Ectopic Expression of Innate Immune Protein, Lipocalin-2, in Lactococcus lactis Protects Against Gut and Environmental Stressors
Conclusions: Our findings suggest that Lcn2 expression can be exploited to enhance the survivability of probiotic bacteria during inflammation, which could further improve its efficacy to treat experimental colitis. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - June 19, 2017 Category: Gastroenterology Tags: Original Basic Science Articles Source Type: research
Complementary Roles of Nod2 in Hematopoietic and Nonhematopoietic Cells in Preventing Gut Barrier Dysfunction Dependent on MLCK Activity
Conclusions: Our study demonstrates how hematopoietic and nonhematopoietic Nod2 regulate intestinal barrier function, improving our knowledge on the mechanisms involved in CD pathogenesis. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - June 19, 2017 Category: Gastroenterology Tags: Original Basic Science Articles Source Type: research
RNA-seq Reveals Transcriptomic Differences in Inflamed and Noninflamed Intestinal Mucosa of Crohn's Disease Patients Compared with Normal Mucosa of Healthy Controls
Background: Aberrant gene expression in the gut mucosa might contribute to the initiation and progression of Crohn's disease (CD). RNA sequencing (RNA-seq) provides precise measurements of expression levels of transcripts and their isoforms. The aim of this study was to use RNA-seq to investigate transcriptomic differences and identify significantly differentially expressed transcripts in inflamed and noninflamed intestinal mucosa of CD patients.
Methods: RNA-seq was performed on 13 pairs of inflamed and noninflamed intestinal mucosa from 13 CD patients and on sex-matched normal mucosa of 13 healthy controls. Significantl...
Source: Inflammatory Bowel Diseases - June 19, 2017 Category: Gastroenterology Tags: Original Basic Science Articles Source Type: research
Pumping Iron: Exploring Novel Gene-environment Interactions in the Inflammatory Bowel Diseases
No abstract available (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - June 19, 2017 Category: Gastroenterology Tags: Commentary Source Type: research
Dietary Iron and Heme Iron Consumption, Genetic Susceptibility, and Risk of Crohn's Disease and Ulcerative Colitis
Conclusion: In 2 large prospective cohort studies, dietary total and heme iron were not associated with risk of CD or UC. Our suggestive finding that the association between dietary heme iron intake and risk of UC may be modified by a coding variant in FcγRIIA gene warrants additional investigation. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - June 19, 2017 Category: Gastroenterology Tags: Clinical Review Article Source Type: research
Efficacy and Factors Associated with Treatment Response of Intravenous Immunoglobulin in Inpatients with Refractory Inflammatory Bowel Diseases
Conclusions: Our study demonstrates that IVIG is beneficial in patients with medically refractory IBD, and that concomitant CDI is a risk factor for the treatment failure of IVIG for refractory disease. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - June 19, 2017 Category: Gastroenterology Tags: Future Directions and Methods for IBD Research Source Type: research
Development of a Novel Predictive Model for the Clinical Course of Crohn's Disease: Results from the CONNECT Study
Conclusions: This is the first validated surgery risk prediction model for Korean patients with CD; it provides accurate individualized estimates of the probability of surgery using clinical parameters collected at diagnosis. This model might guide appropriate patient selection for the early intensive treatment of CD. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - June 19, 2017 Category: Gastroenterology Tags: Future Directions and Methods for IBD Research Source Type: research
Pediatric-to-adult Transition and Medication Adherence in Patients with Inflammatory Bowel Disease
Conclusions: TR patients did not have worse adherence than YAs diagnosed in adulthood. Protective factors may include previous treatment in pediatric centers and the salient symptomatology of inflammatory bowel disease, whereas increasing concerns over medications contribute to nonadherence in YAs. Pharmacist-led counselling improves adherence in these patients. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - June 19, 2017 Category: Gastroenterology Tags: IBD LIVE Source Type: research
Patient Understanding of the Risks and Benefits of Biologic Therapies in Inflammatory Bowel Disease: Insights from a Large-scale Analysis of Social Media Platforms
Conclusions: Social media reveals a wide range of themes governing patients' experience and choice with IBD biologics. The complexity of navigating their risk–benefit profiles suggests merit in creating online tailored decision tools to support IBD patients' decision-making with biologic therapies. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - June 19, 2017 Category: Gastroenterology Tags: IBD LIVE Source Type: research
Effects of Transient and Persistent Anti-drug Antibodies to Certolizumab Pegol: Longitudinal Data from a 7-Year Study in Crohn's Disease
Background: Anti-drug antibodies (ADAbs) may decrease the efficacy of biologics and increase the risk of adverse events. A single positive test may not preclude further treatment because of variations in assays used, test timing, and patient variables. We evaluated the longitudinal patterns of immunogenicity during 7 years of antitumor necrosis factor-alpha drug certolizumab pegol (CZP) treatment for moderate-to-severe Crohn's disease.
Methods: PRECiSE 3 patients (n = 595) received open-label CZP 400 mg every 4 weeks up to 7 years. CZP–ADAb expression, plasma CZP concentration, Harvey-Bradshaw Index, C-reactive protein,...
Source: Inflammatory Bowel Diseases - June 19, 2017 Category: Gastroenterology Tags: IBD LIVE Source Type: research
Relationship Between Patient Knowledge and Medication Adherence in Inflammatory Bowel Disease
No abstract available (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - May 24, 2017 Category: Gastroenterology Tags: Online Only: Letters to the Editor Source Type: research
Interleukin-17A Inhibitor–induced Crohn's Disease/Behçet's Disease–like Lesions
No abstract available (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - May 24, 2017 Category: Gastroenterology Tags: Online Only: Letters to the Editor Source Type: research
Beyond Efficacy: The Acceptability of Antidepressant Treatment to Patients with Inflammatory Bowel Disease
No abstract available (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - May 24, 2017 Category: Gastroenterology Tags: Online Only: Letters to the Editor Source Type: research
Early Life Exposure, Lifestyle, and Comorbidity as Risk Factors for Microscopic Colitis: A Case–Control Study
Conclusions: Early life exposure to microbial antigens and increased hormonal exposure were not found to be protective for MC. Current smoking seems to be an incontestable risk factor for MC. Therefore, exposure to environmental risk factors later may be of relevance in MC pathogenesis and warrants further investigation. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - May 24, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Enteric Infection in Relapse of Inflammatory Bowel Disease: The Utility of Stool Microbial PCR Testing
Conclusions: Enteric infection was detected in 79 (26.8%) symptomatic patients with IBD , with CDI the most frequent followed by E. coli. Negative stool PCR testing was associated with changes in IBD management. Broad enteric PCR testing should be considered during relapse of IBD. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - May 24, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
