Iranian Journal of Allergy, Asthma and Immunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Expression Analysis of Long Noncoding RNA-MALAT1 and Interleukin-6 in Inflammatory Bowel Disease Patients
Iran J Allergy Asthma Immunol. 2023 Oct 29;22(5):482-494. doi: 10.18502/ijaai.v22i5.13997.ABSTRACT Inflammatory bowel disease (IBD) manifests as chronic inflammation within the gastrointestinal tract. The study focuses on a long noncoding RNA (lncRNA) known as Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1). MALAT1's misregulation has been linked with various autoimmune diseases and regulates proinflammatory cytokines. The role of IL6 in immune-triggered conditions, including IBD, is another focal point. In this research, the expression of MALAT1 and IL6 in IBD patients was meticulously analyzed to uncover ...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 12, 2023 Category: Allergy & Immunology Authors: Mohsen Nemati Bajestan Moein Piroozkhah Vahid Chaleshi Naser Elmi Ghiasi Negar Jamshidi Reza Mirfakhraie Hedieh Balaii Shabnam Shahrokh Hamid Asadzadeh Aghdaei Zahra Salehi Ehsan Nazemalhosseini Mojarad Source Type: research

PD-1/PD-L1 Interaction Regulates BCL2, KI67, BAX, and CASP3, Altering Proliferation, Survival, and Apoptosis in Acute Myeloid Leukemia
This study aims to elucidate the effect of PD-L1 stimulation on the proliferation, survival, and apoptosis of acute myeloid leukemia (AML) cell lines. Two human AML cell lines, HL-60 and THP-1 were cultured and treated with phorbol 12-myristate 13-acetate (PMA) to induce PD-L1overexpression. Post-treatment PD-L1 expression was confirmed via flow cytometry. Subsequently, cell surface PD-L1 was stimulated using a recombinant PD-1, 24 hours post-PMA treatment. The expression alterations in pivotal genes including BCL2, MKI67, BAX, and CASP3 were monitored using quantitative real-time polymerase chain reaction 24 and 48 hours ...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 12, 2023 Category: Allergy & Immunology Authors: Mojdeh Soltani Mahshid Vosoughi Mazdak Ganjalikhani-Hakemi Hoorieh Shapoorian Pezhman Beshkar Nahid Eskandari Behrooz Ghezelbash Source Type: research

Combined Treatment of Progressive Encephalitis in an X-linked Agammaglobulinemia Patient
We describe a patient with progressive encephalitis who improved after the use of immunomodulatory treatment with corticosteroids, fluoxetine, and nitazoxanide. In most of the cases the evolution of the progressive encephalitis is complicated and catastrophic. Based on our experience and the review of the literature, we propose the use of this combined treatment to control this devastating complication.PMID:38085151 | DOI:10.18502/ijaai.v22i5.13999 (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - December 12, 2023 Category: Allergy & Immunology Authors: Marco Antonio Yamazaki-Nakashimada Patricia Herrera-Mora Alfonso Mahrx-Bracho Gabriela L ópez-Herrera Juan Carlos Bustamante-Ogando Selma Cecilia Scheffler-Mendoza Source Type: research

The Effect of Oral Montelukast in Controlling Asthma Attacks in Children: A Randomized Double-blind Placebo Control Study
This study was conducted as a double-blind placebo-controlled clinical trial on 80 children aged 1-14 years with asthma who were admitted to the emergency department of Bahrami Children's Hospital (Tehran, Iran) during one year. Patients were randomly divided into case and control groups. In addition to the standard asthma attack treatment, Montelukast was prescribed in the case group and placebo in the control group for one week. Patients were evaluated in terms of asthma attack severity score and oxygen saturation percentage (SpO2) in room air as primary outcomes 1, 4, 8, 24 and 48 hours after admission. In the first 48 ...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 12, 2023 Category: Allergy & Immunology Authors: Mohsen Jafari Masoomeh Sobhani Kambiz Eftekhari Armen Malekiantaghi Mohammad Gharagozlou Alireza Shafiei Source Type: research

Chronic Allergen Exposure Contributes to Steroid Resistance via Increased Phosphorylation of Glucocorticoid Receptors S226 and p38 MAPK in a Mouse Model of Asthma
This study aims to investigate whether chronic allergen exposure can induce steroid resistance and whether it is associated with p38 MAPK activation in asthma. A mouse model of asthma was prepared by sensitizing and challenging mice with chronic ovalbumin (OVA) exposure. Key features of allergic asthma, encompassing bronchial hyperresponsiveness, pathology of lung tissues, cytokine profiles of inflammation in bronchoalveolar lavage fluid (BALF), and serum immunoglobulin (Ig)E concentration were evaluated. Furthermore, suppressive effects of corticosteroid on the splenocytes under stimulation of lipopolysaccharides, glucoco...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 12, 2023 Category: Allergy & Immunology Authors: Yan Zhou Limin Zhou Weizong Jin Chenhui Qiu Hualiang Jin Source Type: research