TIME management by medicinal larvae
Abstract Wound bed preparation (WBP) is an integral part of the care programme for chronic wounds. The acronym TIME is used in the context of WBP and describes four barriers to healing in chronic wounds; namely, dead Tissue, Infection and inflammation, Moisture imbalance and a non‐migrating Edge. Larval debridement therapy (LDT) stems from observations that larvae of the blowfly Lucilia sericata clean wounds of debris. Subsequent clinical studies have proven debriding efficacy, which is likely to occur as a result of enzymatically active alimentary products released by the insect. The antimicrobial, anti‐inflammatory ...
Source: International Wound Journal - July 15, 2015 Category: Surgery Authors: David I Pritchard, Václav Čeřovský, Yamni Nigam, Samantha F Pickles, Gwendolyn Cazander, Peter H Nibbering, Anke Bültemann, Wilhelm Jung Tags: ORIGINAL ARTICLE Source Type: research

The efficacy of hydrogel dressings as a first aid measure for burn wound management in the pre ‐hospital setting: a systematic review of the literature
Abstract The aim of this systematic review was to determine the supporting evidence for the clinical use of hydrogel dressings as a first aid measure for burn wound management in the pre‐hospital setting. Two authors searched three databases (Ovid Medline, Ovid Embase and The Cochrane Library) for relevant English language articles published through September 2014. Reference lists, conference proceedings and non‐indexed academic journals were manually searched. A separate search was conducted using the Internet search engine Google to source additional studies from burns advisory agencies, first aid bodies, military in...
Source: International Wound Journal - July 14, 2015 Category: Surgery Authors: Nicholas S Goodwin, Anneliese Spinks, Jason Wasiak Tags: ORIGINAL ARTICLE Source Type: research

The efficacy of hydrogel dressings as a first aid measure for burn wound management in the pre‐hospital setting: a systematic review of the literature
Abstract The aim of this systematic review was to determine the supporting evidence for the clinical use of hydrogel dressings as a first aid measure for burn wound management in the pre‐hospital setting. Two authors searched three databases (Ovid Medline, Ovid Embase and The Cochrane Library) for relevant English language articles published through September 2014. Reference lists, conference proceedings and non‐indexed academic journals were manually searched. A separate search was conducted using the Internet search engine Google to source additional studies from burns advisory agencies, first aid bodies, military in...
Source: International Wound Journal - July 14, 2015 Category: Surgery Authors: Nicholas S Goodwin, Anneliese Spinks, Jason Wasiak Tags: ORIGINAL ARTICLE Source Type: research

Calendar
(Source: International Wound Journal)
Source: International Wound Journal - July 3, 2015 Category: Surgery Tags: CALENDAR OF EVENTS Source Type: research

News and views
(Source: International Wound Journal)
Source: International Wound Journal - July 3, 2015 Category: Surgery Tags: NEWS Source Type: research

2015 International Working Group on the Diabetic Foot Guidance on the prevention and management of foot problems in diabetes
(Source: International Wound Journal)
Source: International Wound Journal - July 3, 2015 Category: Surgery Authors: Nia J Jones, Keith Harding Tags: EDITORIAL Source Type: research

Differential diagnosis of suspected deep tissue injury
Abstract Deep tissue injury (DTI) can be difficult to diagnose because many other skin and wound problems can appear as purple skin or rapidly appearing eschar. The diagnosis of DTI begins with a thorough history to account for times of exposure to pressure, such as ‘time down’ at the scene or time during which the patient was flat and could not respond. Patients with light skin tones present with classic skin discolouration of purple or maroon tissue, a defined border around the area of injury, and often surrounding erythema is evident. Persistent erythema and hyperpigmentation, rather than blanching, should b...
Source: International Wound Journal - June 30, 2015 Category: Surgery Authors: Joyce M Black, Christopher T Brindle, Jeremy S Honaker Tags: ORIGINAL ARTICLE Source Type: research

Cost consequences due to reduced ulcer healing times – analyses based on the Swedish Registry of Ulcer Treatment
Abstract Resource use and costs for topical treatment of hard‐to‐heal ulcers based on data from the Swedish Registry of Ulcer Treatment (RUT) were analysed in patients recorded in RUT as having healed between 2009 and 2012, in order to estimate potential cost savings from reductions in frequency of dressing changes and healing times. RUT is used to capture areas of improvement in ulcer care and to enable structured wound management by registering patients with hard‐to‐heal leg, foot and pressure ulcers. Patients included in the registry are treated in primary care, community care, private care, and inpatient hospit...
Source: International Wound Journal - June 29, 2015 Category: Surgery Authors: Rut F Öien, Henrik Forssell, Gunnel Ragnarson Tennvall Tags: ORIGINAL ARTICLE Source Type: research

