Clinical Presentations of Lumbar Disc Degeneration and Lumbosacral Nerve Lesions.
Authors: Liyew WA Abstract Lumbar disc degeneration is defined as the wear and tear of lumbar intervertebral disc, and it is mainly occurring at L3-L4 and L4-S1 vertebrae. Lumbar disc degeneration may lead to disc bulging, osteophytes, loss of disc space, and compression and irritation of the adjacent nerve root. Clinical presentations associated with lumbar disc degeneration and lumbosacral nerve lesion are discogenic pain, radical pain, muscular weakness, and cutaneous. Discogenic pain is usually felt in the lumbar region, or sometimes, it may feel in the buttocks, down to the upper thighs, and it is typically pr...
Source: International Journal of Rheumatology - September 12, 2020 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Evaluation Effects of Laser Therapy and Extracorporeal Shock Wave Therapy with Clinical Parameters and Magnetic Resonance Imaging for Treatment of Plantar Fasciitis in Patients with Spondyloarthritis: A Randomized Controlled Trial.
This study is a prospective, randomized, comparative, single-blind clinical study. Voluntarily followed 40 patients with the diagnosis of SpA and having pain at the heels at least for 6 months. Patients were divided randomly into two treatment groups. One group undertook 14 sessions of infrared Ga-Al-As LLLT, and the other group undertook 3 sessions ESWT. Feet functions of the patients were evaluated by American Orthopaedic Foot and Ankle Society (AOFAS) and Roles and Maudsley Scoring; VAS was evaluated for foot pain and function. In clinical assessment, disease activity was carried out by applying the BASDAI, the function...
Source: International Journal of Rheumatology - September 12, 2020 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Vaccinations Do Not Increase Arthritis Flares in Juvenile Idiopathic Arthritis: A Study of the Relationship between Routine Childhood Vaccinations on the Australian Immunisation Schedule and Arthritis Activity in Children with Juvenile Idiopathic Arthritis.
Conclusion: Routine childhood immunisations were not associated with arthritis flare onset in patients with JIA. The risk of arthritis flares in the 90 days following vaccination was lower than the baseline risk. In the context of COVID19, vaccination will not increase interaction with the healthcare system beyond the immunisation encounter. PMID: 32831849 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - August 26, 2020 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Serum Peptidomic Profile as a Novel Biomarker for Rheumatoid Arthritis.
Authors: Abdelati AA, Elnemr RA, Kandil NS, Dwedar FI, Ghazala RA Abstract Over the last decades, there has been an increasing need to discover new diagnostic RA biomarkers, other than the current serologic biomarkers, which can assist early diagnosis and response to treatment. The purpose of this study was to analyze the serum peptidomic profile in patients with rheumatoid arthritis (RA) by using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). The study included 35 patients with rheumatoid arthritis (RA), 35 patients with primary osteoarthritis (OA) as the disease contr...
Source: International Journal of Rheumatology - August 26, 2020 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Are Stem Cells Derived from Synovium and Fat Pad Able to Treat Induced Knee Osteoarthritis in Rats?
Authors: Zare R, Tanideh N, Nikahval B, Mirtalebi MS, Ahmadi N, Zarea S, Hosseinabadi OK, Bhimani R, Ashkani-Esfahani S Abstract Background: Osteoarthritis (OA) is a chronic disease and a significant cause of joint pain, tenderness, and limitation of motion. At present, no specific treatment is available, and mesenchymal stem cells (MSCs) have shown promising potentials in this regard. Herein, we aimed to evaluate the repairing potentials of stem cells derived from the synovium and fat pad in the treatment of OA. Methods: Twenty-eight male rats (220 ± 20 g, aged 10-12 weeks), were randomly divided...
Source: International Journal of Rheumatology - August 13, 2020 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Correlation between C-reactive Protein with Malondialdehyde in Systemic Lupus Erythematosus Patients.
Authors: Atik N, Putri Pratiwi S, Hamijoyo L Abstract Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by an inflammatory process. One of the inflammation markers that can be measured is C-reactive protein (CRP). Another indicator of inflammation is malondialdehyde (MDA), though it is still uncommon to be analyzed in SLE patients. The study looked for the MDA value and found a correlation with CRP. A cross-sectional study design with a correlative analytical was performed. CRP level data was taken from Hasan Sadikin lupus registry data, and MDA levels were analyzed from a bioarchive...
