Strategies for Achieving Healthy Vascular Aging [Brief Reviews]
(Source: Hypertension)
Source: Hypertension - February 7, 2018 Category: Cardiology Authors: Kristen L. Nowak, Matthew J. Rossman, Michel Chonchol, Douglas R. Seals Tags: Vascular Biology, Aging, Hypertension Brief Review Source Type: research
Catheter-Based Renal Nerve Ablation as a Novel Hypertension Therapy [Recent Advances in Hypertension]
(Source: Hypertension)
Source: Hypertension - February 7, 2018 Category: Cardiology Authors: John W. Osborn, Christopher T. Banek Tags: Hypertension Recent Advances in Hypertension Source Type: research
Consensus Document on Improving Hypertension Management in Asian Patients, Taking Into Account Asian Characteristics [Consensus Documents]
(Source: Hypertension)
Source: Hypertension - February 7, 2018 Category: Cardiology Authors: Kazuomi Kario, Chen-Huan Chen, Sungha Park, Chang-Gyu Park, Satoshi Hoshide, Hao-Min Cheng, Qi-Fang Huang, Ji-Guang Wang Tags: Hypertension Consensus Documents Source Type: research
A Universal Standard for the Validation of Blood Pressure Measuring Devices [Consensus Documents]
In the past 30 years, several organizations, such as the US Association for the Advancement of Medical Instrumentation (AAMI), the British Hypertension Society, the European Society of Hypertension (ESH) Working Group on Blood Pressure (BP) Monitoring, and the International Organization for Standardization (ISO), have developed protocols for clinical validation of BP measuring devices. However, it is recognized that science, as well as patients, consumers, and manufacturers, would be best served if all BP measuring devices were assessed for accuracy according to an agreed single validation protocol that had global acceptan...
Source: Hypertension - February 7, 2018 Category: Cardiology Authors: George S. Stergiou, Bruce Alpert, Stephan Mieke, Roland Asmar, Neil Atkins, Siegfried Eckert, Gerhard Frick, Bruce Friedman, Thomas Grassl, Tsutomu Ichikawa, John P. Ioannidis, Peter Lacy, Richard McManus, Alan Murray, Martin Myers, Paolo Palatini, Gianfr Tags: Hypertension Consensus Documents Source Type: research
Clinical Implications [Clinical Implications]
(Source: Hypertension)
Source: Hypertension - February 7, 2018 Category: Cardiology Tags: Clinical Implications Source Type: research
Correction to: Cyclooxygenase-2 Selectively Controls Renal Blood Flow Through a Novel PPAR{beta}/{delta}-Dependent Vasodilator Pathway [Correction]
(Source: Hypertension)
Source: Hypertension - February 7, 2018 Category: Cardiology Tags: Corrections Source Type: research
Correction to: Angiotensin-(1-7) and Vascular Function: The Clinical Context [Correction]
(Source: Hypertension)
Source: Hypertension - February 7, 2018 Category: Cardiology Tags: Corrections Source Type: research
Inhibition of NADPH Oxidase-Dependent Oxidative Stress in the Rostral Ventrolateral Medulla Mediates the Antihypertensive Effects of Acupuncture in Spontaneously Hypertensive RatsNovelty and Significance [Acupuncture and Hypertension]
This study was designed to evaluate the hypothesis that acupuncture exerts an antihypertensive effect via ameliorating oxidative stress and the redox-sensitive pathway in the RVLM of spontaneously hypertensive rats. Two weeks of acupuncture reduced blood pressure and sympathetic nervous system activity in spontaneously hypertensive rats. Oxidative stress in the RVLM was alleviated by acupuncture, accompanied by a decrease in nicotinamide adenine dinucleotide phosphate oxidase activity and expression of its subunits. Acupuncture significantly altered the mitogen-activated protein kinases signaling pathway as assessed by pat...
Source: Hypertension - January 10, 2018 Category: Cardiology Authors: Xue-Rui Wang, Jing-Wen Yang, Cai-Shuo Ji, Xiang-Hong Zeng, Guang-Xia Shi, Marc Fisher, Cun-Zhi Liu Tags: Oxidant Stress, High Blood Pressure, Hypertension Original Articles Source Type: research
Two Pools of Epoxyeicosatrienoic Acids in HumansNovelty and Significance [Epoxyeicosatrienoic Acid and Salt Sensitivity]
We report ultra-performance liquid chromatography/tandem mass spectrometry plasma EETs, DHETs, and their sum (plasma total pool) for the 3 regioisomers (8,9-, 11,12-, 14,15-) and their sum (08,15-). In salt-resistant subjects, urine total pool was unchanged by HiNa, decreased by LoNa, and correlated with urine sodium excretion, fractional excretion of Na+, and Na+/K+ ratio for the 3 days of the experiment combined (P (Source: Hypertension)
Source: Hypertension - January 10, 2018 Category: Cardiology Authors: Fernando Elijovich, Ginger L. Milne, Nancy J. Brown, Michal Laniado-Schwartzman, Cheryl L. Laffer Tags: Clinical Studies, Mechanisms, Pathophysiology, High Blood Pressure Original Articles Source Type: research
Microtubule Regulation of Kv7 Channels Orchestrates cAMP-Mediated Vasorelaxations in Rat Arterial Smooth MuscleNovelty and Significance [Vessels]
This study is the first to show microtubule disruption improves the β-adrenoceptor–mediated relaxations of mesenteric and renal arteries and determine this enhancement to be because of increased membrane expression of the Kv7 voltage-gated potassium channels. (Source: Hypertension)
Source: Hypertension - January 10, 2018 Category: Cardiology Authors: Johanna Lindman, Makhala M. Khammy, Pia R. Lundegaard, Christian Aalkȷar, Thomas A. Jepps Tags: Hypertension Original Articles Source Type: research
Accuracy of Blood Pressure Measurement Devices in PregnancyNovelty and Significance [Blood Pressure Measurement in Pregnancy]
The accurate measurement of blood pressure (BP) in pregnancy is essential to guide medical decision making that affects both mother and fetus. The aim of this systematic review was to determine the accuracy of ambulatory, home, and clinic BP measurement devices in pregnant women. We searched Ovid MEDLINE, The Cochrane Library, EMBASE, CINAHL EBSCO, ClinicalTrials.gov, International Clinical Trials Registry Platform, and dabl from inception through August 3, 2017 for articles that assessed the validity of an upper arm BP measurement device against a mercury sphygmomanometer in pregnant women. Two independent investigators d...