Safety and performance evaluation of a next ‐generation antimicrobial dressing in patients with chronic venous leg ulcers
The objective of this study was to investigate the safety and performance of AQUACEL™ Ag+ dressing, a wound dressing containing a combination of anti‐biofilm and antimicrobial agents, in the management of chronic wounds. Patients (n = 42) with venous leg ulcers exhibiting signs of clinical infection were treated for 4 weeks with AQUACEL™ Ag+ dressing, followed by management with AQUACEL™ wound dressings for 4 weeks. Wound progression, wound size, ulcer pain and clinical evolution of the wound were assessed for up to 8 weeks. Adverse events were recorded throughout the study. AQUACEL™ Ag+ dressing ...
Source: International Wound Journal - June 20, 2015 Category: Surgery Authors: Keith G Harding, Marek Szczepkowski, Jacek Mikosi ński, Krystyna Twardowska‐Saucha, Stephen Blair, Nicola M Ivins, Wojciech Saucha, Jane Cains, Kim Peters, David Parsons, Philip Bowler Tags: ORIGINAL ARTICLE Source Type: research

Risk factors associated with intraoperatively acquired pressure ulcers in the park‐bench position: a retrospective study
This study was conducted at a general hospital during the period of September 2010 to September 2012. Twenty‐one potential risk factors were evaluated using data obtained from the hospital database. IAPUs developed in 30 of 277 patients (11%). Perspiration was statistically found to be independently associated with IAPUs [OR 3·09, 95% confidence interval (Cl) 1.07–8·58, P = 0·037]. A length of surgery of more than 6 hours was identified to be likely associated with IAPUs (OR 2·64, 95% Cl 0·84–9·08, P = 0·095) compared with les...
Source: International Wound Journal - June 4, 2015 Category: Surgery Authors: Mine Yoshimura, Shinji Iizaka, Michihiro Kohno, Osamu Nagata, Takashi Yamasaki, Tomoko Mae, Naoko Haruyama, Hiromi Sanada Tags: ORIGINAL ARTICLE Source Type: research

Risk factors associated with intraoperatively acquired pressure ulcers in the park ‐bench position: a retrospective study
This study was conducted at a general hospital during the period of September 2010 to September 2012. Twenty‐one potential risk factors were evaluated using data obtained from the hospital database. IAPUs developed in 30 of 277 patients (11%). Perspiration was statistically found to be independently associated with IAPUs [OR 3·09, 95% confidence interval (Cl) 1.07–8·58, P = 0·037]. A length of surgery of more than 6 hours was identified to be likely associated with IAPUs (OR 2·64, 95% Cl 0·84–9·08, P = 0·095) compared with less than 6 hours. Furthermore, there ...
Source: International Wound Journal - June 3, 2015 Category: Surgery Authors: Mine Yoshimura, Shinji Iizaka, Michihiro Kohno, Osamu Nagata, Takashi Yamasaki, Tomoko Mae, Naoko Haruyama, Hiromi Sanada Tags: ORIGINAL ARTICLE Source Type: research

Silver ‐based wound dressings reduce bacterial burden and promote wound healing
This study investigated the potential of three silver‐containing dressings, namely KoCarbonAg®, Aquacel® Ag and Acticoat 7, in reducing bacterial survival and promoting wound healing. The ability of these dressings to block the entry of bacteria from external environment and retain intrinsic bacteria was studied in vitro. In addition, the study used a rat model to compare the healing efficiencies of the three dressings and investigate the quantity of collagen synthesis in vivo. In vitro results indicated that the silver‐containing dressings prevented bacterial growth in wounds by blocking the entry of external ...
Source: International Wound Journal - June 3, 2015 Category: Surgery Authors: Yu ‐Hsin Lin, Wei‐Shan Hsu, Wan‐Yu Chung, Tse‐Hao Ko, Jui‐Hsiang Lin Tags: ORIGINAL ARTICLE Source Type: research

