International Journal of Antimicrobial Agents This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Outbreak of IMI-1 Carbapenemase-producing colistin-resistant Enterobacter cloacae on the French island of Mayotte (Indian Ocean)
The emergence of carbapenemase-producing Enterobacteriaceae (CPE) is currently a worldwide public health issue [1]. Significant population flows from southern Africa and the Indian sub-continent to the Indian Ocean islands can contribute to the dissemination of these multidrug resistant bacteria (MDR) in the Mayotte and Reunion islands, two French overseas departments located in the Southwest Indian Ocean, close to Madagascar, with a population of 250,000 and 850,000 inhabitants, respectively. The MDR screening program carried out at the Mayotte Medical Center (MMC) and F élix Guyon University Hospital (FGUH) of Reunion I...
Source: International Journal of Antimicrobial Agents - May 25, 2018 Category: Drugs & Pharmacology Authors: Guillaume Miltgen, R émy A. Bonnin, Catherine Avril, Thierry Benoit-Cattin, Daniel Martak, Alexandre Leclaire, Nicolas Traversier, Bénédicte Roquebert, Marie-Christine Jaffar-Bandjee, Nathalie Lugagne, Laurent Filleul, Marion Subiros, Anne-Marie de Mon Tags: Short Communication Source Type: research

The GISA call to action for the appropriate use of antimicrobials and the control of antimicrobial resistance in Italy
The spread of antibiotic resistance is one of the leading public health problems in Italy. An ECDC country-site visit recently confirmed the major challenges and made important suggestions. In response, the Ministry of Health published the National Plan for Antimicrobial Resistance Containment, and a group of experts belonging to the Italian Group of Antimicrobial Stewardship (GISA), convened to develop a summary of practical recommendations. The GISA document is intended for use by practising physicians; it aims to increase the rational use of antimicrobials and in the treatment of infections, and to change the culture of...
Source: International Journal of Antimicrobial Agents - May 23, 2018 Category: Drugs & Pharmacology Authors: Francesco Menichetti, Marco Falcone, Pierluigi Lopalco, Carlo Tascini, Angelo Pan, Luca Busani, Bruno Viaggi, Gian Maria Rossolini, Fabio Arena, Andrea Novelli, Francesco De Rosa, Stefania Iannazzo, Jonathan Cohen, for the GISA1 (Italian Group for Antimic Tags: Hot Topic Source Type: research

Antimicrobial susceptibility of Clostridium difficile isolated from food and environmental sources in Western Australia
Clostridium difficile infection (CDI) is the leading cause of life-threatening infectious diarrhoea in humans, and a major public health issue in many developed countries [1]. C.  difficile causes a wide range of symptoms, from mild diarrhoea to severe pseudomembranous colitis and, in rare cases, fulminant colitis that may lead to intestinal perforation or megacolon and sepsis [1]. The major risk factor for developing CDI is exposure to antimicrobials, particularly agents w ith activity against commensal bowel flora such as clindamycin, aminopenicillins, extended-spectrum cephalosporins and fluoroquinolones [1]. (Source: ...
Source: International Journal of Antimicrobial Agents - May 23, 2018 Category: Drugs & Pharmacology Authors: Su-Chen Lim, Grace O. Androga, Daniel R. Knight, Peter Moono, Niki F. Foster, Thomas V. Riley Tags: Short Communication Source Type: research

Rapid resolution of multi-drug resistance bacterial genome harbouring mcr-1 and blaCMY-2 using MinION sequencing platform
Whole-genome sequencing technologies have revolutionized clinical microbiology and basic microbiology research in unprecedented cost-effective and highly efficient ways. Although next-generation sequencing has become popular to track infectious diseases and characterize the evolution of pathogens, the inherent short reads (usually less than 1 kbp) always result in incomplete assembly of bacterial genomes divided by repetitive elements, such as the rRNA operon and multi-drug resistance (MDR) regions. (Source: International Journal of Antimicrobial Agents)
Source: International Journal of Antimicrobial Agents - May 21, 2018 Category: Drugs & Pharmacology Authors: Ruichao Li, Miaomiao Xie, Edward Wai Chi Chan, Sheng Chen Tags: Letter to the Editor Source Type: research

Rapid resolution of MDR bacterial genome harboring mcr-1 and blaCMY-2 using MinION sequencing platform
Sir, (Source: International Journal of Antimicrobial Agents)
Source: International Journal of Antimicrobial Agents - May 21, 2018 Category: Drugs & Pharmacology Authors: Ruichao Li, Miaomiao Xie, Edward Wai Chi Chan, Sheng Chen Tags: Letter to the Editor Source Type: research

