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Prevalence of Helicobacter pylori in Gastric Hyperplastic Polyps
Hyperplastic polyps of the stomach are routinely encountered during upper endoscopy and often arise in the setting of abnormal surrounding mucosa, particularly Helicobacter pylori, autoimmune gastritis, and reactive gastropathy. Not infrequently gastroenterologists fail to biopsy the surrounding mucosa, thus determining the underlying etiology of the gastric hyperplastic polyp can be difficult. Recently, the Rodger C. Haggitt Gastrointestinal Pathology Society published guidelines on the use of special stains. The society guidelines indicate that H pylori are not usually present in hyperplastic polyps and special stains in...
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Horvath, B., Pai, R. K. Tags: Original Articles Source Type: research

Immunoexpression of Epithelial Mesenchymal Transition Proteins E-Cadherin, {beta}-Catenin, and N-Cadherin in Oral Squamous Cell Carcinoma
Conclusion. OSCC tissues had high levels of EMT phenotype as compared with the normal oral mucosa. This phenotype was characterized by reduced E-cadherin and β-catenin expression and overexpression of N-cadherin. Aberrant localization of the studied proteins was a hallmark for depicting EMT. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Angadi, P. V., Patil, P. V., Angadi, V., Mane, D., Shekar, S., Hallikerimath, S., Kale, A. D., Kardesai, S. G. Tags: Original Articles Source Type: research

Visualization of Grossly Undetectable Breast Tumors by Refixation in Lymph Node Revealing Solution
Conclusion. Postfixation in LNRS enhances the visualization of grossly undetectable breast lesions and it is worthwhile to use it in problematic cases in order to arrive at a more accurate diagnosis. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Bubis, G., Rath-Wolfson, L., Schwartz, A., Girich, S., Koren, R. Tags: Original Articles Source Type: research

Voluntary Second Opinions in Pediatric Bone and Soft Tissue Pathology: A Retrospective Review of 1601 Cases From a Single Mesenchymal Tumor Consultation Service
The diagnosis of bone and soft tissue tumors in children is challenging. These lesions are especially difficult for general pathologists. We reviewed our experience with pediatric mesenchymal tumors sent in consultation to our service, with the goal of identifying issues that most often prompted second-opinion referral. Roughly 16 000 cases were seen in toto, of which 1601 occurred in children. These included 491 bone cases and 1110 soft tissue cases. The cases were referred by private practices/nonacademic medical centers (85%), academic medical centers (8%), and pediatric hospitals (7%). Reasons for referral were (a) sel...
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Al-Ibraheemi, A., Folpe, A. L. Tags: Original Articles Source Type: research

Desmoplastic Small Round Cell Tumor: Pathology, Genetics, and Potential Therapeutic Strategies
Desmoplastic small round cell tumor (DSRCT) is an aggressive small round cell neoplasm which predominantly occurs intra-abdominally in adolescents and young adults with a male predominance, and which is characterized by a recurrent t(11;22)(p13;q12) translocation leading to formation of the EWSR1-WT1 fusion gene, which generates a chimeric protein with transcriptional regulatory activity. Histologically, DSRCT has a characteristic morphology, of islands of monotonous small cells within prominent sparsely cellular fibroblastic stroma, and immunohistochemically it shows polyphenotypic multidirectional differentiation, with e...
Source: International Journal of Surgical Pathology - October 31, 2016 Category: Pathology Authors: Thway, K., Noujaim, J., Zaidi, S., Miah, A. B., Benson, C., Messiou, C., Jones, R. L., Fisher, C. Tags: Review Source Type: research

Chordoid Glioma of Third Ventricle With an Epidermoid Cyst: Coexistence or Common Histogenesis?
We report a case of CG in a 45-year-old male coexisting with an epidermoid cyst in the third ventricle. Ultrastructural examination of the CG revealed microvilli, junctional complexes, and intermediate filaments within the cytoplasm suggesting origin from specialized ependyma. The association of the 2 lesions appears coincidental as convincing evidence for a common histogenesis was not found. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - September 6, 2016 Category: Pathology Authors: Poyuran, R., Mahadevan, A., Sagar, B. K. C., Saini, J., Srinivas, D. Tags: Case Reports Source Type: research

Dirofilariasis Presenting as an Infiltrative Mass in the Right Buccal Space
Dirofilariasis is caused by filarial nematodes (roundworms) of the genus Dirofilaria. Dirofilariasis of the oral mucosa is very rare. Herein, we report a case of a 79-year-old man who had a slowly growing infiltrative mass in the right buccal space. Histopathologic examination showed an inflammatory infiltrate with eosinophilia, histiocytes, and small organisms (0.2-0.3 mm). Digital images were sent to the Centers for Disease Control and Prevention, which identified the parasite as a nematode in the genus Dirofilaria. It appeared to be dead and degenerating, but external, fine longitudinal cuticular ridges and the presence...
Source: International Journal of Surgical Pathology - September 6, 2016 Category: Pathology Authors: Velez-Perez, A., Liang, L., Syklawer, E., Chavez, V., Zhang, S., Wanger, A. Tags: Case Reports Source Type: research

Ameloblastic Fibrosarcoma of the mandible evolving from a prior Ameloblastic Fibroma after two years: an unusual finding
This article describes the clinical and radiographic features, histological characteristics, immunohistochemical findings, and surgical treatment of the tumor. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - September 6, 2016 Category: Pathology Authors: Bertoni, F., Del Corso, G., Bacchini, P., Marchetti, C., Tarsitano, A. Tags: Case Reports Source Type: research

