Efficacy of a new multifunctional surfactant ‐based biomaterial dressing with 1% silver sulphadiazine in chronic wounds
Abstract Chronic wounds represent a large and growing segment of health care and add considerably to human suffering and economic burden as populations age. More effective materials, especially those promoting ease of use and economy, are needed to treat this increasing number of patients. A case series conducted at a European outpatient tertiary wound centre used a novel surfactant‐based biomaterial dressing containing 1% silver sulphadiazine on 226 chronic wound patients with various aetiologies. Eighty‐eight patients had been undergoing standard of care treatment at the facility, while the remainder (n = 138) began ...
Source: International Wound Journal - September 7, 2014 Category: Surgery Authors: Christoph Z ölß, Jürgen D Cech Tags: ORIGINAL ARTICLE Source Type: research

Neuropathic ulcers in leprosy treated with intralesional platelet ‐rich plasma
We present two patients with four neuropathic leprosy ulcers that have responded satisfactory to PRP treatment. PRP therapy has been growing as a viable treatment alternative for chronic ulcers. However, stronger scientific evidence is required to support its potential benefit for use in chronic wounds. (Source: International Wound Journal)
Source: International Wound Journal - September 7, 2014 Category: Surgery Authors: Elena Conde ‐Montero, Celia Horcajada‐Reales, Petunia Clavo, Irene Delgado‐Sillero, Ricardo Suárez‐Fernández Tags: ORIGINAL ARTICLE Source Type: research

Lactic acid bacterial symbionts in honeybees – an unknown key to honey's antimicrobial and therapeutic activities
Abstract Could honeybees' most valuable contribution to mankind besides pollination services be alternative tools against infections? Today, due to the emerging antibiotic‐resistant pathogens, we are facing a new era of searching for alternative tools against infections. Natural products such as honey have been applied against human's infections for millennia without sufficient scientific evidence. A unique lactic acid bacterial (LAB) microbiota was discovered by us, which is in symbiosis with honeybees and present in large amounts in fresh honey across the world. This work investigates if the LAB symbionts are the sourc...
Source: International Wound Journal - September 7, 2014 Category: Surgery Authors: Tobias C Olofsson, Èile Butler, Pawel Markowicz, Christina Lindholm, Lennart Larsson, Alejandra Vásquez Tags: ORIGINAL ARTICLE Source Type: research

Postoperative wound dealing and superficial surgical site infection in open radical prostatectomy
In conclusion, the postoperative wound status data in this study suggests that no wound intervention after RP resulted in a comparatively lower ratio of superficial SSI than in the wound washing group. (Source: International Wound Journal)
Source: International Wound Journal - September 4, 2014 Category: Surgery Authors: Fukashi Yamamichi, Katsumi Shigemura, Mauso Yamashita, Kazushi Tanaka, Soishi Arakawa, Masato Fujisawa Tags: ORIGINAL ARTICLE Source Type: research

What can vasculitic leg ulcers implicate?
(Source: International Wound Journal)
Source: International Wound Journal - September 3, 2014 Category: Surgery Authors: Edit Szél, Győző Szolnoky, Irma Korom, Zsuzsanna Bata‐Csörgő, Nóra Adamkovich, János K. Annus, László Kovács, László Krenács, Angéla Meszes, Szabolcs Modok, Zoltán Ondrik, Lajos Kemény Tags: LETTER TO THE EDITOR Source Type: research

Subcutaneous injection of epidermal growth factor for skin hydrofluoric acid burns
(Source: International Wound Journal)
Source: International Wound Journal - September 3, 2014 Category: Surgery Authors: Yunanhai Zhang, Liangfang Ni, Xingang Wang, Chunmao Han Tags: LETTER TO THE EDITOR Source Type: research

Cdc42 and p190RhoGAP activation by CCN2 regulates cell spreading and polarity and induces actin disassembly in migrating keratinocytes
Abstract Cell migration requires spatiotemporal integration of signals that regulate cytoskeletal dynamics. In response to a migration‐promoting agent, cells begin to polarise and extend protrusions in the direction of migration. These cytoskeletal rearrangements are orchestrated by a variety of proteins, including focal adhesion kinase (FAK) and the Rho family of GTPases. CCN2, also known as connective tissue growth factor, has emerged as a regulator of cell migration but the mechanism by which CCN2 regulates keratinocyte function is not well understood. In this article, we sought to elucidate the basic mechanism of CCN...
Source: International Wound Journal - September 3, 2014 Category: Surgery Authors: Elizabeth Kiwanuka, Cameron CY Lee, Florian Hackl, Edward J Caterson, Johan PE Junker, Bengt Gerdin, Elof Eriksson Tags: ORIGINAL ARTICLE Source Type: research

