International Journal of Surgical Pathology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Breast Carcinoma With Unrecognized Neuroendocrine Differentiation Metastasizing to the Pancreas: A Potential Diagnostic Pitfall
We report the case of a 73-year-old woman who underwent lumpectomy with a postoperative diagnosis of invasive ductal breast carcinoma. Six weeks after lumpectomy, pancreatic biopsies showed tumor cells with neuroendocrine features. The first immunohistochemical panel showed positivity for synaptophysin and cytokeratins, raising suspicion of a pancreatic neuroendocrine tumor. However, a second panel revealed positivity for estrogen receptors and GATA3. On review of the lumpectomy specimen, a significant neuroendocrine component was found, leading to the final diagnosis of breast carcinoma with neuroendocrine features metast...
Source: International Journal of Surgical Pathology - June 27, 2016 Category: Pathology Authors: Christensen, L., Mortensen, M. B., Detlefsen, S. Tags: Case Reports Source Type: research

Malignant Peripheral Nerve Sheath Tumor With Osseous Heterologous Differentiation in Uncommon Locations (Heart and Retropharynx)
In conclusion, the histology of MPNSTs is very heterogeneous, showing no specific diagnostic immunoprofile or genetic alteration. Thus, it is important to rule out other histologically similar tumors, particularly in cases arising in uncommon locations or tumors with divergent heterologous differentiation. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - June 27, 2016 Category: Pathology Authors: Machado, I., Arana, E., Cruz, J., Brotons, S., Vendrell, J., Escriba, I., Chust, M. L., Martinez-Banaclocha, N., Lavernia, J., Llombart-Bosch, A. Tags: Case Reports Source Type: research

Classical Hodgkin Lymphoma Arising Adjacent to a Breast Implant
Breast implant–associated lymphoma has recently gained wide recognition. Anaplastic large cell lymphoma (ALCL) is the most frequently diagnosed subtype in this setting but the spectrum is broadening. A 66-year-old woman developed swelling and itch around her saline implant 6 years after its insertion. Imaging revealed a fluid collection surrounding the implant with an adjacent mass. Microscopy showed sclerotic tissue punctuated by discrete cellular nodules comprising small lymphocytes, eosinophils and interspersed large atypical Hodgkin Reed-Sternberg (HRS)-like cells. The HRS-like cells stained positively for CD30 a...
Source: International Journal of Surgical Pathology - June 27, 2016 Category: Pathology Authors: Ryan, C., Ged, Y., Quinn, F., Walker, J., Kennedy, J., Gillham, C., Pittaluga, S., McDermott, R., Vandenberghe, E., Grant, C., Flavin, R. Tags: Case Reports Source Type: research

Case Report of a Well-Differentiated Papillary Mesothelioma of the Tunica Vaginalis in an Undescended Testis With Review of Literature
Well-differentiated papillary mesothelioma (WDPM) affecting the tunica vaginalis testis is a rare tumor, and very little is known about the clinicopathological spectrum of this variant as a distinct entity. Most patients with WDPM suffer from scrotal pain or swelling, but hydrocele seems to be the most common presenting symptom. These lesions are usually not aggressive and are accompanied by an indolent clinical behavior. In this article, we report the first case known of WDPM in an undescended testis, and in addition, we review the literature for similar cases. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - June 27, 2016 Category: Pathology Authors: Parcesepe, P., Sina, S., Zanella, C., Pancione, M., Giuliani, J., Detogni, P., Curti, P., Bonetti, A., Manfrin, E., Remo, A. Tags: Case Reports Source Type: research

Rare Primary Adenocarcinoma of the Broad Ligament: Report of Two Cases and a Literature Review
We describe 2 new cases of primary adenocarcinoma of the broad ligament, and we review the previous literature on such rare tumors. In Case 1, a 71-year-old woman presented with a 2-month history of increased yellow vaginal discharge and lower abdominal pain during bowel movement. Transvaginal sonography revealed a 6.5 cm mass located on the dorsum of the uterus and a 7.0 cm mass (with cystic and solid parts) near the right adnexa. We postoperatively diagnosed the mass as a high-grade serous carcinoma of the broad ligament (pT3cNXM0). The patient is currently receiving adjuvant chemotherapy with paclitaxel and carboplatin....
Source: International Journal of Surgical Pathology - June 27, 2016 Category: Pathology Authors: Miyoshi, A., Miyatake, T., Hara, T., Komiya, S., Komura, N., Tanaka, A., Kanao, S., Takeda, M., Mimura, M., Nagamatsu, M., Yamasaki, M., Yokoi, T. Tags: Case Reports Source Type: research

Rhabdoid Myomelanocytic Tumor (PEComa) of the Ovary: A Clinically Benign Case Followed for 7 Years
A 3.0 x 2.5 cm rhabdoid myomelanocytic tumor was incidentally found in the left ovary of a 43-year-old black woman. The tumor cells were cytologically bland with minimal proliferation rate, multifocally weakly or moderately expressed TFE3, strongly expressed smooth muscle markers and SMARCB1/INI1, and focally expressed HMB45. They contained numerous paranuclear whorls of intermediate filaments that were verified by ultrastructure. No other lines of differentiation were detected within the tumor. Neither translocation nor increased number of copies of the TFE3 gene at Xp11.22 was detected by fluorescence in situ hybridizati...
Source: International Journal of Surgical Pathology - June 27, 2016 Category: Pathology Authors: Rampisela, D., Grossmann, P., Donner, L. R. Tags: Case Reports Source Type: research