Source: International Journal of Rheumatology - July 24, 2020 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Oral Complementary Medicine Use among People with Inflammatory Arthritis: An Australian Rheumatology Association Database Analysis.
Authors: Fletcher A, Lassere M, March L, Hill C, Carroll G, Barrett C, Buchbinder R Abstract Objectives: To describe oral complementary medicine (CM) use in people with inflammatory arthritis, associations with use, and changes in use over time. Methods: Demographic, clinical, and patient-reported outcome data from 5,630 participants with rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PsA), and juvenile idiopathic arthritis (JIA) were extracted from the Australian Rheumatology Association Database (ARAD), a national observational database. CM use at entry into ARAD was ascertained ...
Source: International Journal of Rheumatology - June 24, 2020 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Efficacy of Vitamin E in Methotrexate-Induced Hepatotoxicity in Rheumatoid Arthritis: An Open-Label Case-Control Study.
Authors: Vaidya B, Bhochhibhoya M, Nakarmi S Abstract Objective: To examine the efficacy of vitamin E in methotrexate- (MTX-) induced transaminitis in patients with rheumatoid arthritis (RA). Methods: A case-control study was conducted at a tertiary rheumatology center for 12 months. Patients with RA on MTX and deranged aminotransferases were included. Patients with previous liver diseases, baseline transaminitis before methotrexate initiation, alcohol intake, muscle diseases, under hepatotoxic drugs, and aminotransferases> 3 times the upper normal limit were excluded. The patients were divided into treatmen...
Source: International Journal of Rheumatology - May 17, 2020 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Clinical and Immunological Profile of Mixed Connective Tissue Disease and a Comparison of Four Diagnostic Criteria.
Authors: John KJ, Sadiq M, George T, Gunasekaran K, Francis N, Rajadurai E, Sudarsanam TD Abstract Mixed connective tissue disease (MCTD) was initially described as a chronic immune-mediated disease with overlapping features of systemic lupus erythematosus, scleroderma, and polymyositis. We conducted a cross-sectional study to describe the clinical and immunological profile of patients with MCTD and to compare the four diagnostic criteria, namely, Sharp, Kasukawa, Alarcón-Segovia, and Khan criteria. A total of 291 patients who were admitted from June 2007 to June 2017 and fulfilled the inclusion criteria wer...
Source: International Journal of Rheumatology - May 17, 2020 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Changes in Urinary Microalbumin Levels after Correction of Hyperuricemia in Patients with Gout: An Observational Cohort Study.
Conclusions: There is significant reduction in MAU after the use of urate-lowering drugs in patients with gout. PMID: 32308689 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - April 21, 2020 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Role of Secreted Frizzled-Related Protein 1 and Tumor Necrosis Factor- α (TNF-α) in Bone Loss of Patients with Rheumatoid Arthritis.
This study examines the correlation between TNF-α and SFRP-1, with a bone turn over marker (CTX and P1NP). This is a cross-sectional study with 38 subjects of premenopausal female patients with RA. This study found that 60.6% of the patients were in remission or low disease activity. The median of TNF-α was 10.6 pg/mL, mean of SFRP-1 was 9.29 ng/mL, mean of CTX was 2.74 ng/mL, and the median of P1NP was 34.04 pg/ml. There is positive correlation between TNF-α and P1NP (r = 0.363, p = 0.026), also between SFRP-1 and P1NP (r = 0.341; p = 0.036). A low level of TNF-𝛼, high leve...
Source: International Journal of Rheumatology - March 21, 2020 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

The Micro-Immunotherapy Medicine 2LARTH ® Reduces Inflammation and Symptoms of Rheumatoid Arthritis In Vivo.
