Prognostic Factors and Survival Time in Patients with Small Bowel Tumors: A Retrospective Observational Study.
This study examines survival time in patients with small bowel tumors and determines its contributing factors. In this retrospective analytical study, the medical records of 106 patients with small bowel cancer (from 2006 to 2011) were investigated. The patients' data were extracted, including age, gender, clinical presentation, location of tumor, histological type, grade of tumor, site of metastasis, and type of treatment. The Kaplan-Meier test was used to estimate the overall survival time and the Log-rank test to compare the survival curves. The Cox regression was also used to evaluate the effect of the confounding vari...
Source: International Journal of Surgical Oncology - June 13, 2019 Category: Surgery Tags: Int J Surg Oncol Source Type: research

A Concise Review of Pelvic Radiation Therapy (RT) for Rectal Cancer with Synchronous Liver Metastases.
Conclusion: Even in the setting of stage IV rectal cancer with synchronous liver metastases, there may be potential for extended survival and cure by aggressive management of primary tumor and metastases in selected patients. Despite lack of consensus on sequencing of treatment modalities, pelvic RT may serve as a critical component of multidisciplinary management. Resectability of primary rectal tumor and liver metastases, patient preferences, comorbidities, symptomatology, and logistical issues should be thoroughly considered in decision making for optimal management of patients. PMID: 31139467 [PubMed - in process] ...
Source: International Journal of Surgical Oncology - May 30, 2019 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Oral Submucous Fibrosis in Pediatric Patients: A Systematic Review and Protocol for Management.
Conclusion: Such a rapid increase in the rate of OSMF among pediatric population is a potential danger to the society. The habit of areca nut chewing is the major cause for this dreadful condition. Lack of health consciousness and low level of education are the major factors for initiation of this habit among children. Therefore it is imperative for the parents and school as well as government authorities to take serious actions. PMID: 31057961 [PubMed - in process] (Source: International Journal of Surgical Oncology)
Source: International Journal of Surgical Oncology - May 7, 2019 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Soft Tissue Sarcomas of the Thoracic Wall: More Prone to Higher Mortality, and Local Recurrence-A Single Institution Long-Term Follow-up Study.
Conclusions: In this large, single institution, study tumor grade was the key predictor for OS and LRFR. Surgical margin only statistically significantly influenced mortality, not local recurrence. PMID: 30956820 [PubMed - in process] (Source: International Journal of Surgical Oncology)
Source: International Journal of Surgical Oncology - April 10, 2019 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Outcome of Cervical Lymph Nodes Dissection for Thyroid Cancer with Nodal Metastases: A Southeast Asian 3-Year Experience.
Conclusion: High recurrence and reoperative rates were observed in our centre. While the routine prophylactic LND remains controversial, high risk patients may be considered for prophylactic LND. The long-term risk and benefit of prophylactic LND with individualised patient selection in the local setting deserve further studies. PMID: 30941211 [PubMed - in process] (Source: International Journal of Surgical Oncology)
Source: International Journal of Surgical Oncology - April 5, 2019 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Comparison of Survival in Patients with Isolated Peritoneal Carcinomatosis from Colorectal Cancer Treated with Cytoreduction and Melphalan or Mitomycin-C as Hyperthermic Intraperitoneal Chemotherapy Agent.
Conclusions: CRS/HIPEC with MMC had longer median PFS in PC from CRC. PCI≥20 was the only independent predictive factor for survival. Until longer follow-up is available, we recommend using MMC in CRS/HIPEC for PC from CRC. Further prospective randomized studies are necessary. PMID: 30643644 [PubMed - in process] (Source: International Journal of Surgical Oncology)
Source: International Journal of Surgical Oncology - January 16, 2019 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Early Cervical Cancer: Predictive Relevance of Preoperative 3-Tesla Multiparametric Magnetic Resonance Imaging.
