Metastasis of Ewing's Sarcoma to the Thyroid Gland: A Case Report
We present a case of ES with thyroid metastasis. The patient was diagnosed with ES at age 8. Despite aggressive treatment, she suffered disease progression. Surveillance demonstrated a left thyroid lesion. This grew rapidly within 2 months, causing tracheal compression. She underwent hemi-thyroidectomy to prevent airway compromise. Due to her refractory ES, she was enrolled in the Vigil immunotherapy vaccine trial; thus, the specimen was used for vaccine development. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - July 12, 2018 Category: ENT & OMF Authors: Swathi Appachi, Joseph B. Meleca, Paul Krakovitz Tags: Case Report Source Type: research

Personal overview of otology in Africa
Africa has a population of about 1.2 billion people of whom about 40 –50% are under 18 years of age. If the World Health estimates that about 4% of the population in these countries have chronic ear disease is vaguely correct this translates into about 50 million people with perforated eardrums – probably highest amongst the Paediatric population because they are the most prone to ear disease. And nothing is being done about it! (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - July 10, 2018 Category: ENT & OMF Authors: C.A.J. Prescott Tags: Letter to the Editor Source Type: research

Hearing loss in type 1 diabetes: Are we facing another microvascular disease? A meta-analysis
Evidence shows type 1 diabetes(T1D) leads to vascular damage and neuropathy. The purpose of this study was to perform a systematic review and a meta-analysis to assess the evidence of the effects of T1D on hearing function. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - July 10, 2018 Category: ENT & OMF Authors: Mario A. Mujica-Mota, Neel Patel, Issam Saliba Tags: Review Article Source Type: research

Congenital dilatation of the submandibular duct
also known as imperforate submandibular duct is a rare condition of unknown etiology, clinically characterized as a well-defined, fluctuant swelling in the floor of the mouth, and microscopically defined as a cystic cavity covered with pseudostratified columnar epithelium consistent with a dilated salivary duct. A 1-month-old female presented with a translucent, smooth cystic swelling in the floor of the mouth causing breastfeeding difficulty. The lesion was surgically excised and microscopically, a cystic cavity lined with pseudostratified columnar epithelium was observed. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - July 10, 2018 Category: ENT & OMF Authors: Maria Luiza Prosd ócimo, Ana Paula Barreto Nogueira, Maria Aparecida de Albuquerque Cavalcante, Michelle Agostini, Mário José Romañach, Bruno Augusto Benevenuto de Andrade Tags: Case Report Source Type: research

Accuracy of Chest X-Ray Measurements of Pediatric Esophageal Coins
To determine the accuracy of chest x-ray measurements in children using ingested radiopaque foreign bodies of known size. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - July 10, 2018 Category: ENT & OMF Authors: Phillip Huyett, Amber Shaffer, Linda Flom, Jeffrey P. Simons, Noel Jabbour Source Type: research

A novel rat model for assessment of laryngotracheal injury following transoral intubation
Laryngotracheal damage is a well-described complication of endotracheal intubation and animal models are essential for studying the underlying cellular injury cascade. This novel rat model is based on transoral intubation and aims to simulate the common clinical scenario of tube-related airway damage. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - July 10, 2018 Category: ENT & OMF Authors: Jahshan F, Ertracht O, A. Abu-Amar, Ronen O, Srouji S, L. Apel-Sarid, Eisenbach N, Atar S, Sela E, Gruber M Source Type: research

Personal overview of otology in sub-saharan africa
Sub-Saharan Africa has a population of about 1.2 billion people of whom about 40 - 50% are under 18 years of age. If the World Health estimates that about 4% of the population in these countries have chronic ear disease is vaguely correct this translates into about 50 million people with perforated eardrums – probably highest amongst the Paediatric population because they are the most prone to ear disease. And nothing is being done about it! (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - July 10, 2018 Category: ENT & OMF Authors: C.A.J. Prescott Tags: Letter to the Editor Source Type: research

Oral Health Status of Children with Mouth Breathing Due to Adenotonsillar Hypertrophy
This study aimed to determine the oral health status of children aged 3-15 years, with mouth breathing who were due to have surgery for adeno-tonsillar hypertrophy and referred to the Department of Otorhinolaryngology at Children's Hospital of a University in Ankara, Turkey between January-July 2015. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - July 10, 2018 Category: ENT & OMF Authors: Elif Ballikaya, Bahar Guciz Dogan, Ovsen Onay, Meryem Tekcicek Source Type: research