Cost consequences due to reduced ulcer healing times – analyses based on the Swedish Registry of Ulcer Treatment
Abstract Resource use and costs for topical treatment of hard‐to‐heal ulcers based on data from the Swedish Registry of Ulcer Treatment (RUT) were analysed in patients recorded in RUT as having healed between 2009 and 2012, in order to estimate potential cost savings from reductions in frequency of dressing changes and healing times. RUT is used to capture areas of improvement in ulcer care and to enable structured wound management by registering patients with hard‐to‐heal leg, foot and pressure ulcers. Patients included in the registry are treated in primary care, community care, private care, and inpatient hospit...
Source: International Wound Journal - June 1, 2015 Category: Surgery Authors: Rut F Öien, Henrik Forssell, Gunnel Ragnarson Tennvall Tags: ORIGINAL ARTICLE Source Type: research

Safety and performance evaluation of a next‐generation antimicrobial dressing in patients with chronic venous leg ulcers
The objective of this study was to investigate the safety and performance of AQUACEL™ Ag+ dressing, a wound dressing containing a combination of anti‐biofilm and antimicrobial agents, in the management of chronic wounds. Patients (n = 42) with venous leg ulcers exhibiting signs of clinical infection were treated for 4 weeks with AQUACEL™ Ag+ dressing, followed by management with AQUACEL™ wound dressings for 4 weeks. Wound progression, wound size, ulcer pain and clinical evolution of the wound were assessed for up to 8 weeks. Adverse events were recorded throughout the study. AQUACEL™ Ag+ dressing ...
Source: International Wound Journal - June 1, 2015 Category: Surgery Authors: Keith G Harding, Marek Szczepkowski, Jacek Mikosiński, Krystyna Twardowska‐Saucha, Stephen Blair, Nicola M Ivins, Wojciech Saucha, Jane Cains, Kim Peters, David Parsons, Philip Bowler Tags: ORIGINAL ARTICLE Source Type: research

Tap water versus sterile saline solution in the colonisation of skin wounds
Abstract Irrigating wounds with tap water does not increase colonisation, but controlled studies are required for further evidence. Microbial colonisation was assessed in skin wounds, before and after irrigation with tap water, and was compared with irrigation using 0·9% sodium chloride sterile solution. The study included 120 subjects with chronic, traumatic, vascular, pressure or neuropathic wounds. A total of 60 wounds were randomly assigned to be irrigated with tap water (tap water group) and another 60 to be irrigated with 0·9% sodium chloride sterile solution (saline group), at a pressure of 0·46...
Source: International Wound Journal - June 1, 2015 Category: Surgery Authors: Margarida MC Resende, Cleber A Rocha, Nely FM Corrêa, Renato RG Veiga, Sandro JF Passos, Neil F Novo, Yara Juliano, Carlos AV Damasceno Tags: ORIGINAL ARTICLE Source Type: research

Silver‐based wound dressings reduce bacterial burden and promote wound healing
This study investigated the potential of three silver‐containing dressings, namely KoCarbonAg®, Aquacel® Ag and Acticoat 7, in reducing bacterial survival and promoting wound healing. The ability of these dressings to block the entry of bacteria from external environment and retain intrinsic bacteria was studied in vitro. In addition, the study used a rat model to compare the healing efficiencies of the three dressings and investigate the quantity of collagen synthesis in vivo. In vitro results indicated that the silver‐containing dressings prevented bacterial growth in wounds by blocking the entry of external ...
Source: International Wound Journal - June 1, 2015 Category: Surgery Authors: Yu‐Hsin Lin, Wei‐Shan Hsu, Wan‐Yu Chung, Tse‐Hao Ko, Jui‐Hsiang Lin Tags: ORIGINAL ARTICLE Source Type: research

Diabetic foot disease is associated with reduced erythrocyte deformability
Abstract The pathogenesis of diabetic foot disease is multifactorial and encompasses microvascular and macrovascular pathologies. Abnormal blood rheology may also play a part in its development. Using a cell flow analyser (CFA), we examined the association between erythrocyte deformability and diabetic foot disease. Erythrocytes from diabetic patients with no known microvascular complications (n = 11) and patients suffering from a diabetic foot ulcer (n = 11) were isolated and their average elongation ratio (ER) as well as the ER distribution curve were measured. Average ER was decreased in the ...
Source: International Wound Journal - May 29, 2015 Category: Surgery Authors: Avivit Cahn, Leonid Livshits, Ariel Srulevich, Itamar Raz, Shaul Yedgar, Gregory Barshtein Tags: ORIGINAL ARTICLE Source Type: research

