Community-acquired infection caused by small-colony variant of Staphylococcus aureus
Sumit Rai, Pramod Kumar Sharma, Nirpex Tyagi, Sugandh AgarwalIndian Journal of Medical Microbiology 2020 38(2):216-218 Staphylococcus aureus and other Gram negative bacteria produce small colony variants (SCV) which usually emerge after exposure to antimicrobials. They cause repeated infections, treatment failures and often pass unnoticed during cultures due to unusual appearance and incomplete incubation. This infectious disease grand round highlights a similar clinical case with atypical history and appearance of a SCV of S. aureus and why prolonged incubation is necessary for aspirates from patients with recurrent infe...
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: Sumit Rai Pramod Kumar Sharma Nirpex Tyagi Sugandh Agarwal Source Type: research

Functional studies of Plasmodium falciparum & #39;s prohibitin1 and prohibitin 2 in yeast
Savitha Chellappan, Subarna Roy, Jyoti M Nagmoti, Wahida Tabassum, SL Hoti, Mrinal Kanti Bhattacharyya, Praveen Balabaskaran NinaIndian Journal of Medical Microbiology 2020 38(2):213-215 Prohibitins (PHBs) are evolutionarily conserved mitochondrial integral membrane proteins, shown to regulate mitochondrial structure and function, and can be classified into PHB1 and PHB2. PHB1 and PHB2 have been shown to interact with each other, and form heterodimers in mitochondrial inner membrane. Plasmodium falciparum has orthologues of PHB1 and PHB2 in its genome, and their role is unclear. Here, by homology modelling and yeast two-h...
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: Savitha Chellappan Subarna Roy Jyoti M Nagmoti Wahida Tabassum SL Hoti Mrinal Kanti Bhattacharyya Praveen Balabaskaran Nina Source Type: research

Genomic evolution of severe acute respiratory syndrome Coronavirus 2 in India and vaccine impact
Jobin John Jacob, Karthick Vasudevan, Balaji Veeraraghavan, Ramya Iyadurai, Karthik GunasekaranIndian Journal of Medical Microbiology 2020 38(2):210-212 Recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and subsequent containment procedures have impacted the world as never seen before. Therefore, there is considerable curiosity about the genome evolution related to the origin, transmission and vaccine impact of this virus. We have analysed genome sequences of SARS-CoV-2 isolated from Indian patients to gain an in-depth understanding of genomic evolution and transmission in India. Phylogeneti...
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: Jobin John Jacob Karthick Vasudevan Balaji Veeraraghavan Ramya Iyadurai Karthik Gunasekaran Source Type: research

Biofilm synthesis and other virulence factors in multidrug-resistant uropathogenic enterococci isolated in Northern India
Conclusion: VanA and vanB are the prevalent genotypes responsible for vancomycin resistance. The high prevalence of MDR enterococcal strains producing biofilm and virulence determinants raises concern. asa1, hyl, esp, gelE, cyl and other genes are known to express these factors and contribute to biofilm formation. Most uropathogenic enterococci expressed biofilm at moderate level and can be detected effectively by calcofluor-white staining. No correlation was noted between vancomycin resistance and biofilm production. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: Ayan Kumar Das Mridu Dudeja Sunil Kohli Pratima Ray Manvi Singh Preet Simran Kaur Source Type: research

Prevalence of oxacillin-susceptible methicillin-resistant Staphylococcus aureus nasal carriage and their clonal diversity among patients attending public health-care facilities
Conclusions: There is a gradual colonisation shift happening in the infection pattern by S. aureus in Brazil. The Brazilian Epidemic Clone (ST239-SCCmec IIIa-PVL-) seems to be substituted by isolates from different clonal complexes, such as ST5, ST8 and ST30. The non-correlation between phenotypic/genotypic resistance profile observed in some isolates suggests the presence of other methicillin resistance mechanisms different from mecA presence or a difference in the nucleotide sequence, which prevents the primers to identify the specific region during polymerase chain reaction reactions. MRSA identification should be based...
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: Aline Pecanha Muzy Dias Lorrayne Cardoso Guimar & #227;es Livia B. D V. Petrucci J & #233;ssica A Z. Pinheiro Marcos Gabriel Pinheiro Felipe Rodrigues E Silva Helv & #233;cio C C. P & #243;voa F & #225;bio Aguiar-Alves Source Type: research