Unwanted hair growth induced by topical epidermal growth factor during wound healing: true or myth?
(Source: International Wound Journal)
Source: International Wound Journal - August 22, 2014 Category: Surgery Authors: Moo Yeol Hyun, Jang Mi Suk, Kwang Ho Yoo, Beom Joon Kim, Myeung Nam Kim, Chang Kwun Hong Tags: LETTER TO THE EDITOR Source Type: research

Fungal surgical site infections
(Source: International Wound Journal)
Source: International Wound Journal - August 14, 2014 Category: Surgery Authors: Peralam Y Prakash Tags: LETTER TO THE EDITOR Source Type: research

The mobile phone compatible burns dressing
(Source: International Wound Journal)
Source: International Wound Journal - August 14, 2014 Category: Surgery Authors: Thanassi Athanassopoulos, Charles Yuen Yung Loh Tags: LETTER TO THE EDITOR Source Type: research

Vitamin E and wound healing: an evidence‐based review
Abstract Vitamin E has been demonstrated to modulate cellular signalling, gene expression and affect wounds infected with methicillin‐resistant Staphylococcus aureus (MRSA), thus influencing wound healing. This evidence‐based review aimed to identify and evaluate current research assessing the properties of vitamin E in relation to wound healing, through its role as an antioxidant and its influence on connective tissue growth factor (CTGF), MRSA and gene transcription. Literature dated from 1996 to 2012, published in English, involving either animals or adult humans with an acute or chronic wound were included. The dat...
Source: International Wound Journal - August 14, 2014 Category: Surgery Authors: Rachel Hobson Tags: ORIGINAL ARTICLE Source Type: research

Validation of a laser‐assisted wound measurement device in a wound healing model
This study aims to measure the accuracy of the laser‐assisted wound measurement (LAWM) device against traditional methods in the measurement of area, depth and volume. We measured four ‘healing’ wounds in a Play‐Doh®‐based model over five subsequent states of wound healing progression in which the model was irregularly filled in to replicate the healing process. We evaluated the LAWM device against traditional methods including digital photograph assessment with National Institutes of Health ImageJ software, measurements of depth with a ruler and weight‐to‐volume assessment with dental paste. Stat...
Source: International Wound Journal - August 14, 2014 Category: Surgery Authors: Ryan S Constantine, Jessica D Bills, Lawrence A Lavery, Kathryn E Davis Tags: ORIGINAL ARTICLE Source Type: research

Quality of measurements of acute surgical and traumatic wounds using a digital wound‐analysing tool
Abstract The aim of this study was to assess the reliability of measurements using a wound‐analysing tool and their interpretability. Wound surface areas and tissue types, such as granulation, slough and necrosis, in twenty digital photographs were measured using a specific software program. The ratio of these tissue types in a wound was calculated using a wound profile. We calculated the intraclass coefficient or κ for reliability, standard error of measurement (SEM) and smallest detectable change (SDC). The inter‐rater reliability intraclass correlation coefficient (ICC) was 0·99 for surface area, 0&midd...
Source: International Wound Journal - August 14, 2014 Category: Surgery Authors: Dymmie LC Landa, Anne‐Margreet van Dishoeck, Ewout W Steyerberg, Steven ER Hovius Tags: ORIGINAL ARTICLE Source Type: research

Assessment of patients' wound‐related pain experiences in University College Hospital, Ibadan, Nigeria
This study was necessitated by the international recognition of wound‐related pain (WRP) as a must‐address issue and patient‐centred concerns. The aim of this study was to assess patients' WRP experiences at rest and in relation to dressing change. This descriptive study utilised a WRP questionnaire which incorporated a visual analogue scale of 0–10 for data collection. A total of 109 patients participated in this study; 95·4% of the participants experienced wound pain at rest and during performance of activities of daily living, which were moderate (47·1%) and severe (30·8%) in intensity. ...
Source: International Wound Journal - August 14, 2014 Category: Surgery Authors: Helen N Obilor, Prisca O Adejumo, Rose E Ilesanmi Tags: ORIGINAL ARTICLE Source Type: research

Scarless outpatient ablation of pilonidal sinus: a pilot study of a new minimally invasive treatment
Abstract Pain and secretion of purulent materials are symptoms that are often associated with the pilonidal sinus. Generally, these symptoms are neglected by patients for a long time. Patients seek medical attention too late, fearing a prolonged period of pain and inability after surgery. The optimal therapy for pilonidal sinus should have the following characteristics: high healing rate, low recurrence rate, minimal postoperative pain and low cost. The aim of this study is to explore the effectiveness and safety of a new minimally invasive treatment: the scarless outpatient ablation of pilonidal sinus (SOAP). A total of 3...
Source: International Wound Journal - August 14, 2014 Category: Surgery Authors: Benedetto Neola, Stefano Capasso, Luca Caruso, Armando Falato, Giuseppe P Ferulano Tags: ORIGINAL ARTICLE Source Type: research

