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Health Care-Associated Infections in Older Adults
Health care-associated infections (HAIs) are a global public health threat, which disproportionately impact older adults. Host factors including aging-related changes, comorbidities, and geriatric syndromes, such as dementia and frailty, predispose older individuals to infection. The HAI risks from medical interventions such as device use, antibiotic use, and lapses in infection control follow older adults as they transfer among a network of interrelated acute and long-term care facilities. Long-term care facilities are caring for patients with increasingly complex needs, and the home-like communal environment of long-term...
Source: Infectious Diseases Clinics of North America - February 16, 2023 Category: Infectious Diseases Authors: Brenda L. Tesini, Ghinwa Dumyati Source Type: research

Vaccine-Preventable Diseases in Older Adults
Older adults are at an increased risk of vaccine-preventable diseases partly because of physiologic changes in the immune and other body systems related to age and/or accumulating comorbidities that increase the vulnerability to infections and decrease the response to vaccines. Strategies to improve the response to vaccines include using a higher antigenic dose (such as in the high-dose inactivated influenza vaccines) as well as adding adjuvants (such as MF59 in the adjuvanted inactivated influenza vaccine). (Source: Infectious Diseases Clinics of North America)
Source: Infectious Diseases Clinics of North America - February 16, 2023 Category: Infectious Diseases Authors: Maha Al-Jabri, Christian Rosero, Elie A. Saade Source Type: research

Update in Human Immunodeficiency Virus and Aging
Effective and consistent antiretroviral therapy has enabled people with human immunodeficiency virus (HIV) (PWH) to survive longer than previously encountered earlier in the epidemic. Consequently, PWH are subject to the struggles and clinical conditions typically associated with aging. However, the aging process in PWH is not the same as for those who do not have HIV. There is a complex interplay of molecular, microbiologic, and pharmacologic factors that leads to accelerated aging in PWH; this leads to increased risk for certain age-related comorbidities requiring greater vigilance and interventions in routine care. (Sou...
Source: Infectious Diseases Clinics of North America - February 16, 2023 Category: Infectious Diseases Authors: Jason R. Faulhaber, Anthony W. Baffoe-Bonnie, Krisann K. Oursler, Shikha S. Vasudeva Source Type: research

The Intersection of Age and Infections: Understanding the Impacts from Diagnosis to Management
According to the Pew Research Center,1 by the year 2050, there are expected to be 81 million people over the age of 65 living in the United States, more than doubling their numbers from the start of the century. In fact, as a group, older adults are expected to expand faster than the general population, extending their representation to one in every four adults by the year 2060. With aging comes increasing likelihood of acute and chronic comorbid conditions, including infections. Given that over a third of all health care spending in the United States is for people 65 and older, in economic terms alone, this graying of the...
Source: Infectious Diseases Clinics of North America - February 16, 2023 Category: Infectious Diseases Authors: Puja Van Epps, David H. Canaday Tags: Preface Source Type: research

Infections in Older Adults
INFECTIOUS DISEASE CLINICS OF NORTH AMERICA (Source: Infectious Diseases Clinics of North America)
Source: Infectious Diseases Clinics of North America - February 16, 2023 Category: Infectious Diseases Authors: Puja Van Epps, David H. Canaday Source Type: research

Copyright
Elsevier (Source: Infectious Diseases Clinics of North America)
Source: Infectious Diseases Clinics of North America - February 16, 2023 Category: Infectious Diseases Source Type: research

Contributors
HELEN W. BOUCHER, MD, FIDSA, FACP (Source: Infectious Diseases Clinics of North America)
Source: Infectious Diseases Clinics of North America - February 16, 2023 Category: Infectious Diseases Source Type: research

Contents
Puja Van Epps and David H. Canaday (Source: Infectious Diseases Clinics of North America)
Source: Infectious Diseases Clinics of North America - February 16, 2023 Category: Infectious Diseases Source Type: research