Matrix metalloproteinases and risk stratification in patients undergoing surgical revascularisation for critical limb ischaemia
Abstract Critical limb ischaemia (CLI) is the most advanced form of peripheral artery disease (PAD) and it is often associated with foot gangrene, which may lead to major amputation of lower limbs, and also with a higher risk of death due to fatal cardiovascular events. Matrix metalloproteinases (MMPs) seem to be involved in atherosclerosis, PAD and CLI. Aim of this study was to evaluate variations in MMP serum levels in patients affected by CLI, before and after lower limb surgical revascularisation through prosthetic or venous bypass. A total of 29 patients (7 females and 22 males, mean age 73·4 years, rang...
Source: International Wound Journal - May 27, 2015 Category: Surgery Authors: Giovanni De Caridi, Mafalda Massara, Francesco Spinelli, Antonio David, Sebastiano Gangemi, Francesco Fugetto, Raffaele Grande, Lucia Butrico, Roberta Stefanelli, Manuela Colosimo, Stefano Franciscis, Raffaele Serra Tags: ORIGINAL ARTICLE Source Type: research

Tap water irrigation for burn injury
(Source: International Wound Journal)
Source: International Wound Journal - May 23, 2015 Category: Surgery Authors: Kian‐Yong Than, Tzong‐Shiun Li Tags: LETTER TO THE EDITOR Source Type: research

Prospective and randomised evaluation of the protease‐modulating effect of oxidised regenerated cellulose/collagen matrix treatment in pressure sore ulcers
In this study, the levels and activity of elastase and plasmin in wound exudates of pressure sore ulcers were measured to determine the beneficial effect of ORC/collagen matrix treatment compared with control treatment with a foam dressing. A total of 33 patients with pressure sores were enrolled in the study and were followed up for 12 weeks after treatment. Ten control patients were treated with a foam hydropolymer dressing (TIELLE®, Systagenix), and the remaining 23 patients were treated with ORC/collagen matrix plus the foam dressing (TIELLE®, Systagenix) on top. Wound assessments were carried out over 1...
Source: International Wound Journal - May 23, 2015 Category: Surgery Authors: Oliver Kloeters, Frank Unglaub, Erik de Laat, Marjolijn van Abeelen, Dietmar Ulrich Tags: ORIGINAL ARTICLE Source Type: research

Clinical recommendations and practical guide for negative pressure wound therapy with instillation
Abstract Effective wound management involves a comprehensive assessment of the patient and the wound to determine an optimal wound treatment plan. It is critical to identify and address factors that may impair wound healing, prior to selecting the most appropriate therapy for each patient. Negative pressure wound therapy (NPWT) is a well‐established advanced therapy that has been successful in adjunctive management of acute and chronic wounds. In recent years, the introduction of topical wound solution delivery in combination with NPWT has provided further benefits to wound healing. A commercially available system now of...
Source: International Wound Journal - May 23, 2015 Category: Surgery Authors: Subhas Gupta, Allen Gabriel, John Lantis, Luc Téot Tags: INVITED REVIEW Source Type: research

Prospective and randomised evaluation of the protease ‐modulating effect of oxidised regenerated cellulose/collagen matrix treatment in pressure sore ulcers
In this study, the levels and activity of elastase and plasmin in wound exudates of pressure sore ulcers were measured to determine the beneficial effect of ORC/collagen matrix treatment compared with control treatment with a foam dressing. A total of 33 patients with pressure sores were enrolled in the study and were followed up for 12 weeks after treatment. Ten control patients were treated with a foam hydropolymer dressing (TIELLE®, Systagenix), and the remaining 23 patients were treated with ORC/collagen matrix plus the foam dressing (TIELLE®, Systagenix) on top. Wound assessments were carried out over 12 weeks...
Source: International Wound Journal - May 22, 2015 Category: Surgery Authors: Oliver Kloeters, Frank Unglaub, Erik de Laat, Marjolijn van Abeelen, Dietmar Ulrich Tags: ORIGINAL ARTICLE Source Type: research

Necrotising fasciitis by steroid‐induced Sweet's syndrome: a case report
(Source: International Wound Journal)
Source: International Wound Journal - May 19, 2015 Category: Surgery Authors: Jun Ho Lee, Hwan Jun Choi Tags: LETTER TO THE EDITOR Source Type: research

