Persistent suicidal ideation in major depressive disorder patients: still in need of empathic understanding
No abstract available (Source: International Clinical Psychopharmacology)
Source: International Clinical Psychopharmacology - October 15, 2022 Category: Psychiatry Tags: Commentary Source Type: research

Lamotrigine-induced mania: warning report for the identification of vulnerable populations and expert clinical recommendations for prescription
Lamotrigine (LTG) is an anticonvulsant drug used for the prevention of depressive episodes in bipolar disorder (BD) that might induce manic episodes in some cases. A 38-year-old man, stabilized with asenapine due to a brief psychotic episode, presented depressive symptoms and LTG was titrated up to 200 mg/day in 6 weeks. One week later he was diagnosed with a first manic episode with psychotic symptoms [Young Mania Rating Scale (YMRS = 31)] and type I BD (BD-I). LTG was withdrawn and he was treated with lithium and lurasidone. The episode remitted in 1 week. A 45-year-old woman with BD presented persistent depressi...
Source: International Clinical Psychopharmacology - October 15, 2022 Category: Psychiatry Tags: Case Report Source Type: research

The dilemma of polypharmacy in psychosis: is it worth combining partial and full dopamine modulation?
Antipsychotic polypharmacy in psychotic disorders is widespread despite international guidelines favoring monotherapy. Previous evidence indicates the utility of low-dose partial dopamine agonist (PDAs) add-ons to mitigate antipsychotic-induced metabolic adverse effects or hyperprolactinemia. However, clinicians are often concerned about using PDAs combined with high-potency, full dopaminergic antagonists (FDAs) due to the risk of psychosis relapse. We, therefore, conducted a literature review to find studies investigating the effects of combined treatment with PDAs (i.e. aripiprazole, cariprazine and brexpiprazole) and FD...
Source: International Clinical Psychopharmacology - October 15, 2022 Category: Psychiatry Tags: Review Source Type: research

Amisulpride steady-state plasma concentration and adverse reactions in patients with schizophrenia: a study based on therapeutic drug monitoring data
The aim of the study was to evaluate the reference range of amisulpride for Chinese patients with schizophrenia and to assess its possible influencing factors based on therapeutic drug monitoring information. The relative adverse reactions of patients induced by amisulpride were also systematically investigated. A total of 425 patients with schizophrenia were assessed, including Positive and Negative Syndrome Scales, Treatment Emergent Symptom Scale, blood routine examination, hepatorenal function, lipids, hormones, as well as myocardial enzymes at baseline, and following treatment with amisulpride for 8 weeks. The steady-...
Source: International Clinical Psychopharmacology - October 15, 2022 Category: Psychiatry Tags: Original Articles Source Type: research

Clinical correlates and prognostic impact of binge-eating symptoms in major depressive disorder
This study compared two groups of patients with MDD experiencing or not BE symptoms to ascertain differences in terms of clinical manifestations, presence of bipolar features, and antidepressant treatment outcomes. The study involved 482 outpatients collected within the Combining Medications to Enhance Depression Outcomes (CO-MED) trial, who were assessed with scales for depressive and hypomanic symptomatology, suicidality, comorbid mental disorders, and childhood traumas. BE symptoms were reported in 95 patients (20%). Patients with MDD experiencing BE symptoms were characterized by higher scores of negative self-outlook ...
Source: International Clinical Psychopharmacology - October 15, 2022 Category: Psychiatry Tags: Original Articles Source Type: research

Association between neutrophil to lymphocyte ratio and mood polarity in adolescents admitted to an inpatient psychiatric ward
Inflammatory processes are associated with mood disorders, but data on pediatric patients are scarce. The aim of this study was to investigate a possible association between elevated neutrophil/lymphocyte ratio (NLR) – a marker of inflammation and mood polarity (manic/depressed) in adolescents, admitted between 2010 and 2015 due to a mood disorder episode and to an adolescent inpatient ward. Electronic medical records of 305 patients (aged 10–19 years, 60.6% males) admitted during the study period due to a mood disorder episode were reviewed. Of these, 63 were diagnosed with manic episodes and 242 with depressive episo...
Source: International Clinical Psychopharmacology - October 15, 2022 Category: Psychiatry Tags: Original Articles Source Type: research

Risk of conversion to bipolar disorder in patients with late-onset major depression
To evaluate the impact of age at onset on late-life depression course and on risk of conversion to bipolar disorder (BD). A retrospective chart review of 100 elderly patients (age ≥ 65 years) diagnosed with a moderate-to-severe depressive episode and followed up for at least 18 months was conducted. Among patients affected by major depressive disorder (N = 57), follow-up morbidity differences between those with typical onset depression (TOD) ( (Source: International Clinical Psychopharmacology)
Source: International Clinical Psychopharmacology - October 15, 2022 Category: Psychiatry Tags: Original Articles Source Type: research