Extended spectrum beta-lactamase-producing Enterobacteriaceae infections in hematopoietic stem cell transplant recipients: Epidemiology and molecular characterization
Bacterial infections are common complications in hematopoietic stem cell transplant (HSCT) recipients. They represent an important cause of morbidity and mortality in this severely immunocompromised population. These infections are mainly caused by Gram-positive cocci but recently we have noticed the reemergence of Gram-negative rods (GNR) and increasing antimicrobial resistance [1]. (Source: International Journal of Antimicrobial Agents)
Source: International Journal of Antimicrobial Agents - May 18, 2018 Category: Drugs & Pharmacology Authors: Molka Kharrat, Yosra Chebbi, Farah Ben Tanfous, Amel Lakhal, Saloua Ladeb, Tarek Ben Othmen, Wafa Achour Source Type: research

Pooled analysis of the phase 3 REVIVE trials: randomised, double-blind studies to evaluate the safety and efficacy of iclaprim versus vancomycin for treatment of acute bacterial skin and skin-structure infections
Up to 1.8% of all hospitalisations are due to acute bacterial skin and skin-structure infections (ABSSSIs) [1]. Often these serious skin infections require intravenous (i.v.) antimicrobials, hospitalisation and/or surgical intervention [2,3]. The majority of ABSSSIs are caused by Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA), methicillin-susceptible S. aureus and β-haemolytic streptococci [3,4]. Although many antimicrobials are available to treat ABSSSIs, only a few are available for ABSSSI caused by multidrug-resistant bacteria, and some of these are limited by safety, tolerability...
Source: International Journal of Antimicrobial Agents - May 18, 2018 Category: Drugs & Pharmacology Authors: David B. Huang, G. Ralph Corey, Thomas L. Holland, Thomas Lodise, William O'Riordan, Mark H. Wilcox, Thomas M. File, Matthew Dryden, Barbara Balser, Eve Desplats, Antoni Torres Source Type: research

Extended spectrum beta-lactamase producing Enterobacteriaceae infections in haematopoietic stem cell transplant recipients: epidemiology and molecular characterization
Bacterial infections are common complications in hematopoietic stem cell transplant (HSCT) recipients. They represent an important cause of morbidity and mortality in this severely immunocompromised population. These infections are mainly caused by Gram-positive cocci. But, in recent years, we noticed the reemergence of Gram-negative rods (GNR) and the increasing of antibiotimicrobial resistance [1]. (Source: International Journal of Antimicrobial Agents)
Source: International Journal of Antimicrobial Agents - May 18, 2018 Category: Drugs & Pharmacology Authors: Molka Kharrat, Yosra Chebbi, Farah Ben Tanfous, Amel Lakhal, Saloua Ladeb, Tarek Ben Othmen, Wafa Achour Source Type: research

A Pooled Analysis of the Phase 3 REVIVE Trials: Randomized, Double-blind Studies to EValuate the Safety and Efficacy of Iclaprim Versus Vancomycin for trEatment of Acute Bacterial Skin and Skin Structure Infections
Up to 1.8% of all hospitalizations are for an acute bacterial skin and skin structure infections (ABSSSI) [1]. Often these serious skin infections require intravenous antibiotics, hospitalization, and/or surgical intervention [2,3]. The majority of ABSSSI are caused by Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA), methicillin-susceptible S. aureus (MSSA), and beta-hemolytic streptococci [3,4]. Although many antibiotics are available to treat ABSSSI, only a few are available for ABSSSI caused by multidrug resistant (MDR) bacteria, and some of these are limited by safety, tolerability...
Source: International Journal of Antimicrobial Agents - May 18, 2018 Category: Drugs & Pharmacology Authors: David B Huang, G. Ralph Corey, Thomas L Holland, Thomas Lodise, William O'Riordan, Mark H Wilcox, Thomas M File, Matthew Dryden, Barbara Balser, Eve Desplats, Antoni Torres Source Type: research

Plant nutraceuticals as antimicrobial agents in food preservation: terpenoids, polyphenols and thiols
A wide range of synthetic preservatives and antibacterial physical treatments are used to extend food shelf life by inhibiting bacterial growth. Also, some foods require special protection against microbial spoilage during their preparation, storage or distribution in order to increase their shelf life and organoleptic properties, avoiding microbial spoiling, which usually changes taste, odor, color and sensory or texture food properties [1]. Presence of specific microorganisms such as Listeria monocytogenes, Escherichia coli O157:H7, Salmonella spp. (Source: International Journal of Antimicrobial Agents)
Source: International Journal of Antimicrobial Agents - May 17, 2018 Category: Drugs & Pharmacology Authors: Ignacio Guti érrez-del-Río, Javier Fernández, Felipe Lombó Source Type: research