Source: Hypertension - January 10, 2018 Category: Cardiology Authors: Natalie A. Bello, Jonathan J. Woolley, Kirsten Lawrence Cleary, Louise Falzon, Bruce S. Alpert, Suzanne Oparil, Gary Cutter, Ronald Wapner, Paul Muntner, Alan T. Tita, Daichi Shimbo Tags: Hypertension, Preeclampsia Original Articles Source Type: research
Targeting CXCR4 (CXC Chemokine Receptor Type 4) for Molecular Imaging of Aldosterone-Producing AdenomaNovelty and Significance [Primary Aldosteronism]
Primary aldosteronism is the most frequent cause of secondary hypertension and is associated with increased morbidity and mortality compared with hypertensive controls. The central diagnostic challenge is the differentiation between bilateral and unilateral disease, which determines treatment options. Bilateral adrenal venous sampling, currently recommended for differential diagnosis, is an invasive procedure with several drawbacks, making it desirable to develop novel noninvasive diagnostic tools. When investigating the expression pattern of chemokine receptors by quantitative real-time polymerase chain reaction and immun...
Source: Hypertension - January 10, 2018 Category: Cardiology Authors: Britta Heinze, Carmina T. Fuss, Paolo Mulatero, Felix Beuschlein, Martin Reincke, Mona Mustafa, Andreas Schirbel, Timo Deutschbein, Tracy Ann Williams, Yara Rhayem, Marcus Quinkler, Nada Rayes, Silvia Monticone, Vanessa Wild, Celso E. Gomez-Sanchez, Anna- Tags: Translational Studies, Hypertension, Imaging Original Articles Source Type: research
Meta-Analysis and Systematic Review to Assess the Role of Soluble FMS-Like Tyrosine Kinase-1 and Placenta Growth Factor Ratio in Prediction of PreeclampsiaNovelty and Significance [Preeclampsia]
Preeclampsia is a major cause of morbidity and mortality worldwide. Numerous candidate biomarkers have been proposed for diagnosis and prediction of preeclampsia. Measurement of maternal circulating angiogenesis biomarker as the ratio of sFlt-1 (soluble FMS-like tyrosine kinase-1; an antiangiogenic factor)/PlGF (placental growth factor; an angiogenic factor) reflects the antiangiogenic balance that characterizes incipient or overt preeclampsia. The ratio increases before the onset of the disease and thus may help in predicting preeclampsia. We conducted a meta-analysis to explore the predictive accuracy of sFlt-1/PlGF rati...
Source: Hypertension - January 10, 2018 Category: Cardiology Authors: Swati Agrawal, Ana Sofia Cerdeira, Christopher Redman, Manu Vatish Tags: Angiogenesis, Biomarkers, Clinical Studies Original Articles Source Type: research
Cyclooxygenase-2 Selectively Controls Renal Blood Flow Through a Novel PPAR{beta}/{delta}-Dependent Vasodilator PathwayNovelty and Significance [Cyclooxgenase and Renal Blood Flow]
Cyclooxygenase-2 (COX-2) is an inducible enzyme expressed in inflammation and cancer targeted by nonsteroidal anti-inflammatory drugs. COX-2 is also expressed constitutively in discreet locations where its inhibition drives gastrointestinal and cardiovascular/renal side effects. Constitutive COX-2 expression in the kidney regulates renal function and blood flow; however, the global relevance of the kidney versus other tissues to COX-2–dependent blood flow regulation is not known. Here, we used a microsphere deposition technique and pharmacological COX-2 inhibition to map the contribution of COX-2 to regional blood flow i...
Source: Hypertension - January 10, 2018 Category: Cardiology Authors: Nicholas S. Kirkby, Walkyria Sampaio, Gisele Etelvino, Daniele T. Alves, Katie L. Anders, Rafael Temponi, Fisnik Shala, Anitha S. Nair, Blerina Ahmetaj-Shala, Jing Jiao, Harvey R. Herschman, Wang Xiaomeng, Walter Wahli, Robson A. Santos, Jane A. Mitchell Tags: Basic Science Research, Endothelium/Vascular Type/Nitric Oxide, Vascular Disease Original Articles Source Type: research
Geographical Variations in Blood Pressure Level and Seasonality in Hemodialysis PatientsNovelty and Significance [Kidney]
In conclusion, there is a geographical and seasonal gradient of BP in European hemodialysis patients. There is a need to consider these effects when evaluating and treating BP in this population and potentially in others. (Source: Hypertension)
Source: Hypertension - January 10, 2018 Category: Cardiology Authors: Flore Duranton, Anneke Kramer, Ilan Szwarc, Brian Bieber, Nathalie Gayrard, Bernard Jover, Fernando Vetromile, Ziad A. Massy, Christian Combe, Francesca Tentori, Kitty J. Jager, Marie–Francoise Servel, Angel Argiles Tags: Risk Factors, High Blood Pressure Original Articles Source Type: research
