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Low-no-calorie sweeteners exert marked compound-specific impact on the human gut microbiota < em > ex vivo < /em >
This study investigated how a range of sweeteners [tagatose (TA)/maltitol (MA)/sorbitol (SO)/stevia (ST)/sucralose (SU)/acesulfame K (ACK)] impact the gut microbiota of T2D subjects and healthy human adults using the ex vivo SIFR® technology (n = 12). The cohort covered clinically relevant interpersonal and T2D-related differences. ACK/SU remained intact while not impacting microbial composition and metabolite production. In contrast, TA/SO and ST/MA were respectively readily and gradually fermented. ST and particularly TA/SO/MA increased bacterial density and SCFA production product-specifically: SO increased acetate (âˆ...
Source: International Journal of Food Sciences and Nutrition - August 4, 2023 Category: Nutrition Authors: Pieter Van den Abbeele Jonas Poppe Stef Deyaert Ieva Laurie Thorsten Klaus Otto Gravert Anna Abrahamsson Aur élien Baudot Kavita Karnik Davide Risso Source Type: research

Cross-linked phosphorylated RS4 wheat starch reduces glucose and insulin responses after 3 days of pre-feeding in healthy adults: an acute, double-blind, randomized controlled clinical trial
Int J Food Sci Nutr. 2023 Jul 20:1-9. doi: 10.1080/09637486.2023.2236809. Online ahead of print.ABSTRACTWhen this project was designed, there was no evidence that adding resistant starch to available carbohydrate (avCHO) reduced glycaemic and insulinaemic responses (GIR). We compared GIR elicited by a cookie containing cross-linked phosphorylated RS4 wheat starch (Fibersym®) (RS4XL) versus an avCHO-matched control-cookie (CC) after n = 15 adults had consumed RS4XL or CC daily for 3-days using a double-blind, randomised, cross-over design. The difference in glucose iAUC over 0-2 h (primary endpoint) (mmol × min/L) after R...
Source: International Journal of Food Sciences and Nutrition - July 21, 2023 Category: Nutrition Authors: Thomas M S Wolever Clodualdo C Maningat Paul A Seib Janice E Campbell Alexandra L Jenkins Source Type: research

Normal diet ameliorates obesity more safely and effectively than ketogenic diet does in high-fat diet-induced obesity mouse based on gut microbiota and lipid metabolism
Int J Food Sci Nutr. 2023 Jul 20:1-17. doi: 10.1080/09637486.2023.2235899. Online ahead of print.ABSTRACTGrowing evidence supports the efficacy of ketogenic diets for inducing weight loss, but there are also potential health risks due to their unbalanced nutrient composition. We aim at assessing relative effectiveness of a balanced diet and ketogenic diet for reversing metabolic syndrome in a diet-induced C57BL/6J mouse model. Mice were fed high-fat diet to induce obesity. Obese individuals were then fed either ketogenic or balanced diets as an obesity intervention. Serum, liver, fat and faecal samples were analysed. We ob...
Source: International Journal of Food Sciences and Nutrition - July 21, 2023 Category: Nutrition Authors: Yunlong Dong Hongjie Song Andrew J Holmes Jiabao Yan Cuiru Ren Ying Zhang Wei Zhao Jianhui Yuan Yuyang Cheng David Raubenheimer Zhenwei Cui Source Type: research

Cross-linked phosphorylated RS4 wheat starch reduces glucose and insulin responses after 3 days of pre-feeding in healthy adults: an acute, double-blind, randomized controlled clinical trial
Int J Food Sci Nutr. 2023 Jul 20:1-9. doi: 10.1080/09637486.2023.2236809. Online ahead of print.ABSTRACTWhen this project was designed, there was no evidence that adding resistant starch to available carbohydrate (avCHO) reduced glycaemic and insulinaemic responses (GIR). We compared GIR elicited by a cookie containing cross-linked phosphorylated RS4 wheat starch (Fibersym®) (RS4XL) versus an avCHO-matched control-cookie (CC) after n = 15 adults had consumed RS4XL or CC daily for 3-days using a double-blind, randomised, cross-over design. The difference in glucose iAUC over 0-2 h (primary endpoint) (mmol × min/L) after R...
Source: International Journal of Food Sciences and Nutrition - July 21, 2023 Category: Nutrition Authors: Thomas M S Wolever Clodualdo C Maningat Paul A Seib Janice E Campbell Alexandra L Jenkins Source Type: research

