International Journal of Gynecological Cancer This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Number of Nodes Removed With Inguinofemoral Lymphadenectomy and Risk of Isolated Groin Recurrence in Women With FIGO Stage IB–II Squamous Cell Vulvar Cancer
Conclusions Women treated for vulvar cancer in which less than 6 nodes are removed from each groin are at higher risk of groin recurrence. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Vulvar Cancer Source Type: research

Bevacizumab in Metastatic, Recurrent, or Persistent Cervical Cancer: The BC Cancer Experience
Conclusions In this population-based analysis, the combination of bevacizumab and platinum–based chemotherapy as first-line therapy for metastatic, recurrent, or persistent cervical carcinoma was safely delivered and had outcomes comparable to results from the GOG 240 phase III trial. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Cervical Cancer Source Type: research

Prophylactic Extended-Field Irradiation for Patients With Cervical Cancer Treated With Concurrent Chemoradiotherapy: A Propensity-Score Matching Analysis
Conclusions Prophylactic extended-field RT was associated with decreased distant failure and PALNF and showed a trend in improving DFS in patients with cervical cancer treated with CCRT. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Cervical Cancer Source Type: research

Propensity Score Analysis of Radical Hysterectomy Versus Definitive Chemoradiation for FIGO Stage IIB Cervical Cancer
Conclusions The results of this study suggest that RH with adjuvant radiotherapy and definitive CRT are equivalent treatment options for patients with FIGO stage IIB cancer. However, prospective larger studies are needed to confirm this. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Cervical Cancer Source Type: research

Radical Surgery in Advanced Cervical Cancer Patients Receiving Bevacizumab-Containing Chemotherapy: A “Real Life Experience”
Conclusions Radical surgery can be performed in women with CC previously treated with a bevacizumab-containing regimen. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Cervical Cancer Source Type: research

Rising Rates of Upfront Surgery in Early Locally Advanced Cervical Cancer: What Factors Predict for This Treatment Paradigm?
In this study, we analyzed patterns of care for patients with locally advanced cervical cancer to identify predictors for upfront surgery compared with definitive chemoradiation (CRT). Methods The National Cancer Database was queried for patients aged 18 years or older with Federation of Gynecology and Obstetrics IB2–IIB cervical cancer. All patients underwent either upfront hysterectomy with or without postoperative radiation therapy versus definitive CRT. Logistic regression was used to assess variables associated with modality of treatment (surgery vs CRT). Results Of the 9494 patients included, 2151 (22.7%) und...
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Cervical Cancer Source Type: research

The Utility of Pretreatment and Posttreatment Lymphopenia in Cervical Squamous Cell Carcinoma Patients Treated With Definitive Chemoradiotherapy
Objective The aim of this study was to investigate the prognostic significance of pretreatment and posttreatment lymphopenia in locally advanced squamous cell carcinoma (SCC) cervical cancer patients treated with definitive chemoradiotherapy (ChRT). Methods Data from 95 patients with SCC were retrospectively analyzed. Relationships between pretreatment or posttreatment lymphopenia and patient or tumor characteristics, and overall survival (OS) and disease-free survival (DFS) were evaluated. Results Median follow-ups for the entire cohort and survivors were 68 months (range, 3–133 months) and 88 months (range, 22�...
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Cervical Cancer Source Type: research

Tumor Size at Magnetic Resonance Imaging Association With Lymph Node Metastasis and Lymphovascular Space Invasion in Resectable Cervical Cancer: A Multicenter Evaluation of Surgical Specimens
Objective To determine whether gross tumor volume (GTV) and the maximum diameter of resectable cervical cancer at magnetic resonance imaging (MRI) could predict lymph node metastasis (LNM) and lymphovascular space invasion (LVSI). Materials and Methods A total of 315 consecutive patients with cervical cancer were retrospectively identified. Gross tumor volume and the maximum diameter of tumor were evaluated on MRI. Univariate and multivariate logistic regression analyses were performed to determine whether tumor size could predict LNM and LVSI. Cutoffs of GTV, maximum diameter, and the International Federation of Gyne...
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Cervical Cancer Source Type: research

Characterization of Primary Cilia in Normal Fallopian Tube Epithelium and Serous Tubal Intraepithelial Carcinoma
Objectives The aim of this study was to investigate the distribution of primary cilia on secretory cells in normal fallopian tube (FT) and serous tubal intraepithelial carcinoma (STIC). Methods Fallopian tube tissue samples were obtained from 4 females undergoing prophylactic hysterectomies and 6 patients diagnosed with STIC. A mogp-TAg transgenic mouse STIC sample was also compared with a wild-type mouse FT sample. Serous tubal intraepithelial carcinoma was identified by hematoxylin and eosin staining and confirmed by positive Ki-67 and p53 immunohistochemical staining of tissue sections. We assessed the relative dis...
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Basic Science Source Type: research

Other Primary Malignancies Among Women With Adult-Type Ovarian Granulosa Cell Tumors
Conclusions There is an increased risk for thyroid and soft tissue cancer as well as leukemia after AGCT, which may be associated with late effects of carcinogenic treatments and possibly shared risk factors. After breast cancer, the risk for AGCT was higher, which may indicate a shared hormonal etiology. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Predictive Factors for Surgical Morbidities and Adjuvant Chemotherapy Delay for Advanced Ovarian Cancer Patients Treated by Primary Debulking Surgery or Interval Debulking Surgery
Conclusions Comorbidities and intraoperative bleeding are the most relevant findings related to surgical complications. Surgical approach (PDS or IDS) was not related with complications. Surgical complications were significantly related to ACD. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

The BRCA1 Methylation and PD-L1 Expression in Sporadic Ovarian Cancer
Conclusions This is the first study linking BRCA1 hypermethylation variability to PD-L1 protein expression and the clinicopathologic features of OC. The data demonstrated that an epigenetic alteration of BRCA1 was closely associated with serous OC. The expression of PD-L1 was unrelated to the clinicopathologic features or BRCA1 hypermethylation in sporadic OC. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Stereotactic Body Radiation Therapy in Oligometastatic Ovarian Cancer: A Promising Therapeutic Approach
Conclusions In conclusion, SBRT is a feasible and safe approach for selected cases of oligometastatic ovarian cancer, with satisfactory results in terms of LC and disease free survival. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Efficacy of Neoadjuvant Therapy With Cisplatin Plus Mitomycin C in BRCA1-Mutated Ovarian Cancer
Conclusions The combination of cisplatin plus mitomycin C showed promising results in BRCA1-driven OC and therefore deserves further clinical evaluation. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Clinical Outcome After Completion Surgery in Patients With Ovarian Cancer: The Charite Experience
Conclusions Recent research has shown that the most profound impact on survivorship occurs when women get proper care from surgeons trained in the latest techniques for treating ovarian cancer. Completion surgery maintained that even after initial incomplete cytoreduction outside of the high specialized units, after applying appropriate surgery techniques macroscopically, disease-free situation is achievable and outcomes are comparable with the results of primary debulking surgery. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research