Molecular characterisation of methicillin-resistant Staphylococcus aureus isolated from patients at a tertiary care hospital in Hyderabad, South India
Conclusions: ST8 was a dominant type along with other previously reported types ST22, ST239, and ST772 from India. The observations highlight the prevalence of genetically diverse clonal populations of MRSA, suggesting potential multiple origins. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: Ganapuram J Archana Akhauri Yash Sinha Madhavi Annamanedi Kandala Pavan Asrith Satyajit B Kale Nitin V Kurkure Swapnil P Doijad Kammili Nagamani Nagendra R Hegde Source Type: research

Prevalence, toxin gene profile, genotypes and antibiotic susceptibility of Clostridium difficile in a tertiary care hospital in Taif, Saudi Arabia
Conclusion: Further larger studies are required for an accurate understanding of CDI epidemiology in Saudi Arabia. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: Taisir Saber Yousry A Hawash Khadiga A Ismail Amany S Khalifa Khalaf F Alsharif Saleh A Alghamdi Tamer Saber Emad M Eed Source Type: research

Epidemiology and risk factors associated with NTM pulmonary and extrapulmonary infections in a high tuberculosis endemic Region
Conclusions: NTM plays a significant role in causing pulmonary and extrapulmonary infections even in our part of the country with high endemicity of tuberculosis. NTM has emerged as important pathogens even in the immunocompetent patients. There is a need for rapid diagnosis and susceptibility testing of NTM to aid physicians administer timely and appropriate treatment to the patients. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: Sanam Rasool Wani Chand Wattal Reena Raveendran Source Type: research

Genotypic and phenotypic characterisation of clinical isolates of methicillin-resistant Staphylococcus aureus in two different geographical locations of Iran
Conclusion: The high prevalence of MRSA makes it necessary to revisit the antibiotics administration by physicians. Indeed, periodic evaluation of antibacterial susceptibility patterns of the MRSA strains is required for efficient treatment of MRSA infections. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: Shiva Ahmadishoar Nadia Kazemi Pour Javid Sadeghi Mohammad Reza Nahaei Babak Kheirkhah Source Type: research

Investigation of antimicrobial resistance and virulence genes of Campylobacter isolates from patients in a tertiary hospital in Edirne, Turkey
Conclusions: It was detected that there is an increase in antimicrobial resistance of Campylobacter strains in our region, and most of the isolates harbour virulence genes. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: Canan Eryildiz Kiymet Tabakcioglu Gulcan Kuyucuklu Nermin Sakru Source Type: research

Diagnostic utility of serology and polymerase chain reaction for detection of Mycoplasma pneumoniae and Chlamydophila pneumoniae in paediatric community-acquired lower respiratory tract infections
Conclusions: Our study confirms that M. pneumoniae and C. pneumoniae play a significant role in community-acquired LRTIs and a combination of serology and nested PCR is useful for its diagnosis. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: Sanchit Kumar Bineeta Kashyap Surinder Kumar Seema Kapoor Source Type: research

Gender and occupation predict Coronavirus Disease 2019 knowledge, attitude and practices of a cohort of a South Indian state population
Conclusions: The health policy would better serve the purpose of the groups with poor scores are targeted. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: Sridhar Amalakanti Kesava Venkata Raman Arepalli Ravi Kiran Koppolu Source Type: research

