Endoscopic Balloon Dilation Size and Avoidance of Surgery in Stricturing Crohn's Disease
Conclusions: Although dilation calibers larger than 14 to 15 mm were not more protective against future surgery, those reaching 16 to 18 mm underwent maintenance dilation less frequently. The risk of surgery associated with post-EBD anti–tumor necrosis factor initiation suggests that effective therapy is often used too late in the disease course. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - October 1, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
High Demand for Psychotherapy in Patients with Inflammatory Bowel Disease
Background: The relative contribution of psychological factors to the onset and course of inflammatory bowel diseases (IBD) is a matter of constant debate since its beginning, as is the clinical need and the efficacy of psychotherapeutic interventions. However, the perspective of patients with IBD has largely been ignored in this debate.
Methods: Psychometric tests including the Short-Form IBD Questionnaire (SIBDQ), the ADAP test measuring demand for psychotherapy, and the Fear-of-Progression Questionnaire Short Form as well as disease-related questions were positioned on the internet between December 2014 and January 201...
Source: Inflammatory Bowel Diseases - October 1, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Frequency and Variables Associated with Fasting Orders in Inpatients with Ulcerative Colitis: The Audit of Diet Orders—Ulcerative Colitis (ADORE-UC) Study
Conclusions: There is a high burden of unjustified underfeeding among hospitalized patients with UC, particularly in patients admitted without evidence of objective disease flare. This may lead to nutritional compromise in an at-risk population, and further studies are needed to assess the nutritional impact of unjustified bowel rest on patients with UC. Our findings also suggest that targeted quality improvement interventions are needed to decrease the frequency of inappropriate bowel rest among hospitalized patients with UC. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - October 1, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Prevalence and Phenotype of Concurrent Psoriasis and Inflammatory Bowel Disease
Conclusions: The prevalence of IBD in psoriasis was approximately 4 times higher than that in the general population, with the highest risk for psoriasis-PsA patients. Psoriasis-CD patients have a mild (early-onset) psoriasis but an earlier-onset and severe CD-phenotype. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - October 1, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Association of Inflammatory Bowel Disease and Urolithiasis in Hospitalized Pediatric Patients
Conclusions: The diagnosis of urolithiasis in pediatric patients is associated with IBD, and those with ulcerative colitis have longer hospital stays and greater costs. Patients with IBD have fewer urologic procedures associated with their urolithiasis diagnosis. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - October 1, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Combination Therapy in Pediatric Inflammatory Bowel Disease: Yes, No, Maybe
No abstract available (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - October 1, 2017 Category: Gastroenterology Tags: Commentary Source Type: research
Concomitant Therapy with Immunomodulator Enhances Infliximab Durability in Pediatric Inflammatory Bowel Disease
Background: Data on long-term durability of infliximab (IFX) and outcomes of concomitant therapy with immunomodulator in pediatric inflammatory bowel disease are limited.
Methods: Children with inflammatory bowel disease who received IFX ± immunomodulator were retrospectively reviewed. Predictors of induction response were assessed using a binary logistic regression model and long-term outcomes evaluated by Cox proportional hazards model. Propensity score matching examined long-term efficacy of concomitant therapy in patients with Crohn's disease (CD).
Results: Among 148 patients (113 CD, 35 ulcerative colitis; median a...
