Is it truly outrageous to consider radical prostatectomy for men with metastatic prostate cancer?
Gagan GautamIndian Journal of Urology 2014 30(4):366-367Radical prostatectomy is a leading form of treatment for non metastatic prostate cancer. It has been shown to improve survival in the long term as well as delay or prevent the onset of metastatic disease. However, as the treatment of metastatic prostate cancer has evolved in the last few years with the introduction of newer agents, the possible role of 'cytoreductive' radical prostatectomy is now being explored. Preliminary evidence suggests that radical prostatectomy may have a future role in this clinical scenario with a potential to improve quality an...
Source: Indian Journal of Urology - October 1, 2014 Category: Urology & Nephrology Authors: Gagan Gautam Source Type: research

A time of change
Santosh KumarIndian Journal of Urology 2014 30(4):365-365 (Source: Indian Journal of Urology)
Source: Indian Journal of Urology - October 1, 2014 Category: Urology & Nephrology Authors: Santosh Kumar Source Type: research

International Radical Cystectomy Consortium: A way forward
This article summarizes the findings of the IRCC and highlights the future direction of the consortium. (Source: Indian Journal of Urology)
Source: Indian Journal of Urology - July 1, 2014 Category: Urology & Nephrology Authors: Syed Johar RazaErinn FieldAdam S. KibelAlex MottrieAlon Z. WeizerAndrew WagnerAshok K. HemalDouglas S. ScherrFrancis SchanneFranco GaboardiGuan WuJames O. PeabodyJihad KoaukJoan Palou RedortaJohn G. PattarasKoon-Ho RhaLee RichstoneM. Derya BalbayMani Meno Source Type: research

Obituary
Mahendra BhandariIndian Journal of Urology 2014 30(3):363-363 (Source: Indian Journal of Urology)
Source: Indian Journal of Urology - July 1, 2014 Category: Urology & Nephrology Authors: Mahendra Bhandari Source Type: research

Post Prostatectomy Incontinence-A Clinical Guide
Sanjay SinhaIndian Journal of Urology 2014 30(3):362-362 (Source: Indian Journal of Urology)
Source: Indian Journal of Urology - July 1, 2014 Category: Urology & Nephrology Authors: Sanjay Sinha Source Type: research

Application of a fluoroscopy protocol in percutaneous nephrolithotomy to decrease radiation exposure: A feasible option
Gautam Ram ChoudharyIndian Journal of Urology 2014 30(3):360-361 (Source: Indian Journal of Urology)
Source: Indian Journal of Urology - July 1, 2014 Category: Urology & Nephrology Authors: Gautam Ram Choudhary Source Type: research

Renal arteriovenous malformation with inferior vena caval extension mimicking renal cell carcinoma
Anuj Deep Dangi, Ramani Kumar, Nitin S. KekreIndian Journal of Urology 2014 30(3):357-359A young lady presented with complaints of right flank pain and a palpable mass. On contrast-enhanced tomography (CECT), a renal mass with extension into the inferior vena cava (IVC) - suggestive of renal cell carcinoma - was diagnosed and she underwent radical nephrectomy with en bloc excision of the IVC thrombus. Histopathology revealed a benign arteriovenous malformation that had extended into the IVC. Arteriovenous malformation should therefore be kept in the list of differentials for a renal mass with IVC extension. (Source: Indian Journal of Urology)
Source: Indian Journal of Urology - July 1, 2014 Category: Urology & Nephrology Authors: Anuj Deep DangiRamani KumarNitin S. Kekre Source Type: research

Xanthogranulomatous pyelonephritis masquerading as a tumor in an infant
Shirish S. Nandedkar, Kamal Malukani, Pramod SakhiIndian Journal of Urology 2014 30(3):354-356Xanthogranulomatous pyelonephritis (XGP) is an uncommon form of chronic pyelonephritis and a well recognized entity. It is rarely seen in children and neonates. The preoperative diagnosis is difficult and the etiology is still obscure. The condition is mostly diagnosed on nephrectomy specimen. The focal form mimicking neoplastic condition is rare. A case of XGP is reported here in an 8 month old child in which case nephrectomy was done with the clinical diagnosis of malignant renal tumor. Various modalities of preoperative diagnos...
Source: Indian Journal of Urology - July 1, 2014 Category: Urology & Nephrology Authors: Shirish S. NandedkarKamal MalukaniPramod Sakhi Source Type: research

