Accelerated drug approvals in oncology: Pros and cons
Sayanta Thakur, Sandeep LahiryIndian Journal of Cancer 2021 58(1):114-118
The inevitable surge of the accelerated approval process, especially for oncology drugs, has been a success story. However, the use of surrogate end-points and its validation has been debatable over the years. Over the years, US Food and Drug Administration has been rigorously working for the validation of these end-points to capture the real clinical benefit and appropriateness of clinical study designs. However, the high cost imposed by the manufacturer attributed to the faster drug access can be prohibitive and well undermine the whole process. W...
Source: Indian Journal of Cancer - March 24, 2021 Category: Cancer & Oncology Authors: Sayanta Thakur Sandeep Lahiry Source Type: research
Challenging role of new agents in the treatment of ALCL
Carolina V MahuadIndian Journal of Cancer 2021 58(1):112-113 (Source: Indian Journal of Cancer)
Source: Indian Journal of Cancer - March 24, 2021 Category: Cancer & Oncology Authors: Carolina V Mahuad Source Type: research
Successful combination of crizotinib and hematopoietic stem cell transplantation in relapsed ALK-positive ALCL
We report a case wherein a combination of crizotinib and hematopoietic stem cell transplantation (HSCT) cured a 20-year-old woman with relapsed and refractory anaplastic lymphoma kinase-positive anaplastic large cell lymphoma (ALK-positive ALCL). Although she received cyclophosphamide, doxorubicin, vincristine, prednisone, and etoposide (CHOPE) as the first-line chemotherapy from the beginning, the disease progressed rapidly with the emergence of bone marrow invasion and hemophagocytic syndrome. Vincristine, idarubicin, l-asparaginase, and prednisone (VILP) chemotherapy was not effective. Therefore, the patient received of...
Source: Indian Journal of Cancer - March 24, 2021 Category: Cancer & Oncology Authors: Xue Sun Xiaosheng Fang Yujie Jiang Source Type: research
Mediastinal small cell carcinoma with a metastasis to the orbit: A rare carcinoma with an unusual metastatic progression
We presented a case of solitary EOM metastasis from mediastinal small cell cancer (MSCC) for the first time. A 49-year-old man presented with hoarseness. Thorax computed tomography (CT) revealed a mediastinal mass. A fine-needle aspiration biopsy (FNAB) confirmed the diagnosis of MSCC. The patient staged as limited-stage MSCC with a positron emission computed tomography (PET-CT). The patient received radical chemo-radiotherapy (CRT). PET-CT showed a complete response after CRT. Afterward, the patient presented with double vision and a headache. Brain magnetic resonance imaging (MRI) demonstrated a 2 cm metastatic lesion at...
Source: Indian Journal of Cancer - March 24, 2021 Category: Cancer & Oncology Authors: Meltem Kirli Bolukbas Fatma Yalcin Musri Sibel Karaca Source Type: research
Perineum and penile invasion of recurrent prostate carcinoma shown by Ga-68 PSMA PET/CT
Zehra Pinar Koc, Pınar Pelin Özcan, Vehbi ErçolakIndian Journal of Cancer 2021 58(1):101-103
Imaging of prostate cancer has recently had new modalities. Ga-68 Prostate Specific Membrane Antigen (PSMA) Positron Emission Tomography/Computed Tomography (PET/CT) has gained important diagnostic role in the management of the patients with prostate cancer. Patients with progressively elevated serum prostate specific antigen (PSA) level may be evaluated by Ga-68 PSMA PET/CT imaging. This case report presents a seventy five year old man with diagnosis of prostate cancer and progressive serum PSA...
