An investigation of the ability to produce a defined ‘target pressure’ using the PressCise compression bandage
Abstract Compression therapy is the cornerstone in the prevention and treatment of leg ulcers related to chronic venous insufficiency. The application of optimal high pressure is essential for a successful outcome, but the literature has reported difficulty applying the intended pressure, even among highly skilled nurses. The PressCise bandage has a novel design, with both longitudinal and horizontal reference points for correct application. In the current experimental study, the results for the general linear model, where the data set is treated optimally, showed that all 95% confidence intervals of the expected values fo...
Source: International Wound Journal - October 28, 2015 Category: Surgery Authors: Kerstin Wiklander, Annette Erichsen Andersson, Ulrika Källman Tags: ORIGINAL ARTICLE Source Type: research

The application of phenytoin in the treatment of diabetic ulcers
(Source: International Wound Journal)
Source: International Wound Journal - October 28, 2015 Category: Surgery Authors: Yi‐Shan Liu, Tzong‐Shiun Li, Cheuk‐Kwan Sun, Kai‐Che Wei, Chia‐Ju Liu Tags: LETTER TO THE EDITOR Source Type: research

Allogeneic hand transplantation and rehabilitation of hand function: a 10 ‐year follow‐up study
Abstract The purpose of this study is to present the long‐term outcomes of allogenic hand transplantations performed at our centre. Between January 2001 and October 2002, five allogeneic limb transplantations were performed in three patients (two bilateral forearm and one left hand transplantation). Donors and recipients were matched for blood types (ABO/Rh) and had at least two human leukocyte antigen (HLA) matches. A comprehensive rehabilitation plan integrating preoperative, intraoperative and postoperative management was developed for each patient. After 10 years, all transplantations were performed successfully with...
Source: International Wound Journal - October 19, 2015 Category: Surgery Authors: Zhen ‐Yu Zhang, Fu‐chun Li, Ming Shao, Cao Yang, Jian Shang, Zheng‐Gang Bi Tags: ORIGINAL ARTICLE Source Type: research

Abdominal surgical site infection due to Klebsiella pneumoniae carbapenemase‐producing K. pneumoniae
(Source: International Wound Journal)
Source: International Wound Journal - October 16, 2015 Category: Surgery Authors: Edoardo Virgilio, Paolo Castaldo, Federico Catta, Giulia Tarantino, Marco Cavallini Tags: LETTER TO THE EDITOR Source Type: research

Promotion of acute ‐phase skin wound healing by Pseudomonas aeruginosa C4‐HSL
Abstract A Pseudomonas aeruginosa quorum‐sensing system, which produces N‐(3‐oxododecanoyl)‐l‐homoserine lactone (3‐oxo‐C12‐HSL) and N‐butanoyl‐l‐homoserine lactone (C4‐HSL), regulates the virulence factors. In our previous study, 3‐oxo‐C12‐HSL, encoded by lasI gene, was shown to promote wound healing. However, the effect of C4‐HSL, encoded by rhlI gene, remains to be elucidated. We addressed the effect of C4‐HSL on wounds in P. aeruginosa infection. Wounds were created on the backs of Sprague–Dawley SD rats, and P. aeruginosa PAO1 (PAO1) or its rhlI deletion mutant (ΔrhlI) or ...
Source: International Wound Journal - October 15, 2015 Category: Surgery Authors: Emi Kanno, Kazuyoshi Kawakami, Shinichi Miyairi, Hiromasa Tanno, Aiko Suzuki, Rina Kamimatsuno, Naoyuki Takagi, Tomomitsu Miyasaka, Keiko Ishii, Naomasa Gotoh, Ryoko Maruyama, Masahiro Tachi Tags: ORIGINAL ARTICLE Source Type: research

Abdominal surgical site infection due to Klebsiella pneumoniae carbapenemase ‐producing K. pneumoniae
(Source: International Wound Journal)
Source: International Wound Journal - October 15, 2015 Category: Surgery Authors: Edoardo Virgilio, Paolo Castaldo, Federico Catta, Giulia Tarantino, Marco Cavallini Tags: LETTER TO THE EDITOR Source Type: research