An extrafacial amelanotic lentigo maligna of the leg: a case report
(Source: International Wound Journal)
Source: International Wound Journal - August 14, 2014 Category: Surgery Authors: Antonella Tammaro, Diego Orsini, Alessandra Narcisi, Giorgia Cortesi, Francesca R Parisella, Veronica Giulianelli, Claudia Abruzzese, Severino Persechino Tags: LETTER TO THE EDITOR Source Type: research

Scratch wound closure of myoblasts and myotubes is reduced by inflammatory mediators
Abstract Complex interactions exist between muscle repair processes and acute inflammatory responses that are initiated by exercise‐induced muscle damage. The purpose of this study was to examine whether inflammatory mediators secreted by activated macrophages affect the migration of myogenic cells to the injury site. Migration was measured using a scratch wound closure assay in C2C12‐derived myogenic cells incubated in activated macrophage‐conditioned medium. Both myoblast and myotube migrations were significantly reduced in activated macrophage‐conditioned medium compared with control medium. Furthermore, we demo...
Source: International Wound Journal - August 14, 2014 Category: Surgery Authors: Miau‐Hwa Ko, Chia‐Yang Li, Chun‐Feng Lee, Chen‐Kang Chang, Shih‐Hua Fang Tags: ORIGINAL ARTICLE Source Type: research

Incisional negative pressure wound therapy after hemiarthroplasty for femoral neck fractures – reduction of wound complications
Abstract The aim of the study was to evaluate the use of incisional negative pressure wound therapy (iNPWT) in wound healing after femoral neck fracture (FNF) treated with hip hemiarthroplasty (HA) and its influence on postoperative seromas, wound secretion, as well as time and material consumption for dressing changes. The study is a prospective randomised evaluation of iNPWT in patients with large surgical wounds after FNF. Patients were randomised either to be treated by iNPWT (group A) or a standard wound dressing (group B). Follow‐up included ultrasound measurements of seroma volumes on postoperative days 5 and 10, ...
Source: International Wound Journal - August 14, 2014 Category: Surgery Authors: Johannes Pauser, Matthias Nordmeyer, Roland Biber, Jonathan Jantsch, Carsten Kopschina, Hermann J Bail, Matthias H Brem Tags: ORIGINAL ARTICLE Source Type: research

Attitudes towards pressure ulcer prevention: a psychometric evaluation of the Swedish version of the APuP instrument
Abstract The primary aim was to conduct a psychometric evaluation of the Attitude towards Pressure ulcer Prevention (APuP) instrument in a Swedish context. A further aim was to describe and compare attitudes towards pressure ulcer prevention between registered nurses (RNs), assistant nurses (ANs) and student nurses (SNs). In total, 415 RNs, ANs and SNs responded to the questionnaire. In addition to descriptive and comparative statistics, confirmatory factor analyses were performed. Because of a lack of support for the instrument structure, further explorative and consecutive confirmatory tests were conducted. Overall, posi...
Source: International Wound Journal - August 14, 2014 Category: Surgery Authors: Jan Florin, Carina Bååth, Lena Gunningberg, Gunilla Mårtensson Tags: ORIGINAL ARTICLE Source Type: research

Assessment of patients' wound ‐related pain experiences in University College Hospital, Ibadan, Nigeria
This study was necessitated by the international recognition of wound‐related pain (WRP) as a must‐address issue and patient‐centred concerns. The aim of this study was to assess patients' WRP experiences at rest and in relation to dressing change. This descriptive study utilised a WRP questionnaire which incorporated a visual analogue scale of 0–10 for data collection. A total of 109 patients participated in this study; 95·4% of the participants experienced wound pain at rest and during performance of activities of daily living, which were moderate (47·1%) and severe (30·8%) in intensity. ...
Source: International Wound Journal - August 13, 2014 Category: Surgery Authors: Helen N Obilor, Prisca O Adejumo, Rose E Ilesanmi Tags: ORIGINAL ARTICLE Source Type: research

