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Platelet extracellular vesicles: Darkness and light of autoimmune diseases
Int Rev Immunol. 2023 Jun 23:1-11. doi: 10.1080/08830185.2023.2225551. Online ahead of print.ABSTRACTAutoimmune diseases are characterized by a breakdown of immune tolerance, leading to inflammation and irreversible end-organ tissue damage. Platelet extracellular vesicles are cellular elements that are important in blood circulation and actively participate in inflammatory and immune responses through intercellular communication and interactions between inflammatory cells, immune cells, and their secreted factors. Therefore, platelet extracellular vesicles are the "accelerator" in the pathological process of autoimmune dis...
Source: International Reviews of Immunology - June 23, 2023 Category: Allergy & Immunology Authors: Jingru Chen Miao Wang Ying Zhang Fenglin Zhu Yanqiu Xu Guoxiang Yi Runxiu Zheng Bin Wu Source Type: research

Role of natural killer and B cell interaction in inducing pathogen specific immune responses
Int Rev Immunol. 2023;42(4):304-322. doi: 10.1080/08830185.2023.2172406. Epub 2023 Feb 2.ABSTRACTThe innate lymphoid cell (ILC) system comprising of the circulating and tissue-resident cells is known to clear infectious pathogens, establish immune homeostasis as well as confer antitumor immunity. Human natural killer cells (hNKs) and other ILCs carry out mopping of the infectious pathogens and perform cytolytic activity regulated by the non-adaptive immune system. The NK cells generate immunological memory and rapid recall response tightly regulated by the adaptive immunity. The interaction of NK and B cell, and its role t...
Source: International Reviews of Immunology - February 2, 2023 Category: Allergy & Immunology Authors: Nikunj Tandel Sushmita Negi Sarat K Dalai Rajeev K Tyagi Source Type: research