Necrotising fasciitis by steroid ‐induced Sweet's syndrome: a case report
(Source: International Wound Journal)
Source: International Wound Journal - May 17, 2015 Category: Surgery Authors: Jun Ho Lee, Hwan Jun Choi Tags: LETTER TO THE EDITOR Source Type: research

Amniotic membrane is a potential regenerative option for chronic non‐healing wounds: a report of five cases receiving dehydrated human amnion/chorion membrane allograft
This study describes the details of these clinical cases and provides an overview of the current evidence on the use of amniotic tissue in clinical practice. (Source: International Wound Journal)
Source: International Wound Journal - May 15, 2015 Category: Surgery Authors: Andrew Mrugala, Audrey Sui, Malgorzata Plummer, Igor Altman, Elaine Papineau, Devn Frandsen, Danielle Hill, William J Ennis Tags: ORIGINAL ARTICLE Source Type: research

Reply to why use tap water by Nagoba et al. – Explanation in physiological and microbiological view
(Source: International Wound Journal)
Source: International Wound Journal - May 14, 2015 Category: Surgery Authors: Kian‐Yong Than, Ting‐Wei Chiang, Tzong Shiun Li Tags: LETTER TO THE Editor Source Type: research

Reply to why use tap water by Nagoba et al. – Explanation in physiological and microbiological view
(Source: International Wound Journal)
Source: International Wound Journal - May 13, 2015 Category: Surgery Authors: Kian ‐Yong Than, Ting‐Wei Chiang, Tzong Shiun Li Tags: LETTER TO THE Editor Source Type: research

Amniotic membrane is a potential regenerative option for chronic non ‐healing wounds: a report of five cases receiving dehydrated human amnion/chorion membrane allograft
This study describes the details of these clinical cases and provides an overview of the current evidence on the use of amniotic tissue in clinical practice. (Source: International Wound Journal)
Source: International Wound Journal - May 13, 2015 Category: Surgery Authors: Andrew Mrugala, Audrey Sui, Malgorzata Plummer, Igor Altman, Elaine Papineau, Devn Frandsen, Danielle Hill, William J Ennis Tags: ORIGINAL ARTICLE Source Type: research

The fluid dynamics of simultaneous irrigation with negative pressure wound therapy
Abstract Saline irrigation has been shown to be both experimentally and clinically efficacious in decreasing bacterial contamination as well as decreasing infection rates. The dynamics of irrigation delivery fall into two primary categories: simultaneous and intermittent irrigation. An important component to irrigation therapy is distribution of irrigation solution to hard‐to‐reach areas of a wound bed, including undermining and fissure‐like structures. Here we test the effectiveness of simultaneous irrigation to fill the irregular structures of a wound bed. In order to visualise the dynamic movement of irrigation so...
Source: International Wound Journal - May 13, 2015 Category: Surgery Authors: Kathryn E Davis, Kenneth J Moquin, Lawrence A Lavery Tags: ORIGINAL ARTICLE Source Type: research

Calendar
(Source: International Wound Journal)
Source: International Wound Journal - May 12, 2015 Category: Surgery Tags: CALENDAR OF EVENTS Source Type: research

News and views
(Source: International Wound Journal)
Source: International Wound Journal - May 12, 2015 Category: Surgery Tags: NEWS Source Type: research

Is leg pain a significant contributor to health care budget pain?
(Source: International Wound Journal)
Source: International Wound Journal - May 12, 2015 Category: Surgery Authors: Douglas Queen, Mariam Botros, Keith Harding Tags: EDITORIAL Source Type: research

Role of verapamil in preventing and treating hypertrophic scars and keloids
In conclusion, verapamil could act as an effective alternative modality in the prevention and treatment of keloid and hypertrophic scars. More high‐quality, multiple‐centre, large‐sample (RCTs) are required to define the role of verapamil in preventing and treating keloid and hypertrophic scars. (Source: International Wound Journal)
Source: International Wound Journal - May 12, 2015 Category: Surgery Authors: Ru Wang, Yu Mao, Zhenyu Zhang, Zhengyong Li, Junjie Chen, Ying Cen Tags: ORIGINAL ARTICLE Source Type: research