Clinico‐microbiological study of Pseudomonas aeruginosa in wound infections and the detection of metallo‐β‐lactamase production
Abstract Pseudomonas aeruginosa is a common opportunistic pathogen of humans among the Gram‐negative bacilli. Clinically, it is associated with nosocomial infections like burns and surgical‐site wound infections and remains a major health concern, especially among critically ill and immunocompromised patients. This is a prospective laboratory‐based 2 year study conducted to isolate P. aeruginosa from wound specimens and the antimicrobial susceptibility pattern with reference to metallo‐β‐lactamase (MBL) production. Two hundred and twenty‐four samples of P. aeruginosa isolated from wound specimens were incl...
Source: International Wound Journal - October 1, 2015 Category: Surgery Authors: Divya Bangera, Suchitra M Shenoy, Dominic RM Saldanha Tags: ORIGINAL ARTICLE Source Type: research

Effects of Panax ginseng extract on human dermal fibroblast proliferation and collagen synthesis
Abstract Current studies of Panax ginseng (or Korean ginseng) have demonstrated that it has various biological effects, including angiogenesis, immunostimulation, antimicrobial and anti‐inflammatory effects. Therefore, we hypothesised that P. ginseng may also play an important role in wound healing. However, few studies have been conducted on the wound‐healing effects of P. ginseng. Thus, the purpose of this in vitro pilot study was to determine the effects of P. ginseng on the activities of fibroblasts, which are key wound‐healing cells. Cultured human dermal fibroblasts were treated with one of six concentrations o...
Source: International Wound Journal - October 1, 2015 Category: Surgery Authors: Geum‐Young Lee, Kang‐Gyun Park, Sik Namgoong, Seung‐Kyu Han, Seong‐Ho Jeong, Eun‐Sang Dhong, Woo‐Kyung Kim Tags: ORIGINAL ARTICLE Source Type: research

Allogeneic hand transplantation and rehabilitation of hand function: a 10‐year follow‐up study
Abstract The purpose of this study is to present the long‐term outcomes of allogenic hand transplantations performed at our centre. Between January 2001 and October 2002, five allogeneic limb transplantations were performed in three patients (two bilateral forearm and one left hand transplantation). Donors and recipients were matched for blood types (ABO/Rh) and had at least two human leukocyte antigen (HLA) matches. A comprehensive rehabilitation plan integrating preoperative, intraoperative and postoperative management was developed for each patient. After 10 years, all transplantations were performed successfully with...
Source: International Wound Journal - October 1, 2015 Category: Surgery Authors: Zhen‐Yu Zhang, Fu‐chun Li, Ming Shao, Cao Yang, Jian Shang, Zheng‐Gang Bi Tags: ORIGINAL ARTICLE Source Type: research

Risk factors for major amputation in hospitalised diabetic foot patients
The objective of this study was to evaluate the risk factors for major amputation in diabetic foot patients. Eight hundred and sixty diabetic patients were admitted to the diabetic wound centre of the Korea University Guro Hospital for foot ulcers between January 2010 and December 2013. Among them, 837 patients were successfully monitored until complete healing. Ulcers in 809 patients (96·7%) healed without major amputation and those in 28 patients (3·3%) healed with major amputation. Data of 88 potential risk factors including demographics, ulcer condition, vascularity, bioburden, neurology and serology were...
Source: International Wound Journal - October 1, 2015 Category: Surgery Authors: Sik Namgoong, Suyoung Jung, Seung‐Kyu Han, Seong‐Ho Jeong, Eun‐Sang Dhong, Woo‐Kyung Kim Tags: ORIGINAL ARTICLE Source Type: research

Promotion of acute‐phase skin wound healing by Pseudomonas aeruginosa C4‐HSL
Abstract A Pseudomonas aeruginosa quorum‐sensing system, which produces N‐(3‐oxododecanoyl)‐l‐homoserine lactone (3‐oxo‐C12‐HSL) and N‐butanoyl‐l‐homoserine lactone (C4‐HSL), regulates the virulence factors. In our previous study, 3‐oxo‐C12‐HSL, encoded by lasI gene, was shown to promote wound healing. However, the effect of C4‐HSL, encoded by rhlI gene, remains to be elucidated. We addressed the effect of C4‐HSL on wounds in P. aeruginosa infection. Wounds were created on the backs of Sprague–Dawley SD rats, and P. aeruginosa PAO1 (PAO1) or its rhlI deletion mutant (ΔrhlI) or ...
Source: International Wound Journal - October 1, 2015 Category: Surgery Authors: Emi Kanno, Kazuyoshi Kawakami, Shinichi Miyairi, Hiromasa Tanno, Aiko Suzuki, Rina Kamimatsuno, Naoyuki Takagi, Tomomitsu Miyasaka, Keiko Ishii, Naomasa Gotoh, Ryoko Maruyama, Masahiro Tachi Tags: ORIGINAL ARTICLE Source Type: research

