International Journal of Antimicrobial Agents This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

XDRB carriers among travelers: One-third were never hospitalized previously
Since the 2000s, the spread of extensively drug-resistant bacteria (XDRB) is a worldwide phenomenon that represents an important public health issue. Several studies have suggested a higher risk of infection in previously colonized patients [1,2] and a higher risk of morbidity and mortality [3,4], usually related to little antibiotic resources. (Source: International Journal of Antimicrobial Agents)
Source: International Journal of Antimicrobial Agents - June 12, 2018 Category: Drugs & Pharmacology Authors: Lou Macaux, Oulimata Ndoye, Hugues Cordel, Typhaine Billard Pomares, Delphine Seytre, Olivier Bouchaud, Yves Cohen, Jean-Ralph Zahar, Etienne Carbonnelle Source Type: research

High mortality among patients infected with hypervirulent antimicrobial-resistant capsular type K1 Klebsiella pneumoniae strains in Taiwan
Klebsiella pneumoniae are usually responsible for urinary tract infections, pneumonia, bacteraemia, and intra-abdominal infections worldwide [1]. These infections are usually considered classic K. pneumoniae infections and may occur in the community and hospital settings [1]. K. pneumonia strains causing classic infections are also able to acquire antimicrobial resistance, which is usually associated with nosocomial infection. Nevertheless, during the last several decades, K. pneumoniae has emerged as a major cause of community-acquired pyogenic liver abscesses in East Asian countries (especially Taiwan, Korea, and Singapo...
Source: International Journal of Antimicrobial Agents - June 12, 2018 Category: Drugs & Pharmacology Authors: Yi-Tsung Lin, Yi-Hsiang Cheng, Chih-Han Juan, Ping-Feng Wu, Yi-Wei Huang, Sheng-Hua Chou, Tsuey-Ching Yang, Fu-Der Wang Source Type: research

Emergence of tet(A) and blaKPC-2 co-carrying plasmid from a ST11 hypervirulent Klebsiella pneumoniae isolate in patient's gut
Worldwide, reports of carbapenem-resistant Klebsiella pneumoniae (CRKP) are increasing, and CRKP infections are often associated with high morbidity and mortality. Tigecycline is among the few drugs of choice for the treatment of carbapenem-resistant bacterial infections. However, tigecycline-resistant CRKP isolates have been reported in several regions with detection rates of 9.1 –14.5% [1,2]. The mechanisms conferring tigecycline resistance in K. pneumoniae are not well characterized or elucidated. (Source: International Journal of Antimicrobial Agents)
Source: International Journal of Antimicrobial Agents - June 10, 2018 Category: Drugs & Pharmacology Authors: Danxia Gu, Huoyang Lv, Qiaoling Sun, Lingbin Shu, Rong Zhang Tags: Letter to the Editor Source Type: research

Prevalence of pSCFS7-like vectors among cfr-positive staphylococcal population in Spain
As a consequence of the dissemination of meticillin-resistant Staphylococcus aureus (MRSA) strains and the accumulation of several resistant traits, only a few antibiotics (e.g. vancomycin and linezolid) are considered as the last resort antibiotics for treatment of these strains. The finding of a transferable chloramphenicol/florphenicol resistance (cfr) gene, related to linezolid resistance, has compromised the usage of this antimicrobial in clinical practice. Although the prevalence of MRSA strains showing resistance to linezolid remains low, hospital outbreaks due to cfr-positive MRSA strains have been documented in Sp...
Source: International Journal of Antimicrobial Agents - June 10, 2018 Category: Drugs & Pharmacology Authors: L.T.T. Nguyen, F. Rom án, K. Morikawa, P. Trincado, C. Marcos, M.D. Rojo-Martín, F. Cafini Tags: Letter to the Editor Source Type: research

