International Journal of Clinical Practice This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Symptoms at presentation to the emergency department: Predicting outcomes and changing clinical practice?
ConclusionThe number of symptoms did not correlate with the main adverse outcomes (ICU‐admission and in‐hospital mortality). However, clinical practice was influenced by the nature and number of symptoms. This was shown by associations with hospitalisation, length‐of‐stay, use of resources and follow‐up presentations. Furthermore, the number of symptoms correlated with the caregivers’ disease severity ratings and the attributed triage categories. This may indicate that caregivers respond to the number of symptoms by a higher investment in their immediate work‐ups and later follow‐ups. (Source: International...
Source: International Journal of Clinical Practice - October 1, 2017 Category: Internal Medicine Authors: Karin Weigel, Christian H. Nickel, Alexandra Malinovska, Roland Bingisser Tags: ORIGINAL PAPER Source Type: research

Effects of exenatide twice daily, exenatide once weekly or insulin in patients with type 2 diabetes and baseline HbA1c ≥10.0%: Two pooled analyses including 20 randomised controlled trials
ConclusionsFor patients with high HbA1c, treatment with exenatide or insulin both improved glycaemic control. Given the associated weight loss and low risk of hypoglycaemia, exenatide may be a suitable alternative to treatment with insulin in certain patients with T2D and high HbA1c. (Source: International Journal of Clinical Practice)
Source: International Journal of Clinical Practice - October 1, 2017 Category: Internal Medicine Authors: Robert S. Busch, James Ruggles, Jenny Han, Elise Hardy Tags: ORIGINAL PAPER Source Type: research

Deutetrabenazine for tardive dyskinesia: A systematic review of the efficacy and safety profile for this newly approved novel medication —What is the number needed to treat, number needed to harm and likelihood to be helped or harmed?
ConclusionsDeutetrabenazine is the second FDA‐approved agent specifically indicated for the treatment of TD. Head‐to‐head comparisons with other VMAT2 inhibitors among patients with TD in the “real world” are needed. (Source: International Journal of Clinical Practice)
Source: International Journal of Clinical Practice - October 1, 2017 Category: Internal Medicine Authors: Leslie Citrome Tags: SYSTEMATIC REVIEW Source Type: research

Pro ‐protein subtilisin kexin‐9 (PCSK9) inhibition in practice: lipid clinic experience in 2 contrasting UK centres
ConclusionsThis study suggests that PCSK‐9 inhibitors are effective but that prescriptions should not be changed to long‐term delivery until patients have been reviewed and shown to be adherent. (Source: International Journal of Clinical Practice)
Source: International Journal of Clinical Practice - October 1, 2017 Category: Internal Medicine Authors: Monika Kohli, Kinjal Patel, Zofia MacMahon, Radha Ramachandran, Martin A. Crook, Timothy M. Reynolds, Anthony S. Wierzbicki Tags: ORIGINAL PAPER Source Type: research

A practical approach to the management of nocturia
ConclusionsThe cause(s) of nocturia should be first evaluated in all patients. Afterwards, the underlying pathophysiology should be treated specifically, alone with lifestyle interventions or in combination with drugs or (prostate) surgery. (Source: International Journal of Clinical Practice)
Source: International Journal of Clinical Practice - October 1, 2017 Category: Internal Medicine Authors: Matthias Oelke, Stefan De Wachter, Marcus J. Drake, Antonella Giannantoni, Mike Kirby, Susan Orme, Jonathan Rees, Philip Kerrebroeck, Karel Everaert Tags: CONSENSUS Source Type: research

Simplifying medication administration: From daily ingestion to monthly injection
(Source: International Journal of Clinical Practice)
Source: International Journal of Clinical Practice - September 19, 2017 Category: Internal Medicine Authors: Leslie Citrome Tags: EDITORIAL Source Type: research

Issue Information
(Source: International Journal of Clinical Practice)
Source: International Journal of Clinical Practice - September 19, 2017 Category: Internal Medicine Tags: ISSUE INFORMATION Source Type: research

Diabetic foot infection: Antibiotic therapy and good practice recommendations
ConclusionThis paper provides advice on empirical antibiotic therapy that may be used as a framework for local guideline development to support clinicians in the management of diabetic foot infection. (Source: International Journal of Clinical Practice)
Source: International Journal of Clinical Practice - September 11, 2017 Category: Internal Medicine Authors: Nicholas D. Barwell, Marion C. Devers, Brian Kennon, Helen E. Hopkinson, Claire McDougall, Matthew J. Young, Hannah M. A. Robertson, Duncan Stang, Stephanie J. Dancer, Andrew Seaton, Graham P. Leese, Tags: CONSENSUS Source Type: research