Application of vacuum sealing drainage to the treatment of seawater ‐immersed blast‐injury wounds
Abstract The aims of this study were to observe the effects of vacuum sealing drainage (VSD) with three different negative pressures on the wound healing rate, macrophage count and the expression of hyaluronic acid (HA) as well as its receptor CD44 in seawater‐immersed blast‐injury wounds (SIBIW) and to determine the optimal negative pressure value. In a minipig SIBIW model, different suction pressures and routine dressing were applied. Histological and immunohistochemical comparisons as well as molecular biology methods were performed to compare the wound healing conditions, macrophage count and the levels of HA and C...
Source: International Wound Journal - May 7, 2015 Category: Surgery Authors: Bing Shi, Jingjing Sun, Yingli Cao, Fen Yang, Yujia Wu, Xianping Liang, Li Li Tags: ORIGINAL ARTICLE Source Type: research

Handheld fluorescence imaging device detects subclinical wound infection in an asymptomatic patient with chronic diabetic foot ulcer: a case report
Abstract Chronic wounds are a significant burden to global patient and health care infrastructures, and there is a need for better methods of early wound diagnosis and treatment. Traditional diagnosis of chronic wound infection by pathogenic bacteria, using clinical signs and symptoms, is based on visual inspection under white light and microbiological sampling (e.g. swabbing and/or biopsy) of the wound, which are subjective and suboptimal. Diagnosing microbial infection based on traditional clinical signs and symptoms in wounds of asymptomatic patients is especially challenging at the bedside. Bacteria are invisible to th...
Source: International Wound Journal - April 22, 2015 Category: Surgery Authors: Yichao C Wu, Marlie Smith, Ashley Chu, Liis Lindvere‐Teene, Danielle Starr, Kim Tapang, Rachel Shekhman, Olive Wong, Ron Linden, Ralph S DaCosta Tags: ORIGINAL ARTICLE Source Type: research

Hybrid imaging with 99mTc‐WBC SPECT/CT to monitor the effect of therapy in diabetic foot osteomyelitis
This study sought to assess the utility of monitoring response to treatment of diabetic foot osteomyelitis (DFO) with Tc‐99m WBC‐labelled single photon emission computed tomography (SPECT/CT) imaging. This is a retrospective cohort study of 20 patients with DFO with sequential Tc‐99m WBC‐labelled SPECT/CT imaging. Radiologic findings of osteomyelitis were evaluated and imaging results were correlated with clinical outcomes subtracted from chart review. Successful treatment of osteomyelitis was defined by wound healing and/or lack of re‐admission for bone infection of the same site within 1 year. The sensit...
Source: International Wound Journal - April 8, 2015 Category: Surgery Authors: Francisco Lazaga, Suzanne AV Van Asten, Adam Nichols, Kavita Bhavan, Javier La Fontaine, Orhan K Oz, Lawrence A Lavery Tags: ORIGINAL ARTICLE Source Type: research

Efficacy of 1% acetic acid in the treatment of chronic wounds infected with Pseudomonas aeruginosa: prospective randomised controlled clinical trial
Abstract Chronic wounds are those wounds that are persistent and do not respond to any sort of treatment. The concept of using topical antiseptics on open wounds is to prevent and treat infections. They also help to shorten the time taken to heal the wounds. The use of topical agents on wounds to prevent infection is a minimal ability to develop resistance to the microorganisms. Pseudomonas aeruginosa is a Gram‐negative opportunistic pathogen with innate resistance to many antibiotics. In places that are economically backward, these problems get compounded by the inability of patients to afford newer expensive drugs. Top...
Source: International Wound Journal - April 8, 2015 Category: Surgery Authors: VL Madhusudhan Tags: ORIGINAL ARTICLE Source Type: research

Hybrid imaging with 99mTc ‐WBC SPECT/CT to monitor the effect of therapy in diabetic foot osteomyelitis
This study sought to assess the utility of monitoring response to treatment of diabetic foot osteomyelitis (DFO) with Tc‐99m WBC‐labelled single photon emission computed tomography (SPECT/CT) imaging. This is a retrospective cohort study of 20 patients with DFO with sequential Tc‐99m WBC‐labelled SPECT/CT imaging. Radiologic findings of osteomyelitis were evaluated and imaging results were correlated with clinical outcomes subtracted from chart review. Successful treatment of osteomyelitis was defined by wound healing and/or lack of re‐admission for bone infection of the same site within 1 year. The sensitivity, ...
Source: International Wound Journal - April 7, 2015 Category: Surgery Authors: Francisco Lazaga, Suzanne AV Van Asten, Adam Nichols, Kavita Bhavan, Javier La Fontaine, Orhan K Oz, Lawrence A Lavery Tags: ORIGINAL ARTICLE Source Type: research

