Are All Oral COX-2 Selective Inhibitors the Same? A Consideration of Celecoxib, Etoricoxib, and Diclofenac.
Authors: Walker C Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs) have been widely used for the treatment of arthritic conditions. Drugs in this heterogeneous class alleviate pain and inflammation by inhibiting cyclooxygenase-2 (COX-2). Cyclooxygenase-1 (COX-1) inhibition has traditionally been associated with increased gastrointestinal (GI) harm, whereas increased COX-2 selectivity has more recently become associated with greater risk of cardiovascular (CV) harm. When the entirety of data is considered, NSAIDs can be seen to exhibit a range of COX isoform selectivity, with all oral NSAIDs appearing to be as...
Source: International Journal of Rheumatology - January 12, 2019 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

The Effect of Prednisone on Tuberculin Skin Test Reaction in Patients with Rheumatoid Arthritis.
Conclusions: Our results show that the TST reaction size among RA patients may not be affected by prednisone therapy. In addition, the TST reaction of RA patients may present similarly to that of healthy individuals. Therefore, we suggest that the criterion of a TST reaction of 5 mm to define latent TB infection in our population should be reevaluated. PMID: 30420888 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - November 15, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Red Cell Distribution Width Is Positively Correlated with Atherosclerotic Cardiovascular Disease 10-Year Risk Score, Age, and CRP in Spondyloarthritis with Axial or Peripheral Disease.
Conclusions: These data indicate that further study is warranted to evaluate RDW, albumin level, and ALC as potential predictors of CVD in the spondyloarthritis patient population. PMID: 30363719 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - October 27, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Population-Wide Associations between Common Viral Pathogens and Self-Reported Arthritis: NHANES 2009-2012.
Conclusions: HSV-2 seropositivity and oral HPV DNA positivity were associated with self-reported arthritis and not with comparator outcomes, after adjustment for multiple potential confounders. These findings should be confirmed in longitudinal studies. PMID: 30364066 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - October 27, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Integration of Genome-Wide DNA Methylation and Transcription Uncovered Aberrant Methylation-Regulated Genes and Pathways in the Peripheral Blood Mononuclear Cells of Systemic Sclerosis.
Conclusion. The identified MeDEGs may represent novel candidate factors which lead to the abnormal activation of immune regulatory pathways in the pathogenesis of SSc. They may also be used as diagnostic biomarkers for SSc and clinical complications. PMID: 30245726 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - September 26, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Work Ability and Employment in Rheumatoid Arthritis: A Cross-Sectional Study on the Role of Muscle Strength and Lower Extremity Function.
Authors: Berner C, Haider S, Grabovac I, Lamprecht T, Fenzl KH, Erlacher L, Quittan M, Dorner TE Abstract Objective: The aim of the present study was to assess the association between muscle strength, lower extremity function, employment status, and work ability in RA patients. Methods: One hundred seropositive RA outpatients of working age were included in this cross-sectional study. Employment status was assessed by interview and work ability by the Work Ability Index-Single Item Scale (WAS). Muscle strength was determined using dynamometer measurement of isometric hand grip and knee extensor strength. Lower ...
Source: International Journal of Rheumatology - August 30, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Gum Arabic Fibers Decreased Inflammatory Markers and Disease Severity Score among Rheumatoid Arthritis Patients, Phase II Trial.
Conclusion: Gum Arabic has favorable immune modulator effect on rheumatoid arthritis. It can be utilized in clinical practice as adjuvant therapy. Trial Registration: This trial was registered with ClinicalTrials.gov Identifier: NCT02804581 Registered at 19 June 2016, prospective registration. PMID: 30112005 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - August 17, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Wrist Arthrodesis in Rheumatoid Arthritis Using an LCP Metaphyseal Locking Plate versus an AO Wrist Fusion Plate.
Conclusion: Wrist arthrodesis using an LCP metaphyseal plate was favorable for rheumatoid arthritis patients with comparable stability to that of and a lower risk of plate-related complications than an AO wrist fusion plate. PMID: 30112006 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - August 17, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Possible Modulation of Vascular Function Measures in Rheumatoid Arthritis by Homocysteine.
