Relationship Between 24-Hour Ambulatory Central Systolic Blood Pressure and Left Ventricular MassNovelty and Significance [Heart]
We investigated the relationship between left ventricular mass and brachial office as well as brachial and central ambulatory systolic blood pressure in 7 European centers. Central systolic pressure was measured with a validated oscillometric device, using a transfer function, and mean/diastolic pressure calibration. M-mode images were obtained by echocardiography, and left ventricular mass was determined by one single reader blinded to blood pressure. We studied 289 participants (137 women) free from antihypertensive drugs (mean age: 50.8 years). Mean office blood pressure was 145/88 mm Hg and mean brachial and central ...
Source: Hypertension - November 8, 2017 Category: Cardiology Authors: Thomas Weber, Siegfried Wassertheurer, Arno Schmidt–Trucksass, Enrique Rodilla, Cornelia Ablasser, Piotr Jankowski, Maria Lorenza Muiesan, Cristina Giannattasio, Claudia Mang, Ian Wilkinson, Jorg Kellermair, Bernhard Hametner, Jose Maria Pascual, Ro Tags: Hemodynamics, Hypertrophy, Blood Pressure Original Articles Source Type: research
Aldosterone Target NGAL (Neutrophil Gelatinase-Associated Lipocalin) Is Involved in Cardiac Remodeling After Myocardial Infarction Through NF{kappa}B PathwayNovelty and Significance [Heart]
In conclusion, NGAL, a downstream MR activation target, is a key mediator of post-MI cardiac damage. NGAL may be a potential therapeutic target in cardiovascular pathological situations in which MR is involved. (Source: Hypertension)
Source: Hypertension - November 8, 2017 Category: Cardiology Authors: Ernesto Martinez–Martinez, Mathieu Buonafine, Ines Boukhalfa, Jaime Ibarrola, Amaya Fernandez–Celis, Peter Kolkhof, Patrick Rossignol, Nicolas Girerd, Paul Mulder, Natalia Lopez–Andres, Antoine Ouvrard–Pascaud, Frederic Jaisser Tags: Basic Science Research Original Articles Source Type: research
Myocardial Deformation Measured by 3-Dimensional Speckle Tracking in Children and Adolescents With Systemic Arterial HypertensionNovelty and Significance [Heart]
Systemic arterial hypertension predisposes children to cardiovascular risk in childhood and adult life. Despite extensive study of left ventricular (LV) hypertrophy, detailed 3-dimensional strain analysis of cardiac function in hypertensive children has not been reported. The aim of this study was to evaluate LV mechanics (strain, twist, and torsion) in young patients with hypertension compared with a healthy control group and assess factors associated with functional measurements. Sixty-three patients (26 hypertension and 37 normotensive) were enrolled (mean age, 14.3 and 11.4 years; 54% men and 41% men, respectively). Al...
Source: Hypertension - November 8, 2017 Category: Cardiology Authors: Susanne Navarini, Hannah Bellsham-Revell, Henry Chubb, Haotian Gu, Manish D. Sinha, John M. Simpson Tags: Pediatrics, Hypertension, Echocardiography Original Articles Source Type: research
Brain Regional Blood Flow and Working Memory Performance Predict Change in Blood Pressure Over 2 YearsNovelty and Significance [Brain]
Hypertension is a presumptive risk factor for premature cognitive decline. However, lowering blood pressure (BP) does not uniformly reverse cognitive decline, suggesting that high BP per se may not cause cognitive decline. We hypothesized that essential hypertension has initial effects on the brain that, over time, manifest as cognitive dysfunction in conjunction with both brain vascular abnormalities and systemic BP elevation. Accordingly, we tested whether neuropsychological function and brain blood flow responses to cognitive challenges among prehypertensive individuals would predict subsequent progression of BP. Midlif...
Source: Hypertension - November 8, 2017 Category: Cardiology Authors: J. Richard Jennings, Alicia F. Heim, Lei K. Sheu, Matthew F. Muldoon, Christopher Ryan, H. Michael Gach, Claudiu Schirda, Peter J. Gianaros Tags: Autonomic Nervous System, High Blood Pressure, Hypertension, Functional Magnetic Resonance Imaging (fMRI) Original Articles Source Type: research
Kinin B1 Receptor Promotes Neurogenic Hypertension Through Activation of Centrally Mediated MechanismsNovelty and Significance [Brain]
In this study, we tested the hypothesis that activation of B1R in the brain is involved in the pathogenesis of hypertension, using the deoxycorticosterone acetate–salt model of neurogenic hypertension in wild-type and B1R knockout mice. Deoxycorticosterone acetate–salt treatment in wild-type mice led to significant increases in B1R mRNA and protein levels and bradykinin levels, enhanced gene expression of carboxypeptidase N supporting an increase in the B1R ligand, associated with enhanced blood pressure, inflammation, sympathoexcitation, autonomic dysfunction, and impaired baroreflex sensitivity, whereas these changes...
Source: Hypertension - November 8, 2017 Category: Cardiology Authors: Srinivas Sriramula, Eric Lazartigues Tags: Animal Models of Human Disease, Inflammation, Oxidant Stress, High Blood Pressure, Hypertension Original Articles Source Type: research