Down Syndrome as an Indicator for Pediatric Otolaryngologic Procedures
Down Syndrome (DS) is the most common chromosome abnormality in humans. Due to the phenotype associated with DS, there are many disease states that require otolaryngologic procedures. Our goal is to use national data to study otolaryngologic procedures, their association with DS, and the degree of difference in risk profiles encountered with DS. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - July 9, 2018 Category: ENT & OMF Authors: Terral A. Patel, Shaun A. Nguyen, David R. White Source Type: research

Pediatric vestibular testing: Tolerability of test components in children
Objective of the study is to define rates of successful completion of components of pediatric vestibular testing (VT). (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - July 9, 2018 Category: ENT & OMF Authors: Peter J. Ciolek, Elise Kang, Julie A. Honaker, Erika A. Woodson, Brandon S. Hopkins, Samantha Anne Source Type: research

Two novel homozygous missense mutations identified in the BSND gene in Moroccan patients with Bartter's syndrome
Hearing loss (HL) is one of the most common sensorineural disorders. In the present study, we identified two novel missense mutations in BSND gene causing Bartter syndrome type IV which is a genetic disease with an autosomal recessive transmission, characterized by hypokalaemia, metabolic alkalosis, an elevation in plasma renin activity and hyperaldosteronism as well as sensorineural deafness. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - July 9, 2018 Category: ENT & OMF Authors: Soukaina Elrharchi, Zied Riahi, Sara Salime, Halima Nahili, Hassan Rouba, Mostafa Kabine, Crystel Bonnet, Christine Petit, Abdelhamid Barakat Source Type: research

Extremely common radiographic finding of cochlear nerve deficiency among infants with prelingual single-sided deafness and its clinical implications
To clarify the common radiographic findings of audiologically documented prelingual single-sided deafness (SSD) and identify the prevalence of cochlear nerve deficiency (CND) in SSD infants referred from the newborn hearing screening program. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - July 9, 2018 Category: ENT & OMF Authors: Woongsang Sunwoo, Won-Wook Lee, Byung Yoon Choi Source Type: research

Decreased disulphide/thiol ratio in patients with autosomal recessive non-syndromic hearing loss
In this study, we aim to assess whether thiol-disulphide balance is disrupted in patients with ARNSHL. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - July 9, 2018 Category: ENT & OMF Authors: Burhan Balta, Ramazan Gundogdu, Murat Erdogan, Murat Alisik, Aslihan Kiraz, Ibrahim Ozcan, Ozcan Erel Source Type: research

Effect of Sleep Deprivation on Hearing Levels in Rats
To our knowledge, the influence of sleep deprivation on hearing levels has yet to be assessed in animals. Therefore, we evaluated whether auditory function was affected by sleep deprivation in rats. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - July 6, 2018 Category: ENT & OMF Authors: Jae Hyun Jung, Miryeong Kim, Seung Jae Lee, Eunsang Lee, Se A. Lee, Jong Dae Lee, Ji Ho Choi, Bo Gyung Kim Source Type: research

The Wound Healing Capacity Of Undifferentiated And Differentiated Airway Epithelial Cells In Vitro
Congenital or acquired tracheal lesions alter airway epithelial structure and can lead to long-segment tracheal defects. Tissue engineered tracheal grafts (TETG) have the potential to cure such defects; however, clinical applications have been plagued with numerous complications including delayed graft epithelialization. The knowledge that epithelial cells migrate from native tissue to the TETG raises the possibility that TETG performance can be improved by increasing the rate of epithelialization. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - July 6, 2018 Category: ENT & OMF Authors: Cynthia M. Schwartz, Braedyn A. Dorn, Selam Habtemariam, Cynthia L. Hill, Tendy Chiang, Susan D. Reynolds Source Type: research

Juvenile recurrent parotitis: a systematic review of treatment studies
Juvenile recurrent parotitis is a rare recurrent inflammation of the parotid glands occurring in children. The etiology remains obscure and the treatment is still debated. In the present study, we perform a systematic review of the literature with the purpose of identifying and discussing the treatment options emerged over the last 28 years in order to prevent recurrent episodes of parotitis.We ultimately included 24 studies. The definitions used for juvenile recurrent parotitis varied widely and none of the selected studies referred exactly to the same definition. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - July 4, 2018 Category: ENT & OMF Authors: Werner Garavello, Monica Redaelli, Francesca Galluzzi, Lorenzo Pignataro Tags: Review Article Source Type: research