Emergence of tet(A) variant and blaKPC-2 co-carrying plasmid from a ST11 hypervirulent Klebsiella pneumoniae isolate in patient's gut
Carbapenem-resistant Klebsiella pneumoniae (CRKP) are increasingly reported worldwide and CRKP infections are often associated with high morbidity and mortality. Tigecycline is among the few drugs of choice for the treatment of carbapenem-resistant bacterial infections. However, tigecycline-resistant CRKP isolates have been reported in several regions with the detection rates from 9.1%-14.5% [1,2]. Until now, the mechanisms conferring tigecycline resistance in K. pneumoniae are not well characterized and elucidated. (Source: International Journal of Antimicrobial Agents)
Source: International Journal of Antimicrobial Agents - June 10, 2018 Category: Drugs & Pharmacology Authors: Danxia Gu, Huoyang Lv, Qiaoling Sun, Lingbin Shu, Rong Zhang Tags: Letter to the Editor Source Type: research

Prevalence of pSCFS7-like vectors among cfr positive staphylococcal population in Spain
Sir, (Source: International Journal of Antimicrobial Agents)
Source: International Journal of Antimicrobial Agents - June 10, 2018 Category: Drugs & Pharmacology Authors: Le Thuy Thi Nguyen, Federico Rom án, Kazuya Morikawa, Pilar Trincado, Carmen Marcos, María Dolores Rojo-Martín, Fabio Cafini Tags: Letter to the Editor Source Type: research

Title Page & Editorial Board
(Source: International Journal of Antimicrobial Agents)
Source: International Journal of Antimicrobial Agents - June 1, 2018 Category: Drugs & Pharmacology Source Type: research

Clonal transmission of NDM-5-producing Escherichia coli belonging to high-risk sequence type ST405
Carbapenemase-producing Enterobacteriaceae are a critical public-health problem. The European Survey on Carbapenemase-Producing Enterobacteriaceae (EuSCAPE) reported that 19% of carbapenem-non-susceptible Escherichia coli isolates produced carbapenemases [1]. In Spain, an upward trend in carbapenemase-producing E. coli has been observed, mainly due to the dissemination of OXA-48 [2]; however, sporadic occurrence of NDM-producers has been reported [2,3]. The success of high-risk E. coli clones might be due to factors such as increased transmission and colonisation capacity, antibiotic multiresistance and enhanced virulence....
Source: International Journal of Antimicrobial Agents - June 1, 2018 Category: Drugs & Pharmacology Authors: Laura Barrado, Mar ía Pérez-Vázquez, José Luis del Pozo, Carmen Martín-Salas, José Leiva, Ana Mazón, Carmen Ezpeleta, Jesús Oteo Tags: Letter to the Editor Source Type: research

Review and Mapping of Carbapenem-resistant Enterobacteriaceae in Africa: Using Diverse Data to Inform Surveillance Gaps
: Comprehensive, customized search strategies with analysis and mapping of defined data elements provide an enhanced view of carbapenem resistant E. coli and Klebsiella in Africa. These CRE are widely distributed and generally present at low to moderate levels. While use of diverse and largely clinically derived data has limitations, and cannot substitute for surveillance, it can enhance situational awareness. The approaches utilized can support improved risk understanding and prioritization and may be applied to other organisms and areas where surveillance remains inadequate. (Source: International Journal of Antimicrobial Agents)
Source: International Journal of Antimicrobial Agents - June 1, 2018 Category: Drugs & Pharmacology Authors: Elizabeth A. Mitgang, David M. Hartley, Marissa D. Malchione, Michala Koch, Jesse L. Goodman Source Type: research

Case study on the soil antibiotic resistome in an urban community garden
Environmental antibiotic resistance is attracting extensive research and public health attention due to increasing evidence showing that the evolution and spread of antibiotic resistance in the environment contribute to the occurrence of antibiotic resistance in the clinical environment [1 –4]. Many antibiotic resistance genes found in pathogenic bacteria have evolved or are acquired from environmental microbial communities [5], suggesting an urgent need to understand the environmental reservoir of antibiotic resistance. (Source: International Journal of Antimicrobial Agents)
Source: International Journal of Antimicrobial Agents - May 29, 2018 Category: Drugs & Pharmacology Authors: Abdullah Ibn Mafiz, Liyanage Nirasha Perera, Yingshu He, Wei Zhang, Shujie Xiao, Weilong Hao, Shi Sun, Kequan Zhou, Yifan Zhang Source Type: research