The Micro-Immunotherapy Medicine 2LARTH® Reduces Inflammation and Symptoms of Rheumatoid Arthritis In Vivo. Int J Rheumatol. 2020;2020:1594573 Authors: Floris I, García-González V, Palomares B, Appel K, Lejeune B Abstract Background: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease, which can cause cartilage and bone damages as well as pain and disability. In order to prevent disease progression, reduce pain, and major symptoms of RA, one good strategy consists in targeting proinflammatory cytokines that have the key role in the vicious circle of synovial inflammation...
Source: International Journal of Rheumatology - March 19, 2020 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

A Review of Primary Vasculitis Mimickers Based on the Chapel Hill Consensus Classification.
Authors: Zarka F, Veillette C, Makhzoum JP Abstract Primary systemic vasculitides are rare diseases that may manifest similarly to more commonly encountered conditions. Depending on the size of the vessel affected (large vessel, medium vessel, or small vessel), different vasculitis mimics must be considered. Establishing the right diagnosis of a vasculitis mimic will prevent unnecessary immunosuppressive therapy. PMID: 32148510 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - March 11, 2020 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Demographic and Clinical Patterns of Rheumatoid Arthritis in an Emirati Cohort from United Arab Emirates.
In this study, 414 Emirati patients with RA were evaluated over a 3-year period from April 2015 to April 2018. All patients fulfilled the 2010 RA ACR/EULAR criteria and were assessed for demographic and clinical characteristics. The estimated RA prevalence rate in our population cohort was 2.72%. Females showed predominance (80%) with a higher body mass index (31.4 ± 6.61, P = 0.0001) compared to males (28.8 ± 6.03, P = 0.0001). The most frequent comorbidity observed was dyslipidemia (43.5%) followed by hypertension (37.9%), diabetes mellitus (34.5%), and gastroesophageal reflux di...
Source: International Journal of Rheumatology - October 31, 2019 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Erratum to "Are All Oral COX-2 Selective Inhibitors the Same? A Consideration of Celecoxib, Etoricoxib, and Diclofenac".
Erratum to "Are All Oral COX-2 Selective Inhibitors the Same? A Consideration of Celecoxib, Etoricoxib, and Diclofenac". Int J Rheumatol. 2019;2019:8635073 Authors: Walker C Abstract [This corrects the article DOI: 10.1155/2018/1302835.]. PMID: 31275398 [PubMed - in process] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - July 7, 2019 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

The Contribution of Drugs and Helicobacter pylori to Gastric Mucosa Changes in Patients with Systemic Lupus Erythematosus and Antiphospholipid Syndrome.
Conclusion: There was no evidence of the role of H. pylori in GM damage in the SLE and APS patients. More frequent detection of H. pylori was observed in anticoagulants or low-dose acetylsalicylic acid users than in glucocorticoids and nonsteroidal anti-inflammatory drugs ones. PMID: 31191660 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - June 15, 2019 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Simultaneous Adalimumab and Antitubercular Treatment for Latent Tubercular Infection: An Experience from Nepal.
Conclusions: Our findings indicate that screening for LTBI should be more frequent in patients from high tuberculosis burden countries; treatment of LTBI with rifampicin/isoniazid combination for 3 months is effective in preventing reactivation even when adalimumab is started simultaneously. PMID: 31057626 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - May 8, 2019 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Vertebral Fractures among Patients Referred for Bone Densitometry Screening in Dubai Primary Health Care Facilities.
The objective of this study was to determine the prevalence of vertebral fractures in patients referred for bone densitometry and the most common site of fracture. The study was carried out in the osteoporosis clinic in Dubai primary health care center. A total of 120 patients were examined using the dual energy X-ray absorptiometry. Of all the patients, 48.3% were osteoporotic and 40.9% were osteopenic. The overall prevalence of vertebral fracture was 14.2%. The result showed that the prevalence of vertebral fracture was higher in female compared to male (15.7% and 9.7%, respectively). It was found that patients aged 80 a...
Source: International Journal of Rheumatology - April 9, 2019 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Medication Adherence and Coping Strategies in Patients with Rheumatoid Arthritis: A Cross-Sectional Study.