Normal diet ameliorates obesity more safely and effectively than ketogenic diet does in high-fat diet-induced obesity mouse based on gut microbiota and lipid metabolism
Int J Food Sci Nutr. 2023 Jul 20:1-17. doi: 10.1080/09637486.2023.2235899. Online ahead of print.ABSTRACTGrowing evidence supports the efficacy of ketogenic diets for inducing weight loss, but there are also potential health risks due to their unbalanced nutrient composition. We aim at assessing relative effectiveness of a balanced diet and ketogenic diet for reversing metabolic syndrome in a diet-induced C57BL/6J mouse model. Mice were fed high-fat diet to induce obesity. Obese individuals were then fed either ketogenic or balanced diets as an obesity intervention. Serum, liver, fat and faecal samples were analysed. We ob...
Source: International Journal of Food Sciences and Nutrition - July 21, 2023 Category: Nutrition Authors: Yunlong Dong Hongjie Song Andrew J Holmes Jiabao Yan Cuiru Ren Ying Zhang Wei Zhao Jianhui Yuan Yuyang Cheng David Raubenheimer Zhenwei Cui Source Type: research

Cross-linked phosphorylated RS4 wheat starch reduces glucose and insulin responses after 3 days of pre-feeding in healthy adults: an acute, double-blind, randomized controlled clinical trial
Int J Food Sci Nutr. 2023 Jul 20:1-9. doi: 10.1080/09637486.2023.2236809. Online ahead of print.ABSTRACTWhen this project was designed, there was no evidence that adding resistant starch to available carbohydrate (avCHO) reduced glycaemic and insulinaemic responses (GIR). We compared GIR elicited by a cookie containing cross-linked phosphorylated RS4 wheat starch (Fibersym®) (RS4XL) versus an avCHO-matched control-cookie (CC) after n = 15 adults had consumed RS4XL or CC daily for 3-days using a double-blind, randomised, cross-over design. The difference in glucose iAUC over 0-2 h (primary endpoint) (mmol × min/L) after R...
Source: International Journal of Food Sciences and Nutrition - July 21, 2023 Category: Nutrition Authors: Thomas M S Wolever Clodualdo C Maningat Paul A Seib Janice E Campbell Alexandra L Jenkins Source Type: research

Normal diet ameliorates obesity more safely and effectively than ketogenic diet does in high-fat diet-induced obesity mouse based on gut microbiota and lipid metabolism
Int J Food Sci Nutr. 2023 Jul 20:1-17. doi: 10.1080/09637486.2023.2235899. Online ahead of print.ABSTRACTGrowing evidence supports the efficacy of ketogenic diets for inducing weight loss, but there are also potential health risks due to their unbalanced nutrient composition. We aim at assessing relative effectiveness of a balanced diet and ketogenic diet for reversing metabolic syndrome in a diet-induced C57BL/6J mouse model. Mice were fed high-fat diet to induce obesity. Obese individuals were then fed either ketogenic or balanced diets as an obesity intervention. Serum, liver, fat and faecal samples were analysed. We ob...
Source: International Journal of Food Sciences and Nutrition - July 21, 2023 Category: Nutrition Authors: Yunlong Dong Hongjie Song Andrew J Holmes Jiabao Yan Cuiru Ren Ying Zhang Wei Zhao Jianhui Yuan Yuyang Cheng David Raubenheimer Zhenwei Cui Source Type: research

Cross-linked phosphorylated RS4 wheat starch reduces glucose and insulin responses after 3 days of pre-feeding in healthy adults: an acute, double-blind, randomized controlled clinical trial
Int J Food Sci Nutr. 2023 Jul 20:1-9. doi: 10.1080/09637486.2023.2236809. Online ahead of print.ABSTRACTWhen this project was designed, there was no evidence that adding resistant starch to available carbohydrate (avCHO) reduced glycaemic and insulinaemic responses (GIR). We compared GIR elicited by a cookie containing cross-linked phosphorylated RS4 wheat starch (Fibersym®) (RS4XL) versus an avCHO-matched control-cookie (CC) after n = 15 adults had consumed RS4XL or CC daily for 3-days using a double-blind, randomised, cross-over design. The difference in glucose iAUC over 0-2 h (primary endpoint) (mmol × min/L) after R...
Source: International Journal of Food Sciences and Nutrition - July 21, 2023 Category: Nutrition Authors: Thomas M S Wolever Clodualdo C Maningat Paul A Seib Janice E Campbell Alexandra L Jenkins Source Type: research

