Platelet-rich plasma-derived exosomes promote rotator cuff tendon-bone healing
Tendon-bone interface (TBI) is a specialized structure that connects bone and tendon, effectively distributing stress and enabling efficient load transfer between the two tissues [1]. Rotator cuff tear (RCT) usually occurs at the site of the fibrocartilaginous TBI due to factors such as trauma, overuse, or degeneration, leading to significant shoulder discomfort and dysfunction [2]. RCT prevalence is 22.1% in the general population, with the incidence increasing with age [3]. Injuries affect 9.7% of individuals under the age of 20 on average, rising to 62% in those over the age of 80 [4]. (Source: Injury)
Source: Injury - November 14, 2023 Category: Orthopaedics Authors: Lei Han, Ningrui Hu, Canfeng Wang, Zhengcong Ye, Tuo Wang, Fang Lan Source Type: research
Compression screw internal fixation versus non-weight-bearing cast immobilization for Jones fractures in children
Metatarsal fractures account for less than 6% of all pediatric fractures, with fifth metatarsal fractures being the most common among these [1,2]. Fractures of the fifth metatarsal base were first described by Sir Robert Jones in 1902. He presented six cases of proximal fifth metatarsal fractures caused by indirect violence attributed to plantar flexion of the foot, anterior foot varus, transfer of the body's center of gravity, and sudden contraction of the peroneus brevis [3]. However, Jones did not describe a formal classification system; instead, he described the eponymous fracture as occurring within approximately thre...
Source: Injury - November 14, 2023 Category: Orthopaedics Authors: Yuwei Wen, Danjiang Zhu, Qiang Wang, Baojian Song, Wei Feng Tags: Review Source Type: research
National Analysis of Over and Under-Triage Rates in Relation to Trauma Population Risk Factors and Associated Outcomes Across Various Levels Trauma Centers
: Over and under-triage represent a misallocation of resources that can affect patient outcomes. The purpose of this study is to evaluate over and under-triage rates in relation to risk factors and associated outcomes of trauma patients nationwide. (Source: Injury)
Source: Injury - November 14, 2023 Category: Orthopaedics Authors: Jeffrey Hayashi, Maveric Abella, Denise Nunez, Noah Alter, Jason Kim, Abigail Rosander, Adel Elkbuli Source Type: research
Epidemiology of Distal Radius Fractures: Elucidating Mechanisms, Comorbidities, and Fracture Classification Using the National Trauma Data Bank
Distal radial fractures (DRFs) stand as a notable challenge in the realm of musculoskeletal injuries. Constituting approximately one sixth of emergently presenting fractures, DRFs have garnered significant attention from the medical community due to their impact on patients' lives and burden on the medical system.[1 –3] Due to this large prevalence and impact on patients’ functional capacity, current management of DRFs is often multifactorial, incorporating patient goals, comorbidities, and fracture characteristics. (Source: Injury)
Source: Injury - November 14, 2023 Category: Orthopaedics Authors: Sachin R. Chinta, Michael F. Cassidy, David L. Tran, Hilliard T. Brydges, Daniel J. Ceradini, Jonathan L. Bass, Nikhil A. Agrawal Source Type: research
Cytokines: the links between bone and the immune system
Osteoporosis results from an imbalance in a highly balanced physiological process called bone remodeling, in which osteoclast-mediated bone resorption and osteoblast-mediated bone formation play important roles. Osteoimmunology is a newly discovered interdisciplinary research field that focuses on the relationship between bone and the immune system. Specifically, bone and the immune system interact through cytokines, immune cells secrete cytokines, and cytokines finely regulate bone metabolism by mediating the differentiation and activity of osteoclasts and osteoblasts. (Source: Injury)
Source: Injury - November 13, 2023 Category: Orthopaedics Authors: Liping Cai, You Lv, Qihui Yan, Weiying Guo Tags: Review Source Type: research