Conclusions: Age, sex, monthly net income, and disease duration were found to be associated with an increased risk for medication nonadherence among patients with RA. Coping strategies such as active coping, diversion, and self-encouragement were associated with adherence in univariate models, but not when adjusted for demographic and clinical factors. PMID: 30949207 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - April 6, 2019 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Impact of a Student-Led Rheumatology Interest Group on Medical Student Interest in Rheumatology.
Conclusion: The Rheumatology Interest Group significantly increased medical student engagement in rheumatology. PMID: 30918520 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - March 30, 2019 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Effects of the Cathepsin K Inhibitor ONO-5334 and Concomitant Use of ONO-5334 with Methotrexate on Collagen-Induced Arthritis in Cynomolgus Monkeys.
We examined whether the cathepsin K inhibitor, ONO-5334, administered alone or in combination with methotrexate (MTX), could ameliorate joint destruction evoked by collagen-induced arthritis (CIA) in female cynomolgus monkeys. CIA was induced by immunizing with bovine type II collagen. ONO-5334 (30 mg/kg/day) was orally administered once daily and MTX (10 mg/body/day) twice weekly for 9 weeks. X-ray (evaluation of joint destruction) and swelling (inflammatory) scores of proximal interphalangeal (PIP), distal interphalangeal (DIP), and metacarpophalangeal (MP) joints were evaluated. Urinary concentrations of C-terminal telo...
Source: International Journal of Rheumatology - March 26, 2019 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Febuxostat and Cardiovascular Events: A Systematic Review and Meta-Analysis.
Conclusions: Compared with other SU-lowering treatments, febuxostat does not increase or decrease the risk of cardiovascular disease but may increase the risk of CVD death. More RCTs measuring cardiovascular safety as a primary outcome are needed to adequately evaluate the risk of CVD with febuxostat. PMID: 30863448 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - March 15, 2019 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Comment on "Long-Term Dietary Changes after Diagnosis of Rheumatoid Arthritis in Swedish Women: Data from a Population-Based Cohort".
Comment on "Long-Term Dietary Changes after Diagnosis of Rheumatoid Arthritis in Swedish Women: Data from a Population-Based Cohort". Int J Rheumatol. 2019;2019:1939686 Authors: Petchiappan V, Priyadarshini P, Nagaprabu VN PMID: 30719045 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - February 7, 2019 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Are All Oral COX-2 Selective Inhibitors the Same? A Consideration of Celecoxib, Etoricoxib, and Diclofenac.
Authors: Walker C Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs) have been widely used for the treatment of arthritic conditions. Drugs in this heterogeneous class alleviate pain and inflammation by inhibiting cyclooxygenase-2 (COX-2). Cyclooxygenase-1 (COX-1) inhibition has traditionally been associated with increased gastrointestinal (GI) harm, whereas increased COX-2 selectivity has more recently become associated with greater risk of cardiovascular (CV) harm. When the entirety of data is considered, NSAIDs can be seen to exhibit a range of COX isoform selectivity, with all oral NSAIDs appearing to be as...
Source: International Journal of Rheumatology - January 13, 2019 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

The Effect of Prednisone on Tuberculin Skin Test Reaction in Patients with Rheumatoid Arthritis.
Conclusions: Our results show that the TST reaction size among RA patients may not be affected by prednisone therapy. In addition, the TST reaction of RA patients may present similarly to that of healthy individuals. Therefore, we suggest that the criterion of a TST reaction of 5 mm to define latent TB infection in our population should be reevaluated. PMID: 30420888 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - November 15, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Red Cell Distribution Width Is Positively Correlated with Atherosclerotic Cardiovascular Disease 10-Year Risk Score, Age, and CRP in Spondyloarthritis with Axial or Peripheral Disease.
Conclusions: These data indicate that further study is warranted to evaluate RDW, albumin level, and ALC as potential predictors of CVD in the spondyloarthritis patient population. PMID: 30363719 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - October 28, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Population-Wide Associations between Common Viral Pathogens and Self-Reported Arthritis: NHANES 2009-2012.
Conclusions: HSV-2 seropositivity and oral HPV DNA positivity were associated with self-reported arthritis and not with comparator outcomes, after adjustment for multiple potential confounders. These findings should be confirmed in longitudinal studies. PMID: 30364066 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - October 28, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Integration of Genome-Wide DNA Methylation and Transcription Uncovered Aberrant Methylation-Regulated Genes and Pathways in the Peripheral Blood Mononuclear Cells of Systemic Sclerosis.