The concentrations of bioelements in the hair samples of Jordanian children who stutter
This study investigates the levels of 15 bioelements (calcium, copper, chromium, sodium, iron, magnesium, manganese, zinc, cobalt, selenium, molybdenum, vanadium, potassium, boron, and lithium) in the hair species of Jordanian stutterer. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - July 2, 2018 Category: ENT & OMF Authors: Mazin Alqhazo, Ayat Bani Rashaid Source Type: research

The Concentrations of Bioelements in the Hair Samples of Jordanian Children Who
This study investigates the levels of 15 bioelements (calcium, copper, chromium, sodium, iron, magnesium, manganese, zinc, cobalt, selenium, molybdenum, vanadium, potassium, boron, and lithium) in the hair species of Jordanian stutterer. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - July 2, 2018 Category: ENT & OMF Authors: Mazin Alqhazo, Ayat Bani Rashaid Source Type: research

Bilateral auditory ossicular expansions in a child with beta-thalassemia major: case report and literature review
We report a third paediatric case from Australia. A seven-year-old with thalassemia major demonstrated conductive impairment during surveillance for Deferasirox ototoxicity. Otitis media was assumed, however, CT scan of the petrous temporal bone revealed extramedullary haematopoiesis causing bilateral ossicular expansions and fixed conductive deficit. Reports of hearing loss in the thalassemia population focus on sensorineural impairment from iron chelation therapies. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - July 2, 2018 Category: ENT & OMF Authors: Melisha Sirisena, Catherine S. Birman, Amy J. McKibbin, Katie J. O'Brien Tags: Case Report Source Type: research

Pediatric case of squamous cell carcinoma arising from a keratocystic odontogenic tumor
Keratocystic odontogenic tumors (KCOT) are exceptional in children and adolescents as they usually occur in the third decade. The present study reports the case of a 15 years old girl who was diagnosed with a KCOT that underwent malignant transformation. KCOT diagnostic was based on clinical, radiological, histopathological and immunohistochemical findings. A conservative treatment by enucleation was performed. Histopathological analysis of the surgical specimen concluded to a KCOT, with an infra-centimetric focus of well-differentiated squamous cell carcinoma. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - July 2, 2018 Category: ENT & OMF Authors: Lara Nokovitch, Anne-Gaelle Bodard, Nad ège Corradini, Carole Crozes, Aurélie Guyennon, Sophie Deneuve Tags: Case Report Source Type: research

MicroRNAs for the pediatric otolaryngologist
The scope of pediatric otolaryngology is broad and encompasses a wide variety of diseases in which the fundamental phenotype-causing abnormality exists at the level of gene regulation and expression. Development of novel molecular biology instruments to diagnose disease, monitor treatment response, and prevent recurrence will facilitate the delivery of appropriate surgical and adjuvant medical treatments with lower morbidity. MicroRNAs (miRNAs) have emerged as a relatively new class of molecules that directly modulate gene expression and are abnormally expressed in a multitude of disease processes including those within th...
Source: International Journal of Pediatric Otorhinolaryngology - July 2, 2018 Category: ENT & OMF Authors: Graham M. Strub, Jonathan A. Perkins Tags: Review Article Source Type: research

The child doesn't hear? On breaking bad news as perceived by parents and audiologists
The object of this study was to explore how parents experienced receiving the news of their child's hearing loss, and how audiologists experienced the situation of conveying the diagnosis, in order to examine improvements to the current process. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - July 2, 2018 Category: ENT & OMF Authors: Geal-Dor Miriam, Adelman Cahtia Source Type: research

Pre-operative ultrasound guided wire localization for recurrent or persistent thyroid disease: A series of four cases
We present a small series of patients in which hook wire localization was used to help localize and excise recurrent and/or persistent neck disease during secondary operations. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - July 2, 2018 Category: ENT & OMF Authors: Shruti Zaveri, Jeffrey C. Rastatter, John M. Carter, Stanley Kim, John Maddalozzo Source Type: research

