Compliant Aortic Annulus Sizing With Different Elliptical Ratios Through a Valvuloplasty Balloon Catheter
Conclusion: The measurement of stiffer elliptical annulus phantoms shows good accuracy and high repeatability. Significance: This work represents substantial progress toward improving the selection of TAVI devices by using balloon catheters to improve the sizing of compliant aortic annuli with complex geometry. (Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - June 26, 2023 Category: Biomedical Engineering Source Type: research

Flexible and Scalable Dry Conductive Elastomeric Nanocomposites for Surface Stimulation Applications
Conclusion: Flexatrode provides stable electrical properties combined with high flexibility and elasticity. Electrotherapy treated chronic wounds were 81.9% smaller than baseline at day 10. Wounds that received an inactive device (device without any electrical stimulation) were 58.1% smaller than baseline and wounds that received standard of care treatment were 62.2% smaller than baseline. Significance: The increasing need for wearable bioelectronics requiring long-term monitoring/treatment has highlighted the limitations of sustained use of gel-based electrodes. These can include skin irritation, bacterial overgrowth at t...
Source: IEEE Transactions on Biomedical Engineering - June 23, 2023 Category: Biomedical Engineering Source Type: research

Diffeomorphic Surface Modeling for MRI-Based Characterization of Gastric Anatomy and Motility
Conclusion: These results demonstrate the efficacy of using MRI to model gastric anatomy and function. Significance: The proposed approach is expected to enable non-invasive and accurate mapping of gastric motility for preclinical a- d clinical studies. (Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - June 23, 2023 Category: Biomedical Engineering Source Type: research

ECG Modeling for Simulation of Arrhythmias in Time-Varying Conditions
The present article proposes an ECG simulator that advances modeling of arrhythmias and noise by introducing time-varying signal characteristics. The simulator is built around a discrete-time Markov chain model for simulating atrial and ventricular arrhythmias of particular relevance when analyzing atrial fibrillation (AF). Each state is associated with statistical information on episode duration and heartbeat characteristics. Statistical, time-varying modeling of muscle noise, motion artifacts, and the influence of respiration is introduced to increase the complexity of simulated ECGs, making the simulator well suited for...
Source: IEEE Transactions on Biomedical Engineering - June 22, 2023 Category: Biomedical Engineering Source Type: research

A Review of Low-Cost Ultrasound Compatible Phantoms
Ultrasound-compatible phantoms are used to develop novel US-based systems and train simulated medical interventions. The price difference between lab-made and commercially available ultrasound-compatible phantoms lead to the publication of many papers categorized as low-cost in the literature. The aim of this review was to improve the phantom selection process by summarizing the pertinent literature. We compiled papers on US-compatible spine, prostate, vascular, breast, kidney, and li ver phantoms. We reviewed papers for cost and accessibility, providing an overview of the materials, construction time, shelf life, needle i...
Source: IEEE Transactions on Biomedical Engineering - June 20, 2023 Category: Biomedical Engineering Source Type: research

A Paired Phase and Magnitude Reconstruction for Advanced Diffusion-Weighted Imaging
Conclusion: The joint estimation model PAIR with complementary priors has a good performance on challenging reconstructions under inter-shot motions and a low signal-to-noise ratio. Significance: PAIR has potential in advanced clinical DWI applications and microstructure research. (Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - June 20, 2023 Category: Biomedical Engineering Source Type: research

A Theragnostic HIFU Transducer and System for Inherently Registered Imaging and Therapy
Conclusion: Implementation of imaging and therapy with one HIFU transducer in this manner is feasible and it has potential as a novel strategy for addressing the long-standing problem in the HIFU therapy, possibly pushing this non-invasive technique forward towards wider clinical applications. (Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - June 20, 2023 Category: Biomedical Engineering Source Type: research

A Wearable Co-Located Neural-Mechanical Signal Sensing Device for Simultaneous Bimodal Muscular Activity Detection
The co-located and concurrent measurement of both muscular neural activity and muscular deformation is considered necessary in many applications, such as medical robotics, assistive exoskeletons and muscle function evaluations. Nevertheless, conventional muscle-related signal perception systems either detect only one of these modalities, or are made with rigid and bulky components that cannot provide conformal and flexible interface. Herein, a flexible, easy-to-fabricate, bimodal muscular activity sensing device, which collects neural and mechanical signal at the same muscle location, is reported. The sensing patch include...
Source: IEEE Transactions on Biomedical Engineering - June 20, 2023 Category: Biomedical Engineering Source Type: research