Authors: Alomari MA, Khabour OF, Alawneh K, Shammaa RA Abstract The effect of homocysteine on cardiovascular diseases is still equivocal, especially in rheumatoid arthritis patients. In this investigation, the association between homocysteine with blood flow and vascular resistance in rheumatoid arthritis was examined. Serum levels of homocysteine were determined in thirty-one rheumatoid arthritis patients and nineteen apparently healthy subjects using ELISA. Additionally, strain-gauge plethysmography was used to determine both forearm blood flow and vascular function at rest and after occlusion. Forearm occlusion ...
Source: International Journal of Rheumatology - August 1, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Musculoskeletal Disorders in Patients with Diabetes Mellitus: A Cross-Sectional Study.
Conclusion: MS disorders are frequent in this population and associated with various factors. HbA1c level does not appear to be associated with development of MS disorders. PMID: 30018643 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - July 20, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Long-Term Dietary Changes after Diagnosis of Rheumatoid Arthritis in Swedish Women: Data from a Population-Based Cohort.
Conclusion: Women who had been diagnosed with RA had similar dietary patterns over time as the general population; these women did not remarkably change their diet over time due to their disease. Dietary recommendations for RA patients are needed. PMID: 29991946 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - July 12, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Kuwait Recommendations on Vaccine Use in People with Inflammatory Rheumatic Diseases.
Authors: AlEnizi A, AlSaeid K, Alawadhi A, Hasan E, Husain EH, AlFadhli A, Ghanem A, Abutiban F, Ali Y, Al-Herz A, Mohammed K, Alkandari W, Aldei A, Alhajeri H, Dehrab A, Hayat S Abstract People with IRD are at increased risk of infection, and in 2011 EULAR made general recommendations for vaccination in these patients. Global and European perspectives are important, but they cannot accurately reflect the individual situations of patients in different countries and regions. Based on our clinical experience and opinions, we have sought to tailor the original EULAR recommendations to include advice for vaccination wi...
Source: International Journal of Rheumatology - June 5, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Association between Rheumatoid Arthritis and Respiratory Allergic Diseases in Korean Adults: A Propensity Score Matched Case-Control Study.
This study was designed to examine the association between RA and respiratory allergic diseases in Korean adults. The study utilized the KNHANES 2013-2015 data and excluded individuals diagnosed with RA before being diagnosed with allergic diseases, using age at clinical diagnosis. Total of 253 RA patients were matched 1 : 1 with non-RA patients by a propensity score, using sex and age as matched variables. Multivariate conditional logistic regression analyses were used to evaluate for association between RA and respiratory allergic diseases in the matched 506 participants. RA was associated with an increased...
Source: International Journal of Rheumatology - June 4, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Oral Manifestations of Systemic Lupus Erythematosus Patients in Qatar: A Pilot Study.
Conclusion: This study found high rates of gingivitis, periodontal disease, cavities, and missing teeth among SLE patients in Qatar. It is recommended that healthcare providers of such patients monitor the presence of any oral manifestations in order to arrange for early treatment and prevention efforts. Future prospective longitudinal studies with adequate sample size and power are needed in order to ascertain any causation factors or common etiology pathways. PMID: 29849650 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - June 4, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

AC-CUTE: An Open-Label Study to Evaluate Progression of Structural Joint Damage and Inflammation in Subjects with Moderate to Severe Rheumatoid Arthritis.
Conclusion: Synovitis and DAS28 decreased significantly; however, no significant change in osteitis or joint damage was observed at Week 24. Trial registration: This trial is registered with Clinicaltrials.gov registration number NCT01951170 (ML28703). PMID: 29849651 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - June 4, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Relative Risk Chart Score for the Assessment of the Cardiovascular Risk in Young Patients with Ankylosing Spondylitis.