Open issues in bipolar and antipsychotic treatments
No abstract available (Source: International Clinical Psychopharmacology)
Source: International Clinical Psychopharmacology - October 15, 2022 Category: Psychiatry Tags: Editorial Source Type: research

Allergic reaction induced by subcutaneous administration of ketamine: a case report
Ketamine can be used for depression and suicidal ideation due to its effectiveness and low complication rates; moreover, allergic reactions are rare. Immediately after subcutaneous (SC) ketamine administration, a 22-year-old man rapidly developed hives on the trunk and face without oxygen desaturation. Symptoms disappeared after treatment with prednisolone. This case presents an allergic reaction to ketamine compatible with mast cell activation and release of preformed mediators, without being able to prove whether the event was mediated by immunoglobulin E. This is the only case reported to date of an allergic reaction to...
Source: International Clinical Psychopharmacology - August 6, 2022 Category: Psychiatry Tags: Case Report Source Type: research

Suicidality and psychotic episodes after starting aripiprazole: two case reports
Switching antipsychotic medication must be done carefully to ensure patient safety and a successful response. Here, we present two major psychotic decompensations that occurred following a switch to aripiprazole in two patients with schizophrenia. Mr. X was treated with paliperidone and experienced residual anxiety. Thus, a switch to aripiprazole was planned with risperidone and a gradual decrease in paliperidone. Initially, an increase in aripiprazole resulted in remission of his residual symptoms. However, two weeks later, he presented an anxiety relapse with persecutory ideas which required hospitalization. Mr. Y, who w...
Source: International Clinical Psychopharmacology - August 6, 2022 Category: Psychiatry Tags: Case Report Source Type: research

Unleashing the power of pooled and subgroup analyses in psychiatry
No abstract available (Source: International Clinical Psychopharmacology)
Source: International Clinical Psychopharmacology - August 6, 2022 Category: Psychiatry Tags: Commentary Source Type: research

Efficacy and safety of lurasidone in schizophrenia: pooled analysis of European results from double-blind, placebo-controlled 6-week studies
The objective of this study is to confirm the efficacy and safety of lurasidone in the acute treatment of schizophrenia in European patients. Data were pooled from three studies of patients randomized to 6 weeks of double-blind, placebo-controlled, fixed-dose (40/80 mg and 120/160 mg) lurasidone. The primary efficacy endpoint was a week 6 change in the Positive and Negative Syndrome Scale (PANSS) total score and secondary endpoints included the Clinical Global Impression, Severity scale (CGI-S). In total 328 safety patients were enrolled; 72.6% were completers. Endpoint change was significantly greater in patients treate...
Source: International Clinical Psychopharmacology - August 6, 2022 Category: Psychiatry Tags: Original Articles Source Type: research

Repeated subcutaneous racemic ketamine in treatment-resistant depression: case series
Interest in the use of parenteral ketamine has been increasing over the last 2 decades for the management of treatment-resistant depression (TRD). While intravenous (IV) ketamine has been the most common parenteral route of administration, subcutaneous (SC) and intramuscular options have been described. We developed a clinical treatment protocol for the use of repeated SC racemic ketamine (maximum six treatments, twice per week) in an inpatient psychiatric care setting with inclusion/exclusion criteria, dosing schedule, and description of treatment, assessment, and monitoring procedures. Results from the first 10 consecuti...
Source: International Clinical Psychopharmacology - August 6, 2022 Category: Psychiatry Tags: Original Articles Source Type: research

Effects of acute pain medications on posttraumatic stress symptoms in early aftermath of trauma
Posttraumatic stress symptoms (PTSS) develop as sequelae from traumatic injuries. Limited studies suggest that using opioids to reduce acute pain immediately after trauma may also reduce subsequent PTSS, but other pain medications rarely have been examined for preventing acute PTSS. The current study examined the effects of commonly used pain medications, opioid and nonsteroidal anti-inflammatory drugs (NSAIDs), on PTSS after acute traumatic injuries. Participants (n = 71) were categorized into opioid or NSAID group according to their medical records and self-reported medication use. Their PTSS were assessed using posttrau...
Source: International Clinical Psychopharmacology - August 6, 2022 Category: Psychiatry Tags: Original Articles Source Type: research

Persistence of suicidal ideation within acute phase treatment of major depressive disorder: analysis of clinical predictors
This study aimed to disentangle the contribution of baseline clinical characteristics in SI nonremission at week 6. Research involved 198 outpatients with MDD and SI collected within the Combining Medications to Enhance Depression Outcomes trial and treated with different antidepressant combinations. Although SI decreased from baseline to week 6 (P (Source: International Clinical Psychopharmacology)
Source: International Clinical Psychopharmacology - August 6, 2022 Category: Psychiatry Tags: Original Articles Source Type: research