Adenosine Receptors [Editorial Commentary]
(Source: Hypertension)
Source: Hypertension - July 11, 2018 Category: Cardiology Authors: Kate M. Denton Tags: Animal Models of Human Disease, Basic Science Research, Hypertension Editorial Commentaries Source Type: research
Resistant Hypertension and Obstructive Sleep Apnea [Editorial Commentary]
(Source: Hypertension)
Source: Hypertension - July 11, 2018 Category: Cardiology Authors: Michel Azizi, Laurence Amar, Aurelien Lorthioir Tags: Hypertension Editorial Commentaries Source Type: research
Cell-Derived Exosomes for Cardiovascular Therapies [Editorial Commentary]
(Source: Hypertension)
Source: Hypertension - July 11, 2018 Category: Cardiology Authors: Isotta Chimenti, Giacomo Frati Tags: Cell Therapy, Stem Cells, Translational Studies Editorial Commentaries Source Type: research
Unraveling New Mechanisms of Renal Fibrosis With Potential Therapeutic Implications [Editorial Commentary]
(Source: Hypertension)
Source: Hypertension - July 11, 2018 Category: Cardiology Authors: Francisco Maduell, Nuria Garcia–Fernandez, Joaquin Manrique, Arantxa Gonzalez, Javier Diez Tags: Fibrosis, Oxidant Stress, Hypertension Editorial Commentaries Source Type: research
Natriuretic Peptides in Cardiovascular and Metabolic Crosstalk [Brief Review]
(Source: Hypertension)
Source: Hypertension - July 11, 2018 Category: Cardiology Authors: Jens Jordan, Andreas L. Birkenfeld, Olle Melander, Cedric Moro Tags: Metabolism, Diabetes, Type 2, Diet and Nutrition, Exercise, Obesity Brief Reviews Source Type: research
Hypertension in Blacks [Brief Review]
(Source: Hypertension)
Source: Hypertension - July 11, 2018 Category: Cardiology Authors: J. David Spence, Brian L. Rayner Tags: Genetics, Hypertension, Diagnostic Testing Brief Reviews Source Type: research
Are the American Heart Association/American College of Cardiology High Blood Pressure Guidelines Fit for Global Purpose?: Thoughts From the International Society of Hypertension [Guidelines Conversation]
(Source: Hypertension)
Source: Hypertension - July 11, 2018 Category: Cardiology Authors: Neil R. Poulter, Rafael Castillo, Fadi J. Charchar, Markus P. Schlaich, Aletta E. Schutte, Maciej Tomaszewski, Rhian M. Touyz, Ji-Guang Wang Tags: High Blood Pressure, Hypertension, Ethics and Policy, Health Services, Statements and Guidelines Guidelines Conversation Source Type: research
Impact of the Discordance Between the American College of Cardiology/American Heart Association and American Diabetes Association Recommendations on Hypertension in Patients With Diabetes Mellitus in the United States [Guidelines Conversation]
(Source: Hypertension)
Source: Hypertension - July 11, 2018 Category: Cardiology Authors: Doosup Shin, Chandrashekar Bohra, Kullatham Kongpakpaisarn Tags: Epidemiology, Hypertension Guidelines Conversation Source Type: research
Professor Anthony Fairclough Lever [In Memoriam]
(Source: Hypertension)
Source: Hypertension - July 11, 2018 Category: Cardiology Authors: Anna Dominiczak, John Connell, J. Ian S. Robertson Tags: Hypertension In Memoriam Source Type: research
Clinical Implications [Clinical Implications]
(Source: Hypertension)
Source: Hypertension - July 11, 2018 Category: Cardiology Tags: Clinical Implications Source Type: research
Antihypertensive Treatment Fails to Control Blood Pressure During Exercise
Novelty and Significance
[Exercise Blood Pressure]
An exaggerated blood pressure (BP) response to maximal exercise is an independent risk factor for cardiovascular events and mortality. It is unclear whether treating BP to guideline recommended levels could normalize the rise in BP during exercise, which is mediated by the metaboreflex. We aimed to assess the BP response to incremental exercise testing and metaboreflex activation in treated–controlled hypertension (n=16), treated–uncontrolled hypertension (n=16), and untreated hypertension (n=11) and 16 control participants with normal BP (n=16). All groups were matched for age and body mass index. BP was measured duri...
