Blood Pressure Measurement and Hypertension Diagnosis in the 2017 US Guidelines [Guidelines Conversation]
(Source: Hypertension)
Source: Hypertension - May 9, 2018 Category: Cardiology Authors: George Stergiou, Paolo Palatini, Roland Asmar, Aleȷandro de la Sierra, Martin Myers, Andrew Shennan, Jiguang Wang, Eoin O’Brien, Gianfranco Parati Tags: High Blood Pressure, Hypertension, Blood Pressure Guidelines Conversation Source Type: research

Hypertension Editors Welcome Comments From Regional Hypertension Societies [Guidelines Conversation]
(Source: Hypertension)
Source: Hypertension - May 9, 2018 Category: Cardiology Authors: Anna F. Dominiczak, Rhian M. Touyz Tags: Hypertension, Statements and Guidelines Guidelines Conversation Source Type: research

Case of Severe Hypertension and Nephrotic Range Proteinuria [Clinical-Pathological Conference]
(Source: Hypertension)
Source: Hypertension - May 9, 2018 Category: Cardiology Authors: Michael Bursztyn, Rhian M. Touyz, Cheryl L. Laffer, Robert M. Carey, Anna F. Dominiczak Tags: Clinical – Pathological Conference Source Type: research

Clinical Implications [Clinical Implications]
(Source: Hypertension)
Source: Hypertension - May 9, 2018 Category: Cardiology Tags: Clinical Implications Source Type: research

Correction to: Systematic Review for the 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines [Correction]
(Source: Hypertension)
Source: Hypertension - May 9, 2018 Category: Cardiology Tags: Corrections Source Type: research

Correction to: 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines [Correction]
(Source: Hypertension)
Source: Hypertension - May 9, 2018 Category: Cardiology Tags: Corrections Source Type: research

Correction to: 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines [Correction]
(Source: Hypertension)
Source: Hypertension - May 9, 2018 Category: Cardiology Tags: Corrections Source Type: research

Systematic Review for the 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines [Systematic Review]
Objective—To review the literature systematically and perform meta-analyses to address these questions: 1) Is there evidence that self-measured blood pressure (BP) without other augmentation is superior to office-based measurement of BP for achieving better BP control or for preventing adverse clinical outcomes that are related to elevated BP? 2) What is the optimal target for BP lowering during antihypertensive therapy in adults? 3) In adults with hypertension, how do various antihypertensive drug classes differ in their benefits and harms compared with each other as first-line therapy?Methods—Electronic literature se...
Source: Hypertension - May 9, 2018 Category: Cardiology Authors: David M. Reboussin, Norrina B. Allen, Michael E. Griswold, Eliseo Guallar, Yuling Hong, Daniel T. Lackland, Edgar (Pete) R. Miller III, Tamar Polonsky, Angela M. Thompson-Paul, Suma Vupputuri Tags: Statements and Guidelines Systematic Review Source Type: research

2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines [Clinical Practice Guideline]
(Source: Hypertension)
Source: Hypertension - May 9, 2018 Category: Cardiology Authors: Paul K. Whelton, Robert M. Carey, Wilbert S. Aronow, Donald E. Casey, Jr, Karen J. Collins, Cheryl Dennison Himmelfarb, Sondra M. DePalma, Samuel Gidding, Kenneth A. Jamerson, Daniel W. Jones, Eric J. MacLaughlin, Paul Muntner, Bruce Ovbiagele, Sidney C. Tags: Statements and Guidelines Clinical Practice Guideline Source Type: research

Longitudinal Association Between Orthostatic Hypotension at 30 Seconds Post-Standing and Late-Life DepressionNovelty and Significance [Orthostatic Hypotension and Late-Life Depression]
This study was embedded within the Irish Longitudinal Study on Ageing using data from waves 1 to 3, collected between 2009 and 2014. At 2- and 4-year follow-up, a score ≥9 on the 8-item Center for Epidemiological Studies Depression Scale was used to define incident depression. sOH-30 was defined as a drop in systolic blood pressure ≥20 mm Hg or diastolic blood pressure ≥10 mm Hg at 30 seconds post-standing in conjunction with orthostatic symptoms, such as dizziness, using beat-to-beat measurements. Almost one fifth (proportion, 18%; 95% confidence interval [CI], 16–20) of the study sample had sOH-30. One tenth ...
Source: Hypertension - April 11, 2018 Category: Cardiology Authors: Robert Briggs, Daniel Carey, Sean P. Kennelly, Rose Anne Kenny Tags: Aging, Mental Health, Risk Factors Original Articles Source Type: research

