International Journal of Gynecological Cancer This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Can Teamwork and High-Volume Experience Overcome Challenges of Lymphadenectomy in Morbidly Obese Patients (Body Mass Index of 40 kg/m2 or Greater) with Endometrial Cancer?: A Cohort Study of Robotics and Laparotomy and Review of Literature
This study aimed to compare surgical outcomes and the adequacy of surgical staging in morbidly obese women with a body mass index (BMI) of 40 kg/m2 or greater who underwent robotic surgery or laparotomy for the staging of endometrioid-type endometrial cancer. Methods This is a retrospective cohort study of patients who underwent surgical staging between May 2011 and June 2014. Patients' demographics, surgical outcomes, intraoperative and postoperative complications, and pathological outcomes were compared. Results Seventy-six morbidly obese patients underwent robotic surgery, and 35 underwent laparotomy for surgical ...
Source: International Journal of Gynecological Cancer - May 23, 2018 Category: Cancer & Oncology Tags: Surgeons Corner Source Type: research

Robotic-Assisted Infrarenal Para-aortic Lymphadenectomy in Gynecological Cancers: Technique and Surgical Outcomes
Conclusions Using the transperitoneal technique for PALND, the area between IMA and the renal veins can be reached in more than 80% of the operations, with a very low or 2.5% conversion rate. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - May 23, 2018 Category: Cancer & Oncology Tags: Surgeons Corner Source Type: research

Ovarian Cancer Surgery in Australia and New Zealand: A Survey to Determine Changes in Surgical Practice Over 10 Years
This study aimed to survey all practicing certified gynecological oncologists (CGOs) in Australia and New Zealand to determine their current surgical practice for primary advanced epithelial ovarian cancer (EOC) and compare the findings with an identical survey conducted 10 years previously. Methods/Materials A questionnaire was e-mailed to all 53 practicing CGOs in Australia and New Zealand in July 2017 assessing their definition of optimal debulking for EOC, their use of neoadjuvant chemotherapy, and the surgical procedures they use to achieve cytoreduction. Results were compared with an identical study performed in 2...
Source: International Journal of Gynecological Cancer - May 23, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Combined Plasma Fibrinogen and Neutrophil Lymphocyte Ratio in Ovarian Cancer Prognosis May Play a Role?
Objectives In ovarian cancer (OC), approximately 70% will relapse within 12 months from diagnosis; inflammation plays an important role in cancer initiating and progression; thus, a combination of neutrophil-to-lymphocyte ratio (NLR) and fibrinogen (F-NLR) has been proposed as prognostic marker in several tumors. The aim of our study was to investigate the correlation between NLR, fibrinogen, and F-NLR and survival in OC population. Methods Patients with diagnosis of OC admitted to our institute between 2011 and 2016 were included. Data about pretreatment complete blood count were collected. Neutrophil-to-lymphocyte r...
Source: International Journal of Gynecological Cancer - May 23, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Small Cell Carcinoma of the Ovary: A Rare Tumor With a Poor Prognosis
Objective The aim of this study was to investigate the demographic and clinicopathological characteristics and prognosis of women diagnosed with small cell carcinoma of the ovary. Methods The National Cancer Data Base was accessed, and women diagnosed with small cell carcinoma of the ovary, between 2004 and 2014 were identified. Median and 3- and 5-year overall survival (OS) rates were calculated following generation of Kaplan-Meir curves and compared with the log-rank test. A Cox multivariate model was constructed to identify variables associated with mortality. Results A total 469 women were identified with a med...
Source: International Journal of Gynecological Cancer - May 23, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Examining Survival Outcomes of 852 Women With Advanced Ovarian Cancer: A Multi-institutional Cohort Study
This study examines patterns of clinical practice in the management of women with advanced high-grade serous ovarian carcinoma (HGSC). Methods A total of 852 patients with advanced HGSC were included in this retrospective cohort analysis. Patients underwent primary cytoreductive surgery (PCS) or neoadjuvant chemotherapy (NACT). Wilcoxon rank-sum test and χ2 test were applied. Univariate- and multivariate-analyses were performed, and survival outcomes were measured using Kaplan–Meier curves. Results A total of 449 (53%) of 852 patients underwent PCS, and 403(47%) of 852 patients underwent NACT. The median 5-year ov...
Source: International Journal of Gynecological Cancer - May 23, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