Treatment of interstitial cystitis/painful bladder syndrome as a neuropathic pain condition
Lakshmi Vas, Manorama Pattanik, Vaishali TitarmoreIndian Journal of Urology 2014 30(3):350-353A lady of 52 years with painful bladder syndrome/interstitial cystitis (PBS/IC) presented with chronic pelvic pain, irritative voiding with sphincter dominance on urodynamics. 3 yrs of oral analgesics, antispasmodics and intravesical therapy was ineffective. We surmised her pain, and irritative voiding to be secondary to constant straining against a dysfunctional pelvic floor. We treated PBS/IC as a neuropathic phenomenon with a combination of neuromodulator medications and continuous caudal epidural analgesia to reduce the pain i...
Source: Indian Journal of Urology - July 1, 2014 Category: Urology & Nephrology Authors: Lakshmi VasManorama PattanikVaishali Titarmore Source Type: research

Venous air embolism: A complication during percutaneous nephrolithotomy
We present a case of suspected venous air embolism during air pyelogram in a patient undergoing PCNL. The clinical diagnosis of air embolism was made by fall in end tidal carbon dioxide, blood pressure and Oxygen saturation and was conservatively managed. Early diagnosis with rapid resuscitation is the key to management of a patient with air embolism. (Source: Indian Journal of Urology)
Source: Indian Journal of Urology - July 1, 2014 Category: Urology & Nephrology Authors: Geeta P ParikhSumedha R SondePrachi Kadam Source Type: research

Penile hair tourniquet resulting in hypospadias failure
Lisieux E Jesus, Jailma J Bragança, Julia M Rocha, Samuel Dekermacher, Kleber M AndersonIndian Journal of Urology 2014 30(3):345-347Penile hair tourniquet (PHT) is a painless form of penile ischemia, typically seen in toddlers with long-haired mothers, caused by entanglement of hair on the balano-prepucial sulcus, normally associated with circumcision. Its association with hypospadias has been reported only once. A school-aged boy admitted for surgery to treat hypospadias failure was incidentally detected to have PHT and severe hourglass deformity of the penis. Urethral anastomosis and glanuloplasty were done after ...
Source: Indian Journal of Urology - July 1, 2014 Category: Urology & Nephrology Authors: Lisieux E JesusJailma J Bragan├žaJulia M RochaSamuel DekermacherKleber M Anderson Source Type: research

Adrenocortical carcinoma in pregnancy: A diagnostic dilemma
We present the case of a 31-year-old pregnant woman with rapidly developing symptoms related to hormonally active adrenocortical cancer. (Source: Indian Journal of Urology)
Source: Indian Journal of Urology - July 1, 2014 Category: Urology & Nephrology Authors: Ankush JairathBaldev S Aulakh Source Type: research

Aldosterone and cortisol co-secreting bifunctional adrenal cortical carcinoma: A rare event
We report the case of a 37-yearold female who presented with paresis and facial puffiness. Evaluation revealed hypertension, hyperglycemia, severe hypokalemia and hyperaldosteronemia with elevated plasma aldosterone to renin ratio (ARR). Urinary free cortisol estimation showed elevated levels. Computed tomography scan revealed a right adrenal mass. Radical adrenalectomy specimen revealed ACC (T3N1). Post-operatively, the patient became normotensive and euglycemic with normalization of urinary cortisol and ARR. This case highlights the need for a complete evaluation in patients of hyperaldosteronism if overlapping symptoms ...
Source: Indian Journal of Urology - July 1, 2014 Category: Urology & Nephrology Authors: Puskar Shyam ChowdhuryPrasant NayakSrinivasan GurumurthyDeepak David Source Type: research