The effects of narrative-based language intervention (NBLI) on spoken narrative structures in Persian-speaking cochlear implanted children: A prospective randomized control trial
Previous research has shown that narrative-based language intervention (NBLI) is a feasible approach increasing the narrative skills of hearing-impaired children. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - July 2, 2018 Category: ENT & OMF Authors: Peyman Zamani, Zahra Soleymani, Shohreh Jalaie, Masoud Motasaddi Zarandy Source Type: research

Utilization of a handheld metal detector protocol to reduce radiation exposure in pediatric patients with esophageal COINS
The primary objective of this study is to assess the utility of a handheld metal detector for identification and surveillance of patients with known esophageal coin ingestion to reduce repeat x-rays and associated radiation exposure. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 27, 2018 Category: ENT & OMF Authors: Abdullah Aljasser, Charles A. Elmaraghy, Kris R. Jatana Source Type: research

Comparison of click Auditory Brainstem Response and chirp Auditory Steady-State Response Thresholds in Children
This study aims at comparing and finding correlations between air-conduction thresholds using the traditional click ABR and the relatively recently used chirp ASSR test methods, for a large pediatric population. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 26, 2018 Category: ENT & OMF Authors: Konstantinos Mourtzouchos, Maria Riga, Mario Cebulla, Vasilios Danielides, Stefanos Naxakis Source Type: research

Exposure to air pollution and risk of prevalence of childhood allergic rhinitis: A meta-analysis
Allergic rhinitis (AR), a common chronic inflammatory disease in the upper airways. The prevalence of AR in children seems to be increasing recently, and the most significant causes of the increase are thought to be changes in environmental factors, especially air pollution. However, we could not find any meta-analysis on the risk of air pollution exposure on the prevalence of AR in childhood. The aim of this research was to carry out a meta-analysis on the results of recent studies (21  s t century) to present valid information about exposure to air pollution and risk of prevalence of childhood AR. (Source: Internatio...
Source: International Journal of Pediatric Otorhinolaryngology - June 26, 2018 Category: ENT & OMF Authors: Qi-Yuan Zou, Yang Shen, Xia Ke, Su-Ling Hong, Hou-Yong Kang Tags: Review Article Source Type: research

Evaluation of clinical approaches and physician adherence to guidelines for otitis media with effusion
Otitis media with effusion (OME) is an important clinical entity because of its high prevalence, difficulties in diagnosis, complications and diversities in management. Herein, we aimed to evaluate current physician approaches on OME and determine clinical adherence to current guidelines. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 26, 2018 Category: ENT & OMF Authors: Nisa Eda Cullas Ilarslan, Fatih Gunay, Seda Topcu, Ergin Ciftci Source Type: research

Outcomes after cochlear implant provision in children with cochlear nerve hypoplasia or aplasia
Cochlear nerve aplasia or hypoplasia is found in up to a half of patients with unilateral or bilateral hearing loss. There is an ongoing discussion regarding the indication of cochlear implants for hearing rehabilitation in cases with radiologically-defined aplasia or hypoplasia of the cochlear nerve in those patients, especially in children. At present there is conflicting evidence whether the audiological outcomes of those children with a CI are comparable to those of children with a CI and a radiologically-normal cochlear nerve. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 23, 2018 Category: ENT & OMF Authors: D ésirée Ehrmann-Müller, Heike Kühn, Cordula Matthies, Rudolf Hagen, Wafaa Shehata-Dieler Source Type: research

Adenoid Size by Drug Induced Sleep Endoscopy Compared to Nasopharyngeal Mirror Exam
To establish how assessment of adenoid size is correlated between drug-induced sleep endoscopy (DISE) with indirect mirror nasopharyngoscopy (IMN). (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 22, 2018 Category: ENT & OMF Authors: Habib G. Zalzal, Michele Carr, William Kohler, Steven W. Coutras Source Type: research

Current Management and Referral Patterns of Pediatricians for Acute Otitis Media
This study aims to assess current practice patterns and how they compare to the published guideline. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 20, 2018 Category: ENT & OMF Authors: Shivani Shah-Becker, Michele M. Carr Source Type: research

