International Journal of Mycobacteriology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Genetic diversity, transmission dynamics, and drug resistance of Mycobacterium tuberculosis in Luanda, Angola
Conclusion This first cross-sectional study conducted in Luanda, Angola, provides a framework for future studies and programmatic management of TB in Angola. We provide sufficient evidence for cluster-based transmission with a high predominance of LAM strains, with differential geographic dispersion. The moderate rate of MDR-TB found in this sample has major public health implications and highlights the need for further studies specifically focused on MDR-TB transmission. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - November 11, 2016 Category: Infectious Diseases Source Type: research
Susceptibility to pulmonary tuberculosis: host genetic deficiency in tumor necrosis factor alpha (TNF- α) gene and tumor necrosis factor receptor 2 (TNFR2)
Conclusion Concerning our current study, screening assessments for TNF-α-857 and A238GSNPs in Iran would be important in order to make future decisions for preventive treatments before getting the disease among individuals who are at high risk considering their genotyping. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - November 11, 2016 Category: Infectious Diseases Source Type: research
Activity of drugs against dormant Mycobacterium tuberculosis
Conclusion Lipophilic drugs were more active than hydrophilic agents against dormant Mtb in hypoxic conditions at pH 5.8. The Wayne model under slightly alkaline conditions was set up, and in hypoxic conditions at pH 7.3, rifampin and rifapentine were much more active than other drugs against NR Mtb. Overall, these models can be useful for testing drug activity against dormant Mtb under conditions mimicking the environments of cellular and caseous granulomas. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - November 11, 2016 Category: Infectious Diseases Source Type: research
Use of WGS in Mycobacterium tuberculosis routine diagnosis
Conclusion WGS is a rapid, cost-effective technique that promises to integrate and replace the other tests in routine laboratories for an accurate diagnosis of DR-TB, although it is suitable nowadays for cultured samples only. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - November 10, 2016 Category: Infectious Diseases Source Type: research
The importance of single nucleotide polymorphisms in interferon gamma receptor-1 gene in pulmonary patients infected with rapid grower mycobacterium
Conclusion There is a significant association between SNP of IFNGR1 at –56 and susceptibility to rapid grower infection. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - November 10, 2016 Category: Infectious Diseases Source Type: research
Changes in nitric oxide synthase and nitrite and nitrate serum levels in patients with or without multidrug-resistant tuberculosis undergoing the intensive phase of antituberculosis therapy
Conclusion In patients with pulmonary TB, significantly higher levels of NO activity were observed as compared with the levels in healthy individuals. In patients with recurrent TB and MDR-TB, significantly lower levels of NO indicators were observed in comparison with patients with newly diagnosed pulmonary TB. After 2months on chemotherapy, a significant decrease in iNOS activity and NO metabolites was observed in patients with pulmonary TB, but the decrease in NO indicators was manifested mostly in the newly diagnosed pulmonary TB patients and patients without MDR-TB as opposed to patients with recurrent TB and MDR-TB, ...
Source: International Journal of Mycobacteriology - November 10, 2016 Category: Infectious Diseases Source Type: research
Yield of mycobacteriological study in diagnosis of pleural tuberculosis among HIV-infected patients
Conclusion The diagnostic yield of mycobacteriological studies is higher among HIV-infected patients with TB pleurisy than among HIV-negative patients. This may decrease the need for pleural biopsy among them. Therefore, a diagnostic approach to TB pleurisy may be different among HIV-infected patients. In this group of patients, it is prudent to perform sputum and pleural analysis for the detection of AFB before pleural biopsy. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - November 10, 2016 Category: Infectious Diseases Source Type: research
Tuberculosis in slaughtered cattle and workers in some abattoirs of Baghdad governorate
Conclusion The main conclusion of this study is that two workers were infected with cattle’s strain which confirms the role of slaughtered cattle in the transmission of this dangerous, chronic, and zoonotic disease to man. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - November 10, 2016 Category: Infectious Diseases Source Type: research
The First population structure and comparative genomics analysis of Mycobacterium africanum strains from Ghana reveals higher diversity of Lineage 5
Conclusion This work emphasizes on the possibility that the mpt64-based rapid diagnostic kit would not be effective in MAF endemic settings. More mutations in ESAT-6 secretory system of MAF compared to MTB sensu stricto can affect efficacy of ESAT-6-based vaccines in the future. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - November 10, 2016 Category: Infectious Diseases Source Type: research
Discordance between GeneXpert assay and conventional drug-susceptibility testing in detecting rifampicin-resistant tuberculosis: A perspective of the line probe assay
Conclusion GeneXpert assay is a valid molecular test for TB and RRTB regardless of its discordance with conventional culture and DST. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - November 10, 2016 Category: Infectious Diseases Source Type: research
In vitro effects of water-pipe smoke condensate on the endocytic activity of Type II alveolar epithelial cells (A549) with bacillus Calmette –Guérin
Conclusion WPC exposure increased epithelial cells’ permeability and death and enhanced their capacity for macropinocytosis. Our in vitro data suggest possible harmful effects of WPC on the ability of lung epithelial cells to phagocytose mycobacteria. Further studies will be conducted to understand the mechanism of action of WPC. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - November 10, 2016 Category: Infectious Diseases Source Type: research
Overview of drug-resistant tuberculosis worldwide
Publication date: Available online 11 November 2016 Source:International Journal of Mycobacteriology Author(s): Ali A. Velayati, Parissa Farnia, Amir M. Farahbod Even in the 21st century, we are losing the battle against eradication of tuberculosis (TB). In 2015, 9.6 million people were estimated to have fallen ill with TB, of which 1.5 million people died. This is the real situation despite the well-structured treatment programs and availability of effective treatment options since the 1950s. The high mortality rate has been associated with other risk factors, such as the HIV epidemic, underlying diseases, and declin...
Source: International Journal of Mycobacteriology - November 10, 2016 Category: Infectious Diseases Source Type: research
Importance of the α10 helix for DevR activation: A road map for screening inhibitors against DevR-mediated dormancy of Mycobacterium tuberculosis
Conclusion This study established the importance of the α10 helix for DevR activation in M. tuberculosis and proposed a novel molecular tool to screen small-molecule inhibitors targeting dimerization of DevR in the absence (inactive state) or presence of phosphorylation (active state) to combat latent TB infection. This concept can be extended to screen inhibitors against response regulators where dimerization is crucial for their activation. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - November 10, 2016 Category: Infectious Diseases Source Type: research
Characterization of the CD4 and CD8 T-cell response in the QuantiFERON-TB Gold Plus kit
Conclusion This is the first characterization of CD4 and CD8 T-cell responses to QFT-Plus TB1 and TB2 tubes in individuals with active TB and LTBI enrolled in a low TB-endemic country such as Italy. We demonstrated that the increased sensitivity is a consequence of the ability of TB2 to induce a CD8 T-cell response which is mainly associated with active TB. This assay has the potential to be very useful in conditions of immune depression due to CD4 T-cell impairments. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - November 10, 2016 Category: Infectious Diseases Source Type: research
Evaluation of the Kudoh method for mycobacterial culture: Gambia experience
Conclusion The Kudoh method is simpler and cheaper than the NALC-NaOH method. There was no significant difference in recovery between the methods. The Kudoh method is ideal in overburdened TB laboratories with poor resources in developing countries. The predominant lineages were Euro-American and Indo-Oceanic, followed by M. africanum (West African type 2). (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - November 10, 2016 Category: Infectious Diseases Source Type: research