Novel training methods for robotic surgery
Conclusions: The use of these different entities to create a standardized curriculum for robotic surgery remains elusive. Selection of training modalities and assessment tools should be based upon performance data-based validity and practical feasibility. Comparative assessment of different modalities (cross-modality validity) can help strengthen the development of common skill sets. Constant data collection must occur to guide continuing curriculum improvement. (Source: Indian Journal of Urology)
Source: Indian Journal of Urology - July 1, 2014 Category: Urology & Nephrology Authors: Andrew J SunMonish AronAndrew J Hung Source Type: research

Robotic single port surgery: Current status and future considerations
Conclusions: R-LESS is technically feasible and the benefits of robotic surgery eliminate many of the challenges seen with conventional LESS. However, despite the advantages of the robotic platform, R-LESS is not free of challenges. Instrument clashing remains an issue due to the bulky profile of the current robotic system. Other issues include lack of space for the assistant at the bedside, inability to incorporate the 4 th robotic arm for retraction and difficulties with triangulation. Although solutions for some of these issues are currently under development, R-LESS is still very much in its infancy. (Source: Indian Journal of Urology)
Source: Indian Journal of Urology - July 1, 2014 Category: Urology & Nephrology Authors: Dinesh SamarasekeraJihad H Kaouk Source Type: research

Robotic sacrocolpopexy
Teresa L Danforth, Monish Aron, David A GinsbergIndian Journal of Urology 2014 30(3):318-325Pelvic organ prolapse (POP) is a prevalent condition with 1 in 9 women seeking surgical treatment by the age of 80 years. Goals of treatment are relief and prevention of symptoms, and restoration of pelvic floor support. The gold standard for surgical treatment of POP has been abdominal sacrocolpopexy (ASC). However, emerging technologies have allowed for more minimally invasive approach including the use of laparoscopic assisted sacrocolpopexy and robotic assisted sacrocolpopexy (RASC). We performed a PubMed literature search for s...
Source: Indian Journal of Urology - July 1, 2014 Category: Urology & Nephrology Authors: Teresa L DanforthMonish AronDavid A Ginsberg Source Type: research

International Robotic Radical Cystectomy Consortium: A way forward
This article summarizes the findings of the IRCC and highlights the future direction of the consortium. (Source: Indian Journal of Urology)
Source: Indian Journal of Urology - July 1, 2014 Category: Urology & Nephrology Authors: Syed Johar RazaErinn FieldAdam S. KibelAlex MottrieAlon Z. WeizerAndrew WagnerAshok K. HemalDouglas S. ScherrFrancis SchanneFranco GaboardiGuan WuJames O. PeabodyJihad KoaukJoan Palou RedortaJohn G. PattarasKoon-Ho RhaLee RichstoneM. Derya BalbayMani Meno Source Type: research

Robot-assisted radical cystectomy with intracorporeal neobladder diversion: The karolinska experience
Conclusions: Our experience with totally intracorporeal RARC demonstrates acceptable oncological and functional outcomes that suggest this is a viable alternative to open radical cystectomy. (Source: Indian Journal of Urology)
Source: Indian Journal of Urology - July 1, 2014 Category: Urology & Nephrology Authors: Justin W. CollinsP. SooriakumaranR. Sanchez-SalasR. AhonenT. NybergN. P. WiklundA. Hosseini Source Type: research

Robotic radical cystectomy and intracorporeal urinary diversion: The USC technique
We describe our technique for robotic radical cystectomy (RRC) and intracorporeal urinary diversion (ICUD), that replicates open surgical principles, and present our preliminary results. Materials and Methods: Specific descriptions for preoperative planning, surgical technique, and postoperative care are provided. Demographics, perioperative and 30-day complications data were collected prospectively and retrospectively analyzed. Learning curve trends were analyzed individually for ileal conduits (IC) and neobladders (NB). SAS ® Software Version 9.3 was used for statistical analyses with statistical significance set at P
Source: Indian Journal of Urology - July 1, 2014 Category: Urology & Nephrology Authors: Andre Luis de Castro AbreuSameer ChopraRaed A AzharAndre K BergerGus MirandaJie CaiInderbir S GillMonish AronMihir M Desai Source Type: research