Source: Indian Journal of Cancer - March 24, 2021 Category: Cancer & Oncology Authors: Zehra Pinar Koc P & #305;nar Pelin & #214;zcan Vehbi Er & #231;olak Source Type: research
A rare RET mutation in an Indian pedigree with familial medullary thyroid carcinoma
We report a rare RET mutation of c.2671T>G; p.Ser891Ala in Exon 15 of the RET gene in an Indian pedigree where seven family members out of 14 screened were found to be positive for the same. RET genetic analysis should be considered as an early approach in the diagnosis of medullary thyroid carcinoma (MTC) since it improves the prognosis and permits surveillance of other family members. (Source: Indian Journal of Cancer)
Source: Indian Journal of Cancer - March 24, 2021 Category: Cancer & Oncology Authors: Roopa Vijayan Vasantha Nair Usha Menon Harish Kumar Source Type: research
MCQs on & #8220;Reoperation does not provide a survival advantage in patients with recurrent Glioblastoma treated with irinotecan/bevacizumab treatment & #8221;
HS Darling, Pradeep Jaiswal, Nishant Lohia, Nishant R TiwariIndian Journal of Cancer 2021 58(1):96-97 (Source: Indian Journal of Cancer)
Source: Indian Journal of Cancer - March 24, 2021 Category: Cancer & Oncology Authors: HS Darling Pradeep Jaiswal Nishant Lohia Nishant R Tiwari Source Type: research
Reoperation does not provide a survival advantage in patients with recurrent Glioblastoma treated with irinotecan/bevacizumab treatment
Conclusion: The second surgery in recurrent GBM has limited effect in clinical course. (Source: Indian Journal of Cancer)
Source: Indian Journal of Cancer - March 24, 2021 Category: Cancer & Oncology Authors: Ozlem Nuray Sever Kadir Oktay Ebru G & #252;zel Vildan Kaya Aslan G & #252;zel Mustafa Y & #305;ld & #305;r & #305;m Source Type: research
Triple intrathecal chemotherapy for leptomeningeal carcinomatosis in solid tumors: Treatment outcomes, response and their determinants
Conclusion: A triple drug combination of methotrexate, cytosine arabinoside and hydrocortisone when given intrathecally for patients with LC showed good control of symptoms and reasonable survival. It may be beneficial in patients with no brain parenchymal involvement. (Source: Indian Journal of Cancer)
Source: Indian Journal of Cancer - March 24, 2021 Category: Cancer & Oncology Authors: Vijay K Srinivasalu Narayana Subramaniam Arun Philip Wesley Jose Keechilat Pavithran Source Type: research
Quality of life and its predictors in Iranian women with breast cancer undergoing chemotherapy and radiotherapy
Conclusion: Fulfilling supportive care needs, helping to understand the curative nature of cancer, as well as empowering complementary health insurances are among intervenable variables to improve QOL among women with breast cancer. (Source: Indian Journal of Cancer)
Source: Indian Journal of Cancer - March 24, 2021 Category: Cancer & Oncology Authors: Fatemeh Mirzaei Azizeh Farshbaf-Khalili Roghaiyeh Nourizadeh Reza Eghdam Zamiri Source Type: research
Effect of corticosteroid ointment on radiation induced dermatitis in head and neck cancer patients: A prospective study
Conclusion: Topical Betamethasone can delay the onset and progression of radiation dermatitis in head and neck cancer, without significant delay in wound healing. (Source: Indian Journal of Cancer)
Source: Indian Journal of Cancer - March 24, 2021 Category: Cancer & Oncology Authors: Rubu Sunku Apurba K Kalita Mouchumee Bhattacharyya Partha P Medhi Shashank Bansal Luri Borah Navin Nayan Ghritashee Bora Moumita Paul Subhalakshmi Saikia Amal C Kataki Source Type: research
Lower pretreatment hemoglobin status and treatment breaks in locally advanced head and neck squamous cell carcinoma during concurrent chemoradiation
Conclusion: Lower pre-T Hb level of ≤ 10.3 g/dL is statistically significantly associated with higher treatment breaks of ≥ 5 days. (Source: Indian Journal of Cancer)
Source: Indian Journal of Cancer - March 24, 2021 Category: Cancer & Oncology Authors: Rajesh Kar Narayanasamy RM Muthusekar Sathiamoorthy Pattanam Nagalingam Sendil Thyagarajan Balasubramaniam Ramakrishnan Karthikeyan Perumal Source Type: research
Therapeutic efficacy of TACE 125I seed implantation and its combination with intra-tumor injection of cisplatin for the treatment of hepatocellular carcinoma
Conclusion: TACE combined with either 125I seed implantation or 125I seed implantation and intra-tumor injection of cisplatin was effective for the treatment of HCC. Of the 2 combination therapies, TACE combined with 125I seed implantation and intra-tumor injection of cisplatin was more effective for the treatment of HCC. (Source: Indian Journal of Cancer)
Source: Indian Journal of Cancer - March 24, 2021 Category: Cancer & Oncology Authors: Zhaomin Song Xiaoqing Guo Chenghui Yin Yongzheng Wang Source Type: research
Cancer incidence in Madras Presidency in 1892 & #8211;1901: William Niblock & #39;s commentary of 1902
Ramya Raman, Anantanarayanan RamanIndian Journal of Cancer 2021 58(1):48-56
William J. Niblock (WJN), an Assistant Surgeon at the Madras General Hospital (MGH), published a paper 'Cancer in India' (2 pages of text and 3 pages of tables) in the Indian Medical Gazette in 1902. He appears to have been a popular surgeon in Madras who surgically treated mouth cancers, testicular filariasis, and calcareous stones in the liver, gall bladder, and kidney. His 'Cancer in India' article is a compilation of numerical data of different cancers recorded in MGH from 1892 to 1901 mostly, and fr...
Source: Indian Journal of Cancer - March 24, 2021 Category: Cancer & Oncology Authors: Ramya Raman Anantanarayanan Raman Source Type: research
Advances in palliative care in 2020: Palliative care and oncology in India - Looking ahead from 2020
Indian Journal of Cancer 2021 58(1):45-47 (Source: Indian Journal of Cancer)
Source: Indian Journal of Cancer - March 24, 2021 Category: Cancer & Oncology Source Type: research