Age‐associated changes in regenerative capabilities of mesenchymal stem cell: impact on chronic wounds repair
Abstract Mesenchymal stem cells (MSCs) represent an ideal source of autologous cell‐based therapy for chronic wounds. Functional characteristics of MSCs may benefit wound healing by exerting their multi‐regenerative potential. However, cell ageing resulting from chronic degenerative diseases or donor age could cause inevitable effects on the regenerative abilities of MSCs. A variety of studies have shown the relationship between MSC ageing and age‐related dysfunction, but few associate these age‐related impacts on MSCs with their ability of repairing chronic wounds, which are common in the elderly population. Here,...
Source: International Wound Journal - October 1, 2015 Category: Surgery Authors: Bin Yao, Sha Huang, Dongyun Gao, Jiangfan Xie, Nanbo Liu, Xiaobing Fu Tags: ORIGINAL ARTICLE Source Type: research

Unusual cause of lower extremity wounds: Cobb syndrome
We report a 32‐year‐old male with the Cobb syndrome associated with lower extremity painful wounds and acute‐onset paraplegia due to metameric vascular malformations. (Source: International Wound Journal)
Source: International Wound Journal - October 1, 2015 Category: Surgery Authors: Bahareh Abtahi‐naeini, Ali Saffaei, Mohsen Pourazizi Tags: CASE REPORT Source Type: research

Improving wound healing and preventing surgical site complications of closed surgical incisions: a possible role of Incisional Negative Pressure Wound Therapy. A systematic review of the literature
Abstract Advances in preoperative care, surgical techniques and technologies have enabled surgeons to achieve primary closure in a high percentage of surgical procedures. However, often, underlying patient comorbidities in addition to surgical‐related factors make the management of surgical wounds primary closure challenging because of the higher risk of developing complications. To date, extensive evidence exists, which demonstrate the benefits of negative pressure dressing in the treatment of open wounds; recently, Incisional Negative Pressure Wound Therapy (INPWT) technology as delivered by Prevena™ (KCI USA, In...
Source: International Wound Journal - October 1, 2015 Category: Surgery Authors: Alessandro Scalise, Roberto Calamita, Caterina Tartaglione, Marina Pierangeli, Elisa Bolletta, Matteo Gioacchini, Rosaria Gesuita, Giovanni Di Benedetto Tags: ORIGINAL ARTICLE Source Type: research

Age ‐associated changes in regenerative capabilities of mesenchymal stem cell: impact on chronic wounds repair
Abstract Mesenchymal stem cells (MSCs) represent an ideal source of autologous cell‐based therapy for chronic wounds. Functional characteristics of MSCs may benefit wound healing by exerting their multi‐regenerative potential. However, cell ageing resulting from chronic degenerative diseases or donor age could cause inevitable effects on the regenerative abilities of MSCs. A variety of studies have shown the relationship between MSC ageing and age‐related dysfunction, but few associate these age‐related impacts on MSCs with their ability of repairing chronic wounds, which are common in the elderly population. Here,...
Source: International Wound Journal - September 30, 2015 Category: Surgery Authors: Bin Yao, Sha Huang, Dongyun Gao, Jiangfan Xie, Nanbo Liu, Xiaobing Fu Tags: ORIGINAL ARTICLE Source Type: research

Case report: clear cell hidradenocarcinoma of the nail bed
(Source: International Wound Journal)
Source: International Wound Journal - September 29, 2015 Category: Surgery Authors: Eun T Son, Hwan J Choi, Hyun J Lee Tags: LETTER TO THE EDITOR Source Type: research

Plasma MMP and TIMP evaluation in patients with deep venous thrombosis: could they have a predictive role in the development of post‐thrombotic syndrome?
Abstract Post‐thrombotic syndrome (PTS) is a condition that can develop in about half of the patients with deep vein thrombosis (DVT) of lower limbs. In the present study, we evaluated the expression of inflammatory biomarkers in the early phases of DVT and their correlation with the onset of PTS. Patients were enrolled after the first episode of DVT and were followed up for 1, 4, 8, 12 and 18 months. At each visit, blood sample was collected to evaluate plasma levels of matrix metalloproteinase (MMP)‐1,‐2,‐3,‐7,‐8 and ‐9 MMP inhibitors, TIMP‐1,‐2, neutrophil gelatinase‐associated lipocalin (NGAL) and c...
Source: International Wound Journal - September 25, 2015 Category: Surgery Authors: Stefano Franciscis, Luca Gallelli, Bruno Amato, Lucia Butrico, Alessio Rossi, Gianluca Buffone, Francesco G Caliò, Giovanni De Caridi, Raffaele Grande, Raffaele Serra Tags: ORIGINAL ARTICLE Source Type: research