Healthcare facilities in low- and middle-income countries affected by COVID-19: Time to upgrade basic infection control and prevention practices
Archana Angrup, Rimjhim Kanaujia, Pallab Ray, Manisha BiswalIndian Journal of Medical Microbiology 2020 38(2):139-143 COVID-19 as a pandemic has spanned across all continents. With the increasing numbers in cases worldwide, even the countries with the best of healthcare facilities are reeling under the burden of the disease. Therefore, in countries with limited access to resources and poor healthcare infrastructure, the low and middle-income countries (LMICs), limiting spread becomes even more challenging. Low- and middle-income countries (LMICs) are severely hit by any outbreak and pandemics and face the lack of infrastr...
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: Archana Angrup Rimjhim Kanaujia Pallab Ray Manisha Biswal Source Type: research

Moving beyond clinical medicine: Revised mandate for public health microbiology
Rahul Narang, Pradeep Deshmukh, Banke Lal SherwalIndian Journal of Medical Microbiology 2020 38(2):137-138 (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: Rahul Narang Pradeep Deshmukh Banke Lal Sherwal Source Type: research

Utility of polymerase chain reaction assays for confirmation of liquid culture test results for Ureaplasma spp.
Swati Khullar, Jyoti Rawre, Neena Khanna, Vishnubhatla Sreenivas, Benu DhawanIndian Journal of Medical Microbiology 2020 38(2):235-236 (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: Swati Khullar Jyoti Rawre Neena Khanna Vishnubhatla Sreenivas Benu Dhawan Source Type: research

Cryptococcosis in non-human immunodeficiency virus-infected patients: A clinical dilemma and diagnostic enigma
Manisha Paul, Mohit Bhatia, Ranjana Rohilla, Udayakumar Sasirekha, Neelam KaisthaIndian Journal of Medical Microbiology 2020 38(2):229-234 Cryptococcosis is a fungal disease with worldwide distribution and wide array of clinical manifestations, caused by encapsulated basidiomycetous yeasts called Cryptococcus spp. It has traditionally been considered an opportunistic infection known to occur in immunocompromised hosts, particularly those who are infected with human immunodeficiency virus. However, this infection has also been reported in phenotypically 'normal' or otherwise clinically non-immunocompromised patient...
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: Manisha Paul Mohit Bhatia Ranjana Rohilla Udayakumar Sasirekha Neelam Kaistha Source Type: research

Catheter-related Brevibacterium casei bloodstream infection in a child with aplastic anaemia
We report a catheter-related bloodstream infection with Brevibacterium casei in a 6-year-old child with aplastic anaemia. Treatment with appropriate antibiotics along with the removal of the catheter resulted in complete cure in our patient. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: Sangeeta Joshi Ruchira Misra Suverna Kirolikar Sujata Mushrif Source Type: research

Burkholderia pseudomallei septic arthritis in Type-2 diabetes mellitus patients: Report of two cases
K Baruah Frincy, Borkakoty Biswajyoti, Satyaki Saikia, Manash P Baruah, Utpala DeviIndian Journal of Medical Microbiology 2020 38(2):222-225 Two cases of Burkholderia pseudomallei septic arthritis are presented with a brief review of the literature. B. pseudomallei septic arthritis most commonly occurs in diabetics and other immunocompromised patients and may prove fatal despite appropriate therapy. Clinical and microbiological suspicion of B. pseudomallei infection may help in providing appropriate empirical therapy. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: K Baruah Frincy Borkakoty Biswajyoti Satyaki Saikia Manash P Baruah Utpala Devi Source Type: research

SARS-CoV-2 viral sepsis with meningoencephalitis
Mitkumar Dharsandiya, Kinjal Shah, Ketan Patel, Tushar Patel, Amrish Patel, Atul PatelIndian Journal of Medical Microbiology 2020 38(2):219-221 SARS-CoV-2 predominantly involves the lungs producing acute lung injury, but it can also give rise to a variety of complications involving the central nervous system, gastrointestinal system, kidney and also viral sepsis. With this case report, we are discussing unusual series of complication from acute lung injury, followed by viral sepsis then encephalitis, followed by progressive macrophage activation syndrome. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: Mitkumar Dharsandiya Kinjal Shah Ketan Patel Tushar Patel Amrish Patel Atul Patel Source Type: research