Incisional negative pressure wound therapy after hemiarthroplasty for femoral neck fractures – reduction of wound complications
Abstract The aim of the study was to evaluate the use of incisional negative pressure wound therapy (iNPWT) in wound healing after femoral neck fracture (FNF) treated with hip hemiarthroplasty (HA) and its influence on postoperative seromas, wound secretion, as well as time and material consumption for dressing changes. The study is a prospective randomised evaluation of iNPWT in patients with large surgical wounds after FNF. Patients were randomised either to be treated by iNPWT (group A) or a standard wound dressing (group B). Follow‐up included ultrasound measurements of seroma volumes on postoperative days 5 and 10, ...
Source: International Wound Journal - August 13, 2014 Category: Surgery Authors: Johannes Pauser, Matthias Nordmeyer, Roland Biber, Jonathan Jantsch, Carsten Kopschina, Hermann J Bail, Matthias H Brem Tags: ORIGINAL ARTICLE Source Type: research

Quality of measurements of acute surgical and traumatic wounds using a digital wound ‐analysing tool
Abstract The aim of this study was to assess the reliability of measurements using a wound‐analysing tool and their interpretability. Wound surface areas and tissue types, such as granulation, slough and necrosis, in twenty digital photographs were measured using a specific software program. The ratio of these tissue types in a wound was calculated using a wound profile. We calculated the intraclass coefficient or κ for reliability, standard error of measurement (SEM) and smallest detectable change (SDC). The inter‐rater reliability intraclass correlation coefficient (ICC) was 0·99 for surface area, 0&midd...
Source: International Wound Journal - August 13, 2014 Category: Surgery Authors: Dymmie LC Landa, Anne ‐Margreet van Dishoeck, Ewout W Steyerberg, Steven ER Hovius Tags: ORIGINAL ARTICLE Source Type: research

Validation of a laser ‐assisted wound measurement device in a wound healing model
This study aims to measure the accuracy of the laser‐assisted wound measurement (LAWM) device against traditional methods in the measurement of area, depth and volume. We measured four ‘healing’ wounds in a Play‐Doh®‐based model over five subsequent states of wound healing progression in which the model was irregularly filled in to replicate the healing process. We evaluated the LAWM device against traditional methods including digital photograph assessment with National Institutes of Health ImageJ software, measurements of depth with a ruler and weight‐to‐volume assessment with dental paste. Stat...
Source: International Wound Journal - August 13, 2014 Category: Surgery Authors: Ryan S Constantine, Jessica D Bills, Lawrence A Lavery, Kathryn E Davis Tags: ORIGINAL ARTICLE Source Type: research

17 β‐Estradiol administration promotes delayed cutaneous wound healing in 40‐week ovariectomised female mice
This study investigated the effect of 17β‐estradiol on wound healing in 40‐week ovariectomised female mice. Thirty‐six‐week‐old female mice were divided into three groups: medication with 17β‐estradiol after ovariectomy (OVX + 17β‐estradiol), ovariectomy (OVX) and sham (SHAM). The mice received two full‐thickness wounds, and the OVX + 17β‐estradiol group was administered 17β‐estradiol at 0·01 g/day until healing. In the OVX + 17β‐estradiol group, the ratio of wound area was significantly smaller than those of the OVX and SHAM groups on days 1–3, 5, 6, 8&ndash...
Source: International Wound Journal - August 5, 2014 Category: Surgery Authors: Kanae Mukai, Yukari Nakajima, Tamae Urai, Emi Komatsu, Nasruddin, Junko Sugama, Toshio Nakatani Tags: ORIGINAL ARTICLE Source Type: research

Effectiveness of prostaglandin E1 in patients with mixed arterial and venous ulcers of the lower limbs
In conclusion, PGE1 infusion is a determinant in the reduction of the healing time of mixed ulcers of the lower limbs. (Source: International Wound Journal)
Source: International Wound Journal - August 5, 2014 Category: Surgery Authors: Giovanni De Caridi, Mafalda Massara, Francesco Stilo, Francesco Spinelli, Raffaele Grande, Lucia Butrico, Stefano de Franciscis, Raffaele Serra Tags: ORIGINAL ARTICLE Source Type: research

The effects of human keratinocyte coculture on human adipose‐derived stem cells
This study was conducted to evaluate the influence of human keratinocyte non‐contact coculture on hADSCs. Human epidermal keratinocytes and hADSCs obtained by lipoaspiration were cultured in keratinogenic growth media, which were divided into the following groups: human adipose‐derived stem cell (hADSC) monoculture, non‐contact coculture of hADSCs and human keratinocytes and keratinocyte monoculture. Cell proliferation was assessed, and keratogenicity was analysed through immunocytochemistry and polymerase chain reaction of early, intermediate and late keratogenic markers. hADSCs cocultured with keratinocytes display...
Source: International Wound Journal - August 5, 2014 Category: Surgery Authors: Bommie F Seo, Ki J Kim, Min K Kim, Jong W Rhie Tags: ORIGINAL ARTICLE Source Type: research