Conclusion. The identified MeDEGs may represent novel candidate factors which lead to the abnormal activation of immune regulatory pathways in the pathogenesis of SSc. They may also be used as diagnostic biomarkers for SSc and clinical complications. PMID: 30245726 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - September 26, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Work Ability and Employment in Rheumatoid Arthritis: A Cross-Sectional Study on the Role of Muscle Strength and Lower Extremity Function.
Authors: Berner C, Haider S, Grabovac I, Lamprecht T, Fenzl KH, Erlacher L, Quittan M, Dorner TE Abstract Objective: The aim of the present study was to assess the association between muscle strength, lower extremity function, employment status, and work ability in RA patients. Methods: One hundred seropositive RA outpatients of working age were included in this cross-sectional study. Employment status was assessed by interview and work ability by the Work Ability Index-Single Item Scale (WAS). Muscle strength was determined using dynamometer measurement of isometric hand grip and knee extensor strength. Lower ...
Source: International Journal of Rheumatology - August 30, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Gum Arabic Fibers Decreased Inflammatory Markers and Disease Severity Score among Rheumatoid Arthritis Patients, Phase II Trial.
Conclusion: Gum Arabic has favorable immune modulator effect on rheumatoid arthritis. It can be utilized in clinical practice as adjuvant therapy. Trial Registration: This trial was registered with ClinicalTrials.gov Identifier: NCT02804581 Registered at 19 June 2016, prospective registration. PMID: 30112005 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - August 17, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Wrist Arthrodesis in Rheumatoid Arthritis Using an LCP Metaphyseal Locking Plate versus an AO Wrist Fusion Plate.
Conclusion: Wrist arthrodesis using an LCP metaphyseal plate was favorable for rheumatoid arthritis patients with comparable stability to that of and a lower risk of plate-related complications than an AO wrist fusion plate. PMID: 30112006 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - August 17, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Possible Modulation of Vascular Function Measures in Rheumatoid Arthritis by Homocysteine.
Authors: Alomari MA, Khabour OF, Alawneh K, Shammaa RA Abstract The effect of homocysteine on cardiovascular diseases is still equivocal, especially in rheumatoid arthritis patients. In this investigation, the association between homocysteine with blood flow and vascular resistance in rheumatoid arthritis was examined. Serum levels of homocysteine were determined in thirty-one rheumatoid arthritis patients and nineteen apparently healthy subjects using ELISA. Additionally, strain-gauge plethysmography was used to determine both forearm blood flow and vascular function at rest and after occlusion. Forearm occlusion ...
Source: International Journal of Rheumatology - August 2, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Musculoskeletal Disorders in Patients with Diabetes Mellitus: A Cross-Sectional Study.
Conclusion: MS disorders are frequent in this population and associated with various factors. HbA1c level does not appear to be associated with development of MS disorders. PMID: 30018643 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - July 20, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Long-Term Dietary Changes after Diagnosis of Rheumatoid Arthritis in Swedish Women: Data from a Population-Based Cohort.
Conclusion: Women who had been diagnosed with RA had similar dietary patterns over time as the general population; these women did not remarkably change their diet over time due to their disease. Dietary recommendations for RA patients are needed. PMID: 29991946 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - July 13, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Kuwait Recommendations on Vaccine Use in People with Inflammatory Rheumatic Diseases.
Authors: AlEnizi A, AlSaeid K, Alawadhi A, Hasan E, Husain EH, AlFadhli A, Ghanem A, Abutiban F, Ali Y, Al-Herz A, Mohammed K, Alkandari W, Aldei A, Alhajeri H, Dehrab A, Hayat S Abstract People with IRD are at increased risk of infection, and in 2011 EULAR made general recommendations for vaccination in these patients. Global and European perspectives are important, but they cannot accurately reflect the individual situations of patients in different countries and regions. Based on our clinical experience and opinions, we have sought to tailor the original EULAR recommendations to include advice for vaccination wi...
