Investigation of the Efficacy and Safety of Nivolumab in Recurrent and Metastatic Nasopharyngeal Carcinoma
Conclusion: Nivolumab is a useful and relatively safe second-line systemic therapy in patients with R/M-NPC, and even patients who do not respond to nivolumab may survive for a long time. (Source: In Vivo)
Source: In Vivo - August 30, 2020 Category: Research Authors: SATO, H., FUSHIMI, C., OKADA, T., MATSUKI, T., KONDO, T., OMURA, G., MIURA, K., YAMASHITA, T., OKAMOTO, I., TSUKAHARA, K. Tags: Clinical Studies Source Type: research
Combining Radiomics and Blood Test Biomarkers to Predict the Response of Locally Advanced Rectal Cancer to Chemoradiation
Conclusion: A non-redundancy between radiomics features and blood-based biomarkers was observed. Furthermore, radiomics features are more valuable in terms of predicting response to nCRT. The importance of combining non-invasive biomarkers in future investigations is highlighted. (Source: In Vivo)
Source: In Vivo - August 30, 2020 Category: Research Authors: JEON, S. H., SONG, C., CHIE, E. K., KIM, B., KIM, Y. H., CHANG, W., LEE, Y. J., CHUNG, J.-H., CHUNG, J. B., LEE, K.-W., KANG, S.-B., KIM, J.-S. Tags: Clinical Studies Source Type: research
A Case Series of BCOR Sarcomas With a New Splice Variant of BCOR/CCNB3 Fusion Gene
Conclusion: We are the first to report a splice variant of BCOR/CCNB3 which reveals the central position of BCOR in the oncogenesis of these tumors, furthermore we highlight the importance of molecular diagnostics in Ewing-like sarcomas and discuss the current treatment options for this rare entity. (Source: In Vivo)
Source: In Vivo - August 30, 2020 Category: Research Authors: KYRIAZOGLOU, A., TOURKANTONI, N., LIONTOS, M., ZAGOURI, F., MAHAIRA, L., PAPAKOSTA, A., MICHALI, D., PATERELI, A., STEFANAKI, K., TZOTZOLA, V., SKOURA, E., BAKA, M., POLYCHRONOPOULOU, S., KATTAMIS, A., DIMITRIADIS, E. Tags: Clinical Studies Source Type: research
Serum Exosomal miRNA-1915-3p Is Correlated With Disease Activity of Korean Rheumatoid Arthritis
Conclusion: Has-miR-1915-3p may be a potential marker for Korean RA disease activity. (Source: In Vivo)
Source: In Vivo - August 30, 2020 Category: Research Authors: LIM, M.-K., YOO, J., SHEEN, D.-H., IHM, C., LEE, S. K., KIM, S. A. Tags: Clinical Studies Source Type: research
Laparoscopic Total Gastrectomy for Gastric Cancer in Elderly Patients
Conclusions: LTG was acceptable for elderly patients as the elderly and non-elderly groups showed comparable short-term and long-term outcomes. (Source: In Vivo)
Source: In Vivo - August 30, 2020 Category: Research Authors: SUEMATSU, H., KUNISAKI, C., MIYAMATO, H., SATO, K., SATO, S., TANAKA, Y., YUKAWA, N., RINO, Y., KOSAKA, T., AKIYAMA, H., ENDO, I., MASUDA, M. Tags: Clinical Studies Source Type: research
Evidence of Common Pathophysiology Between Stress and Urgency Urinary Incontinence in Women
Conclusion: The current treatment options for UUI are based on the hypothesis that UUI is a neurological disorder. This study demonstrated that urinary incontinence in patients with UUI is dependent on an intact anatomical stability of the urethro-vesical junction under pressure. Therefore, treatment modalities should focus on the anatomical repair or support in that area. (Source: In Vivo)
Source: In Vivo - August 30, 2020 Category: Research Authors: JAGER, W., LUDWIG, S., NEUMANN, E., MALLMANN, P. Tags: Clinical Studies Source Type: research
Pros and Cons of Portal Vein Embolization With Hematopoietic Stem Cells Application in Colorectal Liver Metastases Surgery
Conclusion: PVE with aHSC application is a safe and useful method for FLRV growth. It significantly increases secondary CLMs resectability. However, it can cause CLMs progression. Liver resection should, therefore, be performed as soon as possible after achieving optimal increase of FLRV. (Source: In Vivo)
Source: In Vivo - August 30, 2020 Category: Research Authors: TRESKA, V., BRUHA, J., LISKA, V., FICHTL, J., PROCHAZKOVA, K., PETRAKOVA, T., HOSEK, P. Tags: Clinical Studies Source Type: research
The Influence of the Metabolic Syndrome on Early Postoperative Outcomes of Patients With Advanced-stage Endometrial Cancer
