A Simple Ultrasound Score for the Accurate Detection of Inflammatory Activity in Crohn's Disease
This study comprised 2 single-center investigations. The first was a retrospective study on a population that had received colonoscopies (as a gold-standard diagnostic) within 60 days of ultrasound. The second was a prospective study on 2 populations: patients requiring induction with adalimumab and patients on adalimumab maintenance therapy. Ultrasound and endoscopy were preformed within 14 days in both prospective groups. The endoscopy results were graded with the Simple Endoscopic Score and the Rutgeerts score and compared with 5 ultrasound parameters. We used a proportional odds model to determine which ultrasound para...
Source: Inflammatory Bowel Diseases - November 1, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Inflammatory Bowel Diseases in Children and Young Adults with Celiac Disease. A Multigroup Matched Comparison
Conclusions: In conclusion, this article found a highly increased risk of IBD in individuals with CD when comparing with the general population. Bias is the likely explanation for the very high risk increase for IBD in CD because the excess risk was substantially lower when we used individuals with a small intestinal biopsy without villous atrophy as our reference. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - November 1, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Interleukin-27 Is a Potential Rescue Therapy for Acute Severe Colitis Through Interleukin-10–Dependent, T-Cell–Independent Attenuation of Colonic Mucosal Innate Immune Responses
Conclusion: We have defined novel mechanisms of IL-27 immunosuppression toward colonic innate immune responses in vivo. Mucosal delivery of IL-27 has translational potential as a novel therapeutic for inflammatory bowel disease, and it is a future mucosal directed rescue therapy in acute severe inflammatory bowel disease. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - November 1, 2017 Category: Gastroenterology Tags: Original Basic Science Articles Source Type: research
Epicutaneous Tolerance Induction to a Bystander Antigen Abrogates Colitis and Ileitis in Mice
Conclusions: This is the first demonstration that epicutaneous tolerance to a model antigen can lead to bystander suppression of inflammation and prevention of disease progression in preclinical models of IBD. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - November 1, 2017 Category: Gastroenterology Tags: Original Basic Science Articles Source Type: research
Comparison of Stromal Vascular Fraction with or Without a Novel Bioscaffold to Fibrin Glue in a Porcine Model of Mechanically Induced Anorectal Fistula
Conclusions: Scaffold technology may improve cell-based therapy healing rates for Crohn's ARFs. This advance should be investigated by human trials. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - November 1, 2017 Category: Gastroenterology Tags: Original Basic Science Articles Source Type: research
Enhanced TH17 Responses in Patients with IL10 Receptor Deficiency and Infantile-onset IBD
Conclusions: IL10R signaling regulates TH17 polarization and T-cell proliferation in humans but is not required for the generation and in vitro suppression of Tregs. Therapies targeting the TH17 axis might be beneficial for IL10- and IL10R-deficient patients as a bridge to allogeneic hematopoietic stem cell transplantation. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - November 1, 2017 Category: Gastroenterology Tags: Original Basic Science Articles Source Type: research
Large Registry Epidemiology in IBD
Abstract: There are different types of large registries which can be harnessed for inflammatory bowel disease research. Not one registry can answer all types of research questions. It is important for both the researchers using the registries and readers of the reports generated, to be aware of the different strengths and weaknesses of each registry and whether the questions posed can reliably be answered. In this review, the use of large administrative databases/registries are discussed in the context of studying descriptive epidemiology, outcomes of inflammatory bowel disease, pharmacoepidemiology, and etiologic research...
Source: Inflammatory Bowel Diseases - November 1, 2017 Category: Gastroenterology Tags: Clinical Review Article Source Type: research
Cost–utility Analysis: Thiopurines Plus Endoscopy-guided Biological Step-up Therapy is the Optimal Management of Postoperative Crohn's Disease
Conclusions: According to this decision analysis, thiopurines immediately after surgery and addition of biologics guided by endoscopic recurrence is the optimal strategy of postoperative management in patients with Crohn's disease with high risk of recurrence (see Video Abstract, Supplemental Digital Content 1, http://links.lww.com/IBD/B654 ). (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - November 1, 2017 Category: Gastroenterology Tags: Future Directions and Methods for IBD Research Source Type: research
The Association Between Drug Levels and Endoscopic Recurrence in Postoperative Patients with Crohn's Disease Treated with Tumor Necrosis Factor Inhibitors
Background: Endoscopic recurrence is associated with a risk of clinical recurrence in patients with Crohn's disease after ileocecal or small bowel resection. Drug levels and presence of antidrug antibodies are associated with important clinical and endoscopic outcomes in patients with Crohn's disease treated with tumor necrosis factor inhibitors, such association was not evaluated for endoscopic postsurgical recurrence.
Methods: Consecutive patients with Crohn's disease treated with anti–tumor necrosis factors after surgery were identified in the databases of the participating centers. Anti–tumor necrosis factor level...
Source: Inflammatory Bowel Diseases - November 1, 2017 Category: Gastroenterology Tags: Future Directions and Methods for IBD Research Source Type: research
Anti–TNF-α Use During the Third Trimester of Pregnancy in Women with Moderate–severe Inflammatory Bowel Disease and the Risk of Preterm Birth and Low Birth Weight
Conclusions: For anti–TNF-α therapy in the third trimester, we found no statistically significant increased risk of either LBW or preterm birth. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - November 1, 2017 Category: Gastroenterology Tags: IBD LIVE Articles Source Type: research
Long-term Efficacy, Safety, and Immunogenicity of Biosimilar Infliximab After One Year in a Prospective Nationwide Cohort
We report here the 1-year outcomes from a prospective nationwide inflammatory bowel disease cohort.
Methods: A prospective, nationwide, multicenter, observational cohort was designed to examine the efficacy and safety of CT-P13 in the induction and maintenance treatment of Crohn's disease (CD) and ulcerative colitis (UC). Demographic data were collected and a harmonized monitoring strategy was applied. Clinical remission, response, and biochemical response were evaluated at weeks 14, 30, and 54, respectively. Safety data were registered.
Results: Three hundred fifty-three consecutive inflammatory bowel disease (209 CD an...
Source: Inflammatory Bowel Diseases - November 1, 2017 Category: Gastroenterology Tags: IBD LIVE Articles Source Type: research
PUFAs and IBD: Is There a Relationship?
No abstract available (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - November 1, 2017 Category: Gastroenterology Tags: Commentary Source Type: research
Genetic Polymorphisms in Fatty Acid Metabolism Modify the Association Between Dietary n3: n6 Intake and Risk of Ulcerative Colitis: A Prospective Cohort Study
Conclusions: The association between dietary n3:n6 PUFA intake and risk of UC may be modified variants at CYP4F3. Further gene–environment studies of the association between diet and IBD risk are warranted. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - November 1, 2017 Category: Gastroenterology Tags: IBD LIVE Articles Source Type: research
Predictors of Early Readmission in Hospitalized Patients with Inflammatory Bowel Disease
Conclusions: Nineteen percentage of patients with inflammatory bowel disease treated at a referral center are readmitted within 30 days. Our results suggest that patients with comorbid medical conditions, malnutrition or obesity, a new ileostomy, past steroid use, or those discharged on hyperalimentation are at increased risk for readmission. Research is needed to determine if targeted interventions for high-risk patients decreases readmissions. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - November 1, 2017 Category: Gastroenterology Tags: IBD LIVE Articles Source Type: research
Novel Artificial Restriction Fragment Length Polymorphism Methods for Genotyping Immunity-related GTPase M Promoter Polymorphisms
No abstract available (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - October 1, 2017 Category: Gastroenterology Tags: Online Only: Letters to the Editor Source Type: research