Conclusions: RR chart score assessment may help to identify young AS patients at high risk of CV disease. PMID: 29666651 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - April 19, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Effect of Curcuma xanthorrhiza Supplementation on Systemic Lupus Erythematosus Patients with Hypovitamin D Which Were Given Vitamin D3 towards Disease Activity (SLEDAI), IL-6, and TGF- β1 Serum.
Conclusion. Curcuma xanthorrhiza supplementation on vitamin D3 had no effects on SLEDAI and serum levels of IL-6 and TGF-β1. This clinical trial is registered with NCT03155477. PMID: 29445400 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - February 17, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

The Impact of Different Classification Criteria Sets on the Estimated Prevalence and Associated Risk Factors of Diastolic Dysfunction in Rheumatoid Arthritis.
This study compared the estimated prevalence and potential determinants of left ventricular (LV) diastolic dysfunction upon applying different classification criteria in rheumatoid arthritis (RA). LV diastolic function was assessed echocardiographically by pulsed Doppler (E/A), tissue Doppler (E/e', lateral and septal e'), and left atrial volume index in 176 RA patients. Relationships of traditional cardiovascular risk factors and RA characteristics with LV diastolic function and dysfunction according to previous and current criteria were determined in multivariate regression models. Waist-hip ratio was associated with E/A...
Source: International Journal of Rheumatology - January 21, 2018 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Review of Routine Laboratory Monitoring for Patients with Rheumatoid Arthritis Receiving Biologic or Nonbiologic DMARDs.
Authors: Rigby WFC, Lampl K, Low JM, Furst DE Abstract Safety concerns associated with many drugs indicated for the treatment of rheumatoid arthritis (RA) can be attenuated by the early identification of toxicity through routine laboratory monitoring; however, a comprehensive review of the recommended monitoring guidelines for the different available RA therapies is currently unavailable. The aim of this review is to summarize the current guidelines for laboratory monitoring in patients with RA and to provide an overview of the laboratory abnormality profiles associated with each drug indicated for RA. Recommendati...
Source: International Journal of Rheumatology - December 13, 2017 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Gastrointestinal Symptoms and Elevated Levels of Anti-Saccharomyces cerevisiae Antibodies Are Associated with Higher Disease Activity in Colombian Patients with Spondyloarthritis.
Authors: Romero-Sánchez C, Bautista-Molano W, Parra V, De Avila J, Rueda JC, Bello-Gualtero JM, Londoño J, Valle-Oñate R Abstract Background: Spondyloarthritis (SpA) is a group of articular inflammatory rheumatic diseases that their gastrointestinal manifestations are around 10% of their extra-articular symptoms, supporting that the inflammatory response of the intestinal mucosa could be associated with the clinical status. Objectives: To investigate the association between gastrointestinal symptoms and autoantibodies and disease activity between SpA patients, healthy subjects (HS), and pat...
Source: International Journal of Rheumatology - December 9, 2017 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Cross-Cultural Validation of Urdu Version KOOS in Indian Population with Primary Knee Osteoarthritis.
Conclusion: The present results show that KOOS Urdu version is a reliable and valid measure for primary OA knee patients. PMID: 29209370 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - December 8, 2017 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Incidence and Risk Factors for Infections Requiring Hospitalization, Including Pneumocystis Pneumonia, in Japanese Patients with Rheumatoid Arthritis.
Conclusions: Risk factors for infection should be taken into account when deciding treatment for the individual RA patient. PMID: 29181029 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - November 29, 2017 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Knitting the Threads of Silk through Time: Beh çet's Disease-Past, Present, and Future.
Knitting the Threads of Silk through Time: Behçet's Disease-Past, Present, and Future. Int J Rheumatol. 2017;2017:2160610 Authors: Adeeb F, Stack AG, Fraser AD Abstract Behçet's disease (BD) is a chronic relapsing vasculitis that affects vessels of all types and sizes with a broad spectrum of phenotypic heterogeneity and complex immunopathogenesis. Efforts by the scientific community to resolve the unmet needs of BD and gaps in our knowledge have been hampered by considerable challenges that primarily relate to the rare nature of the disease in many parts of the world and its heterogeneit...