Source: Inflammatory Bowel Diseases - October 1, 2017 Category: Gastroenterology Tags: Original Clincial Article Source Type: research
Guanylate Cyclase C Activation Shapes the Intestinal Microbiota in Patients with Familial Diarrhea and Increased Susceptibility for Crohn's Disease
Conclusions: The findings support that the activating mutation in GUCY2C creates an intestinal environment with a major influence on the microbiota, which could contribute to the increased susceptibility to IBD in patients with FGDS. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - October 1, 2017 Category: Gastroenterology Tags: Original Basic Science Articles Source Type: research
Bidirectional Regulation of Circadian Disturbance and Inflammation in Inflammatory Bowel Disease
Conclusions: Our results suggested that inflammation and circadian genes showed complex bidirectional regulations that were relevant to IBD. Consequently, the circadian clock seems to be a potential target for IBD therapy. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - October 1, 2017 Category: Gastroenterology Tags: Original Basic Science Articles Source Type: research
SHANK3 Regulates Intestinal Barrier Function Through Modulating ZO-1 Expression Through the PKCε-dependent Pathway
Conclusions: The expression level of SHANK3 affects ZO-1 expression and the barrier function in intestinal epithelial cells. This may provide novel insights in Crohn's disease pathogenesis and treatment. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - October 1, 2017 Category: Gastroenterology Tags: Original Basic Science Articles Source Type: research
Genetic and Transcriptomic Bases of Intestinal Epithelial Barrier Dysfunction in Inflammatory Bowel Disease
Conclusions: We found genetic and transcriptomic dysregulations of key epithelial barrier genes and components in IBD. Of these, we believe that mucus genes, in particular MUC1 and MUC4, play an essential role in the pathogenesis of IBD and could represent interesting targets for treatment. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - October 1, 2017 Category: Gastroenterology Tags: Original Basic Science Articles Source Type: research
The Current Landscape and Lessons from Fecal Microbiota Transplantation for Inflammatory Bowel Disease: Past, Present, and Future
Abstract: Fecal microbiota transplantation (FMT) has changed the standard of care for Clostridium difficile infection. However, there is limited data focusing on efficacy and safety profile of FMT in patients with C. difficile infection with underlying inflammatory bowel disease (IBD), including the risk of IBD flare. Recently, there is also emerging evidence supporting the role of FMT to treat IBD including promising randomized trials in ulcerative colitis. However, with heterogeneity across these studies, the clinical application of this emerging therapy has yet to be fully elucidated. Here, we aim to review the current ...
Source: Inflammatory Bowel Diseases - October 1, 2017 Category: Gastroenterology Tags: Clinical Review Articles Source Type: research
Systematic Review and Meta-analysis: Fecal Microbiota Transplantation for Treatment of Active Ulcerative Colitis
Conclusions: Among randomized controlled trials, short-term use of FMT shows promise as a treatment to induce remission in active UC based on the efficacy and safety observed. However, there remain many unanswered questions that require further research before FMT can be considered for use in clinical practice. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - October 1, 2017 Category: Gastroenterology Tags: Clinical Review Articles Source Type: research
Safety Considerations with the Use of Corticosteroids and Biologic Therapies in Mild-to-Moderate Ulcerative Colitis
Conclusions: Second-generation corticosteroids, beclomethasone dipropionate and budesonide multimatrix system, exhibited a favorable safety profile in patients with mild-to-moderate UC. For biologics, which are only indicated in moderate-to-severe UC, additional studies are needed to further ascertain the benefit to risk profile of these agents in patients with mild-to-moderate disease (see Video Abstract, Supplemental Digital Content, http://links.lww.com/IBD/B653 ). (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - October 1, 2017 Category: Gastroenterology Tags: Clinical Review Articles Source Type: research
Update on the Therapeutic Efficacy of Tregs in IBD: Thumbs up or Thumbs down?
Abstract: Crohn's disease and ulcerative colitis, the 2 major forms of inflammatory bowel disease (IBD) in humans, arise in genetically predisposed individuals because of an abnormal immune response direct against constituents of the gut flora. Defects in counter-regulatory mechanisms are supposed to amplify and maintain the IBD-associated mucosal inflammation. Therefore, restoring the balance between inflammatory and anti-inflammatory pathways in the gut could contribute to halt the IBD-associated tissue-damaging immune response. Various suppressive T cell (Tregs) subsets have been characterized phenotypically and functio...
Source: Inflammatory Bowel Diseases - October 1, 2017 Category: Gastroenterology Tags: Clinical Review Articles Source Type: research