Community-acquired infection caused by small-colony variant of Staphylococcus aureus
Sumit Rai, Pramod Kumar Sharma, Nirpex Tyagi, Sugandh AgarwalIndian Journal of Medical Microbiology 2020 38(2):216-218 Staphylococcus aureus and other Gram negative bacteria produce small colony variants (SCV) which usually emerge after exposure to antimicrobials. They cause repeated infections, treatment failures and often pass unnoticed during cultures due to unusual appearance and incomplete incubation. This infectious disease grand round highlights a similar clinical case with atypical history and appearance of a SCV of S. aureus and why prolonged incubation is necessary for aspirates from patients with recurrent infe...
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: Sumit Rai Pramod Kumar Sharma Nirpex Tyagi Sugandh Agarwal Source Type: research

Functional studies of Plasmodium falciparum & #39;s prohibitin1 and prohibitin 2 in yeast
Savitha Chellappan, Subarna Roy, Jyoti M Nagmoti, Wahida Tabassum, SL Hoti, Mrinal Kanti Bhattacharyya, Praveen Balabaskaran NinaIndian Journal of Medical Microbiology 2020 38(2):213-215 Prohibitins (PHBs) are evolutionarily conserved mitochondrial integral membrane proteins, shown to regulate mitochondrial structure and function, and can be classified into PHB1 and PHB2. PHB1 and PHB2 have been shown to interact with each other, and form heterodimers in mitochondrial inner membrane. Plasmodium falciparum has orthologues of PHB1 and PHB2 in its genome, and their role is unclear. Here, by homology modelling and yeast two-h...
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: Savitha Chellappan Subarna Roy Jyoti M Nagmoti Wahida Tabassum SL Hoti Mrinal Kanti Bhattacharyya Praveen Balabaskaran Nina Source Type: research

Genomic evolution of severe acute respiratory syndrome Coronavirus 2 in India and vaccine impact
Jobin John Jacob, Karthick Vasudevan, Balaji Veeraraghavan, Ramya Iyadurai, Karthik GunasekaranIndian Journal of Medical Microbiology 2020 38(2):210-212 Recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and subsequent containment procedures have impacted the world as never seen before. Therefore, there is considerable curiosity about the genome evolution related to the origin, transmission and vaccine impact of this virus. We have analysed genome sequences of SARS-CoV-2 isolated from Indian patients to gain an in-depth understanding of genomic evolution and transmission in India. Phylogeneti...
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: Jobin John Jacob Karthick Vasudevan Balaji Veeraraghavan Ramya Iyadurai Karthik Gunasekaran Source Type: research

Biofilm synthesis and other virulence factors in multidrug-resistant uropathogenic enterococci isolated in Northern India
Conclusion: VanA and vanB are the prevalent genotypes responsible for vancomycin resistance. The high prevalence of MDR enterococcal strains producing biofilm and virulence determinants raises concern. asa1, hyl, esp, gelE, cyl and other genes are known to express these factors and contribute to biofilm formation. Most uropathogenic enterococci expressed biofilm at moderate level and can be detected effectively by calcofluor-white staining. No correlation was noted between vancomycin resistance and biofilm production. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: Ayan Kumar Das Mridu Dudeja Sunil Kohli Pratima Ray Manvi Singh Preet Simran Kaur Source Type: research