Application of vacuum sealing drainage to the treatment of seawater‐immersed blast‐injury wounds
Abstract The aims of this study were to observe the effects of vacuum sealing drainage (VSD) with three different negative pressures on the wound healing rate, macrophage count and the expression of hyaluronic acid (HA) as well as its receptor CD44 in seawater‐immersed blast‐injury wounds (SIBIW) and to determine the optimal negative pressure value. In a minipig SIBIW model, different suction pressures and routine dressing were applied. Histological and immunohistochemical comparisons as well as molecular biology methods were performed to compare the wound healing conditions, macrophage count and the levels of HA and C...
Source: International Wound Journal - April 1, 2015 Category: Surgery Authors: Bing Shi, Jingjing Sun, Yingli Cao, Fen Yang, Yujia Wu, Xianping Liang, Li Li Tags: ORIGINAL ARTICLE Source Type: research

Negative pressure wound therapy for seroma prevention and surgical incision treatment in spinal fracture care
This study is a prospective randomised evaluation of NPWT in patients with large surgical wounds after surgical stabilisation of spinal fractures by internal fixation. Patients were randomised to either standard wound dressing treatment (group A) or NPWT (group B). The wound area was examined by ultrasound to measure seroma volumes in both groups on the 5th and 10th day after surgery. Furthermore, data on economic aspects such as nursing time for wound care and material used for wound dressing were evaluated. A total of 20 patients (10 in each group) were enrolled. Throughout the whole study, mean seroma volume was signifi...
Source: International Wound Journal - April 1, 2015 Category: Surgery Authors: Matthias Nordmeyer, Johannes Pauser, Roland Biber, Jonathan Jantsch, Siegfried Lehrl, Carsten Kopschina, Christian Rapke, Hermann J Bail, Raimund Forst, Matthias H Brem Tags: ORIGINAL ARTICLE Source Type: research

Cutaneous lymphoma misdiagnosed as chronic lymphadenitis
We present the case of a 60‐year‐old man with 7‐month history of a growing inguinal mass/tumour, which was misdiagnosed as inguinal chronic lymphadenitis. Recognition of the correct entity, primary cutaneous diffuse large B‐cell lymphoma leg type, led to an appropriate therapeutic strategy, knowing that these types of tumours behave more aggressively than other types of primary cutaneous B‐cell lymphomas. The patient was discharged with rituximab + chemotherapy indication and favourable outcome. The aim of the presentation is to describe these common skin manifestations, however seen in a primary cu...
Source: International Wound Journal - April 1, 2015 Category: Surgery Authors: Mircea Munteanu, Georgiana S Mohor, Flavia Baderca, Caius Solovan Tags: ORIGINAL ARTICLE Source Type: research

Electrical stimulation therapy for the treatment of pressure ulcers in individuals with spinal cord injury: a systematic review and meta‐analysis
Abstract To conduct a systematic review and meta‐analysis on the effects of electrical stimulation therapy (EST) on healing pressure ulcers in individuals with spinal cord injury (SCI). CINAHL, The Cochrane Library, PubMed, SCOPUS, EMBASE, Nursing & Allied Health and Dissertation & Theses databases were searched for relevant English language articles from the date of inception to 31 January 2014. Separate searches were conducted in Google Scholar and academic journals specialised in wound care. Two reviewers independently assessed study eligibility. Studies were included if EST was used to treat pressure ulcers i...
Source: International Wound Journal - April 1, 2015 Category: Surgery Authors: Deena Lala, Sandi J Spaulding, Shauna M Burke, Pamela E Houghton Tags: ORIGINAL ARTICLE Source Type: research

Immunomodulator ‘mushroom beta glucan’ induces Wnt/β catenin signalling and improves wound recovery in tilapia and rat skin: a histopathological study
Abstract The present study aims to investigate the effects of mushroom beta glucan (MBG) on wound recovery in partial hepatectomy (PH) in Nile tilapia (Oreochromis niloticus) and in rat skin wound healing examination. Following PH, we focussed on the effects on liver repair ability using in vitro and in vivo tests. In vitro, we examined whether the MBG has an impact on liver cell proliferation, mainly through 3‐(4,5‐dimethylthiazolyl‐2)‐2,5‐diphenyltetrazolium bromide (MTT) assays and bromodeoxyuridine (BrdU) cell proliferation assay detection method. Results showed that MBG treatment was remarkable in enhancing ...
Source: International Wound Journal - April 1, 2015 Category: Surgery Authors: Chien‐Mei Hsiao, Yu‐Sheng Wu, Fan‐Hua Nan, Shih‐Ling Huang, Lynette Chen, Shiu‐Nan Chen Tags: ORIGINAL ARTICLE Source Type: research

