Colonic Phenotypes Are Associated with Poorer Response to Anti-TNF Therapies in Patients with IBD
Conclusions: Our results may help to optimize the use of anti-TNF agents in clinical practice and position these therapies appropriately as clinicians strive for a more personalized approach to managing IBD. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - July 19, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Infliximab Trough Levels at Induction to Predict Treatment Failure During Maintenance
Conclusions: This study suggests that patients who do not respond to any optimization strategy have lower IFX TLs during induction at week 6. IFX TLs measured early on at induction might predict treatment failure to IFX during maintenance. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - July 19, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Hydrodynamic IL10 Gene Transfer in Human Colon: Results from an “EX VIVO” Study with Potential Clinical Application in Crohn's Disease
Background: The aim of this work is to evaluate the efficacy of hydrodynamic venous IL10 gene delivery to “ex vivo” human colon segments and to determine its potential interest in Crohn's disease treatment.
Methods: Twenty human colon segments were obtained from surgical resections. Hydrodynamic transfection through the main vein of the pedicle with 50 mL of hIL10 plasmid (20 μg/mL) solution was performed on 13 of them. Tissue sections were cultured and DNA, RNA, and protein copies were determined after 1, 2, and 4 days. Data obtained were compared with 6 nontransfected specimens. Finally, 1 specimen was injected wit...
Source: Inflammatory Bowel Diseases - July 19, 2017 Category: Gastroenterology Tags: Original Basic Science Articles Source Type: research
Characterization and Expansion of Autologous GMP-ready Regulatory T Cells for TREG-based Cell Therapy in Patients with Ulcerative Colitis
Conclusions: Patient-derived rapamycin-expanded CD25+ cells are stable and functional, and as such, ready to serve in a phase I dose-escalation safety study in UC. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - July 19, 2017 Category: Gastroenterology Tags: Original Basic Science Articles Source Type: research
Cideb Deficiency Aggravates Dextran Sulfate Sodium-induced Ulcerative Colitis in Mice by Exacerbating the Oxidative Burden in Colonic Mucosa
Conclusions: Our data suggest that Cideb plays a protective role against the development of UC by reducing the lipid accumulation and oxidative damage in the colonic mucosa. Therefore, Cideb could be a potential therapeutic target for UC. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - July 19, 2017 Category: Gastroenterology Tags: Original Basic Science Articles Source Type: research
miR-4728-3p Functions as a Tumor Suppressor in Ulcerative Colitis-associated Colorectal Neoplasia Through Regulation of Focal Adhesion Signaling
Background: As mechanisms of neoplasia in patients with ulcerative colitis (UC) remain poorly understood, we sought to identify pathways of carcinogenesis in this high-risk population.
Methods: MicroRNA (miRNA) and mRNA expression was examined in nondysplastic rectosigmoid mucosa from UC patients with (n = 19) or without remote colon neoplasia (n = 23). We developed a method to identify miRNA-regulated pathways based on differentially expressed miRNAs and their putative mRNAs targets in the same samples. One key pathway identified in the analysis, miR-4728-3p regulation of focal adhesion signaling was further evaluated in...
Source: Inflammatory Bowel Diseases - July 19, 2017 Category: Gastroenterology Tags: Original Basic Science Articles Source Type: research
Systematic Review and Meta-analysis: Adalimumab Monotherapy Versus Combination Therapy with Immunomodulators for Induction and Maintenance of Remission and Response in Patients with Crohn's Disease
Conclusions: The combination of ADA and immunomodulators does not seem superior to ADA monotherapy for induction and maintenance of remission and response in Crohn's disease. Combination therapy is associated with lower immunogenicity. Analyses associating combination therapy with better induction of remission in anti-TNF–experienced patients and a higher rate of opportunistic infections deserve further evaluation. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - July 19, 2017 Category: Gastroenterology Tags: Clinical Review Articles Source Type: research
Understanding the Cautions and Contraindications of Immunomodulator and Biologic Therapies for Use in Inflammatory Bowel Disease
Abstract: Ulcerative colitis and Crohn's disease are chronic inflammatory bowel diseases for which there are no cures. These diseases are immunopathogenic, and medical treatment is centered on the temperance of a dysregulated immune response to allow mucosal healing and prevent the sequelae of fistulation and stenosis. Accordingly, the armamentarium of medications, which has expanded immensely in recent history, is not without significant infectious and neoplastic risks. Many of these untoward effects can be mitigated by screening and avoidance of contraindicated medications. This review seeks to highlight the cautions for...