Prevalence of oxacillin-susceptible methicillin-resistant Staphylococcus aureus nasal carriage and their clonal diversity among patients attending public health-care facilities
Conclusions: There is a gradual colonisation shift happening in the infection pattern by S. aureus in Brazil. The Brazilian Epidemic Clone (ST239-SCCmec IIIa-PVL-) seems to be substituted by isolates from different clonal complexes, such as ST5, ST8 and ST30. The non-correlation between phenotypic/genotypic resistance profile observed in some isolates suggests the presence of other methicillin resistance mechanisms different from mecA presence or a difference in the nucleotide sequence, which prevents the primers to identify the specific region during polymerase chain reaction reactions. MRSA identification should be based...
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: Aline Pecanha Muzy Dias Lorrayne Cardoso Guimar & #227;es Livia B. D V. Petrucci J & #233;ssica A Z. Pinheiro Marcos Gabriel Pinheiro Felipe Rodrigues E Silva Helv & #233;cio C C. P & #243;voa F & #225;bio Aguiar-Alves Source Type: research

Molecular characterisation of methicillin-resistant Staphylococcus aureus isolated from patients at a tertiary care hospital in Hyderabad, South India
Conclusions: ST8 was a dominant type along with other previously reported types ST22, ST239, and ST772 from India. The observations highlight the prevalence of genetically diverse clonal populations of MRSA, suggesting potential multiple origins. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: Ganapuram J Archana Akhauri Yash Sinha Madhavi Annamanedi Kandala Pavan Asrith Satyajit B Kale Nitin V Kurkure Swapnil P Doijad Kammili Nagamani Nagendra R Hegde Source Type: research

Prevalence, toxin gene profile, genotypes and antibiotic susceptibility of Clostridium difficile in a tertiary care hospital in Taif, Saudi Arabia
Conclusion: Further larger studies are required for an accurate understanding of CDI epidemiology in Saudi Arabia. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: Taisir Saber Yousry A Hawash Khadiga A Ismail Amany S Khalifa Khalaf F Alsharif Saleh A Alghamdi Tamer Saber Emad M Eed Source Type: research

Epidemiology and risk factors associated with NTM pulmonary and extrapulmonary infections in a high tuberculosis endemic Region
Conclusions: NTM plays a significant role in causing pulmonary and extrapulmonary infections even in our part of the country with high endemicity of tuberculosis. NTM has emerged as important pathogens even in the immunocompetent patients. There is a need for rapid diagnosis and susceptibility testing of NTM to aid physicians administer timely and appropriate treatment to the patients. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: Sanam Rasool Wani Chand Wattal Reena Raveendran Source Type: research

Genotypic and phenotypic characterisation of clinical isolates of methicillin-resistant Staphylococcus aureus in two different geographical locations of Iran
Conclusion: The high prevalence of MRSA makes it necessary to revisit the antibiotics administration by physicians. Indeed, periodic evaluation of antibacterial susceptibility patterns of the MRSA strains is required for efficient treatment of MRSA infections. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: Shiva Ahmadishoar Nadia Kazemi Pour Javid Sadeghi Mohammad Reza Nahaei Babak Kheirkhah Source Type: research

Investigation of antimicrobial resistance and virulence genes of Campylobacter isolates from patients in a tertiary hospital in Edirne, Turkey
Conclusions: It was detected that there is an increase in antimicrobial resistance of Campylobacter strains in our region, and most of the isolates harbour virulence genes. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: Canan Eryildiz Kiymet Tabakcioglu Gulcan Kuyucuklu Nermin Sakru Source Type: research

Diagnostic utility of serology and polymerase chain reaction for detection of Mycoplasma pneumoniae and Chlamydophila pneumoniae in paediatric community-acquired lower respiratory tract infections
Conclusions: Our study confirms that M. pneumoniae and C. pneumoniae play a significant role in community-acquired LRTIs and a combination of serology and nested PCR is useful for its diagnosis. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: Sanchit Kumar Bineeta Kashyap Surinder Kumar Seema Kapoor Source Type: research

