International Journal of Antimicrobial Agents This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Carbapenems vs. alternative β-lactams for the treatment of nosocomial pneumonia: A systematic review and meta-analysis
Pneumonia is one of the most common hospital-acquired infections in the United States with the Center for Disease Control estimating over 150 000 cases per year [1]. Nosocomial pneumonias, particularly ventilator-associated pneumonias (VAP), are associated with significant morbidity and mortality [2]. Prompt and adequate treatment of patients with these infectious diseases is essential to decrease the risk of mortality [3-7]. Current gu idelines from the Infectious Diseases Society of America and the American Thoracic Society recommend empirical treatments targeted at likely pathogens, such as Pseudomonas aeruginosa and ...
Source: International Journal of Antimicrobial Agents - April 14, 2018 Category: Drugs & Pharmacology Authors: J Nicholas O'Donnell, Nathaniel J Rhodes, Jenna Lopez, Rebecca Jett, Marc H Scheetz Source Type: research

Activity of a nitric oxide-generating wound treatment system against wound pathogen biofilms
The microbial burden of acute and chronic wounds plays an important role in impaired healing and development of infection-related complications. Prevalence of infection in chronic wounds is reported as 53% [1]. Inadequate infection management of chronic wounds can result in lower limb amputation and bloodstream invasion, and complications, such as sepsis, multi-organ failure and death [2]. Biofilm formation is now thought to exacerbate wound infection and delay healing in chronic wounds and following acute injury [3 –5]. (Source: International Journal of Antimicrobial Agents)
Source: International Journal of Antimicrobial Agents - April 14, 2018 Category: Drugs & Pharmacology Authors: Richard D. Waite, Joanne E. Stewart, Abish S. Stephen, Robert P. Allaker Source Type: research

Absence of TetB Identifies Minocycline-Susceptible Isolates of Acinetobacter baumannii
Acinetobacter spp. is one of the ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) pathogens, for which there are limited treatment choices available [1]. (Source: International Journal of Antimicrobial Agents)
Source: International Journal of Antimicrobial Agents - April 14, 2018 Category: Drugs & Pharmacology Authors: Olga Lomovskaya, Dongxu Sun, Debora Rubio-Aparicio, Kirk J. Nelson, Visanu Thamlikitkul, Michael N. Dudley, Mark A. Redell Source Type: research

Acute kidney injury during treatment with high-dose cloxacillin: A report of 23 cases and literature review
Cloxacillin, a member of the isoxazolyl penicillin group with oxacillin, dicloxacillin, and flucloxacillin, is a major anti-staphylococcal agent, recommended as first line treatment for a broad range of severe infections due to meticillin-susceptible Staphylococcus aureus (MSSA), and included on the World Health Organization (WHO) list of essential medicines. According to the cloxacillin prescribing information, the maximum dose is 6 g/day, but doses recommended by the European Society of Cardiology for infective endocarditis [1], or the French Society of Infectious Diseases for osteoarticular infections [2] are 8-12 g/day...
Source: International Journal of Antimicrobial Agents - April 14, 2018 Category: Drugs & Pharmacology Authors: Aur élie Lavergne, Cécile Vigneau, Elisabeth Polard, Louise Triquet, Nathalie Rioux-Leclercq, Pierre Tattevin, Léonard Golbin Source Type: research

NDM-1- and OXA-23-producing Acinetobacter baumannii isolated from Intensive Care Unit patients in Tunisia
Acinetobacter baumannii has become a troublesome emerging pathogen because of its wide range of resistance determinants and its environmental resilience [1]. It is responsible for severe nosocomial infections in intensive care unit (ICU) patients, mainly ventilator associated pneumonia, bacteremia, and central nervous system infections [2,3]. Most of A. baumannii strains are multidrug-resistant (MDR) [1] and have become endemic in several healthcare environments, often causing sustained outbreaks. (Source: International Journal of Antimicrobial Agents)
Source: International Journal of Antimicrobial Agents - April 14, 2018 Category: Drugs & Pharmacology Authors: Elaa Maamar, Carla Andrea Alonso, Sana Ferjani, Ali Jendoubi, Zaineb Hamzaoui, Alia Jebri, Mabrouka Saidani, Salma Ghedira, Carmen Torres, Ilhem Boutiba-Ben Boubaker Source Type: research

Activity of a Nitric Oxide Generating Wound Treatment System against Wound Pathogen Biofilms
The microbial burden of acute and chronic wounds plays an important role in impaired healing and development of infection-related complications. Prevalence of infection in chronic wounds is reported as 53 % [1]. In these patients, inadequate infection management can result in lower limb amputation and bloodstream invasion, with complications such as sepsis, multi-organ failure and death [2]. Biofilm formation is now thought to exacerbate wound infection and delay healing, not only in chronic wounds [3, 4] but also following acute injury [5]. (Source: International Journal of Antimicrobial Agents)
Source: International Journal of Antimicrobial Agents - April 14, 2018 Category: Drugs & Pharmacology Authors: Richard D. Waite, Joanne E. Stewart, Abish S. Stephen, Robert P. Allaker Source Type: research

Carbapenems versus alternative β-lactams for the treatment of nosocomial pneumonia: A systematic review and meta-analysis
Pneumonia is one of the most common hospital-acquired infections in the United States with the Center for Disease Control estimating over 150,000 cases per year [1]. Nosocomial pneumonias, particularly ventilator-associated pneumonias (VAP), are associated with significant morbidity and mortality [2]. Prompt and adequate treatment of these patients is essential to decrease the risk of mortality [3 –7]. Current guidelines from the Infectious Diseases Society of America and the American Thoracic Society recommend empiric treatments targeted at likely pathogens such as Pseudomonas aeruginosa and other resistant Gram-negativ...
Source: International Journal of Antimicrobial Agents - April 14, 2018 Category: Drugs & Pharmacology Authors: J. Nicholas O'Donnell, Nathaniel J. Rhodes, Jenna Lopez, Rebecca Jett, Marc H. Scheetz Source Type: research

Is antimicrobial administration to food animals a direct threat to human health? A rapid systematic review.
Limiting antimicrobial use in food animals reduces antimicrobial resistance in food animals, and probably reduces antimicrobial resistance in humans. The magnitude of the effect cannot be quantified. (Source: International Journal of Antimicrobial Agents)
Source: International Journal of Antimicrobial Agents - April 13, 2018 Category: Drugs & Pharmacology Authors: Anna Mae Scott, Elaine Beller, Paul Glasziou, Justin Clark, Respati W. Ranakusuma, Oyungerel Byambasuren, Mina Bakhit, Stephen W. Page, Darren Trott, Chris Del Mar Tags: Review Source Type: research