Authors: Roh HJ, Kim KB, Lee JH, Kim HJ, Kwon YS, Lee SH Abstract Objective: We assess the predictive significance of preoperative 3-Tesla multiparametric MRI findings. Methods: A total of 260 patients with FIGO IA2-IIA cervical cancer underwent primary surgical treatment between 2007 and 2016. Univariable and multivariable logistic regression analyses were used to assess the incremental prognostic significance. Results: The clinical predictive factors associated with pT2b disease were MRI parametrial invasion (PMI) (adjusted odds ratio (AOR) 3.77, 95% confidence interval(CI) 1.62-8.79; P=0.02) and MRI uter...
Source: International Journal of Surgical Oncology - August 31, 2018 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Adrenal Metastasis of Hepatocellular Carcinoma in Patients following Liver Resection or Liver Transplantation: Experience from a Tertiary Referral Center.
Conclusion: Metachronous adrenal metastasis occured in less than 1% of HCC patients. Adrenalectomy is a safe procedure and leads to acceptable survival rates even after liver transplantion. Therefore, it should be performed whenever the primary tumor is well controlled and the patient is in adequate physical condition. PMID: 30151282 [PubMed - in process] (Source: International Journal of Surgical Oncology)
Source: International Journal of Surgical Oncology - August 30, 2018 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Myxoid Liposarcoma: Prognostic Factors and Metastatic Pattern in a Series of 148 Patients Treated at a Single Institution.
Authors: Muratori F, Bettini L, Frenos F, Mondanelli N, Greto D, Livi L, Franchi A, Roselli G, Scorianz M, Capanna R, Campanacci D Abstract Objectives: The authors reported a retrospective study on myxoid liposarcomas (MLs), evaluating factors that may influence overall survival (OS), local recurrence-free survival (LRFS), metastasis-free survival (MFS), and analyzing the metastatic pattern. Methods: 148 MLs were analyzed. The sites of metastases were investigated. Results: Margins (p = 0.002), grading (p = 0,0479), and metastasis (p
Source: International Journal of Surgical Oncology - July 8, 2018 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Granulosa Cell Tumor of the Ovary: A Retrospective Study of 31 Cases and a Review of the Literature.
Conclusion: GCTs have a long natural history with common late relapses. Hence, long active follow-up is recommended. In Tunisian patients, hepatic metastases were more frequent than occidental series. The prognosis remains good and initial staging at diagnosis is an important prognostic factor. PMID: 29796312 [PubMed - in process] (Source: International Journal of Surgical Oncology)
Source: International Journal of Surgical Oncology - May 30, 2018 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Radical Gastrectomy: Still the Cornerstone of Curative Treatment for Gastric Cancer in the Perioperative Chemotherapy Era-A Single Institute Experience over a Decade.
Conclusion: More than 60% patients with resectable gastric carcinoma did not undergo NACT. Radical gastrectomy with lymphadenectomy remained the cornerstone of treatment in this period. PMID: 29568650 [PubMed - in process] (Source: International Journal of Surgical Oncology)
Source: International Journal of Surgical Oncology - March 27, 2018 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Treatment Outcome of Carcinoma Vulva Ten-Year Experience from a Tertiary Cancer Centre in South India.
Conclusion: The treatment of carcinoma vulva should be individualized with multidisciplinary cooperation. The paucity of data, especially from India, necessitates the need for more studies, preferably multicentric, keeping in mind the low prevalence. PMID: 29387486 [PubMed - in process] (Source: International Journal of Surgical Oncology)
Source: International Journal of Surgical Oncology - February 3, 2018 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Invasive Candida Infection after Upper Gastrointestinal Tract Surgery for Gastric Cancer.
Authors: Brotfain E, Sebbag G, Friger M, Kirshtein B, Borer A, Koyfman L, Frank D, Bichovsky Y, Peiser JG, Klein M Abstract Upper gastrointestinal tract (GIT) surgical procedures are more likely to cause nosocomial Candida peritonitis than lower GIT procedures and they thus constitute an independent risk factor for mortality. Because of the severity of postsurgical fungal infections complications, intensivists and surgeons need to be extremely aware of their clinical importance in critically ill postsurgical intensive care unit (ICU) patients. We analyzed the clinical and microbiological data of 149 oncologic patie...