Gender and occupation predict Coronavirus Disease 2019 knowledge, attitude and practices of a cohort of a South Indian state population
Conclusions: The health policy would better serve the purpose of the groups with poor scores are targeted. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: Sridhar Amalakanti Kesava Venkata Raman Arepalli Ravi Kiran Koppolu Source Type: research

Healthcare facilities in low- and middle-income countries affected by COVID-19: Time to upgrade basic infection control and prevention practices
Archana Angrup, Rimjhim Kanaujia, Pallab Ray, Manisha BiswalIndian Journal of Medical Microbiology 2020 38(2):139-143 COVID-19 as a pandemic has spanned across all continents. With the increasing numbers in cases worldwide, even the countries with the best of healthcare facilities are reeling under the burden of the disease. Therefore, in countries with limited access to resources and poor healthcare infrastructure, the low and middle-income countries (LMICs), limiting spread becomes even more challenging. Low- and middle-income countries (LMICs) are severely hit by any outbreak and pandemics and face the lack of infrastr...
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: Archana Angrup Rimjhim Kanaujia Pallab Ray Manisha Biswal Source Type: research

Moving beyond clinical medicine: Revised mandate for public health microbiology
Rahul Narang, Pradeep Deshmukh, Banke Lal SherwalIndian Journal of Medical Microbiology 2020 38(2):137-138 (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: Rahul Narang Pradeep Deshmukh Banke Lal Sherwal Source Type: research

Can The March of COVID-19 be Halted
Poonam Loomba, Chand Wattal, Anita Chakravarti, Sanghmitra Dutta, Mala Chabbra, Pratibha Kale, Devjani De, Shobha Broor, Ekta GuptaIndian Journal of Medical Microbiology 2020 38(1):128-133 (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - July 24, 2020 Category: Microbiology Authors: Poonam Loomba Chand Wattal Anita Chakravarti Sanghmitra Dutta Mala Chabbra Pratibha Kale Devjani De Shobha Broor Ekta Gupta Source Type: research

Two cases of Nocardia bacteraemia in solid organ transplant recipients
We report two cases of Nocardia bacteraemia in solid organ transplant recipients-Nocardia cyriacigeorgica bacteraemia in liver transplant recipient and concomitant Nocardia farcinica bacteraemia and cyclosporiasis in a heart transplant recipient. Prompt recognition of early bacteraemia with initiation of antibiotic therapy may avoid the complications of disseminated disease in the solid organ transplant recipients. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - July 24, 2020 Category: Microbiology Authors: Ranganathan N Iyer Jangam Rekha Rao Shivaprakash M Rudramurthy Dharmesh Kapoor Source Type: research

Safety and efficacy of tocilizumab in the treatment of severe acute respiratory syndrome coronavirus-2 pneumonia: A retrospective cohort study
Conclusions: TCZ is likely a safe and effective modality of treatment for improving clinical and laboratory parameters of SARS CoV-2 patients with a reduction in ICU stay and ventilatory care need. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - July 24, 2020 Category: Microbiology Authors: Atul Patel Kinjal Shah Mitkumar Dharsandiya Ketan Patel Tushar Patel Mukesh Patel Tea Reljic Ambuj Kumar Source Type: research

Candidaemia in a tertiary care centre of developing country: Monitoring possible change in spectrum of agents and antifungal susceptibility
Conclusion: Local epidemiology of candidaemia at our centre was distinct regarding prevalence and change of spectrum of species. The identification of rare species was possible after the introduction of MALDI-TOF. With the emergence of multidrug-resistant C. auris and resistance in other species, routine AFST has become imperative. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - July 24, 2020 Category: Microbiology Authors: Harsimran Kaur Shreya Singh Shivaprakash M Rudramurthy Anup Kumar Ghosh Muralidharan Jayashree Yaddanapudi Narayana Pallab Ray Arunaloke Chakrabarti Source Type: research