Conclusion: The association of metabolic syndrome significantly influences the risk of postoperative complications in patients with endometrial cancer; moreover, in certain cases, it might preclude the achievement of freedom from residual disease. (Source: In Vivo)
Source: In Vivo - August 30, 2020 Category: Research Authors: BACALBASA, N., DIACONU, C., ILIESCU, L., SAVU, C., SAVU, C., BALALAU, C., DIMITRIU, M., FILIPESCU, A., BRATU, O. G., NEACSU, A., CRETOIU, D., HALMACIU, I., BALESCU, I. Tags: Clinical Studies Source Type: research
Cytoplasmic CK1{varepsilon} Protein Expression Is Correlated With Distant Metastasis and Survival in Patients With Melanoma
Conclusion: CK1 protein expression might serve as a prognostic indicator in the treatment of patients with melanoma. (Source: In Vivo)
Source: In Vivo - August 30, 2020 Category: Research Authors: LU, J.-W., LIN, S.-H., YEH, C.-M., YEH, K.-T., HUANG, L.-R., CHEN, C.-Y., LIN, Y.-M. Tags: Clinical Studies Source Type: research
Improvement in Left Cardiac Function Following Mitral Valve Repair: Analyses Based on Cardiac Magnetic Resonance Imaging
Conclusion: Restoration of LA and LV functions after a successful MVR was not associated with structural improvement in LA and LV. (Source: In Vivo)
Source: In Vivo - August 30, 2020 Category: Research Authors: HAYATA, Y., SAWABATA, N., ABE, T., HIROSE, T., YAMASHITA, K., HIRAGA, S., FUKUBA, R., TAKEMURA, J., NAKANO, T., SAITO, Y., TANIGUCHI, S. Tags: Clinical Studies Source Type: research
Prediction of Therapeutic Effects from One Course of TPF Chemotherapy for Advanced Hypopharyngeal Laryngeal Cancer
Conclusion: PFS rate in this study may have been improved by selecting surgical treatment for patients for whom chemoradiotherapy seemed less effective. One cycle of TPF in induction chemotherapy appeared effective for chemoselection. (Source: In Vivo)
Source: In Vivo - August 30, 2020 Category: Research Authors: MARUYAMA, R., OKAMOTO, I., SATO, H., KATSUBE, Y., KONDO, T., TSUKAHARA, K. Tags: Clinical Studies Source Type: research
Proton Therapy for Primary Renal Cell Carcinoma: The First Nationwide Retrospective Study in Japan
Conclusion: Despite the small number of patients, high-dose PBT can control RCC while maintaining their renal function with high probability, and could be and alternative curative therapy especially for inoperable patients. (Source: In Vivo)
Source: In Vivo - August 30, 2020 Category: Research Authors: FUKUMITSU, N., ISHIKAWA, H., ARIMURA, T., WADA, H., OKIMOTO, T., SATO, Y., IWATA, H., SHIMIZU, S., SAKURAI, H. Tags: Clinical Studies Source Type: research
Impact of Body Composition in Overweight and Obese Patients With Localised Renal Cell Carcinoma
Conclusion: Sarcopenia was frequently associated with localised RCC at the initial diagnosis. Body composition did not affect morbidity or outcomes. BMI was involved in morbidity and there was paradoxically longer survival in the obesity group. (Source: In Vivo)
Source: In Vivo - August 30, 2020 Category: Research Authors: DARBAS, T., FORESTIER, G., LEOBON, S., PESTRE, J., JESUS, P., LACHATRE, D., TUBIANA-MATHIEU, N., DESCAZEAUD, A., DELUCHE, E. Tags: Clinical Studies Source Type: research
Prediction of Results of Radiotherapy With Ku70 Expression and an Artificial Neural Network
Conclusion: We demonstrated a possibility to predict the radiotherapy treatment results in prostate and hypopharyngeal cancer using ANN in combination with Ku70 expression and clinical factors as inputs. (Source: In Vivo)
Source: In Vivo - August 30, 2020 Category: Research Authors: HASEGAWA, T., SOMEYA, M., HORI, M., TSUCHIYA, T., FUKUSHIMA, Y., MATSUMOTO, Y., SAKATA, K.-I. Tags: Clinical Studies Source Type: research
Neutrophil-to-Lymphocyte Ratio as a Prognostic Marker for Anaplastic Thyroid Cancer Treated With Lenvatinib
Conclusion: The baseline NLR is a potential prognostic marker, and the change of NLR can be an early indicator of response for ATC patients treated with lenvatinib. (Source: In Vivo)
Source: In Vivo - August 30, 2020 Category: Research Authors: FUKUDA, N., TODA, K., FUJIWARA, Y., WANG, X., OHMOTO, A., URASAKI, T., HAYASHI, N., SATO, Y., NAKANO, K., YUNOKAWA, M., ONO, M., TOMOMATSU, J., MITANI, H., TAKAHASHI, S. Tags: Clinical Studies Source Type: research