Source: International Journal of Rheumatology - June 6, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Association between Rheumatoid Arthritis and Respiratory Allergic Diseases in Korean Adults: A Propensity Score Matched Case-Control Study.
This study was designed to examine the association between RA and respiratory allergic diseases in Korean adults. The study utilized the KNHANES 2013-2015 data and excluded individuals diagnosed with RA before being diagnosed with allergic diseases, using age at clinical diagnosis. Total of 253 RA patients were matched 1 : 1 with non-RA patients by a propensity score, using sex and age as matched variables. Multivariate conditional logistic regression analyses were used to evaluate for association between RA and respiratory allergic diseases in the matched 506 participants. RA was associated with an increased...
Source: International Journal of Rheumatology - June 4, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Oral Manifestations of Systemic Lupus Erythematosus Patients in Qatar: A Pilot Study.
Conclusion: This study found high rates of gingivitis, periodontal disease, cavities, and missing teeth among SLE patients in Qatar. It is recommended that healthcare providers of such patients monitor the presence of any oral manifestations in order to arrange for early treatment and prevention efforts. Future prospective longitudinal studies with adequate sample size and power are needed in order to ascertain any causation factors or common etiology pathways. PMID: 29849650 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - June 4, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

AC-CUTE: An Open-Label Study to Evaluate Progression of Structural Joint Damage and Inflammation in Subjects with Moderate to Severe Rheumatoid Arthritis.
Conclusion: Synovitis and DAS28 decreased significantly; however, no significant change in osteitis or joint damage was observed at Week 24. Trial registration: This trial is registered with Clinicaltrials.gov registration number NCT01951170 (ML28703). PMID: 29849651 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - June 4, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Relative Risk Chart Score for the Assessment of the Cardiovascular Risk in Young Patients with Ankylosing Spondylitis.
Conclusions: RR chart score assessment may help to identify young AS patients at high risk of CV disease. PMID: 29666651 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - April 19, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Effect of Curcuma xanthorrhiza Supplementation on Systemic Lupus Erythematosus Patients with Hypovitamin D Which Were Given Vitamin D3 towards Disease Activity (SLEDAI), IL-6, and TGF- β1 Serum.
Conclusion. Curcuma xanthorrhiza supplementation on vitamin D3 had no effects on SLEDAI and serum levels of IL-6 and TGF-β1. This clinical trial is registered with NCT03155477. PMID: 29445400 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - February 17, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

The Impact of Different Classification Criteria Sets on the Estimated Prevalence and Associated Risk Factors of Diastolic Dysfunction in Rheumatoid Arthritis.
This study compared the estimated prevalence and potential determinants of left ventricular (LV) diastolic dysfunction upon applying different classification criteria in rheumatoid arthritis (RA). LV diastolic function was assessed echocardiographically by pulsed Doppler (E/A), tissue Doppler (E/e', lateral and septal e'), and left atrial volume index in 176 RA patients. Relationships of traditional cardiovascular risk factors and RA characteristics with LV diastolic function and dysfunction according to previous and current criteria were determined in multivariate regression models. Waist-hip ratio was associated with E/A...
Source: International Journal of Rheumatology - January 21, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Review of Routine Laboratory Monitoring for Patients with Rheumatoid Arthritis Receiving Biologic or Nonbiologic DMARDs.
Authors: Rigby WFC, Lampl K, Low JM, Furst DE Abstract Safety concerns associated with many drugs indicated for the treatment of rheumatoid arthritis (RA) can be attenuated by the early identification of toxicity through routine laboratory monitoring; however, a comprehensive review of the recommended monitoring guidelines for the different available RA therapies is currently unavailable. The aim of this review is to summarize the current guidelines for laboratory monitoring in patients with RA and to provide an overview of the laboratory abnormality profiles associated with each drug indicated for RA. Recommendati...
Source: International Journal of Rheumatology - December 13, 2017 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Gastrointestinal Symptoms and Elevated Levels of Anti-Saccharomyces cerevisiae Antibodies Are Associated with Higher Disease Activity in Colombian Patients with Spondyloarthritis.