The role of adult tissue‐derived stem cells in chronic leg ulcers: a systematic review focused on tissue regeneration medicine
Abstract Wound healing is an articulated process that can be impaired in different steps in chronic wounds. Chronic leg ulcers are a special type of non‐healing wounds that represent an important cause of morbidity and public cost in western countries. Because of their common recurrence after conventional managements and increasing prevalence due to an ageing population, newer approaches are needed. Over the last decade, the research has been focused on innovative treatment strategies, including stem‐cell‐based therapies. After the initial interest in embryonic pluripotent cells, several different types of adult stem...
Source: International Wound Journal - September 24, 2015 Category: Surgery Authors: Bruno Amato, Rita Compagna, Maurizio Amato, Lucia Butrico, Francesco Fugetto, Mariia D Chibireva, Andrea Barbetta, Marco Cannistrà, Stefano de Franciscis, Raffaele Serra Tags: ORIGINAL ARTICLE Source Type: research

Cleansing of wounds by tap water? Would it be safe to use in developing countries?
(Source: International Wound Journal)
Source: International Wound Journal - September 24, 2015 Category: Surgery Authors: Basavraj S Nagoba, Namdev M Suryawanshi, Sohan P Selkar Tags: LETTER TO THE EDITOR Source Type: research

An unusual case of processionary moth reaction
(Source: International Wound Journal)
Source: International Wound Journal - September 24, 2015 Category: Surgery Authors: Tammaro Antonella, Cortesi Giorgia, Di Vito Eleonora, Parisella F Romana, Pigliacelli Flavia, Persechino Severino Tags: LETTER TO THE EDITOR Source Type: research

Adalimumab treatment leads to reduction of tissue tumor necrosis factor‐alpha correlated with venous leg ulcer improvement: a pilot study
Abstract Venous leg ulcers (VLUs) have higher tumor necrosis factor‐α (TNF‐α) levels compared with normal skin. Refractory VLUs of long duration have higher TNF‐α levels compared with VLUs of shorter duration. As up to 75% of VLUs fail to heal with standard care, we sought to evaluate the role of anti‐TNF‐α therapy for patients with refractory VLUs. Evaluable data were obtained in four of five subjects with recalcitrant VLUs treated with 80 mg of subcutaneous adalimumab at week 0 and with 40 mg at week 2 along with compression therapy and were followed‐up for 6 weeks...
Source: International Wound Journal - September 24, 2015 Category: Surgery Authors: Joshua D Fox, Katherine L Baquerizo‐Nole, Brian R Keegan, Flor Macquhae, Julia Escandon, Aliette Espinosa, Carmen Perez, Paolo Romanelli, Robert S Kirsner Tags: ORIGINAL ARTICLE Source Type: research

Eccrine porocarcinoma mimicking a venous leg ulcer
(Source: International Wound Journal)
Source: International Wound Journal - September 24, 2015 Category: Surgery Authors: Cornelia Erfurt‐Berge, Michael Erdmann, Kathrin Brauner, Juergen Bauerschmitz Tags: LETTER TO THE EDITOR Source Type: research

Acral melanoma with satellitosis, disguised as a longstanding diabetic ulcer: a great mimicry
We describe here an elderly female patient treated for a non‐healing foot ulcer interpreted as a diabetic ulcer, which after 2 years was diagnosed as acral melanoma with satellitosis. Histopathological examination of the amputated distal phalanx revealed an advanced stage melanoma with 1·2 cm Breslow thickness and of Clark level 5. Dermoscopy of the bluish papulonodules scattered on the dorsal foot showed characteristic findings described for metastasis of skin melanoma. This case underlines the importance of considering skin malignancies in case of chronic, non‐healing ulcers in diabetic patients....
Source: International Wound Journal - September 24, 2015 Category: Surgery Authors: A Tulin Mansur, Gulsen T Demirci, Omer Ozel, Emre Ozker, Semsi Yıldız Tags: CASE REPORT Source Type: research