Robotic-assisted laparoscopic approaches to the ureter: Pyeloplasty and ureteral reimplantation
Conclusions: Robotic-assisted laparoscopic pyeloplasty is gaining popularity, likely due to the shorter learning curve, greater surgeon comfort, and easier intracorporeal suturing. This has allowed more surgeons to perform the procedure, improving accessibility. Robotic technology is also beneficial in the field of LESS. Nevertheless, the procedure still is not as cost-effective as the conventional laparoscopic approach, and until more affordable robotic technology is available, it will not be universally offered. (Source: Indian Journal of Urology)
Source: Indian Journal of Urology - July 1, 2014 Category: Urology & Nephrology Authors: Dinesh SamarasekeraRobert J Stein Source Type: research

Robotic assisted kidney transplantation
Pranjal Modi, Bipinchandra Pal, Jayesh Modi, Suresh Kumar, Akshay Sood, Mani MenonIndian Journal of Urology 2014 30(3):287-292Kidney transplantation is the standard of care for patients with end stage renal disease. While open surgery remains the gold standard, minimally invasive surgery has recently been introduced for the recipient undergoing kidney transplantation. We review the evolution of techniques of minimally invasive surgery for kidney transplantation with specific emphasis on technical aspects of robotic assisted kidney transplantation. (Source: Indian Journal of Urology)
Source: Indian Journal of Urology - July 1, 2014 Category: Urology & Nephrology Authors: Pranjal ModiBipinchandra PalJayesh ModiSuresh KumarAkshay SoodMani Menon Source Type: research

Technical considerations in robotic nephrectomy with vena caval tumor thrombectomy
Ronney AbazaIndian Journal of Urology 2014 30(3):283-286Robotic surgery has been applied to increasingly complex urologic procedures since its initial widespread adoption for prostatectomy. While laparoscopic nephrectomy was initially reported over 2 decades ago, renal tumors involving the inferior vena cava (IVC) appeared to be a limitation to the application of laparoscopy. Laparoscopic management had only been reported in a limited fashion for short tumor thrombi not requiring cross-clamping of the IVC. The first robotic nephrectomy for renal cancer with IVC tumor thrombus was performed in 2008 with the first series rep...
Source: Indian Journal of Urology - July 1, 2014 Category: Urology & Nephrology Authors: Ronney Abaza Source Type: research

Robotic nephron-sparing surgery for renal tumors: Current status
Raed A Azhar, Inderbir S Gill, Monish AronIndian Journal of Urology 2014 30(3):275-282There have been a number of advances in robotic partial nephrectomy (RPN) for renal masses. We reviewed these advances with emphasis on the evolution of technique and outcomes as well as the expanding indications for RPN. Literature in the English language was reviewed using the National Library of Medicine database. Relevant articles were extracted, and their citations were utilized to broaden our search. The identified articles were reviewed and summarized with a focus on novel developments. RPN is an evolving procedure and is an emergi...
Source: Indian Journal of Urology - July 1, 2014 Category: Urology & Nephrology Authors: Raed A AzharInderbir S GillMonish Aron Source Type: research

Robotic surgery beyond the prostate
Monish AronIndian Journal of Urology 2014 30(3):273-274 (Source: Indian Journal of Urology)
Source: Indian Journal of Urology - July 1, 2014 Category: Urology & Nephrology Authors: Monish Aron Source Type: research