Source: Inflammatory Bowel Diseases - July 19, 2017 Category: Gastroenterology Tags: Clinical Review Articles Source Type: research
A Systematic Review of Internet Decision-Making Resources for Patients Considering Surgery for Ulcerative Colitis
Conclusions: Available information for patients considering surgery for UC is generally low quality. The development of a new decision aid to support patients considering surgery for UC is recommended. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - July 19, 2017 Category: Gastroenterology Tags: Clinical Review Articles Source Type: research
Receptive Anal Intercourse in Patients with Inflammatory Bowel Disease: A Clinical Review
Abstract: Receptive anal intercourse and its association with sexually transmitted infections and human papillomavirus–related anal dysplasia has been well studied in various at-risk groups including men who have sex with men. However, the relationship between receptive anal intercourse and its potential complications in patients with inflammatory bowel disease is not fully understood. This narrative review discusses sexually transmitted infections and anal dysplasia in patients with inflammatory bowel disease who engage in receptive anal intercourse and the lack of evidence-based data to guide clinical practice. It addr...
Source: Inflammatory Bowel Diseases - July 19, 2017 Category: Gastroenterology Tags: Clinical Review Articles Source Type: research
Looking into Enteric Virome in Patients with IBD: Defining Guilty or Innocence?
Background: Although there is some evidence suggesting that certain viruses may be involved in the onset of inflammatory bowel disease (IBD), data regarding viral prevalence and viral load in blood and mucosa of patients with IBD are scarce. The main aim of this study is to evaluate the prevalence and viral load of common Epstein–Barr virus (EBV), cytomegalovirus (CMV), and human herpes virus 6 in blood and mucosa of adult patients with endoscopic active IBD.
Methods: From January to December 2014, ulcerative colitis and Crohn's disease patients with active endoscopic disease were consecutively enrolled. Subjects underg...
Source: Inflammatory Bowel Diseases - July 19, 2017 Category: Gastroenterology Tags: IBD LIVE Articles Source Type: research
Clinical Predictors of the Risk of Early Colectomy in Ulcerative Colitis: A Population-based Study
Conclusions: Patients hospitalized for UC have a high risk of early colectomy. This is particularly true in middle-aged men, those living in rural areas, and those without response to infliximab. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - July 19, 2017 Category: Gastroenterology Tags: IBD LIVE Articles Source Type: research
Cost of Ulcerative Colitis in Quebec, Canada: A Retrospective Cohort Study
Conclusions: The mean UC daily cost decreased from 2005 to 2011 as compared to 1998 to 2004 because of a decrease in rates of colectomy and other gastrointestinal hospitalizations and emergency department visits. Further investigation is required to determine the reasons for these changes. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - July 19, 2017 Category: Gastroenterology Tags: IBD LIVE Articles Source Type: research
Inflammatory Bowel Disease Pharmacist Adherence Counseling Improves Medication Adherence in Crohn's Disease and Ulcerative Colitis
Background: While inflammatory bowel diseases (IBD) require long-term medication usage to maintain remission, nonadherence is common and adversely associated with poorer clinical outcomes. Personalized IBD Pharmacist Adherence Counselling, based on the Health Beliefs Model of medication perception, may increase medication adherence.
Methods: This prospective multi-center longitudinal parallel study recruited consecutive IBD subjects that were classified as baseline medication non-adherers and adherers. Non-adherers received a single IBD Pharmacist Adherence Counselling intervention at baseline, while adherers served as co...
Source: Inflammatory Bowel Diseases - July 19, 2017 Category: Gastroenterology Tags: IBD LIVE Articles Source Type: research
Coping with Inflammatory Bowel Disease: Engaging with Information to Inform Health-Related Decision Making in Daily Life
Conclusions: Findings illustrate the changing needs for health-related information over the course of IBD, and with evolving health and life circumstances. Practitioners can be responsive to information needs of people with IBD by having high-quality information available at the right time in a variety of formats and by supporting the incorporation of information in daily life. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - July 19, 2017 Category: Gastroenterology Tags: IBD LIVE Articles Source Type: research