Source: International Journal of Rheumatology - November 1, 2017 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Review of Current Immunologic Therapies for Hidradenitis Suppurativa.
Authors: Shanmugam VK, Zaman NM, McNish S, Hant FN Abstract Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory disease of apocrine gland-bearing skin which affects approximately 1-4% of the population. The disease is more common in women and patients of African American descent and approximately one-third of patients report a family history. Obesity and smoking are known risk factors, but associations with other immune disorders, especially inflammatory bowel disease, are also recognized. The pathogenesis of HS is poorly understood and host innate or adaptive immune response, defective keratinocyte...
Source: International Journal of Rheumatology - September 16, 2017 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Clinically Apparent Arterial Thrombosis in Persons with Systemic Vasculitis.
CONCLUSION: Atherothrombotic rates were elevated in patients identified as having primary systemic vasculitis. While incident rates of cardiovascular comorbidities were also increased, the substantial elevation in AMIs seen in young adults suggests a disease-specific component which requires further investigation. PMID: 28713428 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - July 18, 2017 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Evaluation of Vitamin D Status in Rheumatoid Arthritis and Its Association with Disease Activity across 15 Countries: "The COMORA Study".
Evaluation of Vitamin D Status in Rheumatoid Arthritis and Its Association with Disease Activity across 15 Countries: "The COMORA Study". Int J Rheumatol. 2017;2017:5491676 Authors: Hajjaj-Hassouni N, Mawani N, Allali F, Rkain H, Hassouni K, Hmamouchi I, Dougados M Abstract The aims of this study are to evaluate vitamin D status in 1413 RA patients of COMORA study from 15 countries and to analyze relationship between patients' RA characteristics and low levels of vitamin D. All demographic, clinical, and biological data and RA comorbidities were completed. The results showed that the average ...
Source: International Journal of Rheumatology - June 29, 2017 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

The CEDAR Study: A Longitudinal Study of the Clinical Effects of Conventional DMARDs and Biologic DMARDs in Australian Rheumatology Practice.
CONCLUSIONS: In this large Australian cohort of unselected community RA patients, the choices of cDMARDs/bDMARDs are aligned with current international guidelines. PMID: 28630629 [PubMed - in process] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - June 22, 2017 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

The Nonradiographic Axial Spondyloarthritis, the Radiographic Axial Spondyloarthritis, and Ankylosing Spondylitis: The Tangled Skein of Rheumatology.
Authors: Malaviya AN, Rawat R, Agrawal N, Patil NS Abstract Since 1984 the diagnosis of ankylosing spondylitis (AS) has been based upon the modified New York (mNY) criteria with mandatory presence of radiographic sacroiliitis, without which the diagnosis is not tenable. However, it may take years or decades for radiographic sacroiliitis to develop delaying the diagnosis for long periods. It did not matter in the past because no effective treatment was available. However, with the availability of a highly effective treatment, namely, tumour necrosis factor-α inhibitors (TNFi), the issue of early diagnosis of A...
Source: International Journal of Rheumatology - June 1, 2017 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Tofacitinib versus Biologic Treatments in Moderate-to-Severe Rheumatoid Arthritis Patients Who Have Had an Inadequate Response to Nonbiologic DMARDs: Systematic Literature Review and Network Meta-Analysis.
Conclusion. In most cases, tofacitinib had similar efficacy and discontinuation rates due to adverse events compared to biologic DMARDs. PMID: 28377787 [PubMed - in process] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - April 6, 2017 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Interobserver Agreement in Magnetic Resonance of the Sacroiliac Joints in Patients with Spondyloarthritis.
Conclusions. Our study shows that rheumatologists may have similar MRI interpretations of SI joints in SpA patients as an expert radiologist. PMID: 28286523 [PubMed - in process] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - March 15, 2017 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Hard Physical Work Intensifies the Occupational Consequence of Physician-Diagnosed Back Disorder: Prospective Cohort Study with Register Follow-Up among 10,000 Workers.