Histological evaluation of nerve sparing technique in robotic assisted radical prostatectomy
The objective of this study is to compare intrafascial nerve-sparing (NS), interfascial NS and non-NS prostatecomy specimens to assess the feasibility of NS technique in Robot-assisted radical prostatectomies (RARP). Materials and Methods: The records of the first 43 consecutive patients (86 prostatic sides (lobe) who underwent NS RARP (6 intrafascial NS, 46 interfacial NS, 34 non-NS) were reviewed and histopathological examinations were performed. The presence and distribution of periprostatic neurovascular structures were histologically evaluated using mid-gland section of each prostate lobe in the prostatectomy specime...
Source: Indian Journal of Urology - July 1, 2014 Category: Urology & Nephrology Authors: Kazushi TanakaKatsumi ShigemuraNobuyuki HinataMototsugu MuramakiHideaki MiyakeMasato Fujisawa Source Type: research

Prospective randomized study to evaluate the feasibility and outcome of transmesocolic laparoscopic pyeloplasty and compare it with retrocolic laparoscopic pyeloplasty in pediatric and adolescent patients
Conclusions: The transmesocolic approach for left sided pyeloplasty enables a shorter operative time even in the presence of large pelvis, aberrant vessel and stones without increasing morbidity in comparison to RLP approach. (Source: Indian Journal of Urology)
Source: Indian Journal of Urology - July 1, 2014 Category: Urology & Nephrology Authors: Sanjeet Kumar SinghJatinder KumarAN SachinRakesh KapoorAneesh SrivastavaMS Ansari Source Type: research

Commentary on Transperitoneal laparoscopic left versus right live donor nephrectomy: Comparison of outcomes
Rajesh K AhlawatIndian Journal of Urology 2014 30(3):261-262 (Source: Indian Journal of Urology)
Source: Indian Journal of Urology - July 1, 2014 Category: Urology & Nephrology Authors: Rajesh K Ahlawat Source Type: research

Transperitoneal laparoscopic left versus right live donor nephrectomy: Comparison of outcomes
Conclusions: RLDN has a safety profile comparable with LLDN, even in those with complex vascular anatomy, and can be successfully performed by the transperitoneal route with no added morbidity. RLDN requires lesser operative time with comparable morbidity. (Source: Indian Journal of Urology)
Source: Indian Journal of Urology - July 1, 2014 Category: Urology & Nephrology Authors: Shrinivas Rudrapatna PandarinathBabulal ChoudharyHarvinder Singh ChouhanShivashankar RudramaniDeepak Dubey Source Type: research

Misinterpretation of the international prostate symptom score questionnaire by Indian patients
Conclusion: Our results show that our patients misinterpret the IPSS questionnaire. This problem can lead to significant errors in interpretation of the symptom severity. (Source: Indian Journal of Urology)
Source: Indian Journal of Urology - July 1, 2014 Category: Urology & Nephrology Authors: Tarun JindalRajan Kumar SinhaSubhabrata MukherjeeSoumendra Nath MandalDilip Karmakar Source Type: research

Telomere instability in papillary bladder urothelial carcinomas: Comparison with grading and risk of recurrence
This study aims to investigate the relationship between tumor grade and recurrence in relation to telomere length (TL), telomerase activity (TA) and telomere-binding proteins expression (TBPs) in patients with non-muscle invasive bladder cancer (NMIBC). Materials and Methods: Tumor/healthy tissues were collected from 58 patients (35 with and 23 without NMIBC). Cystoscopy was performed at 3, 6 and 12 months to determine recurrence. Tumor grades and recurrence were correlated with TL, TA and TBPs using the Kruskal-Wallis non-parametric test. Results were considered significant at P
Source: Indian Journal of Urology - July 1, 2014 Category: Urology & Nephrology Authors: Giuseppe MucciardiAlessandro Gali'Valeria BarresiMassimo MucciardiM'Hammemd AguennouzAntonino InferreraCarlo Magno Source Type: research