Mature Cystic Teratoma of the Ovary With Three Kinds of Entire Gastrointestinal Wall and Complete Bronchial Structure in a Pregnant Woman
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - June 27, 2016 Category: Pathology Authors: Shi, X.-X., Shen, H., Chen, T., Pan, Z.-Y., Wu, X.-F., Zou, Z.-N., Zhang, S.-S., Sun, D.-J., Zhang, Y.-Z. Tags: Images in Pathology Source Type: research

Heterotopic Bone in the Distal Esophagus
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - June 27, 2016 Category: Pathology Authors: Goebel, E. A., Walsh, J. C. Tags: Images in Pathology Source Type: research

Pseudopapillary Granulosa Cell Tumor: A Case of This Rare Subtype
Conclusion. The pseudopapillary pattern of granulosa cell tumor is rare and must be suspected in order to utilize appropriate immunohistochemistry and reach the correct diagnosis. Inhibin positivity is particularly helpful. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - June 27, 2016 Category: Pathology Authors: Heller, D., Haddad, A., Cracchiolo, B. Tags: Pitfalls in Pathology Source Type: research

Solid Variant of Adenoid Cystic Carcinoma: Difficulties in Diagnostic Recognition
We describe a case of solid variant ACC of the paranasal sinuses, which showed an almost entirely solid pattern of growth (in >95% of cells) and which on initial biopsy showed no features of classical ACC. This highlights the potential for diagnostic misinterpretation with a variety of other neoplasms, which is particularly important because of the significant difference in treatment for ACC and tumors in its differential diagnosis. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - June 27, 2016 Category: Pathology Authors: Ben Salha, I., Bhide, S., Mourtzoukou, D., Fisher, C., Thway, K. Tags: Pitfalls in Pathology Source Type: research

Immunohistochemical Expression of GLUT-1 and HIF-1{alpha} in Tooth Germ, Ameloblastoma, and Ameloblastic Carcinoma
Hypoxia-inducible factor-1α (HIF-1α) promotes proteins that enable cell survival during hypoxia, such as glucose transporter 1 (GLUT-1). Their coexpression has been associated with aggressiveness in malignancies and has not been studied in odontogenic tumors. Immunohistochemical expression of HIF-1α and GLUT-1 was analyzed in 13 tooth germs (TGs), 55 ameloblastomas (AMs), and 3 ameloblastic carcinomas (ACs). HIF-1α was negative in all TGs, and just 1 case of AM and 1 of AC had nuclear positivity. GLUT-1 expressed in ameloblastic cells of all TGs, AMs, and ACs, with an increasing intensity, respectiv...
Source: International Journal of Surgical Pathology - June 27, 2016 Category: Pathology Authors: Sanchez-Romero, C., Bologna-Molina, R., Mosqueda-Taylor, A., Paes de Almeida, O. Tags: Original Articles Source Type: research

Audit of Turnaround Time for a Training Oral Histopathology Laboratory in Malaysia
Conclusion. A TAT goal appropriate for this laboratory may hence be established based on this study. Collective efforts to improve the TAT for various specimens are essential for better laboratory performance in the future. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - June 27, 2016 Category: Pathology Authors: Chan, S. W., Liew, L. H., Wong, G. R., Kallarakkal, T. G., Abraham, M. T., Ramanathan, A., Zain, R. B. Tags: Original Articles Source Type: research

Interleukin-33 Expression Indicates a Favorable Prognosis in Malignant Salivary Gland Tumors
The cytokine interleukin-33 (IL-33) is abundantly expressed in epithelial barrier tissues such as salivary glands. Here, we characterized nuclear IL-33 protein expression by immunohistochemistry in benign and malignant salivary gland tumors and associated it with disease outcome. Most benign salivary gland tumors expressed IL-33, and all Warthin’s tumors showed strong and consistent IL-33 expression in the basally oriented cells of their bilayered epithelium. In the malignant group of neoplasms, nuclear IL-33 expression was limited to specific tumor entities—for example, to epithelial-myopepithelial carcinomas ...
Source: International Journal of Surgical Pathology - June 27, 2016 Category: Pathology Authors: Rössle, M., Cathomas, G., Bonapace, L., Sachs, M., Dehler, S., Storz, M., Huber, G., Moch, H., Junt, T., Mertz, K. D. Tags: Original Articles Source Type: research

Mediastinal Gray Zone Lymphoma: A Wider Category Than We Think?
Conclusion. Thus, the MGZL may be a wider category than we think and hence the use of a wide immunopanel is recommended to identify the aggressively behaving mediastinal B-cell lymphomas. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - June 27, 2016 Category: Pathology Authors: Verma, A., Shet, T., Epari, S., Gupta, M., Gujral, S., Khanna, N., Laskar, S., Sengar, M., Arora, B., Menon, H., Banavali, S. Tags: Original Articles Source Type: research

Aberrant Expression of Napsin A in Breast Carcinoma With Apocrine Features
An incidental finding of napsin A–positive breast carcinoma with apocrine features during workup for metastatic cancer in an axillary lymph node led to our investigation of the incidence of napsin A expression in breast carcinomas, focusing on those with apocrine features. We included 97 cases of breast carcinomas and performed immunohistochemistry with napsin A, GATA-3, thyroid transcription factor-1, and GCDFP-15. There was a statistically significant difference between apocrine and nonapocrine cases with respect to polyclonal napsin A H-scores (P < .00152), monoclonal napsin A H-scores (P < .00631), GATA-3 H...
Source: International Journal of Surgical Pathology - June 27, 2016 Category: Pathology Authors: Vitkovski, T., Chaudhary, S., Sison, C., Nasim, M., Esposito, M. J., Bhuiya, T. Tags: Original Articles Source Type: research