Source: Hypertension - June 13, 2018 Category: Cardiology Authors: Benjamin Chant, Majda Bakali, Thomas Hinton, Amy E. Burchell, Angus K. Nightingale, Julian F.R. Paton, Emma C. Hart Tags: High Blood Pressure, Hypertension Original Articles Source Type: research
Age-Related Blood Pressure Sensitivity to Aldosterone in Blacks and WhitesNovelty and Significance [Aldosterone]
Aldosterone sensitivity, defined as the magnitude of the association of plasma aldosterone concentration with blood pressure (BP), seems to be a function of plasma volume. It increases as plasma renin activity decreases, and it is more significant in blacks but less so in whites. Age is a strong determinant of BP, and an increase in aldosterone sensitivity could contribute to the increase in BP. In the present study, we tested the hypothesis that aldosterone sensitivity increases with age. We used observational data collected from normotensive blacks and whites enrolled in a prospective cohort study. They were studied as c...
Source: Hypertension - June 13, 2018 Category: Cardiology Authors: Wanzhu Tu, Ruohong Li, Vivek Bhalla, George J. Eckert, J. Howard Pratt Tags: Hypertension Original Articles Source Type: research
Vascular Nox (NADPH Oxidase) Compartmentalization, Protein Hyperoxidation, and Endoplasmic Reticulum Stress Response in HypertensionNovelty and Significance [Oxidative Stress]
Vascular Nox (NADPH oxidase)-derived reactive oxygen species and endoplasmic reticulum (ER) stress have been implicated in hypertension. However, relationships between these processes are unclear. We hypothesized that Nox isoforms localize in a subcellular compartment-specific manner, contributing to oxidative and ER stress, which influence the oxidative proteome and vascular function in hypertension. Nox compartmentalization (cell fractionation), O2− (lucigenin), H2O2 (amplex red), reversible protein oxidation (sulfenylation), irreversible protein oxidation (protein tyrosine phosphatase, peroxiredoxin oxidation), and ER...
Source: Hypertension - June 13, 2018 Category: Cardiology Authors: Livia L. Camargo, Adam P. Harvey, Francisco J. Rios, Sofia Tsiropoulou, Renee de Nazare Oliveira Da Silva, Zhenbo Cao, Delyth Graham, Claire McMaster, Richard J. Burchmore, Richard C. Hartley, Neil Bulleid, Augusto C. Montezano, Rhian M. Touyz Tags: Hypertension Original Articles Source Type: research
Endothelial PPAR{gamma} (Peroxisome Proliferator-Activated Receptor-{gamma}) Is Essential for Preventing Endothelial Dysfunction With AgingNovelty and Significance [Oxidative Stress]
Little is known about mechanisms that control vascular aging, particularly at the cell-specific level. PPARγ (peroxisome proliferator–activated receptor-γ) exerts protective effects in the vasculature when activated pharmacologically. To gain insight into the cell-specific impact of PPARγ, we examined the hypothesis that genetic interference with endothelial PPARγ would augment age-induced vascular dysfunction. We studied carotid arteries from adult (11.6±0.3 months) and old (24.7±0.6 months) mice with endothelial-specific expression of a human dominant negative mutation in PPARγ driven by the vascular cadherin pr...
Source: Hypertension - June 13, 2018 Category: Cardiology Authors: T. Michael De Silva, Ying Li, Dale A. Kinzenbaw, Curt D. Sigmund, Frank M. Faraci Tags: Vascular Biology, Vascular Disease Original Articles Source Type: research
Cerebrospinal Fluid Protein Changes in PreeclampsiaNovelty and Significance [Preeclampsia]
The molecular mechanisms underlying seizure susceptibility in preeclampsia are unknown. We hypothesized that altered expression of distinct proteins in the cerebrospinal fluid (CSF) may reflect pathophysiological changes in the central nervous system that contribute to the neurological manifestations of severe preeclampsia. We obtained CSF samples from 13 patients with preeclampsia and 14 control patients during spinal anesthesia before delivery and analyzed them by SOMAscan, an aptamer-based proteomics platform for alterations in 1310 protein levels. Ingenuity Pathway Analysis was conducted to highlight relationships betw...
Source: Hypertension - June 13, 2018 Category: Cardiology Authors: Erin Ciampa, Yunping Li, Simon Dillon, Edouard Lecarpentier, Laura Sorabella, Towia A. Libermann, S. Ananth Karumanchi, Philip E. Hess Tags: Angiogenesis, Biomarkers, Inflammation, Hypertension, Preeclampsia Original Articles Source Type: research