Scrotal reconstruction using a superficial circumflex iliac artery perforator flap following Fournier's gangrene
Abstract Fournier's gangrene is a type of necrotising fasciitis around the scrotum and perineum. Because of its aggressive nature, patients should be treated with broad‐spectrum antibiotics and emergency, radical debridement during the acute phase. After recovering from the acute phase, reconstruction of the scrotal and perineal soft tissue defects is needed and is often challenging. Traditionally, various reconstruction methods have been used, including skin grafts, fasciocutaneous flaps and musculocutaneous flaps, each with its pros and cons. We successfully covered a wide scrotal defect using a superficial circumflex ...
Source: International Wound Journal - August 5, 2014 Category: Surgery Authors: Hyun H Han, Jung H Lee, Sue M Kim, Young J Jun, Young J Kim Tags: CASE REPORT Source Type: research

The effects of human keratinocyte coculture on human adipose ‐derived stem cells
This study was conducted to evaluate the influence of human keratinocyte non‐contact coculture on hADSCs. Human epidermal keratinocytes and hADSCs obtained by lipoaspiration were cultured in keratinogenic growth media, which were divided into the following groups: human adipose‐derived stem cell (hADSC) monoculture, non‐contact coculture of hADSCs and human keratinocytes and keratinocyte monoculture. Cell proliferation was assessed, and keratogenicity was analysed through immunocytochemistry and polymerase chain reaction of early, intermediate and late keratogenic markers. hADSCs cocultured with keratinocytes display...
Source: International Wound Journal - August 4, 2014 Category: Surgery Authors: Bommie F Seo, Ki J Kim, Min K Kim, Jong W Rhie Tags: ORIGINAL ARTICLE Source Type: research

Long‐term follow‐up of negative pressure wound therapy with instillation: a limb salvage procedure?
We report our experience of treating three patients with complex wounds and associated noble structure exposition conservatively with NPWTi and flap coverage. In a long‐term follow‐up (5 years), we were able to achieve a stable surgery reconstruction on preserved limbs, without evidence of chronic infection and other sequelae or complications. Despite the fact that our experience is limited , as it is based on only a few cases, it suggests how NPWTi could be considered useful in a conservative approach to the treatment of acute complex wounds of the lower extremities. In these patients with high risk of amputati...
Source: International Wound Journal - August 1, 2014 Category: Surgery Authors: Daniele Bollero, Kiran Degano, Ezio N Gangemi, Domenico Aloj, Valeria Malvasio, Maurizio Stella Tags: ORIGINAL ARTICLE Source Type: research

VAC therapy for the treatment of complex wounds after cardio‐thoracic surgery
In conclusion, VAC therapy promotes faster wound healing, with shorter hospital stay and subsequent lesser in‐hospital cost, reducing the mortality rate in the long run. It also promotes early rehabilitation and alleviates the need for a second procedure, thus improving patient satisfaction, with minimal discomfort or inconvenience. (Source: International Wound Journal)
Source: International Wound Journal - August 1, 2014 Category: Surgery Authors: Giovanni De Caridi, Raffaele Serra, Mafalda Massara, Mario Barone, Raffaele Grande, Lucia Butrico, Pasquale Mastroroberto, Stefano Franciscis, Francesco Monaco Tags: ORIGINAL ARTICLE Source Type: research

Wound healing activity of methanolic stem extract of Musa paradisiaca Linn. (Banana) in Wistar albino rats
This study is designed to explore the phytochemical, antibacterial and wound healing activity of methanolic stem extract of Musa paradisiaca Linn. (Banana). The phytochemical analysis was performed for the methanolic stem extract of Musa paradisiaca Linn. Results indicates that the Musa paradisiaca Linn. was rich in glucosides, tannins and alkaloids, saponins, flavonoids and phenols were present in moderate quantities. The extract shows antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus with the zone of inhibition of Pseudomonas aeruginosa was 21 mm and Staphylococcus aureus was 19&thins...
Source: International Wound Journal - August 1, 2014 Category: Surgery Authors: Kuppusamy Amutha, Ulagesan Selvakumari Tags: ORIGINAL ARTICLE Source Type: research