Contact sensitisation in patients with chronic leg ulcers
Abstract The aim of our study is to identify the allergens in patients with leg ulcers who have contact dermatitis surrounding the skin of the ulcer and compare them with a control group consisting of patients with lower extremity contact dermatitis. A total of 40 patients with chronic leg ulcers (CLU) and contact dermatitis around the skin of ulcer were included in the study. As a control group, 20 patients with contact dermatitis of lower extremity without leg ulcers were included. The patient and control groups were patch tested with 37 allergens of the European Standard Series. Of the 40 patients, 31 (77·5%) had...
Source: International Wound Journal - April 1, 2015 Category: Surgery Authors: Ferda Artüz, Emrah Yılmaz, Seray Külcü Çakmak, Arife Polat Düzgün Tags: ORIGINAL ARTICLE Source Type: research

A rheumatology perspective on cutaneous vasculitis: assessment and investigation for the non‐rheumatologist
Abstract Vasculitis, by definition, is inflammation of the vasculature. This inflammation can result in either vessel wall destruction causing aneurysm or rupture, or stenosis causing ischaemia or necrosis. This autoimmune response does not always have a clear cause. Vasculitis is a heterogeneous group of disorders that has been categorised not only by primary and secondary causes, but also by the size of the affected vessel. The secondary causes that can trigger vasculitis include infection (particularly hepatitis B and C and haemorrhagic fever);cancer, autoimmune diseases such as rheumatoid arthritis (RA), systemic lupus...
Source: International Wound Journal - March 27, 2015 Category: Surgery Authors: Charlotte R Rawlings, Georgina A Fremlin, Julian Nash, Keith Harding Tags: INVITED REVIEW Source Type: research

Severe postoperative wound healing disturbance in a patient with alpha‐1‐antitrypsin deficiency: the impact of augmentation therapy
Abstract Wound healing disturbance is a common complication following surgery, but the underlying cause sometimes remains elusive. A 50‐year‐old Caucasian male developed an initially misunderstood severe wound healing disturbance following colon and abdominal wall surgery. An untreated alpha‐1‐antitrypsin (AAT) deficiency in the patient's medical history, known since 20 years and clinically apparent as a mild to moderate chronic obstructive pulmonary disease, was eventually found to be at its origin. Further clinical work‐up showed AAT serum levels below 30% of the lower reference value; phenotype testing ...
Source: International Wound Journal - March 26, 2015 Category: Surgery Authors: Marionna Cathomas, Alexandra Schüller, Daniel Candinas, Roman Inglin Tags: CASE REPORT Source Type: research

Estimating the costs associated with the management of patients with chronic wounds using linked routine data
Abstract Chronic wounds are known to represent a significant burden to patients and National Health Service (NHS) alike. However, previous attempts to estimate the costs associated with the management of chronic wounds have been based on literature studies or broad estimates derived from incidence rates and extrapolations from relatively small‐scale studies. The aim of this study is therefore to determine the extent of resource utilisation by patients classed as having chronic wounds within Wales using linked routine data – available through the Secure Anonymised Information Linkage (SAIL) database &...
Source: International Wound Journal - March 26, 2015 Category: Surgery Authors: Ceri J Phillips, Ioan Humphreys, Jacqui Fletcher, Keith Harding, George Chamberlain, Steven Macey Tags: ORIGINAL ARTICLE Source Type: research

Calendar
(Source: International Wound Journal)
Source: International Wound Journal - March 20, 2015 Category: Surgery Tags: CALENDAR OF EVENTS Source Type: research

News and views
(Source: International Wound Journal)
Source: International Wound Journal - March 20, 2015 Category: Surgery Tags: NEWS Source Type: research

The use of an online community to take the ‘Leg Club’ model to the next level
(Source: International Wound Journal)
Source: International Wound Journal - March 20, 2015 Category: Surgery Authors: Douglas Queen Tags: EDITORIAL Source Type: research