In conclusion, the occupational consequence of physician-diagnosed back disorder on LTSA is greater among employees with hard physical work. PMID: 28255304 [PubMed - in process] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - March 5, 2017 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Isolated Ro52 Antibodies as Immunological Marker of a Mild Phenotype of Undifferentiated Connective Tissue Diseases.
The objective of this retrospective study was to investigate if there was a milder subgroup of UCTD with a special clinical profile consisting only in the presence of anti-Ro52 autoantibodies. Immunological and clinical records of 62 patients attending the hospital during 30 months were studied. Results showed a target population formed by mostly women, aged between 40 and 80 years at the moment of the study, with a registered age of onset between 40 and 60 years. Speckled pattern was the most frequent pattern found by indirect immunofluorescence. Given the obtained results and keeping in mind possible limitations because ...
Source: International Journal of Rheumatology - February 18, 2017 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Physicians' Perspectives on the Diagnosis and Treatment of Chronic Nonbacterial Osteomyelitis.
Conclusion. The diagnostic approach and disease activity monitoring for CNO varied among surveyed physicians. Our survey findings provided important background for the development of consensus treatment plans for CNO. PMID: 28167963 [PubMed - in process] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - February 10, 2017 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Validation of Administrative Osteoarthritis Diagnosis Using a Clinical and Radiological Population-Based Cohort.
Conclusions. The validity of administrative OA in British Columbia varied due to case definitions and reference standards. AOA2 is more suitable for identifying OA cases for research using this Canadian database. PMID: 28127309 [PubMed - in process] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - January 29, 2017 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Corrigendum to "An Insight into Methods and Practices in Hip Arthroplasty in Patients with Rheumatoid Arthritis".
Corrigendum to "An Insight into Methods and Practices in Hip Arthroplasty in Patients with Rheumatoid Arthritis". Int J Rheumatol. 2016;2016:1741420 Authors: Mosleh-Shirazi MS, Ibrahim M, Pastides P, Khan W, Rahman H, Jahangiri L Abstract [This corrects the article DOI: 10.1155/2015/140143.]. PMID: 28115937 [PubMed - in process] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - January 25, 2017 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Serum Amyloid A Level in Egyptian Children with Familial Mediterranean Fever.
Conclusion. High SAA levels were detected two weeks after last FMF attack in a large percentage of Egyptian FMF children. This indicates that subclinical inflammation continues during attack-free periods, and SAA could be used as a marker of it. PMID: 28070191 [PubMed - in process] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - January 12, 2017 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Immune Mediators in Osteoarthritis: Infrapatellar Fat Pad-Infiltrating CD8+ T Cells Are Increased in Osteoarthritic Patients with Higher Clinical Radiographic Grading.
Authors: Apinun J, Sengprasert P, Yuktanandana P, Ngarmukos S, Tanavalee A, Reantragoon R Abstract Osteoarthritis is a condition of joint failure characterized by many pathologic changes of joint-surrounding tissues. Many evidences suggest the role of both innate and adaptive immunity that interplay, resulting either in initiation or in progression of osteoarthritis. Adaptive immune cells, in particular T cells, have been demonstrated to play a role in the development of OA in animal models. However, the underlying mechanism is yet unclear. Our aim was to correlate the frequency and phenotype of tissue-infiltrating...
Source: International Journal of Rheumatology - January 12, 2017 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Deferoxamine Suppresses Collagen Cleavage and Protease, Cytokine, and COL10A1 Expression and Upregulates AMPK and Krebs Cycle Genes in Human Osteoarthritic Cartilage.
This study reports the effects of the iron chelator deferoxamine (DFO) on collagen cleavage, inflammation, and chondrocyte hypertrophy in relation to energy metabolism-related gene expression in osteoarthritic (OA) articular cartilage. Full-depth explants of human OA knee articular cartilage from arthroplasty were cultured with exogenous DFO (1-50 μM). Type II collagen cleavage and phospho-adenosine monophosphate-activated protein kinase (pAMPK) concentrations were measured using ELISAs. Gene expression studies employed real-time PCR and included AMPK analyses in PBMCs. In OA explants collagen cleavage was freque...