Validation of a Drooling questionnaire in Indian children with Cerebral palsy
Drooling of saliva is a common problem in children with cerebral palsy. In addition to causing impairment in articulation, drooling also affects socialization, interpersonal relationships and integration into society for these children. There are various methods to assess drooling which measure directly the amount of saliva drooled. However the most convenient and popular method is the use of questionnaires which are mostly western based and need slight modification for the Indian scenario Aim-Validation of a modified questionnaire for the assessment of drooling in children with cerebral palsy. (Source: International Journ...
Source: International Journal of Pediatric Otorhinolaryngology - June 19, 2018 Category: ENT & OMF Authors: Anjana Job, P. Naina, Syed Kamran Asif, Maya Thomas, Mary John, Ajoy Mathew Varghese Source Type: research

Expression of surfactant Protein-A in the Haemophilus influenzae-induced otitis media in a rat model
The objective of this study was to investigate the expression and the role of surfactant protein A (SP-A) in the middle ear (ME) mucosa in response to bacterial infection in a rat model. Otitis media (OM) was induced by surgical inoculation of non-typeable Haemophilus influenza (NTHi) into the ME cavity of Sprague-Dawley rats. The rats were divided into an NTHi-induced OM group and a phosphate-buffered saline-injected control group. The NTHi-induced OM and control groups were subdivided into sets of 6 rats, one for each of the 6 time points (0, 1, 2, 4, 7, and 14 days post-inoculation), at which point the rats were euthani...
Source: International Journal of Pediatric Otorhinolaryngology - June 19, 2018 Category: ENT & OMF Authors: Gun Hee Yu, Hee Bok Kim, Seo Hyun Ko, Youn Woo Kim, Yun-Sung Lim, Seok-Won Park, Chang Gun Cho, Joo Hyun Park Source Type: research

Efficient Decellularization of Rabbit Trachea to Generate a Tissue Engineering Scaffold Biomatrix
The objectives of this study were: 1) to generate a tracheal extracellular matrix scaffold using an efficient decellularization process and 2) to characterize the decellularized scaffold to assess its suitability for tissue engineering applications. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 19, 2018 Category: ENT & OMF Authors: Paul Hong, Michael Bezuhly, M. Elise Graham, Paul F. Gratzer Source Type: research

Predicting postoperative hemorrhage after pediatric tonsillectomy
I read with great interest the article by Hsueh et al. in a recent issue of the journal [1]. The authors performed a retrospective study on 17,326 children who underwent inpatient tonsillectomies and concluded that age, surgical indication, comorbidities, and drug administration were associated with readmission or reoperation. The authors should be congratulated for performing a well-designed study in an important topic (e.g., complications) in pediatric patients undergoing surgery [2,3]. Moreover, the need to reduce readmissions and perioperative costs is a very relevant topic in perioperative medicine [4,5]. (Source: Int...
Source: International Journal of Pediatric Otorhinolaryngology - June 18, 2018 Category: ENT & OMF Authors: Mark C. Kendall Tags: Letter to the Editor Source Type: research

Reply to the letter regarding "Population-based survey of inpatient pediatric tonsillectomy and postoperative hemorrhage in Taiwan, 1997-2012."
We thank Dr. Mark C. Kendall for his valuable comments on our population-based study, and the questions raised regarding methodological approach in this manuscript [1]. In Taiwan, the National Health Insurance covers 99% of country's 23 million inhabitants [2]. The National Health Insurance Research Database (NHIRD) in Taiwan allows researchers to conduct population-based epidemiologic analyses of diseases and procedures to facilitate daily practice of clinical physicians [2,3]. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 18, 2018 Category: ENT & OMF Authors: Chia-Fan Lee, Chia-Hsuan Lee, Kun-Tai Kang Tags: Letter to the Editor Source Type: research

Vocal cord paralysis appears to be an acquired lesion in children with repaired esophageal atresia/tracheoesophageal fistula
Determine whether vocal cord paresis or paralysis (VCP/P) following surgical repair of congenital esophageal atresia/tracheoesophageal fistula (EA/TEF) is generally a primary anomaly, or is secondary to EA/TEF repair. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 18, 2018 Category: ENT & OMF Authors: Thomas Kovesi, Federica Porcaro, Francesca Petreschi, Marilena Trozzi, Sergio Bottero, Renato Cutrera Source Type: research

