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Publication date: July–December 2017 Source:International Journal of Epilepsy, Volume 4, Issue 2 (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - December 13, 2017 Category: Neurology Source Type: research
Teaching EES series
Publication date: July–December 2017 Source:International Journal of Epilepsy, Volume 4, Issue 2 (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - December 13, 2017 Category: Neurology Source Type: research
From the Editor ’s Desk
Publication date: July–December 2017 Source:International Journal of Epilepsy, Volume 4, Issue 2 Author(s): Man Mohan Mehndiratta (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - December 13, 2017 Category: Neurology Source Type: research
Evaluation of DNA damage and mutation screening of exon 26 of SCN1A gene in patients with epilepsy
Conclusion These data confirmed that there is certainly DNA damage and mutations in the SCN1A gene; hence the genetic instability has occurred in epileptic patients. (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - November 13, 2017 Category: Neurology Source Type: research
Disseminated cysticercosis and role of spin echo short tau inversion recovery sequence imaging: case based review
Publication date: Available online 28 October 2017 Source:International Journal of Epilepsy Author(s): Lakshmi Narasimhan Ranganathan, Venkatraman Karthikeayan, Arun Shivaraman MM, Guhan R, Venkateswaran KJ, Thamil Pavai N, Manmohan Mehndiratta (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - October 28, 2017 Category: Neurology Source Type: research
Correlation of Medial Temporal Lobe Atrophy with Seizures in Alzheimer ’s disease and Mild Cognitive Impairment: A case control study
Conclusions Seizures are common in dementia of Alzheimer’s type and not uncommon in MCI. They have the potential to worsen the cognitive profile of the patient and need attention in these patients. (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - October 27, 2017 Category: Neurology Source Type: research
Involvement of N-methyl-D-aspartate receptors and nitric oxide in the anticonvulsant effects of dantrolene against pentylenetetrazole-induced seizures in mice
Conclusion Dantrolene protected animals against PTZ-induced seizures and mortality. The inhibition of NO synthase and NMDA receptors may contribute to the dantrolene anticonvulsant effects on the PTZ-induced seizure. (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - October 11, 2017 Category: Neurology Source Type: research
Amelioration of caffeine-induced seizures by modulators of sigma, N-methyl-d-Aspartate and ryanodine receptors in mice
Conclusion Opipramol attenuated seizures produced by high doses of caffeine. Moreover, the activation of sigma receptors and inhibition of ryanodine receptors may produce synergistic effects against caffeine-induced seizures. Our study may imply that different mechanisms such as inhibition of gamma-aminobutyric acid-A receptors, activation of NMDA and ryanodine receptors may contribute to the caffeine-induced seizures. (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - September 29, 2017 Category: Neurology Source Type: research
A Fatal Case of Valproate-Induced Hyperammonemic Encephalopathy: an update on proposed pathogenic mechanisms and treatment options
Publication date: Available online 14 September 2017 Source:International Journal of Epilepsy Author(s): Gloria Wai Yue Yeung, Kei Wai Chau, Yat Ming Peter Woo, Hoi Tung Wong, Kwong Yau Chan (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - September 15, 2017 Category: Neurology Source Type: research
Divergent Interaction Profiles of Gabapentin and Levetiracetam with Dipalmitoylphosphatidylcholine Lipids
Conclusions According to the corresponding findings depending on concentrations both drugs incorporate into phosphatidylcholines, perturbing the packing of lipids and affecting their thermotropic properties. Their binding affinity to acyl chains and hydrophilic parts of lipids was found to highly correlate with lipid-water partition and their solubility degree in water. Hence, the obtained results may offer evaluation of partition profile of the drugs into biological membranes depending on concentration. (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - September 15, 2017 Category: Neurology Source Type: research
GM2 Activator Protein Deficiency, Mimic Of Tay-Sachs Disease
We report a case of a female child who presented with clinical features similar to classical Tay-Sachs disease, but with normal beta hexosaminidase enzyme levels. Molecular study revealed a novel homozygous intronic mutation which confirmed the diagnosis of GM2 Activator protein deficiency. GM2 Activator protein deficiency is a mimic of Classical Tay-Sachs disease and should be a differential diagnosis in children who present with neuroregression, cherry red spots without hepatosplenomegaly and with normal beta hexosaminidase enzyme levels. (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - August 17, 2017 Category: Neurology Source Type: research
Hypermotor Seizures without Involvement of the Frontal Lobes
Publication date: Available online 16 August 2017 Source:International Journal of Epilepsy Author(s): Sikawat Thanaviratananich, Asim Shahid, Hans O. Lüders (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - August 16, 2017 Category: Neurology Source Type: research
Taurine supplementation to anti-seizure drugs as the promising approach to treat pharmacoresistant epilepsy: A pre-clinical study
Conclusions These findings emphasize that supplementation of taurine with ASDs may be useful to treat pharmacoresistant epilepsy. Thus, further clinical validation is encouraged. (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - July 26, 2017 Category: Neurology Source Type: research
Correlation between serum and salivary phenytoin drug metabolite levels to phenytoin influenced gingival overgrowth in adult male subjects. A prospective cohort study
Conclusion No correlation between the drug concentration in either the serum or saliva can be correlated to PIGO. Whole Saliva could be a useful tool in therapeutic drug monitoring of phenytoin. (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - July 19, 2017 Category: Neurology Source Type: research
Cognitive deficits in the first 24hours after the onset of first unprovoked generalized Tonic and clonic seizure
Conclusion Our data suggested that even with a one-time seizure episode, patients are susceptible to verbal memory impairment. (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - June 16, 2017 Category: Neurology Source Type: research