Identification of risk factors associated with the development of skin tears in hospitalised older persons: a case–control study
Abstract To identify the risk factors associated with the development of skin tears in older persons four hundred and fifty three patients (151 cases and 302 controls) were enrolled in a case–control study in a 500‐bed metropolitan tertiary hospital in Western Australia between December 2008 and June 2009. Case eligibility was defined by a skin tear on admission, which had occurred in the last 5 days; or, a skin tear developed during hospitalisation. For each case, two controls who did not have a skin tear and had been admitted within 1 day of the case, were also enrolled. Data collected from the nurs...
Source: International Wound Journal - September 24, 2015 Category: Surgery Authors: Gill F Lewin, Nelly Newall, Janine J Alan, Keryln J Carville, Nick M Santamaria, Pam A Roberts Tags: ORIGINAL ARTICLE Source Type: research

The role of adult tissue ‐derived stem cells in chronic leg ulcers: a systematic review focused on tissue regeneration medicine
Abstract Wound healing is an articulated process that can be impaired in different steps in chronic wounds. Chronic leg ulcers are a special type of non‐healing wounds that represent an important cause of morbidity and public cost in western countries. Because of their common recurrence after conventional managements and increasing prevalence due to an ageing population, newer approaches are needed. Over the last decade, the research has been focused on innovative treatment strategies, including stem‐cell‐based therapies. After the initial interest in embryonic pluripotent cells, several different types of adult stem...
Source: International Wound Journal - September 23, 2015 Category: Surgery Authors: Bruno Amato, Rita Compagna, Maurizio Amato, Lucia Butrico, Francesco Fugetto, Mariia D Chibireva, Andrea Barbetta, Marco Cannistr à, Stefano de Franciscis, Raffaele Serra Tags: ORIGINAL ARTICLE Source Type: research

Adalimumab treatment leads to reduction of tissue tumor necrosis factor ‐alpha correlated with venous leg ulcer improvement: a pilot study
Abstract Venous leg ulcers (VLUs) have higher tumor necrosis factor‐α (TNF‐α) levels compared with normal skin. Refractory VLUs of long duration have higher TNF‐α levels compared with VLUs of shorter duration. As up to 75% of VLUs fail to heal with standard care, we sought to evaluate the role of anti‐TNF‐α therapy for patients with refractory VLUs. Evaluable data were obtained in four of five subjects with recalcitrant VLUs treated with 80 mg of subcutaneous adalimumab at week 0 and with 40 mg at week 2 along with compression therapy and were followed‐up for 6 weeks. Wound biopsies take...
Source: International Wound Journal - September 23, 2015 Category: Surgery Authors: Joshua D Fox, Katherine L Baquerizo ‐Nole, Brian R Keegan, Flor Macquhae, Julia Escandon, Aliette Espinosa, Carmen Perez, Paolo Romanelli, Robert S Kirsner Tags: ORIGINAL ARTICLE Source Type: research

Calendar
(Source: International Wound Journal)
Source: International Wound Journal - September 16, 2015 Category: Surgery Tags: CALENDAR OF EVENTS Source Type: research

Society news
(Source: International Wound Journal)
Source: International Wound Journal - September 16, 2015 Category: Surgery Tags: NEWS Source Type: research

News and views
(Source: International Wound Journal)
Source: International Wound Journal - September 16, 2015 Category: Surgery Tags: NEWS Source Type: research

Founder of Leg Club model awarded Order of the British Empire in recent Queen's Birthday Honours
(Source: International Wound Journal)
Source: International Wound Journal - September 16, 2015 Category: Surgery Authors: Keith Harding, Douglas Queen Tags: EDITORIAL Source Type: research

The 2015 IWGDF guidance on the prevention and management of foot problems in diabetes
(Source: International Wound Journal)
Source: International Wound Journal - September 8, 2015 Category: Surgery Authors: Karel Bakker, Jan Apelqvist, Ben A Lipsky, Jaap J Van Netten, Nicolaas C Schaper Tags: LETTER TO THE EDITOR Source Type: research