Source: International Journal of Surgical Oncology - December 14, 2017 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Results from Survey to Assess Current Trends in Surgical Practice in the Management of Women with Early Stage Cervical Cancer within the BGCS Community with an Emphasis on Routine Frozen Section Examination.
Authors: Gubbala K, Laios A, Madhuri TK, Pathiraja P, Haldar K, Kehoe S Abstract In the UK, more than 3,200 new cases of cervical cancer are diagnosed each year. Early stage cervical cancer (IA2-IB1) treatment comprises central surgery mainly in the form of radical hysterectomy or fertility sparing surgery including trachelectomy as well as systematic pelvic lymphadenectomy to detect metastases and adjust treatment accordingly. Given the variation in determining the lymph node (LN) status, a major prognosticator, we reviewed the current UK practice of LN assessment in women undergoing surgery for early cervical can...
Source: International Journal of Surgical Oncology - August 12, 2017 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Pancreatogastrostomy versus Pancreatojejunostomy: An Up-to-Date Meta-Analysis of RCTs.
DISCUSSION: There is no difference between the two anastomotic techniques regarding the rate of clinically significant POPF. Given several limitations, more large scale high quality RCTs are required. PMID: 28798875 [PubMed - in process] (Source: International Journal of Surgical Oncology)
Source: International Journal of Surgical Oncology - August 12, 2017 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Endoscopic Stenting as Bridge to Surgery versus Emergency Resection for Left-Sided Malignant Colorectal Obstruction: An Updated Meta-Analysis.
Authors: Allievi N, Ceresoli M, Fugazzola P, Montori G, Coccolini F, Ansaloni L Abstract INTRODUCTION: Emergency resection represents the traditional treatment for left-sided malignant obstruction. However, the placement of self-expanding metallic stents and delayed surgery has been proposed as an alternative approach. The aim of the current meta-analysis was to review the available evidence, with particular interest for the short-term outcomes, including a recent multicentre RCT. METHODS: We considered randomized controlled trials comparing stenting as a bridge to surgery and emergency surgery for the manageme...
Source: International Journal of Surgical Oncology - August 2, 2017 Category: Surgery Tags: Int J Surg Oncol Source Type: research

En Bloc Pancreaticoduodenectomy for Locally Advanced Right Colon Cancers.
Authors: A─čalar C, Canda AE, Unek T, Sokmen S Abstract Locally advanced right colon cancer may invade adjacent tissue and organs. Direct invasion of the duodenum and pancreas necessitates an en bloc resection. Previously, this challenging procedure was associated with high morbidity and mortality; however, today, this procedure can be done more safely in experienced centers. The aim of this study is to report our experience on en bloc right colectomy with pancreaticoduodenectomy for locally advanced right colon cancers. Between 2000 and 2012, 5 patients underwent en bloc multivisceral resection. No major morbiditi...
Source: International Journal of Surgical Oncology - July 29, 2017 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Dermal Substitutes Use in Reconstructive Surgery for Skin Tumors: A Single-Center Experience.
Conclusions. Use of dermal substitutes in oncology can be an option for reconstruction after extended resections, providing good aesthetical and functional results. PMID: 28751990 [PubMed - in process] (Source: International Journal of Surgical Oncology)
Source: International Journal of Surgical Oncology - July 29, 2017 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Management Options for Advanced Low or Intermediate Grade Gastroenteropancreatic Neuroendocrine Tumors: Review of Recent Literature.
