Spatial and temporal coordination of antiviral responses by group 1 ILCs
SummaryGroup 1 innate lymphocytes consist of a phenotypically, spatially, and functionally heterogeneous population of NK cells and ILC1s that are engaged during pathogen invasion. We are only beginning to understand the context ‐dependent roles that different subsets of group 1 innate lymphocytes play during homeostatic perturbations. With a focus on viral infection, this review highlights the organization and regulation of spatially and temporally distinct waves of NK cell and ILC1 responses that collectively serve to a chieve optimal viral control. (Source: Immunological Reviews)
Source: Immunological Reviews - October 7, 2018 Category: Allergy & Immunology Authors: Nicholas M. Adams,
Joseph C. Sun Tags: INVITED REVIEW Source Type: research
Deconstructing deployment of the innate immune lymphocyte army for barrier homeostasis and protection
SummaryThe study of the immune system has shifted from a purely dichotomous separation between the innate and adaptive arms to one that is now highly complex and reshaping our ideas of how steady ‐state health is assured. It is now clear that immune cells do not neatly fit into these two streams and immune homeostasis depends on continual dialogue between multiple lineages of the innate (including dendritic cells, innate lymphoid cells, and unconventional lymphocytes) and adaptive (T and B lymphocytes) arms together with a finely tuned synergy between the host and microbes which is essential to ensure immune homeostasis....
Source: Immunological Reviews - October 7, 2018 Category: Allergy & Immunology Authors: Francisca F. Almeida,
Nicolas Jacquelot,
Gabrielle T. Belz Tags: INVITED REVIEW Source Type: research
New insights into the function, development, and plasticity of type 2 innate lymphoid cells
SummaryGroup 2 innate lymphoid cells (ILC2s) are the most well defined group of ILCs. ILC2 development is controlled by the GATA ‐3 transcription factor and these cells produce archetypal type 2 cytokines, such as IL‐5 and IL‐13. These cytokines mediate parasite expulsion and tissue repair, but also contribute to type 2 inflammatory diseases, including allergy, asthma and chronic rhinosinusitis with nasal polyps. In res ponse to tightly regulated local environmental cues ILCs can generate characteristics of other subtypes, a process known as plasticity. Recent advances in the ILC2 field has led to the discovery that ...
Source: Immunological Reviews - October 7, 2018 Category: Allergy & Immunology Authors: Lisette Krabbendam,
Suzanne M. Bal,
Hergen Spits,
Korneliusz Golebski Tags: INVITED REVIEW Source Type: research
Neuroendocrine regulation of innate lymphoid cells
SummaryThe activities of the immune system in repairing tissue injury and combating pathogens were long thought to be independent of the nervous system. However, a major regulatory role of immunomodulatory molecules released locally or systemically by the neuroendocrine system has recently emerged. A number of observations and discoveries support indeed the notion of the nervous system as an immunoregulatory system involved in immune responses. Innate lymphoid cells (ILCs), including natural killer (NK) cells and tissue ‐resident ILCs, form a family of effector cells present in organs and mucosal barriers. ILCs are invol...
Source: Immunological Reviews - October 7, 2018 Category: Allergy & Immunology Authors: Linda Quatrini,
Eric Vivier,
Sophie Ugolini Tags: INVITED REVIEW Source Type: research
The group 2 innate lymphoid cell (ILC2) regulatory network and its underlying mechanisms
SummaryGroup 2 innate lymphoid cells (ILC2s) play critical roles in the induction of type 2 inflammation, response to parasite infection, metabolic homeostasis, and tissue repair. These multifunctional roles of ILC2s are tightly controlled by complex regulatory systems in the local microenvironment, the disruption of which may cause various health problems. This review summarizes up ‐to‐date knowledge regarding positive and negative regulators for ILC2s based on their function and signaling pathways, including activating cytokines (IL‐33, IL‐25; MAPK, NF‐κB pathways), co‐stimulatory cytokines (IL‐2, IL‐7, ...
Source: Immunological Reviews - October 7, 2018 Category: Allergy & Immunology Authors: Hiroki Kabata,
Kazuyo Moro,
Shigeo Koyasu Tags: INVITED REVIEW Source Type: research
JAK/STAT signaling in regulation of innate lymphoid cells: The gods before the guardians
SummaryImmunity to pathogens is ensured through integration of early responses mediated by innate cells and late effector functions taking place after terminal differentiation of adaptive lymphocytes. In this context, innate lymphoid cells (ILCs) and adaptive T cells represent a clear example of how prototypical effector functions, including polarized expression of cytokines and/or cytotoxic activity, can occur with overlapping modalities but different timing. The ability of ILCs to provide early protection relies on their poised epigenetic state, which determines their propensity to quickly respond to cytokines and to act...