Transcanal Incision and Drainage of a Parapharyngeal Abscess in a Pediatric Patient: A Novel Technique
We report a novel approach to an abscess that was drained through the external auditory canal (EAC). An otherwise healthy 2-year-old female presented with a 4-day history of fevers, decreased oral intake, neck stiffness, and voice changes. CT neck with contrast revealed a deep abscess in the left neck extending from the peritonsillar space into the parapharyngeal space in close proximity to the anterior aspect of the EAC. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 18, 2018 Category: ENT & OMF Authors: Tyler R. Schwartz, Miranda D. Colletta, Michael E. McCormick Tags: Case Report Source Type: research

Diagnosing nontuberculous mycobacterial cervicofacial lymphadenitis in children: A systematic review
This study intends to gather the available evidence with respect to diagnosing NTM cervicofacial lymphadenitis. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 18, 2018 Category: ENT & OMF Authors: S.H. Willemse, M.A.E.M. Oomens, J. De Lange, L.H.E. Karssemakers Tags: Review Article Source Type: research

Response to “Infantile-onset deafness in m.7445A > G carriers may be multicausal ”
We would like to thank Dr. Josef Finsterer and Dr. Zarrouk-Mahjoub for their insightful and constructive comments on our study [1]. At first, m.7445A>G heteroplasmy rates reported by Tranah et al. was based on the analysis on platelets [2] and our study was based on the analysis on whole blood cells. Thus, the heteroplasmy rates of the two studies cannot be compared because heteroplasmy rates are various in various organs in cases with mitochondrial diseases [3,4]. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 14, 2018 Category: ENT & OMF Authors: Tatsuo Matsunaga, Kana Matsushima, Kei Murayama Tags: Letter to the Editor Source Type: research

Infantile-onset deafness in m.7445A > G carriers may be multicausal
In a recent paper, Matsushima et al. reported about a 2 years and 6 months-old male who developed non-syndromic, progressive impaired hearing by the age of 9 months [1]. The family history was positive for hypoacusis in the father, mother, one maternal and paternal uncle each, maternal grandmother and grandfather, maternal grand uncle, and maternal great-grandmother [1]. Hearing impairment in the index case was attributed to the variant m.7445A>G variant outside the tRNA (Ser) gene [1]. The index case had also inherited the variant c.235delC in the GJB2 gene from his father [1]. (Source: International Journal of Pediatr...
Source: International Journal of Pediatric Otorhinolaryngology - June 14, 2018 Category: ENT & OMF Authors: Josef Finsterer, Sinda Zarrouk-Mahjoub Tags: Letter to the Editor Source Type: research

Toll-like receptor 4 plays an important role to enhance bacterial clearance from the nose in synergy with triggering receptor expressed on myeloid cells (TREM)-1 expression on polymorphonuclear neutrophils
Acute rhinosinusitis (ARS) is among the most common infectious diseases. Neutrophils play a major role in innate host defenses against pathogenic microorganisms such as fungi and bacteria. Recently, in neutrophils, ligation of the triggering receptor expressed on myeloid cells (TREM)-1 was found to activate the full spectrum of neutrophil effector mechanisms, including the release of inflammatory mediators, degranulation, phagocytosis, and oxidative burst in synergy with Toll-like receptors (TLRs). (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 14, 2018 Category: ENT & OMF Authors: Munehito Moriyama, Takashi Hirano, Toshiaki Kawano, Yoshinori Kadowaki, Satoru Kodama, Masashi Suzuki Source Type: research

The effect of peri-intraventricular hemorrhage on the auditory pathway of infants
To verify the effect of peri-intraventricular hemorrhage on the auditory pathway of preterm infants. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 13, 2018 Category: ENT & OMF Authors: Leticia Saia da Silva, Georgea Espindola Ribeiro, Jair Cortez Montovani, Daniela Polo Camargo Silva Source Type: research

Application of “banana cochleostomy” and looped electrode insertion for cochlear implantation in children with common cavity malformation and cystic forms of cochlear hypoplasia
Patients with profound hearing loss due to inner ear malformations may benefit from cochlear implantation; however, the surgery may present a substantial problem for the cochlear implant surgeon due to anatomical variations.The authors describe a new surgical and technical advancement for implantation in patients with small inner ear cavities that make the surgery easier and safer. On the basis of experience involving five consecutive surgeries performed in four patients with inner ear malformations, we present the advantages and application possibilities of the technique. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 12, 2018 Category: ENT & OMF Authors: J ózef Mierzwiński, Egwin Van Den Heuvel, Andrew J. Fishman, Arnaldo L. Rivera, Karolina Haber, Jiri Skrivan Source Type: research

