Considerations for the long term treatment of pediatric sarcoma survivors
Kurt R Weiss, Melissa N ZimelIndian Journal of Orthopaedics 2018 52(1):77-80Sarcomas are primary malignancies of the connective tissues. They are exceedingly rare in adults, but much more common in children. The historically recent advent of cytotoxic chemotherapy for pediatric sarcomas has revolutionized the treatment of these diseases and dramatically improved their prognoses. There is thus a population of pediatric sarcoma survivors that are “coming of age” as adults. However, this progress is not without consequences. Due to aggressive treatment protocols that include various combinations of s...
Source: Indian Journal of Orthopaedics - January 10, 2018 Category: Orthopaedics Authors: Kurt R Weiss Melissa N Zimel Source Type: research
Does radiotherapy after surgery affect outcomes in Ewing & #39;s sarcoma of the pelvis ?
Conclusions: The decision to offer PORT after surgical excision in pelvic Ewing's sarcoma is multifactorial; the absence of PORT in selected cases is not detrimental to local control. Poor responders to chemotherapy had poorer survival while PORT did not impact on outcomes. (Source: Indian Journal of Orthopaedics)
Source: Indian Journal of Orthopaedics - January 10, 2018 Category: Orthopaedics Authors: Ajay Puri Ashish Gulia Saniya Crasto Tushar Vora Nehal Khanna Siddharth Laskar Source Type: research
Gait analysis in patients with wide resection and endoprosthesis replacement around the knee
Vivek Ajit Singh, Chan Wei Heng, Nor Faissal YasinIndian Journal of Orthopaedics 2018 52(1):65-72Background: Limb salvage surgery with endoprosthesis for bone tumor around the knee is reported to have good functional and oncological outcomes. However, the functional assessment using musculoskeletal tumor society (MSTS) and Toronto extremity scoring system remains subjective. We performed gait analysis as an objective assessment of their functional outcome. Materials and Methods: Gait analysis was performed in 20 patients with endoprosthesis replacement around the knee. The temporal parameters assessed during gait analysis ...
Source: Indian Journal of Orthopaedics - January 10, 2018 Category: Orthopaedics Authors: Vivek Ajit Singh Chan Wei Heng Nor Faissal Yasin Source Type: research
Methotrexate free chemotherapy and limb salvage surgery for paediatric osteosarcoma in India
Conclusions: High dose methotrexate free chemotherapy can give good OAS in localized disease and LSS is feasible in most of the pediatric OS patients. However the modest DFS even for localized disease with PAI chemotherapy and extremely poor outcomes in the metastatic OS, demand further research and innovations in systemic therapy to improve outcomes. (Source: Indian Journal of Orthopaedics)
Source: Indian Journal of Orthopaedics - January 10, 2018 Category: Orthopaedics Authors: Reghu Kesavapillai Sukumaran Binitha Rajeshwari Subin Sugath S Guruprasad Chellappan Priyakumari Thankamony Kusumakumary Parukuttyamma Source Type: research
Benign aggressive lesions of femoral head and neck: Is salvage possible ?
Conclusion: Benign aggressive lesions affecting femoral head and neck in young and middle-aged adults pose a treatment challenge. A sturdy, lasting reconstruct with acceptable functional outcome and minimal recurrence rate can be achieved by salvaging the femoral head and neck using curettage and reconstruction, obviating the need for replacement at such an early age. (Source: Indian Journal of Orthopaedics)
Source: Indian Journal of Orthopaedics - January 10, 2018 Category: Orthopaedics Authors: Yogesh Panchwagh Sujit K Joshi Parag K Sancheti Source Type: research
Effect of intravenous zoledronic acid on histopathology and recurrence after extended curettage in giant cell tumors of bone: A comparative prospective study
Conclusions: We observed that bisphosphonates reduce osteoclast activity and affects stromal cells in GCT, resulting in the reduction of their numbers and noticeable apoptosis. This results in better marginalization of the lesions and reduced recurrence. Extended curettage of friable GCT became easier and adequate which otherwise might not have been possible. (Source: Indian Journal of Orthopaedics)
Source: Indian Journal of Orthopaedics - January 10, 2018 Category: Orthopaedics Authors: Zile Singh Kundu Rajeev Sen Ankur Dhiman Pankaj Sharma Ramchander Siwach Parveen Rana Source Type: research
Soft-tissue sarcomas
This article discusses the epidemiology, diagnosis, and management of primary soft-tissue sarcomas (STS). These musculoskeletal tumors are a rare and heterogeneous group of malignancies, which are best managed by multidisciplinary teams in specialist sarcoma referral centers. Historically, the standard for local control of these tumors has been amputation. Evolutions in multimodality treatment have seen a shift toward preservation of the limb. Advances in limb-sparing surgery have seen the quality of life in sarcoma patients to improve drastically; however, unplanned surgical excision of STS remains a major treatment dilem...