Topical use of citric acid for wound bed preparation
Abstract Wound bed preparation is the management of a wound in order to accelerate endogenous healing or to facilitate the effectiveness of split‐skin grafting. The formation of a healthy wound bed is a prerequisite to the use of advanced wound care products. Unless this is achieved, even the most sophisticated and expensive materials are unlikely to function correctly. An attempt has been made to use 3% citric acid ointment for wound bed preparation to prepare wound for grafting in five cases of wounds with large raw areas infected with multiple antibiotic‐resistant bacteria. (Source: International Wound Journal)
Source: International Wound Journal - August 1, 2014 Category: Surgery Authors: Rajendra G Malu, Basavraj S Nagoba, Chetan R Jaju, Namdev M Suryawanshi, Santosh A Mali, Vishav S Goyal, Nikhil S Misal Tags: ORIGINAL ARTICLE Source Type: research

Quality of life psychosocial characteristics in Greek patients with leg ulcers: a case control study
Abstract Chronic leg ulcers are a public health problem that can have a significant impact on the patient's physical, socioeconomic and psychological status. The aim of this study is to evaluate the quality of life, anxiety and depression, self‐esteem and loneliness in patients suffering from leg ulcers. A total of 102 patients were enrolled in the study. The quality of life, anxiety and depression, self‐esteem and loneliness of the patient were assessed using the Dermatology Life Quality Index (DLQI), Hospital Anxiety and Depression Scale (HADS), Rosenberg`s Self‐esteem Scale (RSES) and the UCLA Loneliness Scale (UC...
Source: International Wound Journal - August 1, 2014 Category: Surgery Authors: Anargyros Kouris, Kalliopi Armyra, Christos Christodoulou, Themis Sgontzou, Dimitrios Karypidis, George Kontochristopoulos, Fotini Liordou, Nikoletta Zakopoulou, Eftychia Zouridaki Tags: ORIGINAL ARTICLE Source Type: research

A case report of a 19‐week gravid patient with a dehisced abdominal wound and treated with V.A.C. ATS® Therapy System
We report the case of a 19‐week pregnant patient where V.A.C.® Therapy was applied to her dehisced laparotomy wound with satisfactory results. The patient was a 30‐year‐old female who was referred to our hospital from her previous doctor because of the presence of an ovarian cyst on the left ovary. The patient presented at 14 weeks into her pregnancy, and surgery was considered because of no reduction in the size of the cyst. An oophorocystectomy was performed, and then the surgical incision was re‐opened at postoperative day (POD) 10 due to a surgical site infection. V.A.C.® Therapy was initiated on...
Source: International Wound Journal - August 1, 2014 Category: Surgery Authors: Kei Asukai, Masaki Kashiwazaki, Kaori Koizumi, Toshikatsu Nobunaga, Hiroshi Yano Tags: CASE REPORT Source Type: research

Partial fingertip necrosis following a digital surgical procedure in a patient with primary Raynaud's phenomenon
Abstract Raynaud's phenomenon is a common clinical disorder consisting of recurrent, long‐lasting and episodic vasospasm of the fingers and toes often associated with exposure to cold. In this article, we present a case of partial fingertip necrosis following digital surgical procedure in a patient with primary Raynaud's phenomenon. (Source: International Wound Journal)
Source: International Wound Journal - August 1, 2014 Category: Surgery Authors: Safak Uygur, Serhan Tuncer Tags: CASE REPORT Source Type: research

Neuropathic ulcers in leprosy treated with intralesional platelet‐rich plasma
We present two patients with four neuropathic leprosy ulcers that have responded satisfactory to PRP treatment. PRP therapy has been growing as a viable treatment alternative for chronic ulcers. However, stronger scientific evidence is required to support its potential benefit for use in chronic wounds. (Source: International Wound Journal)
Source: International Wound Journal - August 1, 2014 Category: Surgery Authors: Elena Conde‐Montero, Celia Horcajada‐Reales, Petunia Clavo, Irene Delgado‐Sillero, Ricardo Suárez‐Fernández Tags: ORIGINAL ARTICLE Source Type: research

Association of diabetic foot care and amputation rates in Germany
Abstract Podologists are nurses who care for the diabetic foot (orthotics, offloading devices, blisters, calluses, treatment of fungus infection and patient education). In contrast to podiatrists, they are not qualified to perform any surgical treatment or wound care. We analysed whether there is an association between the decrease in major amputations and the number of podologic foot care (PFC) visits prescribed in Germany. Detailed list of all major lower limb amputations (OPS 5‐864) performed from 2007 to 2011 was provided by the Federal Statistical Office. Data were separated for the 16 federal states in Germany. Det...
Source: International Wound Journal - August 1, 2014 Category: Surgery Authors: Knut Kröger, Theodoros Moysidis, Michel Feghaly, Erika Schäfer, Alexander Bufe, Tags: ORIGINAL ARTICLE Source Type: research