Authors: Neychev V, Kebebew E Abstract Our understanding of the biology, genetics, and natural history of neuroendocrine tumors (NETs) of the gastrointestinal tract and pancreas has improved considerably in the last several decades and the spectrum of available therapeutic options is rapidly expanding. The management of patients with metastatic low or intermediate grade NETs has been revolutionized by the development of new treatment strategies such as molecular targeting therapies with everolimus and sunitinib, somatostatin analogs, tryptophan hydroxylase inhibitors, and peptide receptor radionuclide therapy that ...
Source: International Journal of Surgical Oncology - June 9, 2017 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Noninvasive Encapsulated Follicular Variant of Papillary Thyroid Cancer: Clinical Lessons from a Community-Based Endocrine Surgical Practice.
Conclusions. Early clinical follow-up data suggests that the majority of noninvasive EFVPTC tumors exhibit indolent behavior, but clinical decision-making with regard to completion thyroidectomy, central lymph node dissection, and adjunctive radioiodine therapy often depends on the amount and type of synchronous thyroid cancer detected elsewhere in the thyroid gland and the central neck. PMID: 28487771 [PubMed - in process] (Source: International Journal of Surgical Oncology)
Source: International Journal of Surgical Oncology - May 11, 2017 Category: Surgery Tags: Int J Surg Oncol Source Type: research

The Role of [(18)F]FDG-PET/CT in Predicting Malignant Transformation of Plexiform Neurofibromas in Neurofibromatosis-1.
Conclusion. This systematic review is able to demonstrate that FDG-PET/CT is a useful noninvasive test for discriminating between benign and malignant lesions but has limitations and requires further prospective trials. PMID: 28058117 [PubMed - in process] (Source: International Journal of Surgical Oncology)
Source: International Journal of Surgical Oncology - January 11, 2017 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Preoperative Radiation Therapy Followed by Reexcision May Improve Local Control and Progression-Free Survival in Unplanned Excisions of Soft Tissue Sarcomas of the Extremity and Chest-Wall.
In this study, we compare outcomes of UE versus planned excision (PE) and determine an optimal treatment for UE in STS. Methods. From 2000 to 2014 a review was performed on all patients treated with localized STS. Clinical outcomes including local recurrence-free survival (LRFS), progression-free survival (PFS), and overall survival (OS) were evaluated using the Kaplan-Meier estimate. Univariate (UVA) and multivariate (MVA) analyses were performed to determine prognostic variables. For MVA, Cox proportional hazards model was used. Results. 245 patients were included in the analysis. 14% underwent UE. Median follow-up was 2...
Source: International Journal of Surgical Oncology - November 3, 2016 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Neoadjuvant Therapy in Differentiated Thyroid Cancer.
Conclusions. Thus, chemotherapy in the neoadjuvant setting could possibly be useful for managing advanced DTC. Additionally, some of the new tyrosine kinase inhibitors (TKIs) hold promise for use in the neoadjuvant setting in DTC. PMID: 27747102 [PubMed - in process] (Source: International Journal of Surgical Oncology)
Source: International Journal of Surgical Oncology - October 18, 2016 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Liposarcoma of the Spermatic Cord: Impact of Final Surgical Intervention-An Institutional Experience.
Conclusion. An incomplete first surgical step increases the number of positive margins leading to local recurrences and adverse prognoses. Aggressive surgery should be attempted to attain 3-dimensional negative margins. PMID: 27190644 [PubMed - in process] (Source: International Journal of Surgical Oncology)
Source: International Journal of Surgical Oncology - May 19, 2016 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Current Practice of Therapeutic Mammaplasty: A Survey of Oncoplastic Breast Surgeons in England.
Discussion. There is a wide variation in the practice of TM amongst OBS. Further research and guidance would be useful to standardise practice, particularly management of involved margins and coding for optimal reimbursement. PMID: 27110398 [PubMed - in process] (Source: International Journal of Surgical Oncology)
Source: International Journal of Surgical Oncology - April 27, 2016 Category: Surgery Tags: Int J Surg Oncol Source Type: research

A Structured Assessment to Decrease the Amount of Inconclusive Endometrial Biopsies in Women with Postmenopausal Bleeding.