Infectious Disease Clinics of North America
Sexually Transmitted Infections (Source: Infectious Diseases Clinics of North America)
Source: Infectious Diseases Clinics of North America - February 16, 2023 Category: Infectious Diseases Source Type: research

After the COVID-19 Crisis: Update on Complex Infectious Diseases Issues in the Intensive Care Unit
INFECTIOUS DISEASE CLINICS OF NORTH AMERICA (Source: Infectious Diseases Clinics of North America)
Source: Infectious Diseases Clinics of North America - December 1, 2022 Category: Infectious Diseases Authors: Naomi P. O ’Grady, Sameer S. Kadri Source Type: research

After the COVID-19 Crisis: Update on Complex Infectious Disease Issues in the Intensive Care Unit
INFECTIOUS DISEASE CLINICS OF NORTH AMERICA (Source: Infectious Diseases Clinics of North America)
Source: Infectious Diseases Clinics of North America - November 29, 2022 Category: Infectious Diseases Authors: Naomi P. O ’Grady, Sameer S. Kadri Source Type: research

Vaccines for the Prevention of Coronavirus Disease 2019 in Older Adults
Institutionalized and community-dwelling older adults have been greatly impacted by the coronavirus disease 2019 (COVID-19) pandemic with increased morbidity and mortality. The advent of vaccines and their widespread use in this population has brought about a dramatic turnaround in COVID-19 outcomes. The immunogenicity and effectiveness of the various vaccine options worldwide are discussed. Optimization of vaccine usage will still be important to maximize protection due to reduced initial immunity, development of variant strains, and fading of immunity over time. There are also lessons learned specific to older population...
Source: Infectious Diseases Clinics of North America - November 3, 2022 Category: Infectious Diseases Authors: Oladayo A. Oyebanji, Eleftherios Mylonakis, David H. Canaday Source Type: research

Epidemiology and Clinical Presentation of COVID-19 in Older Adults
SARS-CoV-2 infection remains asymptomatic in 33 to 90% of older adults depending on their immune status from prior infection, vaccination and circulating strain. Older adults symptomatic with SARS-CoV-2 often both present atypically, such as with a blunted fever response, and develop more severe disease. Early and late reports showed that older adults have increased severity of COVID-19 with higher case fatality rates and higher intensive care needs compared to younger adults. Infection and vaccine-induced antibody response and long-term effects of COVID-19 also differ in older adults. (Source: Infectious Diseases Clinics of North America)
Source: Infectious Diseases Clinics of North America - November 3, 2022 Category: Infectious Diseases Authors: Yasin Abul, Ciera Leeder, Stefan Gravenstein Source Type: research

Vaccines for the prevention of COVID-19 in older adults
Institutionalized and community-dwelling older adults have been greatly impacted by the COVID-19 pandemic with increased morbidity and mortality. The advent of vaccines and their widespread use in this population has brought about a dramatic turnaround in COVID-19 outcomes. The immunogenicity and effectiveness of the various vaccine options worldwide will be discussed. Optimization of vaccine usage will still be important to maximize protection due to reduced initial immunity, development of variant strains, and fading of immunity over time. There are also lessons learned specific to older populations for future pandemics ...
Source: Infectious Diseases Clinics of North America - November 3, 2022 Category: Infectious Diseases Authors: Oladayo A. Oyebanji, Eleftherios Mylonakis, David H. Canaday Source Type: research

Cytokine Release Syndrome and Sepsis
Both cytokine release syndrome (CRS) and sepsis are clinical syndromes rather than distinct diseases and share considerable overlap. It can often be challenging to distinguish between the two, but it is important given the availability of targeted treatment options. In addition, several other clinical syndromes overlap with CRS and sepsis, further making it difficult to differentiate them. This has particularly been highlighted in the recent coronavirus disease-2019 pandemic. As we start to understand the differences in the inflammatory markers and presentations in these syndromes, hopefully we will be able to enhance trea...
Source: Infectious Diseases Clinics of North America - November 1, 2022 Category: Infectious Diseases Authors: Janhavi Athale, Lindsay M. Busch, Naomi P. O ’Grady Source Type: research