Primary Colon Adenosquamous Carcinoma in a Patient With Lynch Syndrome: A New Histologic Subtype Associated With Microsatellite Instability?
We report a case of a 53-year-old woman who presented with rectal bleeding and a 9.5 cm hemicircumferential ascending colon mass. Histology revealed adenosquamous carcinoma (ASC), a rare subtype comprised of malignant squamous and glandular elements. Immunohistochemistry revealed loss of MLH1/PMS2 expression and retained MSH2/MSH6 expression in squamous and glandular components, indicative of microsatellite instability (MSI). MSI is caused by loss-of-function defects in DNA mismatch repair genes, leading to increased susceptibility to a variety of neoplasms; the role of MSI in colorectal ASC is unknown. The tumor was negat...
Source: International Journal of Surgical Pathology - September 6, 2016 Category: Pathology Authors: Duncan, V. E., Harada, S., Stevens, T. M. Tags: Case Reports Source Type: research

Granulomatous Insulitis as a Cause of Acute-Onset Insulin-Dependent Diabetes Mellitus in a Patient With a Pancreatic Endocrine Carcinoma
We report a unique case of granulomatous insulitis in a patient with an endocrine tumor of the pancreas that clinically manifested as acute-onset insulin-dependent diabetes mellitus. Granulomata were present in islets with complete disappearance of β cells, as well as in the primary tumor, metastases, and lymph nodes. We postulate that these granulomata represent a sarcoid-like reaction to the tumor with secondary injury to nonneoplastic endocrine cells through a mechanism of molecular mimicry. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - September 6, 2016 Category: Pathology Authors: Saab, J., Qin, L., Jessurun, J. Tags: Case Reports Source Type: research

Ciliated Foregut Cyst of the Common Hepatic Duct: An Unusual Mimic of a Type II Choledochal Cyst
Ciliated foregut cysts typically arise in the liver and pancreas, with rare cases reported to arise in the gallbladder wall. Herein, we describe an unusual case of a patient with a ciliated foregut cyst arising from the wall of the common hepatic duct, which has not been reported previously. As a result of its unique anatomical location, the cyst was mistaken for a type II choledochal cyst on preoperative imaging. The cyst caused intermittent biliary obstruction that resolved following surgical resection. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - September 6, 2016 Category: Pathology Authors: Cottreau, J., Costa, A., Walsh, M., Arnason, T. Tags: Case Reports Source Type: research

Hepatocellular Adenoma of the Placenta With Updated Immunohistochemical and Molecular Markers: A Case Report
We describe the clinicopathological, immunohistochemical, and molecular features of an unusual case of a hepatocellular adenoma of the placenta presenting as a subchorionic intervillous mass lesion in a diamnionic dichorionic placenta. A well-circumscribed 0.8 cm round nodule was identified in one of the twin placental discs, wherein, on microscopic review, the lesional cells morphologically and immunophenotypically resembled fetal hepatocytes. Given the rarity of this lesion, we performed an updated immunohistochemical and molecular analysis, including makers for β-catenin activation and well-differentiated hepatocel...
Source: International Journal of Surgical Pathology - September 6, 2016 Category: Pathology Authors: Yee, E. U., Hale, G., Liu, X., Lin, D. I. Tags: Case Reports Source Type: research

Mesonephric (Wolffian) Pseudoendometrioid Carcinoma of the Broad Ligament, Arising From a Papillary Cystadenoma
This article describes the case of a 70-year-old woman with an adnexal cystadenocarcinoma located in the right broad ligament and displaying a striking resemblance to a well-differentiated endometrioid adenocarcinoma. The uniqueness of this pseudoendometrioid carcinoma lies in the fact that its mesonephric nature is revealed by the origin from a papillary cystadenoma of the broad ligament, where remnants of the mesonephric duct are seated, and the immunohistochemical profile, particularly a uniform negativity for estrogen and progesterone receptors, apical-luminal positivity for CD10, and strong nuclear positivity for GATA...
Source: International Journal of Surgical Pathology - September 6, 2016 Category: Pathology Authors: Moerman, P., Amant, F., Vergote, I. Tags: Case Reports Source Type: research

Follicular Dendritic Cell Sarcoma of Appendix Presenting as Acute Appendicitis: An Exceptionally Rare Case Report
Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm that originates from dendritic cells of lymphoid follicles and shows low to intermediate malignant potential. It most commonly arises from lymph nodes, but may originate from a variety of extranodal sites. FDCS of appendix is exceptionally rare, and only a single case has been reported. Herein, we describe the clincopathological features of a case of FDCS originating from appendix with emphasis on being able to recognize this rare neoplasm in the context of the differential diagnosis of more common intraabdominal spindle cell tumors. (Source: International Journal...
Source: International Journal of Surgical Pathology - September 6, 2016 Category: Pathology Authors: Ahmed, A., Ud Din, N., Alvi, A. R., Rubin, B. P. Tags: Case Reports Source Type: research

Coexistence of Multiple Ileal Neuroendocrine Tumors and Idiopathic Myointimal Hyperplasia of Mesenteric Veins: Coincidence or Consequence? Case Report and Review of Literature
In the present case, we report the association of multiple ileal neuroendocrine tumors and idiopathic myointimal hyperplasia of the mesenteric veins, 2 rare conditions that could have an etiopathogenetic relationship. Idiopathic myointimal hyperplasia of mesenteric veins implies a near-total obliteration of venular vessels, which can lead to hypoxic disorders. Hypoxia in tumors is associated with increased metastatic potential and resistance to radiotherapy and chemotherapy. Herein we speculated on the existence of a relationship between hypoxia and multiple location of neuroendocrine tumors. (Source: International Journal...
Source: International Journal of Surgical Pathology - September 6, 2016 Category: Pathology Authors: Guadagno, E., Del Basso De Caro, M., Del Prete, E., DArmiento, F. P., Campione, S. Tags: Case Reports Source Type: research