Using Bayesian Neural Networks to Select Features and Compute Credible Intervals for Personalized Survival Prediction
An Individual Survival Distribution (ISD) models a patient's personalized survival probability at all future time points. Previously, ISD models have been shown to produce accurate and personalized survival estimates (for example, time to relapse or to death) in several clinical applications. However, off-the-shelf neural-network-based ISD models are usually opaque models due to their limited support for meaningful feature selection and uncertainty estimation, which hinders their wide clinical adoption. Here, we introduce a Bayesian-neural-network-based ISD (BNN-ISD) model that produces accurate survival estimates but also...
Source: IEEE Transactions on Biomedical Engineering - June 20, 2023 Category: Biomedical Engineering Source Type: research

Dynamic Control of Contractile Force in Engineered Heart Tissue
Conclusion: EHT contractility can be regulated dynamically through feedback control of effective boundary stiffness. Significance: The capacity to alter the mechanical boundary conditions of an engineered tissue dynamically offers a new way to probe tissue mechanics. This could be used to mimic afterload changes that occur naturally in disease, or to improve mechanical techniques for EHT maturation. (Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - June 20, 2023 Category: Biomedical Engineering Source Type: research

On Merging Feature Engineering and Deep Learning for Diagnosis, Risk Prediction and Age Estimation Based on the 12-Lead ECG
Conclusion: We found that for traditional 12-lead ECG based diagnosis tasks, DL did not yield a meaningful improvement over FE, while it improved significantly the nontraditional regression task. We also found that combining FE with DL did not improve over DL alone, which suggests that the FE was redundant with the features learned by DL. Significance: Our findings provides important recommendations on 12-lead ECG based machine learning strategy and data regime to choose for a given task. When looking at maximizing performance as the end goal, if the task is nontraditional and a large dataset is available then DL is prefer...
Source: IEEE Transactions on Biomedical Engineering - June 20, 2023 Category: Biomedical Engineering Source Type: research

A Multi-Center Clinical Trial for Wireless Stethoscope-Based Diagnosis and Prognosis of Children Community-Acquired Pneumonia
Community-Acquired Pneumonia (CAP) is a significant cause of child mortality globally, due to the lack of ubiquitous monitoring methods. Clinically, the wireless stethoscope can be a promising solution since lung sounds with crackles and tachypnea are considered as the typical symptoms of CAP. In this paper, we carried out a multi-center clinical trial in four hospitals to investigate the feasibility of using a wireless stethoscope for children CAP diagnosis and prognosis. The trial collects both the left and right lung sounds from children with CAP at the time of diagnosis, improvement, and recovery. A bilateral pulmonary...
Source: IEEE Transactions on Biomedical Engineering - June 20, 2023 Category: Biomedical Engineering Source Type: research

Design, Control, and Experiments of a Novel Robotic Uterine Manipulator With the Motorized 3-DoF Manipulation Rod
To address the issue of declining performance over time with manual uterine manipulation during minimally invasive gynecologic surgery, we propose a novel uterine manipulation robot that consists of a 3-DoF remote center of motion (RCM) mechanism and a 3-DoF manipulation rod. This allows for tireless, stable, and safer manipulation in place of a human assistant. For the RCM mechanism, we propose a single-motor bilinear-guided mechanism that can achieve a wide range of pitch motion (−50 $sim$ 34 degrees) while maintaining a compact structure. This novel uterine manipulation robot is equipped with a manipulation rod t...
Source: IEEE Transactions on Biomedical Engineering - June 20, 2023 Category: Biomedical Engineering Source Type: research

KUBAI: Sensor Fusion for Non-Invasive Fetal Heart Rate Tracking
Conclusion: The results support the effectiveness of KUBAI, the proposed sensor fusion algorithm, to non-invasively and accurately estimate fetal heart rate with varying levels of noise in the measurements. Significance: The presented method can benefit other multi-sensor measurement setups, which may be challenged by low measurement frequency, low signal-to-noise ratio, or intermittent loss of measured signal. (Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - June 20, 2023 Category: Biomedical Engineering Source Type: research

Deep Learning for Multiple Sclerosis Differentiation Using Multi-Stride Dynamics in Gait
Conclusion: We used advanced DL and dynamics across domain knowledge-based spatiotemporal and kinetic gait parameters to successfully classify MS gait across distinct walking trials and unseen participants. Significance: Our proposed DL algorithms might contribute to efforts to automate MS diagnoses. (Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - June 20, 2023 Category: Biomedical Engineering Source Type: research