Normal diet ameliorates obesity more safely and effectively than ketogenic diet does in high-fat diet-induced obesity mouse based on gut microbiota and lipid metabolism
Int J Food Sci Nutr. 2023 Jul 20:1-17. doi: 10.1080/09637486.2023.2235899. Online ahead of print.ABSTRACTGrowing evidence supports the efficacy of ketogenic diets for inducing weight loss, but there are also potential health risks due to their unbalanced nutrient composition. We aim at assessing relative effectiveness of a balanced diet and ketogenic diet for reversing metabolic syndrome in a diet-induced C57BL/6J mouse model. Mice were fed high-fat diet to induce obesity. Obese individuals were then fed either ketogenic or balanced diets as an obesity intervention. Serum, liver, fat and faecal samples were analysed. We ob...
Source: International Journal of Food Sciences and Nutrition - July 21, 2023 Category: Nutrition Authors: Yunlong Dong Hongjie Song Andrew J Holmes Jiabao Yan Cuiru Ren Ying Zhang Wei Zhao Jianhui Yuan Yuyang Cheng David Raubenheimer Zhenwei Cui Source Type: research

Cross-linked phosphorylated RS4 wheat starch reduces glucose and insulin responses after 3 days of pre-feeding in healthy adults: an acute, double-blind, randomized controlled clinical trial
Int J Food Sci Nutr. 2023 Jul 20:1-9. doi: 10.1080/09637486.2023.2236809. Online ahead of print.ABSTRACTWhen this project was designed, there was no evidence that adding resistant starch to available carbohydrate (avCHO) reduced glycaemic and insulinaemic responses (GIR). We compared GIR elicited by a cookie containing cross-linked phosphorylated RS4 wheat starch (Fibersym®) (RS4XL) versus an avCHO-matched control-cookie (CC) after n = 15 adults had consumed RS4XL or CC daily for 3-days using a double-blind, randomised, cross-over design. The difference in glucose iAUC over 0-2 h (primary endpoint) (mmol × min/L) after R...
Source: International Journal of Food Sciences and Nutrition - July 21, 2023 Category: Nutrition Authors: Thomas M S Wolever Clodualdo C Maningat Paul A Seib Janice E Campbell Alexandra L Jenkins Source Type: research

Normal diet ameliorates obesity more safely and effectively than ketogenic diet does in high-fat diet-induced obesity mouse based on gut microbiota and lipid metabolism
Int J Food Sci Nutr. 2023 Jul 20:1-17. doi: 10.1080/09637486.2023.2235899. Online ahead of print.ABSTRACTGrowing evidence supports the efficacy of ketogenic diets for inducing weight loss, but there are also potential health risks due to their unbalanced nutrient composition. We aim at assessing relative effectiveness of a balanced diet and ketogenic diet for reversing metabolic syndrome in a diet-induced C57BL/6J mouse model. Mice were fed high-fat diet to induce obesity. Obese individuals were then fed either ketogenic or balanced diets as an obesity intervention. Serum, liver, fat and faecal samples were analysed. We ob...
Source: International Journal of Food Sciences and Nutrition - July 21, 2023 Category: Nutrition Authors: Yunlong Dong Hongjie Song Andrew J Holmes Jiabao Yan Cuiru Ren Ying Zhang Wei Zhao Jianhui Yuan Yuyang Cheng David Raubenheimer Zhenwei Cui Source Type: research

Cross-linked phosphorylated RS4 wheat starch reduces glucose and insulin responses after 3 days of pre-feeding in healthy adults: an acute, double-blind, randomized controlled clinical trial
Int J Food Sci Nutr. 2023 Jul 20:1-9. doi: 10.1080/09637486.2023.2236809. Online ahead of print.ABSTRACTWhen this project was designed, there was no evidence that adding resistant starch to available carbohydrate (avCHO) reduced glycaemic and insulinaemic responses (GIR). We compared GIR elicited by a cookie containing cross-linked phosphorylated RS4 wheat starch (Fibersym®) (RS4XL) versus an avCHO-matched control-cookie (CC) after n = 15 adults had consumed RS4XL or CC daily for 3-days using a double-blind, randomised, cross-over design. The difference in glucose iAUC over 0-2 h (primary endpoint) (mmol × min/L) after R...
Source: International Journal of Food Sciences and Nutrition - July 21, 2023 Category: Nutrition Authors: Thomas M S Wolever Clodualdo C Maningat Paul A Seib Janice E Campbell Alexandra L Jenkins Source Type: research