Activated protein C to heal pressure ulcers
Abstract Pressure ulcers present a major clinical challenge, are physically debilitating and place the patient at risk of serious comorbidities such as septic shock. Recombinant human activated protein C (APC) is an anticoagulant with anti‐inflammatory, cytoprotective and angiogenic effects that promote rapid wound healing. Topical negative pressure wound therapy (TNP) has become widely used as a treatment modality in wounds although its efficacy has not been proven through randomised controlled trials. The aim of this study was to determine the preliminary efficacy and safety of treatment with APC for severe chronic pre...
Source: International Wound Journal - August 1, 2014 Category: Surgery Authors: Aruna Wijewardena, Sepehr S Lajevardi, Elle Vandervord, John Vandervord, Thomas C Lang, Gregory Fulcher, Christopher J Jackson Tags: CASE REPORT Source Type: research

Fournier's gangrene current approaches
The objective of this study is to analyse the demographics, clinical feature and treatment approaches as well as outcomes of Fournier's gangrene. Data were collected retrospectively from medical records and operative notes. Patient data were analysed by demographics, aetiological factors, clinical features, treatment approaches and outcomes. Twelve patients (five female and seven male) were enrolled in this study. The most common aetiology was perianal abscess (41·6%). Wound cultures showed a mixture of microorganisms in six (50%) patients. For faecal diversion, while colostomy was performed in six cases (50%), Flex...
Source: International Wound Journal - August 1, 2014 Category: Surgery Authors: Omer F Ozkan, Neset Koksal, Ediz Altinli, Atilla Celik, Mehmet A Uzun, Oztekin Cıkman, Alpaslan Akbas, Ersin Ergun, Hasan A Kiraz, Muammer Karaayvaz Tags: ORIGINAL ARTICLE Source Type: research

Suture granuloma mimicking a recurrent sacro‐coccygeal pilonidal sinus after Limberg flap
We report about a case of suture granuloma in the area of a Limberg flap after recurrent pilonidal sinus with extrusion of the suture material, thus mimicking recurrence. In case of recurrent pilonidal sinus following plastic coverage or primary closure, respectively, the differential diagnosis of suture granuloma should be considered. (Source: International Wound Journal)
Source: International Wound Journal - August 1, 2014 Category: Surgery Authors: Michael Ardelt, Yves Dittmar, Birte Schulz, Falk Rauchfuss, Hubert Scheuerlein, Utz Settmacher Tags: CASE REPORT Source Type: research

17β‐Estradiol administration promotes delayed cutaneous wound healing in 40‐week ovariectomised female mice
This study investigated the effect of 17β‐estradiol on wound healing in 40‐week ovariectomised female mice. Thirty‐six‐week‐old female mice were divided into three groups: medication with 17β‐estradiol after ovariectomy (OVX + 17β‐estradiol), ovariectomy (OVX) and sham (SHAM). The mice received two full‐thickness wounds, and the OVX + 17β‐estradiol group was administered 17β‐estradiol at 0·01 g/day until healing. In the OVX + 17β‐estradiol group, the ratio of wound area was significantly smaller than those of the OVX and SH...
Source: International Wound Journal - August 1, 2014 Category: Surgery Authors: Kanae Mukai, Yukari Nakajima, Tamae Urai, Emi Komatsu, Nasruddin, Junko Sugama, Toshio Nakatani Tags: ORIGINAL ARTICLE Source Type: research

Getting evidence‐based pressure ulcer prevention into practice: a multi‐faceted unit‐tailored intervention in a hospital setting
Abstract The aim of the study was to evaluate whether a multi‐faceted, unit‐tailored intervention using evidenced‐based pressure ulcer prevention affects (i) the performance of pressure ulcer prevention, (ii) the prevalence of pressure ulcers and (iii) knowledge and attitudes concerning pressure ulcer prevention among registered and assistant nurses. A quasi‐experimental, clustered pre‐ and post‐test design was used. Five units at a hospital setting were included. The intervention was based on the PARIHS framework and included a multi‐professional team, training and repeated quality measurements. An establish...
Source: International Wound Journal - July 25, 2014 Category: Surgery Authors: Eva Sving, Marieann Högman, Anna‐Greta Mamhidir, Lena Gunningberg Tags: ORIGINAL ARTICLE Source Type: research

Getting evidence ‐based pressure ulcer prevention into practice: a multi‐faceted unit‐tailored intervention in a hospital setting
Abstract The aim of the study was to evaluate whether a multi‐faceted, unit‐tailored intervention using evidenced‐based pressure ulcer prevention affects (i) the performance of pressure ulcer prevention, (ii) the prevalence of pressure ulcers and (iii) knowledge and attitudes concerning pressure ulcer prevention among registered and assistant nurses. A quasi‐experimental, clustered pre‐ and post‐test design was used. Five units at a hospital setting were included. The intervention was based on the PARIHS framework and included a multi‐professional team, training and repeated quality measurements. An establish...
Source: International Wound Journal - July 24, 2014 Category: Surgery Authors: Eva Sving, Marieann H ögman, Anna‐Greta Mamhidir, Lena Gunningberg Tags: ORIGINAL ARTICLE Source Type: research

