Syringoid eccrine carcinoma of the nipple in a male patient with lymph node metastasis: A case report
Indian J Pathol Microbiol. 2024 Feb 19. doi: 10.4103/ijpm.ijpm_716_23. Online ahead of print.ABSTRACTSyringoid eccrine carcinoma of nipple is an extremely rare neoplasm of adnexal origin with variable clinical appearance and diverse histologic findings. Syringoid eccrine carcinoma (SEC) is often a diagnostic dilemma due to its morphology and presentation. Usually, these malignancies arise as non-ulcerated nodules or plaques in the head & neck region including the trunk. They are locally aggressive and have an infiltrative growth pattern with a propensity for metastasis. SEC is characterized by syringoma-like tadpole mo...
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: Mukund Sable Nibedita Sahoo Chinamyee Panigrahi Pritinanda Mishra Pradeep Kumar Source Type: research

Correlation between intestinal stem cell niche changes and small bowel crypt failure in patients with treatment-na ïve celiac disease
CONCLUSIONS: Our data suggests that ISC niche failure is a plausible hypothesis for villous flattening in patients with CeD, resulting from pericrypt IgA anti-TG2 antibody complex-mediated stromal depletion.PMID:38427764 | DOI:10.4103/ijpm.ijpm_760_23 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: Prasenjit Das Sudha Battu Lalita Mehra Alka Singh Muzaffar Ahmad Ashish Agarwal Ashish Chauhan Anam Ahmad Sreenivas Vishnubhatla Siddhartha Datta Gupta Vineet Ahuja Govind Makharia Source Type: research

Primary diffuse large B-cell lymphoma of the prostate: Histopathological diagnosis of a rare entity in the prostate
Indian J Pathol Microbiol. 2024 Feb 19. doi: 10.4103/ijpm.ijpm_325_23. Online ahead of print.ABSTRACTLymphoma of the prostate is rare whether it is primary extranodal lymphoma or secondary involvement of the prostate by primary lymphoma elsewhere. Of all the lymphomas of the prostate, primary lymphomas of the prostrate are very rare. Although less frequent, it should be a differential diagnosis when evaluating prostate tumors. Here, we report a case of a 61-year-old man who presented with hematuria with clot retention. A cystoscopy with clot removal and transurethral resection of the prostate (TURP) was performed. This bio...
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: Richa Sharma Sumit Bansal Aparna Gangoli Source Type: research

Staphylococcal scalded skin syndrome in neonate: Another face of CA-MRSA
Indian J Pathol Microbiol. 2024 Feb 19. doi: 10.4103/ijpm.ijpm_833_23. Online ahead of print.ABSTRACTStaphylococcal scalded skin syndrome (SSSS), also known as Ritter's disease, in its severe form occurs predominantly in infants and children. It is caused by infection with group II (often phage group 71) Staphylococcus aureus. The foci of infection include nasopharynx, less commonly umbilicus, urinary tract, superficial abrasion, conjunctivae, and blood. Staphylococci are non-motile, non-spore-forming, catalase-positive, gram-positive cocci that appear predominantly as grape-like clusters. Although this organism is frequen...
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: M Mohamadiya Rizwana S Shanmugapriya M Jaya Sudha B Appalaraju S Ramesh Source Type: research

Knowledge, attitudes, and practices toward COVID-19 and its prevention among medical and dental students in an educational institution in Telangana
CONCLUSION: Curriculum modifications and creative teaching strategies can fill the lacunae in the KAP scores. Medical and dental students, as torchbearers of the healthcare fraternity, can play a critical role in raising awareness during public health emergencies.PMID:38427767 | DOI:10.4103/ijpm.ijpm_582_23 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: Preeti U Deshpande Anuradha Basavaraju Nagapraveen Veerapu Ashish Akula Source Type: research

Evaluation of the significance of tumor stromal patterns and peri-tumoral inflammation in head and neck squamous cell carcinoma with special reference to the Yamamoto-Kohama classification
CONCLUSION: SR and the tumor invasive pattern in HNSCC are related to prognosis and may indicate tumor aggressiveness.PMID:38427768 | DOI:10.4103/ijpm.ijpm_426_23 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: Geet Bhuyan Prabir Hazarika Anju M Rabha Source Type: research

A serious warning: A case report on localized amyloidosis of the oral cavity
Indian J Pathol Microbiol. 2024 Feb 19. doi: 10.4103/ijpm.ijpm_720_23. Online ahead of print.ABSTRACTAmyloidosis is a relatively rare condition with an array of complex pathophysiology. Localized amyloidosis is a rare and benign condition that practically never results in any clinical repercussions in the head and neck area. Multiple soft nodules of the tongue, lip, and cheek are the most commonly described defining characteristics of localized oral amyloidosis. These nodules originate due to the proliferation of abnormally folded protein aggregates in the body's extracellular tissue compartments, which destroy organ struc...
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: Sharon John Priyambadha Subba Aravindhan Aramugam Shalini Gupta Richa Khanna Source Type: research

Schwannoma-like pleomorphic adenoma: A pathological quandary
Indian J Pathol Microbiol. 2024 Feb 19. doi: 10.4103/ijpm.ijpm_552_23. Online ahead of print.ABSTRACTPleomorphic adenoma usually presents as a painless growing mass in locations of the salivary glands and is notorious for local recurrence if previous surgical resection is incomplete. Schwannoma is a benign peripheral nerve tumor with microscopic features of sheets of spindle-shaped cells with nuclear palisading. However, when a pathologist encounters a salivary gland tumor with microscopic morphological features of biphasic components with areas of schwannoma-like morphology, it is crucial to make a prudent diagnosis by di...
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: Rashmi Gautam Reena Tomar Deepika Rana Nita Khurana Ishwar Singh Source Type: research