Conclusion. A structured reassessment of endometrial biopsies samples, which were classified as inconclusive due to insufficient material, did not change the conclusion. Although it might be helpful for pathologists to have diagnostic criteria for adequacy and/or inadequacy of an endometrial biopsy sample, the gain in efficiency is likely to be small. PMID: 27034826 [PubMed - as supplied by publisher] (Source: International Journal of Surgical Oncology)
Source: International Journal of Surgical Oncology - April 3, 2016 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Prognostic Relevance of the Peritoneal Surface Disease Severity Score Compared to the Peritoneal Cancer Index for Colorectal Peritoneal Carcinomatosis.
Conclusion. PCI is superior to PSDSS in predicting OS and PFS and remains the prognostic score of choice in CPC patients undergoing CRS/HIPEC. PMID: 27006828 [PubMed - in process] (Source: International Journal of Surgical Oncology)
Source: International Journal of Surgical Oncology - March 25, 2016 Category: Surgery Tags: Int J Surg Oncol Source Type: research

A Review of the Literature on Extrarenal Retroperitoneal Angiomyolipoma.
Conclusions. With the report of two cases of metastases ensuing surgical resection of the primary lesions there is need for academic pathologists to debate and review angiomyolipomas to decide whether to reclassify angiomyolipomas as slow-growing malignant tumours or whether the reported cases of metastases were de novo tumours or metastatic lesions. PMID: 26989509 [PubMed - in process] (Source: International Journal of Surgical Oncology)
Source: International Journal of Surgical Oncology - March 19, 2016 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Neoadjuvant Chemotherapy in Locally Advanced and Borderline Resectable Nonsquamous Sinonasal Tumors (Esthesioneuroblastoma and Sinonasal Tumor with Neuroendocrine Differentiation).
Conclusion. NACT in sinonasal tumours has a response rate of 80%. The protocol of NACT followed by local treatment is associated with improvement in outcomes as compared to our historical cohort. PMID: 26955484 [PubMed - in process] (Source: International Journal of Surgical Oncology)
Source: International Journal of Surgical Oncology - March 10, 2016 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Influence of Individual Surgeon Volume on Oncological Outcome of Colorectal Cancer Surgery.
Authors: Buurma M, Kroon HM, Reimers MS, Neijenhuis PA Abstract Background. Surgery performed by a high-volume surgeon improves short-term outcomes. However, not much is known about long-term effects. Therefore we performed the current study to evaluate the impact of high-volume colorectal surgeons on survival. Methods. We conducted a retrospective analysis of our prospectively collected colorectal cancer database between 2004 and 2011. Patients were divided into two groups: operated on by a high-volume surgeon (>25 cases/year) or by a low-volume surgeon (
Source: International Journal of Surgical Oncology - October 2, 2015 Category: Surgery Tags: Int J Surg Oncol Source Type: research

A Single Centre Analysis of Clinical Characteristics and Treatment of Endocrine Pancreatic Tumours.
Conclusion. Majority of PENs are nonfunctioning. They are more likely malignant if they are nonfunctioning and large in size, show cystic appearance, and are situated in the pancreatic head. Early surgery leads to good long term survival with acceptable postoperative morbidity. PMID: 26167298 [PubMed - in process] (Source: International Journal of Surgical Oncology)
Source: International Journal of Surgical Oncology - July 15, 2015 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Gastrectomy and D2 Lymphadenectomy for Gastric Cancer: A Meta-Analysis Comparing the Harmonic Scalpel to Conventional Techniques.