International Study of Primary Mucinous Ovarian Carcinomas Managed at Tertiary Medical Centers
Conclusions Most patients (74%) presented with stage I disease. Nearly 50% were treated with adjuvant chemotherapy using various regimens across institutions. The PFS outcomes were favorable for those with early-stage disease and lower but acceptable for those who underwent fertility preservation. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - May 23, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Angiogenesis Inhibitors for the Treatment of Ovarian Cancer: An Updated Systematic Review and Meta-analysis of Randomized Controlled Trials
Conclusions Combination treatment with angiogenesis inhibitors and chemotherapy significantly improved PFS and OS in both patients with high-risk of progression and recurrent ovarian cancer, with an increased incidence of common adverse events. Conversely, we detected no statistically significant survival benefit in the pure maintenance setting. The main limitation of the review is clinical heterogeneity across the studies. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - May 23, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Cellular Senescence in the Treatment of Ovarian Cancer
Conclusions In the near future, cellular senescence therapy could be a powerful tool for ovarian cancer treatment. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - May 23, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Prognostic Significance of Lymphovascular Space Invasion in the Absence of Lymph Node Metastases in Early-Stage Endometrial Cancer
This study aimed to determine if LVSI provides any prognostic significance in pathologic node-negative surgically staged (T1N0) endometrial cancer patients. Methods/Materials This retrospective cohort study included all patients with pathologic stage T1N0 endometrial carcinoma treated at The Ottawa Hospital Cancer Centre from 1998 to 2007. Patient demographics, pathologic findings, treatment, and outcome data were collected. Univariate and multivariate cox regression modeling was used to assess significance and adjust for demographic and histopathologic covariates. Kaplan-Meier curves were used to estimate the 5-year ov...
Source: International Journal of Gynecological Cancer - May 23, 2018 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research

Factors Predictive of Receiving Adjuvant Radiotherapy in High-Intermediate–Risk Stage I Endometrial Cancer
Objectives Randomized trials have shown a local control benefit with adjuvant radiotherapy (RT) in high-intermediate–risk endometrial cancer patients, although not all such patients receive RT. We reviewed the National Cancer Data Base to investigate which patient/tumor-related factors are associated with delivery of adjuvant RT. Methods The National Cancer Data Base was queried for patients diagnosed with International Federation of Gynecology and Obstetrics 2009 stage I endometrioid adenocarcinoma from 1998 to 2012 who underwent surgery +/− adjuvant RT. Exclusion criteria were unknown stage/grade, nonsurgical pr...
Source: International Journal of Gynecological Cancer - May 23, 2018 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research

Blood Vessel Invasion Is a Strong Predictor of Postoperative Recurrence in Endometrial Cancer
Objectives Although lymphovascular space invasion is a prognostic factor for the recurrence of resectable endometrial cancer, the differential impacts of lymphatic vessel invasion (LVI) and blood vessel invasion (BVI) on the recurrence of endometrial cancer are poorly described. We investigated the prognostic significance of LVI and BVI on the recurrence of endometrial cancer and their association with patterns of recurrence. Methods We retrospectively reviewed 376 patients with stage I to III endometrial cancer who underwent surgery with curative intent at our institution between 2007 and 2015. The associations of th...
Source: International Journal of Gynecological Cancer - May 23, 2018 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research

Comparison of Mayo and Milwaukee Risk Stratification Models for Predicting Lymph Node Metastasis in Endometrial Cancer
Conclusions Although Milwaukee risk stratification model had a lower false positive rate and can decrease the number of lymphadenectomies, FNR of this new model was found as 10.7% in the present study. Furthermore, we found that Mayo model had a lower FNR and higher sensitivity. Therefore, Mayo model still looks more beneficial to predict lymph node metastasis in patients with endometrioid EC and Milwaukee risk stratification model still requires external validation. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - May 23, 2018 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research

A Predictor of Tumor Recurrence in Patients With Endometrial Carcinoma After Complete Resection of the Tumor: The Role of Pretreatment Apparent Diffusion Coefficient
Conclusions Pretreatment tumor ADCmean and nADCmean were important imaging biomarkers for predicting recurrence in patients after complete resection of the tumor. They might improve existing risk stratification. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - May 23, 2018 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research

Patterns of Recurrence, Long-term Survival and Toxicity Analysis of Endometrial Adenocarcinoma Patients Reclassified Under the Recent ESMO-ESGO-ESTRO Stratification: Seven-Year Results From a Single Institution
Conclusions Recurrence rates, survival rates, and the patterns of recurrence are comparable with published literature and partly validates the ESMO-ESGO-ESTRO consensus statement. Addition of EBRT significantly increases risk of late proctitis as compared with VBT alone. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - May 23, 2018 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research