International Journal for Parasitology: Drugs and Drug Resistance 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Managing anthelmintic resistance in cyathostomin parasites: Investigating the benefits of refugia-based strategies
This study made use of the cyathostomin model to evaluate the influence of treatment strategies with between 1 and 8 yearly treatment occasions, where either 1) all horses were treated, 2) a predetermined proportion of the herd remained untreated, or 3) horses were treated if their FEC exceeded thresholds between 100 and 600 strongyle eggs per gram. Weather data representing four different climatic zones was used and three different herd age structures were compared; 1) all yearlings, 2) all mature horses 10–20 years old, and 3) a mixed age structure of 1–20 years of age. Results indicated a consistent effect of age st...
Source: International Journal for Parasitology: Drugs and Drug Resistance - August 29, 2019 Category: Parasitology Source Type: research
Successful treatment by adding thalidomide to glucantime in a case of refractory anthroponotic mucocutaneous leishmaniasis
Publication date: Available online 27 August 2019Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Vahid Mashayekhi Goyonlo, Sadegh Vahabi-Amlashi, Faezeh TaghaviAbstractMucosal leishmaniasis (ML) is mostly associated with Leishmania braziliensis; however, a few cases of Leishmania tropica induced mucocutaneous leishmaniasis have been reported. The standard treatment for leishmaniasis is pentavalent antimonials, but several other drugs for resistant cases have been proposed including amphotericin and miltefosine. Here we present a case of multiple treatment resistant mucocutaneous leishman...
Source: International Journal for Parasitology: Drugs and Drug Resistance - August 28, 2019 Category: Parasitology Source Type: research
Evaluation of synergy between host and pathogen-directed therapies against intracellular Leishmania donovani
Publication date: Available online 21 August 2019Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): M. Shamim Hasan Zahid, Monica M. Johnson, Robert J. Tokarski, Abhay R. Satoskar, James R. Fuchs, Eric M. Bachelder, Kristy M. AinslieAbstractVisceral leishmaniasis (VL) is associated with treatment complications due to the continued growth of resistant parasites toward currently available pathogen-directed therapeutics. To limit the emergence and combat resistant parasites there is a need to develop new anti-leishmanial drugs and alternative treatment approaches, such as host-directed therape...
Source: International Journal for Parasitology: Drugs and Drug Resistance - August 22, 2019 Category: Parasitology Source Type: research
In-situ immune profile of polymorphic vs. macular Indian Post Kala-azar Dermal Leishmaniasis
Publication date: Available online 22 August 2019Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Ritika Sengupta, Shibabrata Mukherjee, Srija Moulik, Sneha Mitra, Surya Jyati Chaudhuri, Nilay Kanti Das, Uttara Chatterjee, Mitali ChatterjeeAbstractPost Kala-azar Dermal Leishmaniasis (PKDL), a sequel of apparently cured Visceral Leishmaniasis presents in South Asia with papulonodular (polymorphic) or hypomelanotic lesions (macular). Till date, the polymorphic variant was considered predominant, constituting 85–90%. However, following active-case surveillance, the proportion of macular PK...
Source: International Journal for Parasitology: Drugs and Drug Resistance - August 22, 2019 Category: Parasitology Source Type: research
Development of amplicon sequencing for the analysis of benzimidazole resistance allele frequencies in field populations of gastrointestinal nematodes
This study provides proof of concept of a practical, accurate, sensitive and scalable method to determine frequency of anthelmintic resistance mutations in gastrointestinal nematodes in field studies and as a management tool for livestock farmers.Graphical abstract (Source: International Journal for Parasitology: Drugs and Drug Resistance)
Source: International Journal for Parasitology: Drugs and Drug Resistance - August 14, 2019 Category: Parasitology Source Type: research
The combination therapy of meglumine antimoniate and oxiranes (epoxy-α-lapachone and epoxymethyl-lawsone) enhance the leishmanicidal effect in mice infected by Leishmania (Leishmania) amazonensis
In this study we analyzed the potential of the association of meglumine antimoniate (MA) with the oxiranes epoxy-α-lapachone (LAP) or epoxymethyl-lawsone (LAW). Results demonstrated that association between these drugs enhanced leishmanicidal activity on Leishmania (Leishmania) amazonensis infection. The compounds were tested in monotherapy or in combinations (3:1; 1:1 and 1:3) and reduced intracellular parasite numbers, measured by the endocytic index, in all tested conditions. The most effective combination regimens were MA/LAP or MA/LAW in 3:1 ratio, which achieved a reduction of 98.3% and 93.6% in the endocytic index,...
Source: International Journal for Parasitology: Drugs and Drug Resistance - August 13, 2019 Category: Parasitology Source Type: research
Activity of methylgerambullin from Glycosmis species (Rutaceae) against Entamoeba histolytica and Giardia duodenalis in vitro
Publication date: Available online 10 August 2019Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Mirjana Drinić, Adriane Raninger, Andrea Zraunig, Florian Astelbauer, David Leitsch, Andreas Obwaller, Julia Walochnik, Harald Greger, Michael DuchêneAbstractEntamoeba histolytica and Giardia duodenalis are widespread intestinal protozoan parasites which both spread via cysts that have to be ingested to infect a new host. Their environment, the small intestine for G. duodenalis and the colon for E. histolytica, contains only very limited amounts of oxygen, so both parasites generate energy ...