Animal ‐inflicted open wounds in rural Turkey: lessons learned and a proposed treatment algorithm for uncertain scenarios
This study focusus on different circumstances dealt with by plastic surgeons in a rural setting in Turkey and aims to configure what the general approach should be through an analysis of a wide spectrum of patients. Between June 2013 and December 2014, 205 patients who presented to the emergency department for animal‐inflicted injuries were retrospectively analysed. Patients who consulted for plastic surgery were included in the analysis to determine which wounds require further attention. Patients with past animal‐inflicted injuries who presented to the outpatient plastic surgery clinic with concerns such as non‐hea...
Source: International Wound Journal - September 7, 2015 Category: Surgery Authors: Billur Sezgin, Mbaraka Ljohiy, Sultan Tuna Akgol Gur Tags: ORIGINAL ARTICLE Source Type: research

The 2015 IWGDF guidance on the prevention and management of foot problems in diabetes
(Source: International Wound Journal)
Source: International Wound Journal - September 7, 2015 Category: Surgery Authors: Karel Bakker, Jan Apelqvist, Ben A Lipsky, Jaap J Van Netten, Nicolaas C Schaper Tags: LETTER TO THE EDITOR Source Type: research

Vitamin C promotes wound healing through novel pleiotropic mechanisms
In conclusion, VitC favorably on proliferation. Histological analysis showed improved wound matrix deposition and organisation in sufficient and deficient +AscA mice. Wounds from VitC sufficient and deficient + AscA mice had reduced expression of pro‐inflammatory mediators and higher expression of wound healing mediators. Supplementation of HnDF with AscA induced the expression of self‐renewal genes and promoted fibroblast proliferation. VitC favourably impacts the spatiotemporal expression of transcripts associated with early resolution of inflammation and tissue remodelling. (Source: International Wound Journal)
Source: International Wound Journal - August 20, 2015 Category: Surgery Authors: Bassem M Mohammed, Bernard J Fisher, Donatas Kraskauskas, Susan Ward, Jennifer S Wayne, Donald F Brophy, Alpha A Fowler, Dorne R Yager, Ramesh Natarajan Tags: ORIGINAL ARTICLE Source Type: research

Autologous platelet ‐rich fibrin in treatment of scleroderma ulcer
(Source: International Wound Journal)
Source: International Wound Journal - August 19, 2015 Category: Surgery Authors: Shricharith Shetty, Shruthakirti D Shenoi Tags: LETTER TO THE EDITOR Source Type: research

Methods to assess area and volume of wounds – a systematic review
The objective of this systematic review was to evaluate evidence from the literature on accuracy, agreement, reliability and feasibility of wound measurement techniques described since 1994. Studies were identified by searching the electronic databases PubMed, Embase and Cochrane Library. Of the 12 013 studies identified, 43 were included in the review. A total of 30 papers evaluated techniques for measuring wound area and 13 evaluated techniques for measuring wound volume. The six approaches for measuring wound area were simple ruler method (10 papers), mathematical models (5 papers), manual planimetry (10 papers),...
Source: International Wound Journal - August 6, 2015 Category: Surgery Authors: Line Bisgaard Jørgensen, Jens A Sørensen, Gregor BE Jemec, Knud B Yderstræde Tags: ORIGINAL ARTICLE Source Type: research

Patients with pyoderma gangrenosum – analyses of the German DRG data from 2012
We described the worldwide largest PG population and confirmed a wide range of potentially relevant and partly not yet described cofactors and comorbidities such as metabolic syndrome. (Source: International Wound Journal)
Source: International Wound Journal - August 5, 2015 Category: Surgery Authors: Finja Jockenh öfer, Joachim Klode, Knut Kröger, Alexander Roesch, Philipp Al Ghazal, Joachim Dissemond Tags: ORIGINAL ARTICLE Source Type: research

Methods to assess area and volume of wounds – a systematic review
The objective of this systematic review was to evaluate evidence from the literature on accuracy, agreement, reliability and feasibility of wound measurement techniques described since 1994. Studies were identified by searching the electronic databases PubMed, Embase and Cochrane Library. Of the 12 013 studies identified, 43 were included in the review. A total of 30 papers evaluated techniques for measuring wound area and 13 evaluated techniques for measuring wound volume. The six approaches for measuring wound area were simple ruler method (10 papers), mathematical models (5 papers), manual planimetry (10 papers), digita...
Source: International Wound Journal - August 5, 2015 Category: Surgery Authors: Line Bisgaard Jørgensen, Jens A Sørensen, Gregor BE Jemec, Knud B Yderstræde Tags: ORIGINAL ARTICLE Source Type: research