Metallothionein gene expression in renal cell carcinoma
Deeksha Pal, Ujjawal Sharma, Shrawan Kumar Singh, Arup Kumar Mandal, Rajendra PrasadIndian Journal of Urology 2014 30(3):241-244Introduction: Metallothioneins (MTs) are a group of low-molecular weight, cysteine-rich proteins. In general, MT is known to modulate three fundamental processes: (1) the release of gaseous mediators such as hydroxyl radical or nitric oxide, (2) apoptosis and (3) the binding and exchange of heavy metals such as zinc, cadmium or copper. Previous studies have shown a positive correlation between the expression of MT with invasion, metastasis and poor prognosis in various cancers. Most of the previou...
Source: Indian Journal of Urology - July 1, 2014 Category: Urology & Nephrology Authors: Deeksha PalUjjawal SharmaShrawan Kumar SinghArup Kumar MandalRajendra Prasad Source Type: research

The shrinking world
Rajeev KumarIndian Journal of Urology 2014 30(3):239-240 (Source: Indian Journal of Urology)
Source: Indian Journal of Urology - July 1, 2014 Category: Urology & Nephrology Authors: Rajeev Kumar Source Type: research

Pseudotumor of urinary bladder by infected hernia mesh: Where is the evidence of infection?
Debajyoti Mohanty, Anjay Kumar, Ashwani Kumar DalalIndian Journal of Urology 2014 30(2):237-237 (Source: Indian Journal of Urology)
Source: Indian Journal of Urology - March 29, 2014 Category: Urology & Nephrology Authors: Debajyoti MohantyAnjay KumarAshwani Kumar Dalal Source Type: research

L.I.F.T. study: Prostatic urethral lift for the treatment of LUTS associated with BPH
Saurabh GuptaIndian Journal of Urology 2014 30(2):235-236 (Source: Indian Journal of Urology)
Source: Indian Journal of Urology - March 29, 2014 Category: Urology & Nephrology Authors: Saurabh Gupta Source Type: research

Supernumerary testis: Imaging appearance of a rare entity
We describe a case of polyorchidism detected incidentally in a 52-year-old with renal failure. (Source: Indian Journal of Urology)
Source: Indian Journal of Urology - March 29, 2014 Category: Urology & Nephrology Authors: Sandeep G JakhereShenaz A SaifiAbhinav A Ranwaka Source Type: research

Keratinizing squamous metaplasia of the upper urinary tract in a child with a solitary kidney
We report a rare case of keratinizing squamous metaplasia of the upper urinary tract in a child with a single kidney. Squamous metaplasia has rarely been reported in the upper urinary tract, and is even rarer in children. (Source: Indian Journal of Urology)
Source: Indian Journal of Urology - March 29, 2014 Category: Urology & Nephrology Authors: Prashant JainAshwani MishraDeepti Shukla Misra Source Type: research

Appendicocalicostomy: A case of mistaken identity
S Sharma, K Shah, BS Santhosh, SJ RizviIndian Journal of Urology 2014 30(2):228-229Anatomical structures with similar appearance may at times be confused for each other. This situation can be compounded by lack of normal anatomical planes. We did ureterocalicostomy on a 32-year-female with secondary pelvi-ureteral junction obstruction. Post-operatively, it was discovered that she had a long appendix running parallel to ureter in retroperitoneum, which was misidentified as ureter and anastomosed to the lower pole of the kidney. She was re-explored, appendix was removed, ureter was identified and ureterocalicostomy was done....
Source: Indian Journal of Urology - March 29, 2014 Category: Urology & Nephrology Authors: S SharmaK ShahBS SanthoshSJ Rizvi Source Type: research

Mesenchymal chondrosarcoma of kidney
Ruchita Tyagi, Nandita Kakkar, Rakesh Kumar Vasishta, Mayank Mohan AggarwalIndian Journal of Urology 2014 30(2):225-227Mesenchymal chondrosarcoma of the kidney is a very rare entity with no definite treatment protocol. Herein, we describe one such case with discussion of its diagnosis and management. The patient had a well circumscribed mass in right kidney extending into the inferior vena cava and metastasis to both the lungs. Right nephrectomy was performed and the histopathological examination confirmed the diagnosis to be renal mesenchymal chondrosarcoma. After surgical removal of the tumor, the patient was given chemo...
Source: Indian Journal of Urology - March 29, 2014 Category: Urology & Nephrology Authors: Ruchita TyagiNandita KakkarRakesh Kumar VasishtaMayank Mohan Aggarwal Source Type: research

