 2023 Jun 16;22(3):319-326. doi: 10.18502/ijaai.v22i3.13060.ABSTRACTHenoch-Sch├Ânlein purpura nephritis (HSPN) is a common vasculitis that mostly affects children, and previous studies have indicated that genetic factors may influence disease susceptibility. The aim of this study was to evaluate a possible association of three interleukin-2 (IL-2) gene polymorphisms (rs3136534, rs2069776, and rs2069762) with HSPN in the Chinese population. A total of 81 patients with HSPN and 200 healthy children were enrolled. The distribution of genotypes, allelic frequencies, and haplotype frequencies among...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Jiajia Cao Junfeng Zhang Hui Xu Wei Li Jianrong Shi Qing Ye Source Type: research