Development and Validation of a Path Length Calculation for Carotid-Femoral Pulse Wave Velocity MeasurementNovelty and Significance [Pulse Wave Velocity Measurement]
Current distance measurement techniques for pulse wave velocity (PWV) calculation are susceptible to intercenter variability. The aim of this study was to derive and validate a formula for this distance measurement. Based on carotid femoral distance in 1183 whole-body magnetic resonance angiograms, a formula was derived for calculating distance. This was compared with distance measurements in 128 whole-body magnetic resonance angiograms from a second study. The effects of recalculation of PWV using the new formula on association with risk factors, disease discrimination, and prediction of major adverse cardiovascular event...
Source: Hypertension - April 11, 2018 Category: Cardiology Authors: Jonathan R. Weir-McCall, Liam Brown, Jennifer Summersgill, Piotr Talarczyk, Michael Bonnici-Mallia, Sook C. Chin, Faisel Khan, Allan D. Struthers, Frank Sullivan, Helen M. Colhoun, Angela C. Shore, Kunihiko Aizawa, Leif Groop, Jan Nilsson, John R. Cockcro Tags: Cardiovascular Disease, Risk Factors, Magnetic Resonance Imaging (MRI), Mortality/Survival Original Articles Source Type: research

History of Asthma From Childhood and Arterial Stiffness in Asymptomatic Young AdultsNovelty and Significance [Arterial Stiffness]
Asthma is related to various cardiovascular risk. Whether a history of asthma from childhood contributes to arterial stiffness in adulthood, a noninvasive surrogate for cardiovascular events, is unknown. Prospective analyses were performed among 1746 Bogalusa Heart Study participants aged 20 to 51 years with data on self-report asthma collected since childhood. Aorta–femoral pulse wave velocity (af-PWV, m/s) was repeatedly assessed among adults ≥aged 18 years. Generalized linear mixed models and generalized linear models were fitted for the repeated measurements of af-PWV and its changes between the last and the first ...
Source: Hypertension - April 11, 2018 Category: Cardiology Authors: Dianjianyi Sun, Xiang Li, Yoriko Heianza, Hoirun Nisa, Xiaoyun Shang, Felicia Rabito, Tanika Kelly, Emily Harville, Shengxu Li, Jiang He, Lydia Bazzano, Wei Chen, Lu Qi Tags: Obesity, Risk Factors, High Blood Pressure, Echocardiography Original Articles Source Type: research

Changes in Cerebral Arteries and Parenchymal Arterioles With AgingNovelty and Significance [Cerebrovascular Dysfunction With Aging]
Vascular aging fundamentally contributes to large and small vessel disease. Despite the importance of such changes for brain function, mechanisms that mediate such changes are poorly defined. We explored mechanisms that underlie changes with age, testing the hypothesis that ROCK (Rho kinase) plays an important role. In C57BL/6 mice, baseline diameters of isolated pressurized parenchymal arterioles were similar in adult (4–5 month) and old mice (22±1 month; ≈15±1 µm). Endothelium-dependent dilation was impaired in old mice compared with adults in a pathway-specific manner. Vasodilation to NS-309 (which activates smal...
Source: Hypertension - April 11, 2018 Category: Cardiology Authors: T. Michael De Silva, Mary L. Modrick, Fabrice Dabertrand, Frank M. Faraci Tags: Basic Science Research, Vascular Biology, Cerebrovascular Disease/Stroke, Vascular Disease Original Articles Source Type: research

Diabetes Mellitus in Pregnancy Leads to Growth Restriction and Epigenetic Modification of the Srebf2 Gene in Rat FetusesNovelty and Significance [Epigenetics and Maternal Diabetes]
In conclusion, diabetic and hyperlipidemic pregnancy induces neurological, metabolic, and epigenetic alterations in the rat fetus. Srebf2 is a potential candidate mediating intrauterine environment-driven epigenetic changes and later diabetic offspring health. (Source: Hypertension)
Source: Hypertension - April 11, 2018 Category: Cardiology Authors: Michaela Golic, Violeta Stoȷanovska, Ivo Bendix, Anika Wehner, Florian Herse, Nadine Haase, Kristin Kraker, Caroline Fischer, Natalia Alenina, Michael Bader, Till Schutte, Mirȷam Schuchardt, Markus van der Giet, Wolfgang Henrich, Dominik N. Tags: Animal Models of Human Disease, Diabetes, Type 2, Pregnancy, Epigenetics Original Articles Source Type: research

Preconception Blood Pressure Levels and Reproductive Outcomes in a Prospective Cohort of Women Attempting PregnancyNovelty and Significance [Pregnancy and Hypertension]
Elevated blood pressure in young adulthood is an early risk marker for cardiovascular disease. Despite a strong biological rationale, little research has evaluated whether incremental increases in preconception blood pressure have early consequences for reproductive health. We evaluated preconception blood pressure and fecundability, pregnancy loss, and live birth in the EAGeR trial (Effects of Aspirin on Gestational and Reproduction; 2007–2011), a randomized clinical trial of aspirin and reproductive outcomes among 1228 women attempting pregnancy with a history of pregnancy loss. Systolic and diastolic blood pressure we...
Source: Hypertension - April 11, 2018 Category: Cardiology Authors: Carrie J. Nobles, Pauline Mendola, Sunni L. Mumford, Ashley I. Naimi, Edwina H. Yeung, Keewan Kim, Hyojun Park, Brian Wilcox, Robert M. Silver, Neil J. Perkins, Lindsey Sjaarda, Enrique F. Schisterman Tags: Epidemiology, Pregnancy, Women Original Articles Source Type: research