Source: Indian Journal of Orthopaedics - January 10, 2018 Category: Orthopaedics Authors: Domagoj Ante Vodanovich Peter F M Choong Source Type: research
The values of receptor activator nuclear Kappa-B ligand expression in stage III giant cell tumor of the bone
Conclusion: RANKL expression is generally high in Stage III GCT and is a reliable prognostic marker in predicting the risk of local recurrence however not in lung metastasis. (Source: Indian Journal of Orthopaedics)
Source: Indian Journal of Orthopaedics - January 10, 2018 Category: Orthopaedics Authors: Sabrina Abdul Ghani Wan Faisham Wan Ismail Md Salzihan Md. Salleh Sahran Yahaya Zawawi Muhamad Syahrul Fitri Source Type: research
Navigation in musculoskeletal oncology: An overview
Guy Vernon Morris, Jonathan D Stevenson, Scott Evans, Michael C Parry, Lee JeysIndian Journal of Orthopaedics 2018 52(1):22-30Navigation in surgery has increasingly become more commonplace. The use of this technological advancement has enabled ever more complex and detailed surgery to be performed to the benefit of surgeons and patients alike. This is particularly so when applying the use of navigation within the field of orthopedic oncology. The developments in computer processing power coupled with the improvements in scanning technologies have permitted the incorporation of navigational procedures into day-to-day practi...
Source: Indian Journal of Orthopaedics - January 10, 2018 Category: Orthopaedics Authors: Guy Vernon Morris Jonathan D Stevenson Scott Evans Michael C Parry Lee Jeys Source Type: research
Distal medullary canal decompression in long stem hip replacement in long bone metastasis: Does it reduce cardiopulmonary complications ?
Conclusion: Distal femoral canal decompression is an effective method in reducing the risk of cardiopulmonary embolic events associated with LHR. (Source: Indian Journal of Orthopaedics)
Source: Indian Journal of Orthopaedics - January 10, 2018 Category: Orthopaedics Authors: Vivek Ajit Singh Siamak Sarrafan Ramesh Singh Veriah Source Type: research
Retrospective analysis of giant cell tumor lower end radius treated with En bloc excision and translocation of ulna
We report the outcome of series of twenty cases where we did en bloc excision of tumor with translocation of ulna. Materials and Methods: Twenty cases of giant cell tumor (GCT) of lower end of radius were included in this retrospective study. The mean age of patients was 33.15 years (range 21-55 years). We had 14 of Campanacci Grade III and 6 of Grade II. Preoperative radiographs and magnetic resonance imaging of the involved wrist and forearm were done. Results: Of all twenty patients, 14 were males and 6 were females. Mean followup duration was 3.9 years (range 1.5–17 years). Mean grip strength of involved s...
Source: Indian Journal of Orthopaedics - January 10, 2018 Category: Orthopaedics Authors: Amit Vyas Purnima Patni Narender Saini Rahul Sharma Vinit Arora SP Gupta Source Type: research
Fibulectomy for primary proximal fibular bone tumors: A functional and clinical outcome in 46 patients
Conclusions: With good reconstruction of lateral ligament we can achieve good results after proximal fibulectomy for benign as well as malignant tumor without much instability. With partial upper tibial resection (i.e., the extra-articular resection of proximal tibiofibular joint) adequate margins are feasible even in malignant tumors. (Source: Indian Journal of Orthopaedics)
Source: Indian Journal of Orthopaedics - January 10, 2018 Category: Orthopaedics Authors: Zile Singh Kundu Milind Tanwar Parveen Rana Rajeev Sen Source Type: research
Musculoskeletal oncology: Finding its place in the sun!
Ajay PuriIndian Journal of Orthopaedics 2018 52(1):1-2 (Source: Indian Journal of Orthopaedics)
Source: Indian Journal of Orthopaedics - January 10, 2018 Category: Orthopaedics Authors: Ajay Puri Source Type: research
Erratum: Current concepts in sports injury rehabilitation
Indian Journal of Orthopaedics 2017 51(6):724-724 (Source: Indian Journal of Orthopaedics)
Source: Indian Journal of Orthopaedics - November 6, 2017 Category: Orthopaedics Source Type: research
Legends of Indian orthopedics: Dr. Brij Bhushan Joshi
Ram Prabhoo, Bhavuk GargIndian Journal of Orthopaedics 2017 51(6):722-723 (Source: Indian Journal of Orthopaedics)
Source: Indian Journal of Orthopaedics - November 6, 2017 Category: Orthopaedics Authors: Ram Prabhoo Bhavuk Garg Source Type: research