Authors: Romero-Sánchez C, Bautista-Molano W, Parra V, De Avila J, Rueda JC, Bello-Gualtero JM, Londoño J, Valle-Oñate R Abstract Background: Spondyloarthritis (SpA) is a group of articular inflammatory rheumatic diseases that their gastrointestinal manifestations are around 10% of their extra-articular symptoms, supporting that the inflammatory response of the intestinal mucosa could be associated with the clinical status. Objectives: To investigate the association between gastrointestinal symptoms and autoantibodies and disease activity between SpA patients, healthy subjects (HS), and pat...
Source: International Journal of Rheumatology - December 9, 2017 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Cross-Cultural Validation of Urdu Version KOOS in Indian Population with Primary Knee Osteoarthritis.
Conclusion: The present results show that KOOS Urdu version is a reliable and valid measure for primary OA knee patients. PMID: 29209370 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - December 8, 2017 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Incidence and Risk Factors for Infections Requiring Hospitalization, Including Pneumocystis Pneumonia, in Japanese Patients with Rheumatoid Arthritis.
Conclusions: Risk factors for infection should be taken into account when deciding treatment for the individual RA patient. PMID: 29181029 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - November 29, 2017 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Knitting the Threads of Silk through Time: Beh çet's Disease-Past, Present, and Future.
Knitting the Threads of Silk through Time: Behçet's Disease-Past, Present, and Future. Int J Rheumatol. 2017;2017:2160610 Authors: Adeeb F, Stack AG, Fraser AD Abstract Behçet's disease (BD) is a chronic relapsing vasculitis that affects vessels of all types and sizes with a broad spectrum of phenotypic heterogeneity and complex immunopathogenesis. Efforts by the scientific community to resolve the unmet needs of BD and gaps in our knowledge have been hampered by considerable challenges that primarily relate to the rare nature of the disease in many parts of the world and its heterogeneit...
Source: International Journal of Rheumatology - November 1, 2017 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Review of Current Immunologic Therapies for Hidradenitis Suppurativa.
Authors: Shanmugam VK, Zaman NM, McNish S, Hant FN Abstract Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory disease of apocrine gland-bearing skin which affects approximately 1-4% of the population. The disease is more common in women and patients of African American descent and approximately one-third of patients report a family history. Obesity and smoking are known risk factors, but associations with other immune disorders, especially inflammatory bowel disease, are also recognized. The pathogenesis of HS is poorly understood and host innate or adaptive immune response, defective keratinocyte...
Source: International Journal of Rheumatology - September 16, 2017 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Clinically Apparent Arterial Thrombosis in Persons with Systemic Vasculitis.
CONCLUSION: Atherothrombotic rates were elevated in patients identified as having primary systemic vasculitis. While incident rates of cardiovascular comorbidities were also increased, the substantial elevation in AMIs seen in young adults suggests a disease-specific component which requires further investigation. PMID: 28713428 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - July 18, 2017 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Evaluation of Vitamin D Status in Rheumatoid Arthritis and Its Association with Disease Activity across 15 Countries: "The COMORA Study".
Evaluation of Vitamin D Status in Rheumatoid Arthritis and Its Association with Disease Activity across 15 Countries: "The COMORA Study". Int J Rheumatol. 2017;2017:5491676 Authors: Hajjaj-Hassouni N, Mawani N, Allali F, Rkain H, Hassouni K, Hmamouchi I, Dougados M Abstract The aims of this study are to evaluate vitamin D status in 1413 RA patients of COMORA study from 15 countries and to analyze relationship between patients' RA characteristics and low levels of vitamin D. All demographic, clinical, and biological data and RA comorbidities were completed. The results showed that the average ...
Source: International Journal of Rheumatology - June 29, 2017 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

The CEDAR Study: A Longitudinal Study of the Clinical Effects of Conventional DMARDs and Biologic DMARDs in Australian Rheumatology Practice.
CONCLUSIONS: In this large Australian cohort of unselected community RA patients, the choices of cDMARDs/bDMARDs are aligned with current international guidelines. PMID: 28630629 [PubMed - in process] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - June 22, 2017 Category: Rheumatology Tags: Int J Rheumatol Source Type: research