Response to “Infantile-onset deafness in m.7445A > G carriers may be multicausal ”
We would like to thank Dr. Josef Finsterer and Dr. Zarrouk-Mahjoub for their insightful and constructive comments on our study [1]. At first, m.7445A>G heteroplasmy rates reported by Tranah et al. was based on the analysis on platelets [2] and our study was based on the analysis on whole blood cells. Thus, the heteroplasmy rates of the two studies cannot be compared because heteroplasmy rates are various in various organs in cases with mitochondrial diseases [3,4]. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 14, 2018 Category: ENT & OMF Authors: Tatsuo Matsunaga, Kana Matsushima, Kei Murayama Tags: Letter to the Editor Source Type: research

Infantile-onset deafness in m.7445A > G carriers may be multicausal
In a recent paper, Matsushima et al. reported about a 2 years and 6 months-old male who developed non-syndromic, progressive impaired hearing by the age of 9 months [1]. The family history was positive for hypoacusis in the father, mother, one maternal and paternal uncle each, maternal grandmother and grandfather, maternal grand uncle, and maternal great-grandmother [1]. Hearing impairment in the index case was attributed to the variant m.7445A>G variant outside the tRNA (Ser) gene [1]. The index case had also inherited the variant c.235delC in the GJB2 gene from his father [1]. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 14, 2018 Category: ENT & OMF Authors: Josef Finsterer, Sinda Zarrouk-Mahjoub Tags: Letter to the Editor Source Type: research

Toll-like receptor 4 plays an important role to enhance bacterial clearance from the nose in synergy with triggering receptor expressed on myeloid cells (TREM)-1 expression on polymorphonuclear neutrophils
Acute rhinosinusitis (ARS) is among the most common infectious diseases. Neutrophils play a major role in innate host defenses against pathogenic microorganisms such as fungi and bacteria. Recently, in neutrophils, ligation of the triggering receptor expressed on myeloid cells (TREM)-1 was found to activate the full spectrum of neutrophil effector mechanisms, including the release of inflammatory mediators, degranulation, phagocytosis, and oxidative burst in synergy with Toll-like receptors (TLRs). (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 14, 2018 Category: ENT & OMF Authors: Munehito Moriyama, Takashi Hirano, Toshiaki Kawano, Yoshinori Kadowaki, Satoru Kodama, Masashi Suzuki Source Type: research

The effect of peri-intraventricular hemorrhage on the auditory pathway of infants
To verify the effect of peri-intraventricular hemorrhage on the auditory pathway of preterm infants. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 13, 2018 Category: ENT & OMF Authors: Leticia Saia da Silva, Georgea Espindola Ribeiro, Jair Cortez Montovani, Daniela Polo Camargo Silva Source Type: research

Application of “banana cochleostomy” and looped electrode insertion for cochlear implantation in children with common cavity malformation and cystic forms of cochlear hypoplasia
Patients with profound hearing loss due to inner ear malformations may benefit from cochlear implantation; however, the surgery may present a substantial problem for the cochlear implant surgeon due to anatomical variations.The authors describe a new surgical and technical advancement for implantation in patients with small inner ear cavities that make the surgery easier and safer. On the basis of experience involving five consecutive surgeries performed in four patients with inner ear malformations, we present the advantages and application possibilities of the technique. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 12, 2018 Category: ENT & OMF Authors: J ózef Mierzwiński, Egwin Van Den Heuvel, Andrew J. Fishman, Arnaldo L. Rivera, Karolina Haber, Jiri Skrivan Source Type: research

Genetic heterogeneity of congenital hearing impairment in Algerians from the Gharda ïa province
Consanguinity rate is high in Algeria, and the population is thus at high risk for genetic diseases transmitted on an autosomal recessive mode. Inherited congenital hearing impairment (HI) is a highly heterogeneous disorder, which affects approximately 1 in 800 Algerian newborns. Several hundreds of genes responsible for deafness have been reported among which more than one hundred are responsible for isolated deafness, of which 19 have already been reported to be involved in the Algerian population. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 12, 2018 Category: ENT & OMF Authors: Sonia Talbi, Crystel Bonnet, Zied Riahi, Farid Boudjenah, Malika Dahmani, Jean-Pierre Hardelin, Fabienne Wong, Malek Louha, Fatima Ammar-Khodja, Christine Petit Source Type: research

Application of "banana cochleostomy" and looped electrode insertion for cochlear implantation in children with common cavity malformation and cystic forms of cochlear hypoplasia
Patients with profound hearing loss due to inner ear malformations may benefit from cochlear implantation; however, the surgery may present a substantial problem for the cochlear implant surgeon due to anatomical variations.The authors describe a new surgical and technical advancement for implantation in patients with small inner ear cavities that make the surgery easier and safer. On the basis of experience involving five consecutive surgeries performed in four patients with inner ear malformations, we present the advantages and application possibilities of the technique. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 12, 2018 Category: ENT & OMF Authors: Jozef Mierzwinski, Egwin Van Den Heuvel, Andrew J. Fishman, Arnaldo L. Riviera, Karolina Haber, Jiri Skrivan Source Type: research

