Iranian Journal of Allergy, Asthma and Immunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Macrophage Activation Syndrome Secondary to Histoplasmosis in an Adult Female Carrier of X-linked Chronic Granulomatous Disease with Extreme Lyonization
Iran J Allergy Asthma Immunol. 2023 Dec 28;22(6):609-612. doi: 10.18502/ijaai.v22i6.14650.ABSTRACTnot applicable to a Letter to the Editor.PMID:38477958 | DOI:10.18502/ijaai.v22i6.14650 (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Ximena Le ón-Lara Susana Garc ía-Pavón Osorio Sara Espinosa Padilla Lizbeth Blancas-Galicia Source Type: research

Obituary: Prof. Mohammad-Bagher Eslami (1936-2023)
Iran J Allergy Asthma Immunol. 2023 Dec 28;22(6):510-511. doi: 10.18502/ijaai.v22i6.14640.ABSTRACTNo Abstract No Abstract No Abstract.PMID:38477948 | DOI:10.18502/ijaai.v22i6.14640 (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Maryam Nourizadeh Mostafa Moin Source Type: research

Regulatory Effects of Long Non-coding RNAs on Th17/Treg Differentiation and Imbalance
Iran J Allergy Asthma Immunol. 2023 Dec 28;22(6):512-526. doi: 10.18502/ijaai.v22i6.14641.ABSTRACTScientific research over the past decades has proven the pivotal role of long non-coding RNAs (LncRNAs) in regulating gene expression. The immune responses are controlled through the interaction of pro-inflammatory (predominance of T helper 17 cells (Th17)) and anti-inflammatory cytokines excretion (predominance of Regulatory T cells (Treg)). Recent studies have marked the impact of many diverse LncRNAs on Treg/Th17 imbalances. Moreover, some of the roots and causes of human diseases can be associated with the alterations in t...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Reza Dabbaghipour Elham Ahmadi Mona Entezam Omid Rahbar Farzam Amir Baghbanzadeh Ali Saber Sichani Nazila Jalilzadeh Mahdi Jafarlou Behzad Baradaran Source Type: research

Comparing Budesonide and Fluticasone Propionate in Children with Moderate to Severe Asthma: A Pilot Randomized Controlled Trial
This study aimed to compare the effects of fluticasone propionate (FP) and budesonide (Bud) on the clinical symptoms and control of asthma in children with moderate to severe asthma. In this open-label study, children with moderate to severe asthma were randomly selected to receive either FP 250 mcg or Bud 400 mcg for 3 months. Asthma control test scores were measured in both groups monthly. The clinical symptoms, drug adherence, and rescue medication were also evaluated. A total of 50 patients with ages between 4 and 7 years old were included in the study (25 cases received Bud and 25 cases received FP). Asthma control te...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Mansour Sadeghzadeh Parisa Khoshnevisasl Akefeh Ahmadiafshar Nima Motamed Azadeh Pourmarjani Source Type: research

The Association between the Expression of MicroRNA-4270 and MicroRNA-4441 with some Metabolic Factors in Iranian Rheumatoid Arthritis Patients
Iran J Allergy Asthma Immunol. 2023 Dec 28;22(6):536-550. doi: 10.18502/ijaai.v22i6.14643.ABSTRACTMicroRNAs (miRs) play a role in several diseases, such as rheumatoid arthritis (RA). The purpose of this study was to discover new microRNAs and investigate their involvement in RA, examining their connections with inflammation and metabolic markers. New microRNAs related to RA were predicted using Mirbase and TargetScan databases based on RA target genes. The relationships between miRNAs and targets were visualized with Cytoscape software. Real-time polymerase chain reaction confirmed detectable miRNAs and metabolic factors w...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Sepideh Ghodoosifar Gholamreza Dehghan Reza Safaralizadeh Behzad Baradaran Mehrzad Hajialiloo Source Type: research

Methyltransferase-like 3 (METTL3) Epigenetically Modulates Glutathione Peroxidase 4 (GPX4) Expression to Affect Asthma
In this study, we delved into the regulatory mechanisms governing asthma, focusing on Methyltransferase-like 3 (METTL3). Through an ovalbumin (OVA)-induced mouse model and interleukin-13 (IL-13)-induced cell model, we mimicked the in vivo and in vitro functions of METTL3 in asthma. Our research revealed that METTL3 expression significantly decreased in asthma-induced mice and IL-13-stimulated cells compared to the control group. Moreover, METTL3 overexpression enhanced bronchial epithelial cell viability and proliferation. Mechanistically, we observed elevated levels of total iron, Fe2+, malondialdehyde (MDA), lipid reacti...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Liangfeng Lin Xiaohao Hu Qiaoyu Li Linlin Huang Source Type: research

Mesenchymal Stem Cell-derived Exosome; An Interesting Nanocarrier to Improve Allergen-specific Intranasal Immunotherapy
In conclusion, the Exo-OVA improved the INIT efficacy compared to free OVA. Therefore, this formulation could be introduced as an effective approach for immunomodulatory purposes with a shorter treatment duration and reduced side effects.PMID:38477953 | DOI:10.18502/ijaai.v22i6.14645 (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Sajad Dehnavi Maryam Dadmanesh Negin Hosseini Rouzbahani Mahmood Karimi Ali Asadirad Mohammad Gholami Khodayar Ghorban Source Type: research

Curcumin and Its Semisynthetic Derivative F-Curcumin Ameliorate the Expression of Cytokines in Autoimmune Encephalomyelitis Mouse Models of Multiple Sclerosis
In conclusion, curcumin and F-curcumin significantly modulate cytokine gene expression during EAE induction, potentially alleviating inflammation in MS, with F-curcumin showing a more substantial effect.PMID:38477954 | DOI:10.18502/ijaai.v22i6.14646 (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Saeid Khosropour Elahe Shahvarooghi Hossein Rezaeizadeh Maryam Esmaeelzadeh Source Type: research