The use of growth factors, CD34+ cells and fibrin for the management of chronic venous ulcers
We report the effects of platelet‐rich plasma in patients with chronic venous ulcers, which is able to stimulate fibroblasts, macrophages and mesenchymal cells and growth factors in order to achieve re‐epithelialisation and neovascularisation within the microenviroment of the wound. We also documented the efficacy of this method as the sole treatment without surgical procedures. (Source: International Wound Journal)
Source: International Wound Journal - August 1, 2015 Category: Surgery Authors: Francesco Romano, Francesco M Paolino, Barbara A Rizzo, Antonio Russo, Stephen Southworth, Raffaele Serra, Luca Gallelli Tags: CASE REPORT Source Type: research

Animal‐inflicted open wounds in rural Turkey: lessons learned and a proposed treatment algorithm for uncertain scenarios
This study focusus on different circumstances dealt with by plastic surgeons in a rural setting in Turkey and aims to configure what the general approach should be through an analysis of a wide spectrum of patients. Between June 2013 and December 2014, 205 patients who presented to the emergency department for animal‐inflicted injuries were retrospectively analysed. Patients who consulted for plastic surgery were included in the analysis to determine which wounds require further attention. Patients with past animal‐inflicted injuries who presented to the outpatient plastic surgery clinic with concerns such as non‐hea...
Source: International Wound Journal - August 1, 2015 Category: Surgery Authors: Billur Sezgin, Mbaraka Ljohiy, Sultan Tuna Akgol Gur Tags: ORIGINAL ARTICLE Source Type: research

Symptoms in patients with skin changes due to chronic venous insufficiency often lead to emergency care service: an Italian observational study
Abstract Chronic venous insufficiency (CVI) is the most advanced form of chronic venous disease (CVD), and is often associated with skin changes such as hyperpigmentation, eczema, lipodermatosclerosis and venous skin ulceration that cause discomfort, pain, sleep disturbances, absenteeism in the workplace, disability and deteriorated quality of life (QoL). The purpose of this study is to evaluate the prevalence of CVI and skin changes in patients who turn to Continuous Assistance Services due to the presence of disturbing symptoms of their condition. Data were evaluated by consulting the medical records, during a 16‐month...
Source: International Wound Journal - August 1, 2015 Category: Surgery Authors: Michele Ruggiero, Raffaele Grande, Agostino Naso, Lucia Butrico, Paolo Rubino, Girolamo Domenico Placida, Marco Cannistrà, Raffaele Serra Tags: ORIGINAL ARTICLE Source Type: research

Autologous platelet‐rich fibrin in treatment of scleroderma ulcer
(Source: International Wound Journal)
Source: International Wound Journal - August 1, 2015 Category: Surgery Authors: Shricharith Shetty, Shruthakirti D Shenoi Tags: LETTER TO THE EDITOR Source Type: research

Patients with pyoderma gangrenosum – analyses of the German DRG data from 2012
We described the worldwide largest PG population and confirmed a wide range of potentially relevant and partly not yet described cofactors and comorbidities such as metabolic syndrome. (Source: International Wound Journal)
Source: International Wound Journal - August 1, 2015 Category: Surgery Authors: Finja Jockenhöfer, Joachim Klode, Knut Kröger, Alexander Roesch, Philipp Al Ghazal, Joachim Dissemond Tags: ORIGINAL ARTICLE Source Type: research

Lower temperature at the wound edge detected by thermography predicts undermining development in pressure ulcers: a pilot study
Abstract Undermined pressure ulcers (PUs) are troublesome complications that are likely to delay wound healing. Early skin incision and debridement can prevent the deterioration of undermined PUs, thus it is necessary to identify devitalised tissue areas to determine the appropriate timing for such interventions. This retrospective cohort study evaluated whether a lower temperature at the wound edge than the wound bed and periwound skin, detected by thermography, can predict undermining development in PUs 1 week after the assessment. Twenty‐two participants with category III, IV, or unstageable PUs who were examin...
Source: International Wound Journal - July 24, 2015 Category: Surgery Authors: Toshiki Kanazawa, Aya Kitamura, Gojiro Nakagami, Taichi Goto, Tomomitsu Miyagaki, Akitatsu Hayashi, Sanae Sasaki, Yuko Mugita, Shinji Iizaka, Hiromi Sanada Tags: ORIGINAL ARTICLE Source Type: research