The efficacy and safety of Grafix® for the treatment of chronic diabetic foot ulcers: results of a multi‐centre, controlled, randomised, blinded, clinical trial
Abstract In a randomised, controlled study, we compared the efficacy of Grafix®, a human viable wound matrix (hVWM) (N = 50), to standard wound care (n = 47) to heal diabetic foot ulcers (DFUs). The primary endpoint was the proportion of patients with complete wound closure by 12 weeks. Secondary endpoints included the time to wound closure, adverse events and wound closure in the crossover phase. The proportion of patients who achieved complete wound closure was significantly higher in patients who received Grafix (62%) compared with controls (21%, P = 0·0001). T...
Source: International Wound Journal - July 22, 2014 Category: Surgery Authors: Lawrence A Lavery, James Fulmer, Karry Ann Shebetka, Matthew Regulski, Dean Vayser, David Fried, Howard Kashefsky, Tammy M Owings, Janaki Nadarajah, Tags: ORIGINAL ARTICLE Source Type: research

Comparing the effects of nebivolol and dexpanthenol on wound healing: an experimental study
Abstract Wound healing is a dynamic, interactive process that is initiated in response to injury. A number of investigations and clinical studies have been performed to determine new approaches for the improvement of wound healing. The aim of this study was to compare the effects of dexpanthenol, a molecule that is widely used for improving wound healing, and nebivolol, a molecule that increases nitric oxide release, on wound healing. A total of 30 rats were divided into three equal groups (n = 10). A linear 2 cm incision was made in the rats' skin. No treatment was administered in the first (control) ...
Source: International Wound Journal - July 15, 2014 Category: Surgery Authors: Burak V Ulger, Murat Kapan, Omer Uslukaya, Zubeyir Bozdag, Ahmet Turkoglu, Ulas Alabalık, Akın Onder Tags: ORIGINAL ARTICLE Source Type: research

Changes in the expression of epidermal differentiation markers at sites where cultured epithelial autografts were transplanted onto wounds from burn scar excision
This study investigated the recovery process during which grafted cultured epithelium formed normal epidermis. The subjects were 18 patients whose burn scars were excised at a depth not exposing the fat layer and who subsequently received cultured epithelial autografts. A total of 24 samples were obtained from the grafted sites: 6 samples within 6 weeks (stage 1), 5 samples after 6 weeks and within 6 months (stage 2), 6 samples after 6 months and within 18 months (stage 3) and 7 samples beyond 18 months (stage 4) after transplantation. These samples were stained for monoclonal anti...
Source: International Wound Journal - July 15, 2014 Category: Surgery Authors: Kuniko Kadoya, Satoshi Amano, Toshio Nishiyama, Shinji Inomata, Makoto Tsunenaga, Norio Kumagai, Kyoichi Matsuzaki Tags: ORIGINAL ARTICLE Source Type: research

Calendar
(Source: International Wound Journal)
Source: International Wound Journal - July 14, 2014 Category: Surgery Tags: CALENDAR OF EVENTS Source Type: research

The effectiveness of a twice‐daily skin‐moisturising regimen for reducing the incidence of skin tears
Abstract A cluster randomised controlled trial was conducted to evaluate the effectiveness of a twice‐daily moisturising regimen as compared to ‘usual’ skin care for reducing skin tear incidence. Aged care residents from 14 Western Australian facilities (980 beds) were invited to participate. The facilities were sorted into pairs and matched in terms of bed numbers and whether they provided high or low care. One facility from each matched pair was randomised to the intervention group. Consenting residents in an intervention facility received a twice‐daily application of a commercially available, standardise...
Source: International Wound Journal - July 14, 2014 Category: Surgery Authors: Keryln Carville, Gavin Leslie, Rebecca Osseiran‐Moisson, Nelly Newall, Gill Lewin Tags: ORIGINAL ARTICLE Source Type: research

News and views
(Source: International Wound Journal)
Source: International Wound Journal - July 14, 2014 Category: Surgery Tags: NEWS AND VIEWS Source Type: research

Spanning the globe – an international collaboration over 10 361 miles
(Source: International Wound Journal)
Source: International Wound Journal - July 14, 2014 Category: Surgery Authors: Keith Harding, Ian Griffiths Tags: EDITORIAL Source Type: research