Hepatic and perihepatic PEComas: A study describing a series of five rare cases
CONCLUSIONS: This series highlights the fact that accurate histological diagnosis of hepatic or perihepatic PEComas is important to prevent unnecessary aggressive treatment, unlike primary hepatocellular carcinomas or hepatoid/epithelioid metastatic tumors.PMID:38427771 | DOI:10.4103/ijpm.ijpm_587_23 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: P Vijayanirmala Rajni Yadav Surbhi Goyal Adarsh Barwad Subham Bhowmik Rohan Malik Sujoy Pal Raju Sharma Puja Sakhuja Prasenjit Das Source Type: research

Acute panmylelosis with myelofibrosis - A rare case report with review of literature
We present a case of a 44-year male who came with a short history of fever, generalised weakness, revealed pancytopenia with occasional circulating blast in the peripheral blood smear. Bone marrow aspirate was dry tap,biopsy revealed panmyelosis with myelofibrosis with increased (22%) blasts. Flowcytometric immunophenotyping, cytogenetics and molecular tests were undertaken. Together with clinical details, immunophenotypic profile, cytogenetics and molecular studies, the diagnosis of Acute panmyelosis with myelofibrosis was made and managed accordingly. 32 The WHO 2017 describes APMF as an acute panmyeloid proliferation wi...
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: Surbhi Dahiya Jyoti Kotwal Sabina Langer Amrita Saraf Pallavi Prakhar Deepika Gupta Nitin Gupta Vandana Arya Source Type: research

Papillary glioneuronal tumor: A rare case with recent updates as per 2021 CNS WHO 5th classification
Indian J Pathol Microbiol. 2024 Feb 19. doi: 10.4103/ijpm.ijpm_310_23. Online ahead of print.ABSTRACTThe papillary glioneuronal tumor is a WHO grade 1, rare neuronal-glial tumor and comprises 0.02% of all CNS tumors. Histologically, it is a mixture of glial and neuronal components showing a pseudopapillary pattern with hyalinized vessels. PGNT is considered a low-grade neoplasm, and surgical excision has been curative in most cases. In this paper, we report a new case of papillary glioneuronal tumor in a 44-year-old male having a divergent presentation, to analyze it due to the rarity of its occurrence as per the latest cl...
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: Bandana Mehrotra Mithlesh Bhargav Ashok Kapoor Shubhi Pandey Saumya Brij Vaibhav R Gopal Source Type: research

Direct immunofluorescence (DIF) versus immunohistochemical (IHC) staining of complements and immunoglobulins (Ig) in pemphigus group
CONCLUSION: We conclude that IHC is a useful tool in the diagnosis of PV with the highest sensitivity of IgG and C3d. The combination of IgG and C3d could replace the DIF in almost all of our cases, so IHC on FFPE sections be used as an alternative method to DIF.PMID:38427745 | DOI:10.4103/ijpm.ijpm_113_23 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: Deepika Rana Nita Khurana Shramana Mandal Bijay Laxmi Sahoo Source Type: research

Preoperative evaluation of red blood cell distribution width as a promising biomarker for discriminating between benign and malignant breast tumors and assessing breast cancer activity
CONCLUSIONS: The findings of this study suggest that RDW has the potential to serve as a biomarker for assessing breast cancer activity and could offer substantial advantages in clinical contexts. The present study is not without limitations, and the authors suggest that a larger multicenter prospective study be conducted to further validate it's efficacy over an extended duration.PMID:38427746 | DOI:10.4103/ijpm.ijpm_351_23 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: Ajay Singh Thakur Chandrashekhar Indoria Ruby Sahu Pratima Kujur Renuka Gahine Source Type: research

Epstein-Barr virus (EBV) DNAemia in saliva of viral encephalitis and nasopharyngeal carcinoma patients
Indian J Pathol Microbiol. 2024 Feb 19. doi: 10.4103/ijpm.ijpm_356_23. Online ahead of print.ABSTRACTEpstein-Barr virus (EBV) is a lymphotropic virus that causes diseases ranging from a flu-like illness called infectious mononucleosis to nasopharyngeal carcinoma, Burkitt's lymphoma, and central nervous system (CNS) infection. Detection of EBV DNA is usually done using whole blood samples taken from the patients. We undertook the detection of EBV in blood, cerebrospinal fluid (CSF), and saliva by real-time quantitative PCR in two patients, one with a history of nasopharyngeal carcinoma, and the other having a case of viral ...
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: Nanditha Srinivasan Ramya Barani M Manickavasagan Padma Srikanth Source Type: research

Primitive myxoid mesenchymal tumor of infancy, an enigmatic entity: A case report
Indian J Pathol Microbiol. 2024 Feb 19. doi: 10.4103/ijpm.ijpm_471_23. Online ahead of print.ABSTRACTPrimitive myxoid mesenchymal tumor of infancy (PMMTI) is a rare soft tissue neoplasm of intermediate malignant potential occurring predominantly in infants and younger children. It can show aggressive local infiltration of surrounding structures and frequent relapses but rare metastasis. Morphologically, it is characterized by a proliferation of immature mesenchymal cells in a myxoid background with mild cytologic atypia and branching vessels. The tumor cells demonstrate immunoreactivity with vimentin and BCOR, however, are...
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: Malini Goswami Source Type: research