Source: International Journal of Rheumatology - January 5, 2017 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Association between Air Pollution and the Development of Rheumatic Disease: A Systematic Review.
Authors: Sun G, Hazlewood G, Bernatsky S, Kaplan GG, Eksteen B, Barnabe C Abstract Objective. Environmental risk factors, such as air pollution, have been studied in relation to the risk of development of rheumatic diseases. We performed a systematic literature review to summarize the existing knowledge. Methods. MEDLINE (1946 to September 2016) and EMBASE (1980 to 2016, week 37) databases were searched using MeSH terms and keywords to identify cohort, case-control, and case cross-over studies reporting risk estimates for the development of select rheumatic diseases in relation to exposure of measured air pollutant...
Source: International Journal of Rheumatology - November 18, 2016 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Impact of Anti-Inflammatory Drugs on Pyogenic Vertebral Osteomyelitis: A Prospective Cohort Study.
Conclusion. Anti-inflammatory drugs intake does not affect diagnostic delay, severity at diagnosis, or complications of PVO. PMID: 27833642 [PubMed - in process] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - November 13, 2016 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Risk of Malignant Neoplasm in Patients with Incident Rheumatoid Arthritis 1980-2007 in relation to a Comparator Cohort: A Population-Based Study.
Conclusion. After excluding NMSC, there was a small to moderately increased risk of malignancies in patients with RA. Cancer surveillance is imperative in all patients with RA. PMID: 27630714 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - September 19, 2016 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Severity of Osteoarthritis Is Associated with Increased Arterial Stiffness.
Conclusions. Our results suggest that OA severity is independently associated with increased arterial stiffness and is correlated with expression of adipokines. Thus, increased arterial stiffness and adipokines might play an important role in elevated cardiovascular risk in end-stage OA. PMID: 27493667 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - August 8, 2016 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Erratum to "The Characteristics and Significance of Locally Infiltrating B Cells in Lupus Nephritis and Their Association with Local BAFF Expression".
Erratum to "The Characteristics and Significance of Locally Infiltrating B Cells in Lupus Nephritis and Their Association with Local BAFF Expression". Int J Rheumatol. 2016;2016:7513892 Authors: Sun CY, Shen Y, Chen XW, Yan YC, Wu FX, Dai M, Li T, Yang CD Abstract [This corrects the article DOI: 10.1155/2013/954292.]. PMID: 27413376 [PubMed - as supplied by publisher] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - July 16, 2016 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

The Reliability of a Novel Automated System for ANA Immunofluorescence Analysis in Daily Clinical Practice.
Authors: Alsuwaidi M, Dollinger M, Fleck M, Ehrenstein B Abstract Automated interpretation (AI) systems for antinuclear antibody (ANA) analysis have been introduced based on assessment of indirect immunofluorescence (IIF) patterns. The diagnostic performance of a novel automated IIF reading system was compared with visual interpretation (VI) of IIF in daily clinical practice to evaluate the reduction of workload. ANA-IIF tests of consecutive serum samples from patients with suspected connective tissue disease were carried out using HEp-2 cells according to routine clinical care. AI was performed using a visual anal...
Source: International Journal of Rheumatology - June 2, 2016 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Cardiac Function and Diastolic Dysfunction in Behcet's Disease: A Systematic Review and Meta-Analysis.
Authors: Aslam F, Bandeali SJ, Crowson C, Alam M Abstract Background. Cardiovascular involvement in Behcet's disease (BD) is reported and has variable manifestations. It is not clear if diastolic dysfunction (DD) is increased in BD. Our objective was to evaluate the existing literature to determine if cardiac dysfunction, particularly DD, was more prevalent in these patients. Methods. A systematic review and meta-analysis of the available studies analyzing the echocardiographic findings in BD was conducted using a random-effects model. Mean differences were used to calculate the effect sizes of the echocardiographi...