Whole-genome sequencing of NDM-1-producing ST85 Acinetobacter baumannii isolates from Tunisia
Over the last decade, Acinetobacter baumanni has become the most threatening of the ESKAPE pathogens in hospital settings [1]. The high level of carbapenem-resistant A. baumannii is more commonly mediated by production of acquired class D carbapenem-hydrolysing β-lactamases and, to a lesser extent, class A and B carbapenemases [2,3]. (Source: International Journal of Antimicrobial Agents)
Source: International Journal of Antimicrobial Agents - May 29, 2018 Category: Drugs & Pharmacology Authors: Nadia Jaidane, Thierry Naas, Saoussen Oueslati, Sandrine Bernabeu, Noureddine Boujaafar, Olfa Bouallegue, R émy A. Bonnin Source Type: research

A Case Study on Soil Antibiotic Resistome in an Urban Community Garden
Environmental antibiotic resistance is drawing extensive research and public health attention nowadays because there is increasing evidence showing that the evolution and spread of antibiotic resistance in the environment contribute to the occurrence of antibiotic resistance in the clinical environment [1 –4]. Besides, many antibiotic resistance genes found in pathogenic bacteria have evolved or are acquired from environmental microbial communities [5], suggesting an urgent need to understand the environmental reservoir of antibiotic resistance. (Source: International Journal of Antimicrobial Agents)
Source: International Journal of Antimicrobial Agents - May 29, 2018 Category: Drugs & Pharmacology Authors: Abdullah Ibn Mafiz, Liyanage Nirasha Perera, Yingshu He, Wei Zhang, Shujie Xiao, Weilong Hao, Shi Sun, Kequan Zhou, Yifan Zhang Source Type: research

Whole genome sequencing of NDM-1-producing ST85 Acinetobacter baumannii isolates from Tunisia
Acinetobacter baumanni is becoming in the last decade the most threatening pathogen in hospital settings belonging to the ESKAPE pathogens [1]. The high-level of carbapenem-resistant A. baumannii (CRAb) are more commonly mediated by production of acquired class D carbapenem-hydrolysing β-lactamases and in a lesser extent class A and B carbapenemases [2,3]. (Source: International Journal of Antimicrobial Agents)
Source: International Journal of Antimicrobial Agents - May 29, 2018 Category: Drugs & Pharmacology Authors: Nadia jaidane, Thierry Naas, Saoussen Oueslati, Sandrine Bernabeu, Noureddine Boujaafar, Olfa Bouallegue, R émy A. Bonnin Source Type: research

Comparison of the composition and in vitro activity of polymyxin B products
Polymyxins are cationic cyclic polypeptides derived from various strains of Bacillus polymyxa and have broad-spectrum activity against Gram-negative bacteria. Polymyxin B contains a mixture of polypeptides [1] and is manufactured by several companies in accordance with United States Pharmacopeia (USP) standards. Current USP polymyxin tests and assays evaluate its biological activity, and manufacturers report polymyxin B biological activity in units (using cylinder-plate methods) and potency in units/mg [2,3]. (Source: International Journal of Antimicrobial Agents)
Source: International Journal of Antimicrobial Agents - May 25, 2018 Category: Drugs & Pharmacology Authors: John K. Diep, Jenna Covelli, Rajnikant Sharma, Donna M. Ruszaj, Keith S. Kaye, Jian Li, Robert M. Straubinger, Gauri G. Rao Source Type: research

A Comparison of Composition and In Vitro Activity of Polymyxin B Products
Polymyxins are cationic cyclic polypeptides derived from various strains of Bacillus polymyxa, and have broad-spectrum activity against Gram-negative bacteria. Polymyxin B contains a mixture of polypeptides [1] and is manufactured by several companies in accordance with United States Pharmacopeia (USP) standards. Current USP polymyxin tests and assays evaluate its biological activity, and manufacturers report polymyxin B biological activity in Units (using cylinder-plate methods) and potency in Units/mg [2, 3]. (Source: International Journal of Antimicrobial Agents)
Source: International Journal of Antimicrobial Agents - May 25, 2018 Category: Drugs & Pharmacology Authors: John K. Diep, Jenna Covelli, Rajnikant Sharma, Donna M. Ruszaj, Keith S. Kaye, Jian Li, Robert M. Straubinger, Gauri G. Rao Source Type: research