Authors: Cheng H, Hsiao CW, Clymer JW, Schwiers ML, Tibensky BN, Patel L, Ferko NC, Chekan E Abstract The ultrasonic Harmonic scalpel has demonstrated clinical and surgical benefits in dissection and coagulation. To evaluate its use in gastrectomy, we conducted a systematic review and meta-analysis of randomized controlled trials comparing the Harmonic scalpel to conventional techniques in gastrectomy for patients with gastric cancer. International databases were searched without language restrictions for comparisons in open or laparoscopic gastrectomy and lymphadenectomy. The meta-analysis used a random-effects mo...
Source: International Journal of Surgical Oncology - June 16, 2015 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Now, later of never: multicenter randomized controlled trial call-is surgery necessary after atypical breast core biopsy results in mammographic screening settings?
Authors: Makretsov N Abstract Breast cancer mammographic screening leads to detection of premalignant and preinvasive lesions with an increasing frequency. Nevertheless, current epidemiologic evidence indicates that the screening reduces breast cancer specific mortality, but not overall mortality in breast cancer patients. The evidence is lacking whether aggressive eradication of DCIS (preinvasive form of breast carcinoma) by surgery and radiation is of survival benefit, as long-term breast cancer specific mortality in a cohort of patients with DCIS is already in a single digit percent range. Furthermore, it is cur...
Source: International Journal of Surgical Oncology - May 16, 2015 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Mucus containing cystic lesions "mucocele" of the appendix: the unresolved issues.
Conclusion. Mucocele of the appendix should be considered in the differential diagnosis of cystic lesions in the right lower abdomen. Owing to its rarity, it continues to intrigue the surgeon as well as the radiologist and pathologist alike. For mucinous cystadenocarcinoma, right hemicolectomy is usually needed, whereas for hyperplasia and cystadenoma, appendectomy usually suffices if the resection margins are free. For mucinous tumours of uncertain malignant potential and low grade mucinous tumours as well as pseudomyxoma peritonei, the decision is not as simple. As for laparoscopic surgery, no solid proof exists with or ...
Source: International Journal of Surgical Oncology - April 17, 2015 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Peritoneal Carcinomatosis: Intraoperative Parameters in Open (Coliseum) versus Closed Abdomen Hipec.
Conclusions. Both methods are equal in the HIPEC procedures. Perhaps the closed method is the method of choice for frail patients due to more stable hemodynamic parameters. PMID: 25785194 [PubMed - in process] (Source: International Journal of Surgical Oncology)
Source: International Journal of Surgical Oncology - March 21, 2015 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Implementation of a robotic surgical program in gynaecological oncology and comparison with prior laparoscopic series.
Conclusion. Robotic surgery is comparable to laparoscopic surgery in blood loss; however, the hospital stay in uncomplicated cases appears to be longer in the laparoscopic arm. Surgical robotic time is equivalent to laparoscopic in complex cases but may be longer in cases not requiring lymph node dissection. The robotic surgery team learning curve may be associated with higher rate of morbidity. Further research on the benefits to the surgeon is needed to clarify the whole picture of this versatile novel surgical approach. PMID: 25785195 [PubMed - in process] (Source: International Journal of Surgical Oncology)
Source: International Journal of Surgical Oncology - March 21, 2015 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Pelvic Exenteration: Experience from a Rural Cancer Center in Developing World.
Conclusion. PE related grades 3-5 morbidity of 25.7% and mortality of 2.9% at our resource limited center are encouraging. PMID: 25741445 [PubMed - as supplied by publisher] (Source: International Journal of Surgical Oncology)
Source: International Journal of Surgical Oncology - March 6, 2015 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Minimising unnecessary mastectomies in a predominantly chinese community.
Conclusion. BCT rates exceeding 80% in a predominantly Chinese population are possible with acceptable local and distant control rates, thereby minimising unnecessary mastectomies. PMID: 25692037 [PubMed - in process] (Source: International Journal of Surgical Oncology)
Source: International Journal of Surgical Oncology - February 20, 2015 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Contralateral Risk-Reducing Mastectomy: Review of Risk Factors and Risk-Reducing Strategies.