Source: International Journal of Rheumatology - June 2, 2016 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

SAPHIRE: Stress and Pulmonary Hypertension in Rheumatoid Evaluation-A Prevalence Study.
This study explored the prevalence of PAH in a population of unselected individuals with RA, using exercise echocardiography (EchoCG). The high prevalence of EchoCG-derived elevation of PAP (EDEPP) in this population (14%) suggests that, like other autoimmune conditions, RA may be a risk factor for PAH. Patients with RA may therefore represent another population for whom PAH screening with noninvasive tools such as EchoCG may be justified. PMID: 27200094 [PubMed] (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - May 21, 2016 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

The Diagnostic Value of Alpha-1-Antitrypsin Phenotype in Patients with Granulomatosis with Polyangiitis.
Authors: Pervakova MY, Emanuel VL, Titova ON, Lapin SV, Mazurov VI, Belyaeva IB, Chudinov AL, Blinova TV, Surkova EA Abstract The deficiency of alpha-1 protease inhibitor, or alpha-1-antitrypsin (A1AT), predisposes to chronic lung diseases and extrapulmonary pathology. Besides classical manifestations, such as pulmonary emphysema and liver disease, alpha-1-antitrypsin deficiency (A1ATD) is also known to be associated with granulomatosis with polyangiitis (GPA or Wegener's granulomatosis). The aim of our study was to evaluate the frequency of allelic isoforms of A1AT and their clinical significance among GPA patient...
Source: International Journal of Rheumatology - April 30, 2016 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Vaccination of Adult Patients with Systemic Lupus Erythematosus in Portugal.
Authors: Moraes-Fontes MF, Antunes AM, Gruner H, Riso N Abstract In the wake of the Portuguese vaccination program 50th anniversary it seems appropriate to review vaccination in patients with systemic lupus erythematosus. Controversial issues as regards the association between autoimmune diseases, infections, and vaccines are discussed as well as vaccine safety and efficacy issues as regards chronic immunosuppressant (IS) drug therapy. After a brief overview of national policies, specific recommendations are made as regards vaccination for adult patients with SLE with a particular focus on current IS therapy and un...
Source: International Journal of Rheumatology - April 15, 2016 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Joint Degradation in a Monkey Model of Collagen-Induced Arthritis: Role of Cathepsin K Based on Biochemical Markers and Histological Evaluation.
Authors: Tanaka M, Yamada H, Nishikawa S, Mori H, Ochi Y, Horai N, Li M, Amizuka N Abstract The role of cathepsin K in joint degradation in a model of collagen-induced arthritis (CIA) in cynomolgus monkey was examined using biochemical markers and histology. Joint swelling, urinary C-telopeptide of type II collagen (CTX-II), deoxypyridinoline (DPD), and N- and C-telopeptides of type I collagen (NTX and CTX-I, resp.) were analyzed. Immunohistochemistry of type II collagen, cathepsin K, and CTX-II were performed using joints. Joint swelling reached peak on day 42 and continued at this level. The CTX-II level peaked o...
Source: International Journal of Rheumatology - March 9, 2016 Category: Rheumatology Tags: Int J Rheumatol Source Type: research

Clinical Assessment and Management of Spondyloarthritides in the Middle East: A Multinational Investigation.
The objective was to report on the characteristics, disease burden, and treatment of SpA in the Middle East region and to highlight where management strategies could be improved, with the overall aim of achieving better patient outcomes. This multicenter, observational, cross-sectional study collected demographic, clinical, laboratory, and treatment data on 169 consecutive SpA patients at four centers (Egypt, Kuwait, Qatar, and Saudi Arabia). The data collected presents the average time from symptom onset to diagnosis along with the presence of comorbidities in the region and comparisons between treatment with NSAIDs and b...
Source: International Journal of Rheumatology - January 24, 2016 Category: Rheumatology Tags: Int J Rheumatol Source Type: research