Exploring the Impact of Leishmania Major on Mesenchymal Stem Cells: Evaluating Differentiation, and Immunomodulatory Function
In this study, we examined how Leishmania major (L. major) promastigotes affect the properties of MSCs. MSCs were isolated from adipose tissue and categorized into two groups: one group left untreated and the other group exposed to L. major. Giemsa staining was employed to accurately quantify the number of parasites that entered the cells. After 72 hours, real-time polymerase chain reaction was utilized to assess the expression of TLRs. Additionally, the flow cytometry technique was used to evaluate the expression of surface markers on the MSCs. Our results showed that MSCs can engulf parasites and increase the expression ...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Elham Mashayekh Arezou Khosrojerdi Ahmad Zavaran Hosseini Sara Soudi Source Type: research

Macrophage Activation Syndrome as a Complication of Chronic Granulomatous Disease: A Case Report
We describe a 10-month-old patient with a fatal secondary HLH as a CGD primary manifestation. We carried out an autopsy and found noncaseating granulomas, an aspergilloma in the lung, and hemophagocytosis. We performed a DHR assay on the patient's mother and grandmother, showing a bimodal pattern conclusive of X-linked CGD. Thus, our definitive diagnosis was CGD complicated by macrophage activation syndrome. CGD is caused by phagocytes' inability to control pathogens, resulting in granulomas. Secondary HLH is a severe complication and could be characterized by the proliferation of macrophages and T lymphocytes and the prod...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Eduardo Liquidano-Perez Mariana Carmona Berr ón Rosa Itzel Carrillo Nieto Celso Tom ás Corcuera Delgado Lizbeth Blancas Galicia Selma Cecilia Scheffler Mendoza Source Type: research

A Case of Insidious Onset of Kimura Disease-associated Immunoglobulin A Nephropathy without Eosinophil Infiltration in the Renal Tissue
In this study, we report a case of KD combined with immunoglobulin A nephropathy that first presented as a mass in the inguinal region, followed by recurrent renal involvement. Previous reports suggested that renal involvement caused by KD was due to direct infiltration of eosinophils; however, in this case, no eosinophil infiltration was found in the renal tissue after renal biopsy. This observation reminds us to approach the case from an immune-related molecular perspective to investigate the exact cause of renal damage due to KD.PMID:38477957 | DOI:10.18502/ijaai.v22i6.14649 (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Linxin Liu Haoxian Gou Yongfa Liu Shuai Hu Xiaoli Yang Bo Li Source Type: research

The Effect of Oral Montelukast in Controlling Asthma Attacks in Children: A Randomized Double-blind Placebo Control Study
This study was conducted as a double-blind placebo-controlled clinical trial on 80 children aged 1-14 years with asthma who were admitted to the emergency department of Bahrami Children's Hospital (Tehran, Iran) during one year. Patients were randomly divided into case and control groups. In addition to the standard asthma attack treatment, Montelukast was prescribed in the case group and placebo in the control group for one week. Patients were evaluated in terms of asthma attack severity score and oxygen saturation percentage (SpO2) in room air as primary outcomes 1, 4, 8, 24 and 48 hours after admission. In the first 48 ...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 12, 2023 Category: Allergy & Immunology Authors: Mohsen Jafari Masoomeh Sobhani Kambiz Eftekhari Armen Malekiantaghi Mohammad Gharagozlou Alireza Shafiei Source Type: research

Chronic Allergen Exposure Contributes to Steroid Resistance via Increased Phosphorylation of Glucocorticoid Receptors S226 and p38 MAPK in a Mouse Model of Asthma
This study aims to investigate whether chronic allergen exposure can induce steroid resistance and whether it is associated with p38 MAPK activation in asthma. A mouse model of asthma was prepared by sensitizing and challenging mice with chronic ovalbumin (OVA) exposure. Key features of allergic asthma, encompassing bronchial hyperresponsiveness, pathology of lung tissues, cytokine profiles of inflammation in bronchoalveolar lavage fluid (BALF), and serum immunoglobulin (Ig)E concentration were evaluated. Furthermore, suppressive effects of corticosteroid on the splenocytes under stimulation of lipopolysaccharides, glucoco...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 12, 2023 Category: Allergy & Immunology Authors: Yan Zhou Limin Zhou Weizong Jin Chenhui Qiu Hualiang Jin Source Type: research

Amygdalin Improves Allergic Asthma via the Thymic Stromal Lymphopoietin-dendritic Cell-OX40 Ligand Axis in a Mouse Model
Iran J Allergy Asthma Immunol. 2023 Oct 29;22(5):430-439. doi: 10.18502/ijaai.v22i5.13993.ABSTRACTAsthma, characterized by persistent inflammation and increased sensitivity of the airway, is the most common chronic condition among children. Novel, safe, and reliable treatment strategies are the focus of current research on pediatric asthma. Amygdalin, mainly present in bitter almonds, has anti-inflammatory and immunoregulatory potential, but its effect on asthma remains uninvestigated. Here, the impact of amygdalin on the thymic stromal lymphopoietin (TSLP)-dendritic cell (DC)-OX40L axis was investigated. A BALB/c mouse mo...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 12, 2023 Category: Allergy & Immunology Authors: Wen Cui Huan Zhou Ya-Zun Liu Yan Yang Yi-Zhong Hu Zhao-Peng Han Jian-Er Yu Zheng Xue Source Type: research