Authors: Basu NN, Barr L, Ross GL, Evans DG Abstract Rates of contralateral risk-reducing mastectomy have increased substantially over the last decade. Surgical oncologists are often in the frontline, dealing with requests for this procedure. This paper reviews the current evidence base regarding contralateral breast cancer, assesses the various risk-reducing strategies, and evaluates the cost-effectiveness of contralateral risk-reducing mastectomy. PMID: 25692038 [PubMed - as supplied by publisher] (Source: International Journal of Surgical Oncology)
Source: International Journal of Surgical Oncology - February 20, 2015 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Clinical characteristics and prognosis of incidentally detected lung cancers.
Authors: Quadrelli S, Lyons G, Colt H, Chimondeguy D, Buero A Abstract Objective. To evaluate clinical characteristics and outcomes in incidentally detected lung cancer and in symptomatic lung cancer. Material and Methods. We designed a retrospective study including all patients undergoing pulmonary resection with a curative intention for NSCLC. They were classified into two groups according to the presence or absence of cancer-related symptoms at diagnosis in asymptomatic (ASX)-incidental diagnosis-or symptomatic. Results. Of the 593 patients, 320 (53.9%) were ASX. In 71.8% of these, diagnosis was made by chest X-...
Source: International Journal of Surgical Oncology - February 17, 2015 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Evaluating the feasibility of performing window of opportunity trials in breast cancer.
Authors: Arnaout A, Robertson S, Kuchuk I, Simos D, Pond GR, Addison CL, Namazi M, Clemons M Abstract Background. The waiting period to surgery represents a valuable "window of opportunity" to evaluate novel therapeutic strategies. Interventional studies performed during this period require significant multidisciplinary collaboration to overcome logistical hurdles. We undertook a one-year prospective window of opportunity study to assess feasibility. Methods. Eligible newly diagnosed postmenopausal, estrogen receptor positive breast cancer patients awaiting primary surgery received anastrozole daily until...
Source: International Journal of Surgical Oncology - February 17, 2015 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Clear Cell Adenocarcinoma of the Urethra: Review of the Literature.
Conclusions. Few cases of CCAU have been reported. Urologists, gynaecologists, pathologists, and oncologists should report cases of CCAU they encounter and enter them into a multicentric trial to determine the best treatment options that would improve the prognosis. PMID: 25685552 [PubMed - as supplied by publisher] (Source: International Journal of Surgical Oncology)
Source: International Journal of Surgical Oncology - February 17, 2015 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Emergency Surgery for Metastatic Melanoma.
We report on our 5-year single institution experience with surgical management of metastatic melanoma to the viscera in the emergent setting. From 2009 to 2013, 14 patients with metastatic melanoma were admitted emergently due to an acute abdomen. Clinical manifestations encompassed intestinal obstruction and bleeding. Surgical procedures involved multiple enterectomies with primary anastomoses in 8 patients, and one patient underwent splenectomy, one adrenalectomy, one right colectomy, one gastric wedge resection, one gastrojejunal anastomosis, and one transanal debulking, respectively. The 30-day mortality was 7 percent....
Source: International Journal of Surgical Oncology - December 24, 2014 Category: Surgery Tags: Int J Surg Oncol Source Type: research

Close Margins in Oral Cancers: Implication of Close Margin Status in Recurrence and Survival of pT1N0 and pT2N0 Oral Cancers.
Authors: Gokavarapu S, Chander R, Parvataneni N, Puthamakula S Abstract Introduction. Among all prognostic factors, "margin status" is the only factor under clinician's control. Current guidelines describe histopathologic margin of>5 mm as "clear margin" and 1-5 mm as "close margin." Ambiguous description of positive margin in the published data resulted in comparison of microscopically "involved margin" and "close margin" together with "clear margin" in many publications. Authors attempted to compare the outcome of close and clear margins...
Source: International Journal of Surgical Oncology - December 2, 2014 Category: Surgery Tags: Int J Surg Oncol Source Type: research