Prevalence and antimicrobial profile of Shigella isolates in a tertiary care hospital of North Karnataka: A 12-year study
Conclusions: S. flexneri was the most prevalent species isolated at this centre. Shigella isolates from the study showed alarming resistance to recommended antibiotics. Non-typeable Shigella accounted for 34.4% isolates. Molecular discrimination between Shigella and Escherichia coli is essential. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - July 24, 2020 Category: Microbiology Authors: Pavithra Amrath Jain RD Kulkarni S Dutta Ajanta S Ganavali Anuradha S Kalabhavi Praveen C Shetty C Shubhada Manjunath A Hosamani Suma B Appannanavar Deepa R Hanamaraddi Source Type: research

Association of toll-like receptors 2, 4, 9 and 10 genes polymorphisms and Helicobacter pylori-related gastric diseases in Saudi patients
Conclusion: TLR genes polymorphisms may play a role in H. pylori infection susceptibility and may influence its outcomes; however, the ethnic and other factors may modify this effect. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - July 24, 2020 Category: Microbiology Authors: Emad M Eed Yousry A Hawash Amany S Khalifa Khalaf F Alsharif Saleh A Alghamdi Abdulraheem A Almalki Mazen M Almehmadi Khadiga A Ismail Azza A Taha Taisir Saber Source Type: research

Comparative analysis of clinical characteristics, imaging and laboratory findings of different age groups with COVID-19
Conclusion: The clinical characteristics and imaging/laboratory findings of COVID-19 patients vary in different age groups. Personalised criteria should be formulated according to different age groups in the early screening and diagnosis stage. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - July 24, 2020 Category: Microbiology Authors: Xuemei Liu Jie Lv Lin Gan Ying Zhang Feng Sun Bo Meng Andrew Jheon Fang Yan Bin Li Zhou Xuan Xiumin Ma Muhuyati Wulasihana Source Type: research

Molecular capsular typing and multi locus sequence typing of invasive, non-invasive and commensal Streptococcus pneumoniae isolates from North India
Conclusion: MLST sequence analysis shows that invasive isolates were found to be clustered with non-invasive and commensal isolates. Analysis of MLST suggests the possibility of genetic relatedness and exchange of genetic material between invasive, non-invasive and commensal isolates. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - July 24, 2020 Category: Microbiology Authors: Shefali Jain Bimal Kumar Das Neeraj Mahajan Arti Kapil Rama Chaudhry Seema Sood Sushil Kumar Kabra Sada Nand Dwivedi Source Type: research

Continuous ambulatory peritoneal dialysis peritonitis: Microbiology and outcomes
Conclusions: Direct inoculation of peritoneal fluid into automated blood culture bottles increases the positivity rate and also aids in the early detection of CAPD peritonitis, helping reduce morbidity and mortality of PD patients. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - July 24, 2020 Category: Microbiology Authors: Girisha Pindi Vijendra Kawle Rajeshwar Rao Sunkara Murty Satyanarayana Darbha Sasikala Garikaparthi Source Type: research

Human papillomavirus infection rates before and after the introduction of prophylactic vaccines in Kunming, Yunnan, China
Conclusion: Although the overall HPV infection rate in Kunming did not change significantly after the introduction of HPV vaccines, differences in HPV infection rates and multi-typic HPV infection rates were evident in certain age groups. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - July 24, 2020 Category: Microbiology Authors: Guiqian Z Ziqin D Ya X Qiong W Xin F Limei B Hongyan Z Yi S Source Type: research