Source: International Journal for Parasitology: Drugs and Drug Resistance - August 11, 2019 Category: Parasitology Source Type: research
Erratum to ‘Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni’ [IJP: Drugs and Drug Resistance 8 (2018) 559–570]
Publication date: Available online 2 July 2019Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Gilda Padalino, Salvatore Ferla, Andrea Brancale, Iain W. Chalmers, Karl F. Hoffmann (Source: International Journal for Parasitology: Drugs and Drug Resistance)
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 3, 2019 Category: Parasitology Source Type: research
Route map for the discovery and pre-clinical development of new drugs and treatments for cutaneous leishmaniasis
Publication date: Available online 20 June 2019Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Diana Caridha, Brian Vesely, Katrien van Bocxlaer, Byron Arana, Charlie Mowbray, Sima Rifati, Silvia Uliana, Rosa Regura, Mara Kreishman-Deitrick, Richard Sciotti, Pierre Buffet, Simon L. CroftAbstractAlthough there have been significant advances in the treatment of visceral leishmaniasis (VL) and several novel compounds are currently in pre-clinical and clinical development for this manifestation of leishmaniasis, there have been limited advances in drug research and development (R & D) for cu...
Source: International Journal for Parasitology: Drugs and Drug Resistance - June 20, 2019 Category: Parasitology Source Type: research
Screening the Medicines for Malaria Venture Pathogen Box against piroplasm parasites
In this study, the 400 compounds in the Pathogen Box provided by the Medicines for Malaria Venture foundation were screened against Babesia bovis, Babesia bigemina, Babesia caballi, and Theileria equi. A fluorescence-based method using SYBR Green 1 stain was used for initial in vitro screening and determination of the half maximal inhibitory concentration (IC50). The initial in vitro screening performed using a 1 μM concentration as baseline revealed nine effective compounds against four tested parasites. Two “hit” compounds, namely MMV021057 and MMV675968, that showed IC50 < 0.3 μM and a selectivity inde...
Source: International Journal for Parasitology: Drugs and Drug Resistance - June 19, 2019 Category: Parasitology Source Type: research
Novel and safe single-dose treatment of cutaneous leishmaniasis with implantable amphotericin B-Loaded microparticles
Publication date: Available online 17 June 2019Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Ariane J. Sousa-Batista, Wallace Pacienza-Lima, Maria Inês Ré, Bartira Rossi-BergmannAbstractThe development of an effective amphotericin B (AmB) topical formulation to replace the systemically toxic injections currently used in cutaneous leishmaniasis (CL) treatment is challenging due to poor absorption through the skin. Aiming at an effective local chemotherapy, we designed PLGA (poly lactide-co-glycolide acid) microspheres loaded with deoxycholate amphotericin B (d-AmB) for both macrophage...
Source: International Journal for Parasitology: Drugs and Drug Resistance - June 18, 2019 Category: Parasitology Source Type: research
Perspectives on the utility of moxidectin for the control of parasitic nematodes in the face of developing anthelmintic resistance
Publication date: Available online 15 June 2019Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Roger K. Prichard, Timothy G. GearyAbstractMacrocyclic lactone (ML) anthelmintics are the most important class of anthelmintics because of our high dependence on them for the control of nematode parasites and some ectoparasites in livestock, companion animals and in humans. However, resistance to MLs is of increasing concern. Resistance is commonplace throughout the world in nematode parasites of small ruminants and is of increasing concern in horses, cattle, dogs and other animals. It is suspe...
Source: International Journal for Parasitology: Drugs and Drug Resistance - June 16, 2019 Category: Parasitology Source Type: research
Mining for natural product antileishmanials in a fungal extract library
Publication date: Available online 11 June 2019Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): A.J. Mbekeani, R.S. Jones, M. Bassas Llorens, J. Elliot, C. Regnault, M.P. Barrett, J. Steele, B. Kebede, S.K. Wrigley, L. Evans, P.W. DennyAbstractLeishmaniasis is a Neglected Tropical Disease caused by the insect-vector borne protozoan parasite, Leishmania species. Infection affects millions of the World's poorest, however vaccines are absent and drug therapy limited. Recently, public-private partnerships have developed to identify new modes of controlling leishmaniasis. Most of these collabo...
Source: International Journal for Parasitology: Drugs and Drug Resistance - June 11, 2019 Category: Parasitology Source Type: research
Novel chemical starting points for drug discovery in leishmaniasis and Chagas disease
Publication date: Available online 22 May 2019Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Irene Roquero, Juan Cantizani, Ignacio Cotillo, M. Pilar Manzano, Albane Kessler, J. Julio Martín, Case W. McNamaraAbstractVisceral leishmaniasis (VL) and Chagas disease (CD) are caused by kinetoplastid parasites that affect millions of people worldwide and impart a heavy burden against human health. Due to the partial efficacy and toxicity-related limitations of the existing treatments, there is an urgent need to develop novel therapies with superior efficacy and safety profiles to successfull...
Source: International Journal for Parasitology: Drugs and Drug Resistance - May 24, 2019 Category: Parasitology Source Type: research
Refugia and anthelmintic resistance: Concepts and challenges
Publication date: Available online 17 May 2019Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Jane E. Hodgkinson, Ray M. Kaplan, Fiona Kenyon, Eric R. Morgan, Andrew W. Park, Steve Paterson, Simon A. Babayan, Nicola J. Beesley, Collette Britton, Umer Chaudray, Stephen R. Doyle, Vanessa O. Ezenwa, Andy Fenton, Sue B. Howell, Roz Laing, Barbara K. Mable, Louise Matthews, Jennifer McIntyre, Catherine E. Milne, Thomas A. MorrisonAbstractAnthelmintic resistance is a threat to global food security. In order to alleviate the selection pressure for resistance and maintain drug efficacy, manageme...
Source: International Journal for Parasitology: Drugs and Drug Resistance - May 18, 2019 Category: Parasitology Source Type: research