Source: Immunological Reviews - October 7, 2018 Category: Allergy & Immunology Authors: Helena Stabile,
Gianluca Scarno,
Cinzia Fionda,
Angela Gismondi,
Angela Santoni,
Massimo Gadina,
Giuseppe Scium è Tags: INVITED REVIEW Source Type: research
Thinking differently about ILCs —Not just tissue resident and not just the same as CD4+ T‐cell effectors
AbstractInnate lymphoid cells (ILCs) resemble adaptive T lymphocytes based on transcription factor expression, cytokine production, and their presumptive roles in immunity, but are activated for effector function through cytokine signaling and not antigen ‐specific receptors. The prevailing view is that ILCs adapt to specific microenvironments during development and operate as tissue‐resident cells in co‐operation with antigen‐specific T cells to provide host protection and contribute to tissue maintenance. In particular, conventional models equate the activity of different ILC subsets with CD4+ effector T ‐cell ...
Source: Immunological Reviews - October 7, 2018 Category: Allergy & Immunology Authors: Yuefeng Huang,
Kairui Mao,
Ronald N. Germain Tags: INVITED REVIEW Source Type: research
Metabolic regulation of innate and adaptive lymphocyte effector responses
SummaryInnate and adaptive lymphocytes employ diverse effector programs that provide optimal immunity to pathogens and orchestrate tissue homeostasis, or conversely can become dysregulated to drive progression of chronic inflammatory diseases. Emerging evidence suggests that CD4+ T helper cell subsets and their innate counterparts, the innate lymphoid cell family, accomplish these complex biological roles by selectively programming their cellular metabolism in order to instruct distinct modules of lymphocyte differentiation, proliferation, and cytokine production. Further, these metabolic pathways are significantly influen...
Source: Immunological Reviews - October 7, 2018 Category: Allergy & Immunology Authors: Ann M. Joseph,
Laurel A. Monticelli,
Gregory F. Sonnenberg Tags: INVITED REVIEW Source Type: research
Type 2 innate lymphoid cells in the induction and resolution of tissue inflammation
SummaryType 2 immunity against pathogens is tightly regulated to ensure appropriate inflammatory responses that clear infection and prevent excessive tissue damage. Recent research has shown that type 2 innate lymphoid cells (ILC2s) contribute to steady ‐state tissue integrity and exert tissue‐specific functions. However, upon exposure to inflammatory stimuli, they also initiate and amplify type 2 inflammation by inducing mucus production, eosinophilia, and Th2 differentiation. In this review, we discuss the regulation of ILC2 activation by tra nscription factors and metabolic pathways, as well as by extrinsic signals ...
Source: Immunological Reviews - October 7, 2018 Category: Allergy & Immunology Authors: Antonia Wallrapp,
Samantha J. Riesenfeld,
Patrick R. Burkett,
Vijay K. Kuchroo Tags: INVITED REVIEW Source Type: research
Issue Information
Immunological Reviews, Volume 286, Issue 1, Page 1-3, November 2018. (Source: Immunological Reviews)
Source: Immunological Reviews - October 7, 2018 Category: Allergy & Immunology Tags: ISSUE INFORMATION Source Type: research
Introduction: Basic and emerging concepts in ILC biology
Immunological Reviews, Volume 286, Issue 1, Page 4-5, November 2018. (Source: Immunological Reviews)
Source: Immunological Reviews - October 7, 2018 Category: Allergy & Immunology Authors: Marco Colonna Tags: INTRODUCTION Source Type: research
Issue Information
Immunological Reviews,Volume 285, Issue 1, Page 1-4, September 2018. (Source: Immunological Reviews)
Source: Immunological Reviews - August 12, 2018 Category: Allergy & Immunology Source Type: research
Antiviral interferon response at single ‐cell resolution
Immunological Reviews,Volume 285, Issue 1, Page 72-80, September 2018. (Source: Immunological Reviews)
Source: Immunological Reviews - August 12, 2018 Category: Allergy & Immunology Authors: Soheil Rastgou
Talemi
,
Thomas
H öfer Source Type: research
Insight into treatment of HIV infection from viral dynamics models
Immunological Reviews,Volume 285, Issue 1, Page 9-25, September 2018. (Source: Immunological Reviews)
Source: Immunological Reviews - August 12, 2018 Category: Allergy & Immunology Authors: Alison L.
Hill
,
Daniel I. S.
Rosenbloom
,
Martin A.
Nowak
,
Robert F.
Siliciano Source Type: research
Some deterministic and stochastic mathematical models of na ïve T‐cell homeostasis
Immunological Reviews,Volume 285, Issue 1, Page 206-217, September 2018. (Source: Immunological Reviews)
Source: Immunological Reviews - August 12, 2018 Category: Allergy & Immunology Authors: Grant
Lythe
,
Carmen
Molina ‐París Source Type: research