Ureteral spread of a primary cutaneous diffuse large B‑cell lymphoma, leg type
We report a case of 76-year-old man, with a past medical history of primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT), who presented with ureteral tumor diagnosed as urothelial carcinoma on imaging investigations. Histological examination showed an unusual finding. The tumor was a ureteral localization of the PCDLBCL-LT previously diagnosed. To the best of our knowledge, this is the first case of PCDLBCL-LT with ureteral spread described in the literature. (Source: Indian Journal of Urology)
Source: Indian Journal of Urology - March 29, 2014 Category: Urology & Nephrology Authors: Amira Ben SalemHaifa NfoussiNidham Kchir Source Type: research

Virilizing lipoadenoma of the adrenal gland in a pre-pubertal girl: A rare case
We report a case of a 12-year-old girl who presented with the history of hirsutism. On evaluation, she was found to have testosterone secreting adrenal gland tumor. Histopathological examination of the adrenalectomy specimen revealed a lipoadenoma. (Source: Indian Journal of Urology)
Source: Indian Journal of Urology - March 29, 2014 Category: Urology & Nephrology Authors: Prasad MylarappaAmey PathadeTarun JavaliD Ramesh Source Type: research

BPH and prostate cancer risk
Conclusion: The future workload healthcare practitioners will face regarding BPH, and PCa will substantially increase. Further basic science and large epidemiological studies using a global cohort of men are required prior to the urological community confidently counseling their patients with BPH with regards to their PCa risk. (Source: Indian Journal of Urology)
Source: Indian Journal of Urology - March 29, 2014 Category: Urology & Nephrology Authors: Saiful MiahJames Catto Source Type: research

Management of the complications of BPH/BOO
Mark J Speakman, Xi ChengIndian Journal of Urology 2014 30(2):208-213Most men will develop histological BPH if they live long enough. Approximately, half will develop benign prostatic enlargement (BPE) and about half of these will get BOO with high bladder pressures and low flow, this in turn leads to detrusor wall hypertrophy. Many of these men will only have lower urinary tract symptoms (LUTS) but a significant number will also suffer the other complications of BPH. These include urinary retention (acute and chronic), haematuria, urinary tract infection, bladder stones, bladder wall damage, renal dysfunction, incontinenc...
Source: Indian Journal of Urology - March 29, 2014 Category: Urology & Nephrology Authors: Mark J SpeakmanXi Cheng Source Type: research

Surgical therapy for benign prostatic hypertrophy/bladder outflow obstruction
Nikesh ThiruchelvamIndian Journal of Urology 2014 30(2):202-207Monopolar transurethral resection of the prostate (TURP) with endoscopic electrocautery remains the gold standard surgical technique for benign prostatic hypertrophy (BPH) by which all new procedures are compared. We reviewed the current literature, and international urological guidelines and consensus opinion on various surgical options for BPH and present a brief overview of alternative techniques including bipolar TURP, transurethral incision of the prostate, transurethral vaporization of the prostate, laser prostatectomy (with holmium, thulium and potassium...
Source: Indian Journal of Urology - March 29, 2014 Category: Urology & Nephrology Authors: Nikesh Thiruchelvam Source Type: research

Non‑Hormonal treatment of BPH/BOO
Conclusions: AB are the most well-established pharmacotherapy in the management of men with LUTS/BPH. The emergence of different classes of agent offers the opportunity to target underlying pathophysiologies driving symptoms and better individualize treatment. (Source: Indian Journal of Urology)
Source: Indian Journal of Urology - March 29, 2014 Category: Urology & Nephrology Authors: Nadir I OsmanAltaf MangeraChristopher R Chapple Source Type: research