Phenotypic and genetic resistance traits of Pseudomonas aeruginosa strains infecting cystic fibrosis patients: A French cohort study
Pseudomonas aeruginosa is a ubiquitous Gram-negative bacterium of the aquatic environment and a major opportunistic human pathogen [1]. This organism is responsible for nosocomial infections, which may be life-threatening especially in immunosuppressed patients [1]. It is also the leading cause of morbidity and mortality in cystic fibrosis (CF) patients, causing chronic respiratory tract infections with acute exacerbations, which progressively impair respiratory function [1]. Pseudomonas aeruginosa is naturally resistant to many antibiotics [2] and can develop multidrug resistance, which represents a therapeutic challenge ...
Source: International Journal of Antimicrobial Agents - May 15, 2018 Category: Drugs & Pharmacology Authors: Nathalie Courtois, Yvan Caspar, Max Maurin Source Type: research

Virulence determinants, biofilm production and antimicrobial susceptibility in Staphylococcus aureus causing device-associated infections in a Tunisian hospital
Staphylococcus aureus is a major human pathogen that causes a wide range of clinical infections. The increased use of indwelling medical devices has had considerable impact on the role of S. aureus in clinical medicine [1]. In fact, S. aureus strains causing device related infections (DRI) displayed the ability to form surface-attached communities of cells called biofilms on polymeric surfaces facilitating their persistence in the host, evading host defences mechanisms and allowing bacterial survival at high antimicrobial concentrations [2] (Source: International Journal of Antimicrobial Agents)
Source: International Journal of Antimicrobial Agents - May 15, 2018 Category: Drugs & Pharmacology Authors: I Mesrati, M Saidani, M Jemili, S Ferjeni, A Slim, I Boutiba-Ben Boubaker Source Type: research

Antimicrobial resistance and genetic lineages of faecal enterococci of wild birds: Emergence of vanA and vanB2 harboring Enterococcus faecalis.
Enterococci are ubiquitous microorganisms of the human and animal gut microbiota, but they are also recognized as nosocomial pathogens [1]. Previous studies reported that Enterococcus faecalis and Enterococcus faecium were respectively the third and fourth most frequent pathogens involved in nosocomial infections [2]. In addition to their innate resistance to many antimicrobials, enterococci can carry and transfer a variety of antibiotic resistance genes (ARGs) via mobile genetic elements from/to other pathogenic bacteria. (Source: International Journal of Antimicrobial Agents)
Source: International Journal of Antimicrobial Agents - May 15, 2018 Category: Drugs & Pharmacology Authors: Houssem BEN YAHIA, Sarra CHAIRAT, Nabil HAMDI, Haythem GHARSA, Rym BEN SALLEM, Sara CEBALLOS, Carmen TORRES, Karim BEN SLAMA Source Type: research

The comparative efficacy of antiseptics against Candida auris biofilms
Since its first report in 2009, the emerging multidrug-resistant pathogenic yeast Candida auris has attracted considerable attention as a source of healthcare associated infections. Alarmingly, it has been attributable for a number of nosocomial outbreaks globally, including a UK intensive care unit, whereby almost 20% of colonised patients developed candidaemia [1]. High transmission within critical care units has been reported, with environmental sampling yielding C. auris from beds and chairs, in addition to multiuse patient equipment [2,3]. (Source: International Journal of Antimicrobial Agents)
Source: International Journal of Antimicrobial Agents - May 15, 2018 Category: Drugs & Pharmacology Authors: Ryan Kean, Emily McKloud, Eleanor M Townsend, Leighann Sherry, Christopher Delaney, Brian L Jones, Craig Williams, Gordon Ramage Source Type: research

Phenotypic and genetic resistance traits in Pseudomonas aeruginosa strains infecting cystic fibrosis patients: a French cohort study
Pseudomonas aeruginosa is a ubiquitous Gram-negative bacterium of the aquatic environment and a major opportunistic human pathogen [1]. This organism is responsible for nosocomial infections, which may be life-threatening especially in immunosuppressed patients [1]. It is also the leading cause of morbidity and mortality in cystic fibrosis (CF) patients, causing chronic respiratory tract infections with acute exacerbations, which progressively impair the respiratory functions [1]. This bacterium is naturally resistant to many antibiotics [2], and can develop multi-drug resistance that represents a therapeutic challenge [3]...
Source: International Journal of Antimicrobial Agents - May 15, 2018 Category: Drugs & Pharmacology Authors: Nathalie Courtois, Yvan Caspar, Max Maurin Source Type: research