Colistin susceptibility testing of gram-negative bacilli: Better performance of vitek2 system than E-test compared to broth microdilution method as the gold standard test
Conclusion: Of 138 isolates, meropenem, colistin and dual resistance were detected in 110 (79.7%), 31 (22.5%) and 21 (15.2%) of isolates, respectively. Using the European Committee on Antimicrobial Susceptibility Testing guidelines (susceptible, ≤2 μg/ml), Vitek2 performed better than E-test (essential agreement, 92.2% vs. 63.7%; categorical agreement, 94.1% vs. 93.1%; very major error [VME], 10% vs. 23.3%). However, Vitek2 overcalled resistance than E-test (major error, 4.2% vs. 0%). Considering Chew et al. proposed breakpoints (susceptible, ≤1 μg/ml), VMEs...
Source: Indian Journal of Medical Microbiology - July 24, 2020 Category: Microbiology Authors: Surojit Das Subhanita Roy Samadrita Roy Gaurav Goelv Subir Sinha Purva Mathur Kamini Walia Sanjay Bhattacharya Source Type: research

In vitro and in vivo fitness of clinical isolates of carbapenem-resistant and -susceptible Acinetobacter baumannii
Conclusions: To the best of our knowledge, this is the first study of its kind from India showing difference in fitness of clinical isolates of CRAB and CSAB. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - July 24, 2020 Category: Microbiology Authors: Sunil Kumar Lipika Singhal Pallab Ray Vikas Gautam Source Type: research

Hepatitis E outbreak in Jaipur due to Genotype IA
Conclusion: The outbreak was due to HEV genotype 1A. The municipal water supply was contaminated and sanitary conditions and waste disposal were poor in the area. Boiling of drinking water, fixing the water supply pipes and frequent hand washing helped in controlling the outbreak. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - July 24, 2020 Category: Microbiology Authors: Bharti Malhotra Farah Deba Pratibha Sharma Khushbu Trivedi Jitendra Tiwari Aradhana Chouhan Ruchi Singh Deepa Meena HN Verma Source Type: research

Generating mucosal and systemic immune response following vaccination of vibrio cholerae adhesion molecule against shigella flexneri infection
Conclusions: 37.8 kDa subunit pili can act as a homologous vaccine candidate to prevent V. cholerae and S. flexneri infection. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - July 24, 2020 Category: Microbiology Authors: Sumarno Reto Prawiro Sri Poeranto Aisyah Amalia Elsa Larissa Widyani Genitri Indraswari Merika Soraya Septha Rully Dwi Pradipto Adrian Prasetya Guntur Rizal Hidayat Safira Nur Alitha Putri Source Type: research

Prevalence of campylobacter enteritis in children under 5 years hospitalised for diarrhoea in two cities of Northeast India
Conclusion: The present study reveals that Campylobacter infection is endemic in the studied regions of Northeast India and microbiological laboratories of the region should actively pursue the isolation or detection of Campylobacter spp. in cases of diarrhoea in routine stool cultures. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - July 24, 2020 Category: Microbiology Authors: Biswajyoti Borkakoty Aniruddha Jakharia Mandakini Das Sarmah Rahul Hazarika Pranjal Jyoti Baruah Chandra Jyoti Bora T Temsu Munmun Gohain Utpala Devi Dipankar Biswas Source Type: research

Mortality from acinetobacter infections as compared to other infections among critically ill patients in South India: A prospective cohort study
Conclusion: In our cohort of critically ill adults with VAP and CLABSI, AR-HAI was associated with poor ventilator outcomes and a trend towards higher mortality. These findings add to the evidence suggesting that A. baumannii is a dangerous pathogen, perhaps even more so than others. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - July 24, 2020 Category: Microbiology Authors: Ajoy Oommen John Hema Paul Saranya Vijayakumar Shalini Anandan Thomas Sudarsan Ooriyapadickal Cherian Abraham Veeraraghavan Balaji Source Type: research

Optimal size of sample pooling for RNA pool testing: An avant-garde for scaling up severe acute respiratory syndrome coronavirus-2 testing
Conclusions: The pooling of samples is a practical way for scaling up testing and ultimately containing the further spread of the CoV disease 2019 pandemic. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - July 24, 2020 Category: Microbiology Authors: Arvind Khodare Abhishek Padhi Ekta Gupta Reshu Agarwal Shantanu Dubey Shiv Kumar Sarin Source Type: research