Prospective cohort study of risk factors for extended ‐spectrum ß‐lactamase‐producing Escherichia coli urinary tract infections in elderly patients admitted to hospital
Summary BackgroundExtended‐spectrum beta‐lactamase (ESBL)‐producing Escherichia coli are currently common in community‐onset infections, limiting therapeutic options. In this work we aim to identify the prevalence of and risk factors for ESBL‐producing E. coli in elderly patients with urinary tract infections (UTI) admitted to hospital. MethodsProspective cohort study on elderly patients with E. coli UTI admitted to a university hospital in Spain, from January 2013 to December 2015. Clinical features, microbiology and outcomes were recorded from the electronic medical records and reviewed by two researchers. Ca...
Source: International Journal of Clinical Practice - September 5, 2017 Category: Internal Medicine Authors: Arturo Artero, Ana Esparcia, Juan Alberola, Manuel Madrazo, Jos é M. Nogueira, José M. Eiros Tags: ORIGINAL PAPER Source Type: research

Pain relief of sore throat with a new anti ‐inflammatory throat lozenge, ibuprofen 25 mg: A randomised, double‐blind, placebo‐controlled, international phase III study
ConclusionLow‐dose ibuprofen 25 mg lozenge in repeat dosing provides in adults more efficacious and rapid relief of sore throat pain and is as well tolerated as placebo.Clinical trial registration: ClinicalTrials.gov, NCT01785862. (Source: International Journal of Clinical Practice)
Source: International Journal of Clinical Practice - September 4, 2017 Category: Internal Medicine Authors: Athmane Bouroubi, Yves Donazzolo, Franck Donath, Ron Eccles, Marc Russo, Nadine Harambillet, St éphanie Gautier, Agnès Montagne Tags: ORIGINAL PAPER Source Type: research

Fourteen ‐day high‐dose esomeprazole, amoxicillin and metronidazole as third‐line treatment for Helicobacter pylori infection
ConclusionCure rates of this 14‐day schedule using high‐dose esomeprazole, amoxicillin and metronidazole as a third‐line eradication regimen were suboptimal, especially in patients who had received metronidazole in previous failed eradication regimens. (Source: International Journal of Clinical Practice)
Source: International Journal of Clinical Practice - September 4, 2017 Category: Internal Medicine Authors: Ignasi Puig, Jes ús M. González‐Santiago, Javier Molina‐Infante, Jesús Barrio, Maria Teresa Herranz, Alicia Algaba, Manuel Castro, Javier P. Gisbert, Xavier Calvet Tags: ORIGINAL PAPER Source Type: research

Seasonal pattern of incidence and outcome of Acute Kidney Injury: A national study of Welsh AKI electronic alerts
ConclusionsIn summary we report for the first time in a large national cohort, a seasonal variation in the incidence and outcomes of AKI. The results demonstrate distinct trends in the incidence and outcome of AKI. (Source: International Journal of Clinical Practice)
Source: International Journal of Clinical Practice - September 4, 2017 Category: Internal Medicine Authors: Dafydd Phillips, Oliver Young, Jennifer Holmes, Lowri A. Allen, Gethin Roberts, John Geen, John D. Williams, Aled O. Phillips, Tags: ORIGINAL PAPER Source Type: research

The prevalence and preventability of potentially relevant drug ‐drug interactions in patients admitted for cardiovascular diseases: A cross‐sectional study
ConclusionsUse of drug interaction screening tools can be beneficial risk mitigation strategy for potentially relevant pDDIs in CVD patients. DDI screening software could be linked to the patient's laboratory results or clinical data regarding renal or liver function, as an approach to reinforce DDIs alert quality. (Source: International Journal of Clinical Practice)
Source: International Journal of Clinical Practice - September 4, 2017 Category: Internal Medicine Authors: Milena Kova čević, Sandra Vezmar Kovačević, Branislava Miljković, Slavica Radovanović, Predrag Stevanović Tags: ORIGINAL PAPER Source Type: research

The utility and feasibility of assessing sleep disruption in a men's health clinic using a mobile health platform device: A pilot study
ConclusionsThis pilot study demonstrated the feasibility and potential utility of an mHealth platform to assist clinicians, within a men's health clinic, in detecting sleep disturbances. Disrupted sleep was revealed in well over half of this sample of patients. As a result of the growing evidence linking poor sleep and sleep disorders (eg, OSA) to the conditions relevant to men's health (eg, erectile dysfunction, hypogonadism and BPH), further efforts beyond this pilot study are necessary to identify the aetiological processes underlying the association between specific disrupted sleep disorders and urological conditions. ...
Source: International Journal of Clinical Practice - September 4, 2017 Category: Internal Medicine Authors: Hai H. Le, Rachel Marie E. Salas, Alyssa Gamaldo, Kevin L. Billups, Peter Dziedzic, Seulah Choi, Neftali Bermudez, Roland J. Thorpe, Charlene E. Gamaldo Tags: ORIGINAL PAPER Source Type: research