Intracranial complications of pediatric sinusitis: Identifying risk factors associated with prolonged clinical course
Intracranial extension is one of the most serious and morbid complications of pediatric sinusitis. Managing this complication continues to be challenging even after widespread pneumococcal vaccination adoption. We aim to identify risk factors associated with complicated clinical courses, and to assess for altering microbial communities and increased antibiotic resistance. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 12, 2018 Category: ENT & OMF Authors: Alexander J. Schupper, Wen Jiang, Michael J. Coulter, Matthew Brigger, Javan Nation Source Type: research

Including auditory tube function on models is relevant to assess water exposure after tympanostomy tubes – multiphase computerized fluid dynamics model
Myringotomy with tympanostomy tube is the most common otologic surgery and some patients are still advised to avoid water. However, there is no evidence supporting this, with published papers questioning the need for this advice. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 12, 2018 Category: ENT & OMF Authors: Joao Subtil, Nuno Martins, Teresa Nunes, Didia Covas, Paulo Vera-Cruz, Richard Voegels, Joao Paco Source Type: research

Congenital right bronchial stenosis with high bifurcation: successful management with side to side tracheobronchial anastomosis
Congenital bronchial stenosis is a rare entity [1,2]. While there are some reports of congenital bronchial anomalies and their repair in the thoracic literature this is first report in the literature of a bronchial take off just below the larynx managed with surgical success. Here we present a case of a former 33-weeker born with a tracheoesophageal fistula, Tetralogy of Fallot, and a high bifurcation of the right mainstem bronchus with a concomitant long segment bronchial stenosis. Preoperative planning included printing 3-D reconstructed models of the airway to analyze various treatment options. (Source: International Jo...
Source: International Journal of Pediatric Otorhinolaryngology - June 11, 2018 Category: ENT & OMF Authors: Rachel Georgopoulos, Courtney Hill, Jeffrey S. Heinle, Deepak Mehta Tags: Case Report Source Type: research

Post-myringotomy oto-liquorrhea in children - a case study and literature review
Myringotomy is a surgical incision of tympanic membrane used mainly as therapy for acute otitis media. It is a safe and simple procedure; however possible complications must be considered. In this article is described a case study of a 2-and-a-half-year-old girl with a massive oto-liquorrhea following myringotomy. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 11, 2018 Category: ENT & OMF Authors: Milan Ur ík, Ivo Šlapák, David Laštovička, Jana Jančíková, Denisa Pavlovská, Dagmar Hošnová, Eliška Žarošská, Michaela Ťoukálková Tags: Case Report Source Type: research

Obstructive sleep apnea in children with marfan syndrome: relationships between three-dimensional palatal morphology and apnea-hypopnea index
To evaluate the relationship between the severity degree of OSA (apnea/hypopnea index AHI>1) and palatal area and volume, measured by 3D analysis of digital casts in Marfan children. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 11, 2018 Category: ENT & OMF Authors: V. Paoloni, E. Cretella Lombardo, F. Placidi, G. Ruvolo, P. Cozza, G. Lagan à Source Type: research

Hyperacusis in children: The Edinburgh experience
This study aimed to determine the factors associated with hyperacusis in children referred to an audiology-led paediatric hyperacusis clinic in a Paediatric tertiary centre. It also aimed to identify current management strategies in paediatric hyperacusis and their outcomes. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 11, 2018 Category: ENT & OMF Authors: Ida Amir, Dawn Lamerton, Mary-Louise Montague Source Type: research

Electrical dynamic range is only weakly associated with auditory performance and speech recognition in long-term users of cochlear implants
The electrical dynamic range (EDR) has been suggested to be related to auditory performance in cochlear implant (CI) users. However, few reports have evaluated postlingual CI users who have used CIs for long periods in comparison with prelingual CI users. Here, we evaluated auditory perception and speech performance in terms of the EDR in long-term CI users. The EDR, and auditory and speech performances, were compared between pre- and post-lingual CI users. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 11, 2018 Category: ENT & OMF Authors: So Young Kim, Seul-Ki Jeon, Seung Ha Oh, Jun Ho Lee, Myung-Whan Suh, Sang-Yub Lee, Hyun-Jung Lim, Moo Kyun Park Source Type: research

A review of pediatric middle ear tumors and analysis of the demographics, management, and survival of pediatric rhabdomyosarcomas of the middle ear
To examine the types of pediatric middle ear tumors and review the demographics, management, and survival of pediatric patients with rhabdomyosarcoma (RMS) of the middle ear. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 11, 2018 Category: ENT & OMF Authors: Tyler A. Janz, P.Ryan Camilon, Anthony Y. Cheung, Shaun A. Nguyen, David R. White, Peter C. Weber Source Type: research