Chronic venous ulcer treatment with topical sevoflurane
(Source: International Wound Journal)
Source: International Wound Journal - July 21, 2015 Category: Surgery Authors: Adrián Imbernón, Cristina Blázquez, Ana Puebla, Micaela Churruca, Alejandro Lobato, Marcela Martínez, Antonio Aguilar, Miguel A Gallego Tags: LETTER TO THE EDITOR Source Type: research

Effect of piracetam and nimodipine on full‐thickness skin burns in rabbits
Abstract The potential of several drugs for full‐thickness skin burns has been investigated, but the treatment of such burns remains a challenge in plastic surgery. The present study was designed to determine the effect of systemic and topical administration of piracetam and nimodipine on full‐thickness skin burn wound healing. A total of 36 New Zealand male rabbits were divided into six groups. Full‐thickness skin burns were produced in all the groups, except the control group. Piracetam was administered systemically (piracetam‐IV) and topically (piracetam‐C) for 14 days, and nimodipine was administered s...
Source: International Wound Journal - July 20, 2015 Category: Surgery Authors: Elif Sari, Gungor C Dincel Tags: ORIGINAL ARTICLE Source Type: research

The expression of inflammatory cytokines, TAM tyrosine kinase receptors and their ligands is upregulated in venous leg ulcer patients: a novel insight into chronic wound immunity
Abstract The systemic host defence mechanisms, especially innate immunity, in venous leg ulcer patients are poorly investigated. The aim of the current study was to measure Candida albicans killing activity and gene expressions of pro‐ and anti‐inflammatory cytokines and innate immune response regulators, TAM receptors and ligands of peripheral blood mononuclear cells separated from 69 venous leg ulcer patients and 42 control probands. Leg ulcer patients were stratified into responder and non‐responder groups on the basis of wound healing properties. No statistical differences were found in Candida killing among cont...
Source: International Wound Journal - July 20, 2015 Category: Surgery Authors: Kata Filkor, Tibor Németh, István Nagy, Éva Kondorosi, Edit Urbán, Lajos Kemény, Győző Szolnoky Tags: ORIGINAL ARTICLE Source Type: research

Effect of piracetam and nimodipine on full ‐thickness skin burns in rabbits
Abstract The potential of several drugs for full‐thickness skin burns has been investigated, but the treatment of such burns remains a challenge in plastic surgery. The present study was designed to determine the effect of systemic and topical administration of piracetam and nimodipine on full‐thickness skin burn wound healing. A total of 36 New Zealand male rabbits were divided into six groups. Full‐thickness skin burns were produced in all the groups, except the control group. Piracetam was administered systemically (piracetam‐IV) and topically (piracetam‐C) for 14 days, and nimodipine was administered systemic...
Source: International Wound Journal - July 19, 2015 Category: Surgery Authors: Elif Sari, Gungor C Dincel Tags: ORIGINAL ARTICLE Source Type: research

The efficacy of hydrogel dressings as a first aid measure for burn wound management in the pre‐hospital setting: a systematic review of the literature
Abstract The aim of this systematic review was to determine the supporting evidence for the clinical use of hydrogel dressings as a first aid measure for burn wound management in the pre‐hospital setting. Two authors searched three databases (Ovid Medline, Ovid Embase and The Cochrane Library) for relevant English language articles published through September 2014. Reference lists, conference proceedings and non‐indexed academic journals were manually searched. A separate search was conducted using the Internet search engine Google to source additional studies from burns advisory agencies, first aid bodies, military in...
Source: International Wound Journal - July 17, 2015 Category: Surgery Authors: Nicholas S Goodwin, Anneliese Spinks, Jason Wasiak Tags: ORIGINAL ARTICLE Source Type: research

Comparing visual and objective skin assessment with pressure injury risk
This study used a descriptive correlational design to examine the relationship between measures of skin hydration, colour (melanin and erythema) and lipids at PI‐prone areas amongst geriatric persons (n = 38), obtained using biophysical skin measures and visual skin assessment. Twice daily measures of epidermal hydration, colour and lipids were assessed using the SD202 Skin Diagnostic (Courage + Khazaka GmBH, Cologne, Germany) over pressure‐prone areas of the body of study participants over seven consecutive days. Concurrent visual assessment of skin hydration and colour was performed. Resul...
Source: International Wound Journal - July 15, 2015 Category: Surgery Authors: Caroline J Borzdynski, William McGuiness, Charne Miller Tags: ORIGINAL ARTICLE Source Type: research