Genetic heterogeneity of congenital hearing impairment in Algerians from the Gharda ïa province
Consanguinity rate is high in Algeria, and the population is thus at high risk for genetic diseases transmitted on an autosomal recessive mode. Inherited congenital hearing impairment (HI) is a highly heterogeneous disorder, which affects approximately 1 in 800 Algerian newborns. Several hundreds of genes responsible for deafness have been reported among which more than one hundred are responsible for isolated deafness, of which 19 have already been reported to be involved in the Algerian population. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 12, 2018 Category: ENT & OMF Authors: Sonia Talbi, Crystel Bonnet, Zied Riahi, Farid Boudjenah, Malika Dahmani, Jean-Pierre Hardelin, Fabienne Wong, Malek Louha, Fatima Ammar-Khodja, Christine Petit Source Type: research

Application of "banana cochleostomy" and looped electrode insertion for cochlear implantation in children with common cavity malformation and cystic forms of cochlear hypoplasia
Patients with profound hearing loss due to inner ear malformations may benefit from cochlear implantation; however, the surgery may present a substantial problem for the cochlear implant surgeon due to anatomical variations.The authors describe a new surgical and technical advancement for implantation in patients with small inner ear cavities that make the surgery easier and safer. On the basis of experience involving five consecutive surgeries performed in four patients with inner ear malformations, we present the advantages and application possibilities of the technique. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 12, 2018 Category: ENT & OMF Authors: Jozef Mierzwinski, Egwin Van Den Heuvel, Andrew J. Fishman, Arnaldo L. Riviera, Karolina Haber, Jiri Skrivan Source Type: research

Intracranial complications of pediatric sinusitis: Identifying risk factors associated with prolonged clinical course
Intracranial extension is one of the most serious and morbid complications of pediatric sinusitis. Managing this complication continues to be challenging even after widespread pneumococcal vaccination adoption. We aim to identify risk factors associated with complicated clinical courses, and to assess for altering microbial communities and increased antibiotic resistance. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 12, 2018 Category: ENT & OMF Authors: Alexander J. Schupper, Wen Jiang, Michael J. Coulter, Matthew Brigger, Javan Nation Source Type: research

Including auditory tube function on models is relevant to assess water exposure after tympanostomy tubes – multiphase computerized fluid dynamics model
Myringotomy with tympanostomy tube is the most common otologic surgery and some patients are still advised to avoid water. However, there is no evidence supporting this, with published papers questioning the need for this advice. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 12, 2018 Category: ENT & OMF Authors: Joao Subtil, Nuno Martins, Teresa Nunes, Didia Covas, Paulo Vera-Cruz, Richard Voegels, Joao Paco Source Type: research

Congenital right bronchial stenosis with high bifurcation: successful management with side to side tracheobronchial anastomosis
Congenital bronchial stenosis is a rare entity [1,2]. While there are some reports of congenital bronchial anomalies and their repair in the thoracic literature this is first report in the literature of a bronchial take off just below the larynx managed with surgical success. Here we present a case of a former 33-weeker born with a tracheoesophageal fistula, Tetralogy of Fallot, and a high bifurcation of the right mainstem bronchus with a concomitant long segment bronchial stenosis. Preoperative planning included printing 3-D reconstructed models of the airway to analyze various treatment options. (Source: International Jo...
Source: International Journal of Pediatric Otorhinolaryngology - June 11, 2018 Category: ENT & OMF Authors: Rachel Georgopoulos, Courtney Hill, Jeffrey S. Heinle, Deepak Mehta Tags: Case Report Source Type: research

Post-myringotomy oto-liquorrhea in children - a case study and literature review
Myringotomy is a surgical incision of tympanic membrane used mainly as therapy for acute otitis media. It is a safe and simple procedure; however possible complications must be considered. In this article is described a case study of a 2-and-a-half-year-old girl with a massive oto-liquorrhea following myringotomy. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 11, 2018 Category: ENT & OMF Authors: Milan Ur ík, Ivo Šlapák, David Laštovička, Jana Jančíková, Denisa Pavlovská, Dagmar Hošnová, Eliška Žarošská, Michaela Ťoukálková Tags: Case Report Source Type: research