Hormonal manipulation of lower urinary tract symptoms secondary to benign prostatic obstruction
Adita Raja, Satoshi Hori, James N ArmitageIndian Journal of Urology 2014 30(2):189-193Although the etiology of lower urinary tract symptoms (LUTS) is often multifactorial, a significant proportion of men over the age of 50 suffer from benign prostatic obstruction (BPO) secondary to benign prostatic hyperplasia. Prostate, being an androgen responsive organ is dependent on the male sex hormone, testosterone, for growth. Thus, treatment strategies that manipulate the levels of circulating hormones that influence the level of testosterone and/or prostatic growth represent an important potential option for patients suffering wi...
Source: Indian Journal of Urology - March 29, 2014 Category: Urology & Nephrology Authors: Adita RajaSatoshi HoriJames N Armitage Source Type: research

Pharmacology of the lower urinary tract
Martin Hennenberg, Christian G Stief, Christian GratzkeIndian Journal of Urology 2014 30(2):181-188Pharmacology of the lower urinary tract provides the basis for medical treatment of lower urinary tract symptoms (LUTS). Therapy of LUTS addresses obstructive symptoms (frequently explained by increased prostate smooth muscle tone and prostate enlargement) in patients with benign prostate hyperplasia (BPH) and storage symptoms in patients with overactive bladder (OAB). Targets for medical treatment include G protein-coupled receptors (α1 -adrenoceptors, muscarinic acetylcholine receptors, β3-adrenoceptors) or intrac...
Source: Indian Journal of Urology - March 29, 2014 Category: Urology & Nephrology Authors: Martin HennenbergChristian G StiefChristian Gratzke Source Type: research

Assessment of BPH/BOO
Altaf Mangera, Nadir I Osman, Christopher R ChappleIndian Journal of Urology 2014 30(2):177-180The assessment of men with bladder outflow obstruction relies on an adequate history and examination. Uroflowmetry and post-void residue estimation are very revealing and may be sufficient in the majority of men. The prostate-specific antigen test may be used to select men who are at a high risk of progression. In specific situations, cystometry may be required. We discuss the use of cystometry and the newer less-invasive methods of assessment that have emerged over the last few years, including ultrasound estimation of intravesi...
Source: Indian Journal of Urology - March 29, 2014 Category: Urology & Nephrology Authors: Altaf MangeraNadir I OsmanChristopher R Chapple Source Type: research

Epidemiology and etiology of benign prostatic hyperplasia and bladder outlet obstruction
Nishant D Patel, J Kellogg ParsonsIndian Journal of Urology 2014 30(2):170-176Benign prostatic hyperplasia (BPH) is a histological diagnosis associated with unregulated proliferation of connective tissue, smooth muscle and glandular epithelium. BPH may compress the urethra and result in anatomic bladder outlet obstruction (BOO); BOO may present as lower urinary tract symptoms (LUTS), infections, retention and other adverse events. BPH and BOO have a significant impact on the health of older men and health-care costs. As the world population ages, the incidence and prevalence of BPH and LUTS have increased rapidly. Although...
Source: Indian Journal of Urology - March 29, 2014 Category: Urology & Nephrology Authors: Nishant D PatelJ Kellogg Parsons Source Type: research

BPH management today
Altaf Mangera, Christopher R ChappleIndian Journal of Urology 2014 30(2):169-169 (Source: Indian Journal of Urology)
Source: Indian Journal of Urology - March 29, 2014 Category: Urology & Nephrology Authors: Altaf MangeraChristopher R Chapple Source Type: research

The significance of sperm heads and tails within the vasal fluid during vasectomy reversal
Conclusions: VV was successful in 90.9% of patients undergoing VR in the setting of SHST alone. Even when creamy or pasty fluid was present, the results surpassed the expected patency rate for an EV. Therefore, the presence of only SHST, regardless of fluid quality, should not dissuade the surgeon from performing a VV. (Source: Indian Journal of Urology)
Source: Indian Journal of Urology - March 29, 2014 Category: Urology & Nephrology Authors: Ryan P SmithAbhinav KhannaJason R KovacNiraj BadhiwalaRobert CowardLarry I Lipshultz Source Type: research