Dysregulated Expression of RPS4Y1 (Ribosomal Protein S4, Y-Linked 1) Impairs STAT3 (Signal Transducer and Activator of Transcription 3) Signaling to Suppress Trophoblast Cell Migration and Invasion in PreeclampsiaNovelty and Significance [Preeclampsia]
In this study, we found that RPS4Y1 levels were upregulated in placental samples collected from preeclamptic patients, when compared with the normotensive pregnant women. In vitro, inhibition of RPS4Y1 induced trophoblast cell invasion, promoted placental explant outgrowth, and increased STAT3 (signal transducer and activator of transcription 3) phosphorylation along with elevated expression of N-cadherin and vimentin. Conversely, overexpression of RPS4Y1 results in reduced trophoblast cell invasion and decreased STAT3 phosphorylation. In addition, the suppression of RPS4Y1 promotes trophoblast cell invasion, which could b...
Source: Hypertension - February 7, 2018 Category: Cardiology Authors: Xuehai Chen, Chao Tong, Haiying Li, Wei Peng, Rong Li, Xin Luo, Huisheng Ge, Yuxin Ran, Qin Li, Yamin Liu, Xi Xiong, Yuxiang Bai, Hua Zhang, Philip N. Baker, Xiru Liu, Hongbo Qi Tags: High Blood Pressure, Hypertension, Preeclampsia Original Articles Source Type: research
Pazopanib-Induced Hypertension in Patients With Renal Cell Carcinoma Is Associated With Low Urine Excretion of NO MetabolitesNovelty and Significance [Kidney]
Drugs targeting VEGF (vascular endothelial growth factor) are often associated with rapid development of hypertension by a yet not fully understood mechanism. VEGF is expressed in renal epithelial cells and stimulates NO production. In the renal medulla, inhibition of NO formation by local L-NAME or by impaired endothelin-1 leads to hypertension. The present study was designed to test the hypothesis that VEGF receptor inhibitor treatment leads to hypertension through decreased renal medullary formation of NO and endothelin-1. With a single-center prospective observational design, patients with metastatic renal cell carcino...
Source: Hypertension - February 7, 2018 Category: Cardiology Authors: Anne Robdrup Tinning, Camilla Bengtsen, Niels Viggo Jensen, Lars Bastholt, Boye Lagerbon Jensen, Kirsten Madsen Tags: Nephrology and Kidney, Physiology, Hypertension Original Articles Source Type: research
Proteomic Profiling for Cardiovascular Biomarker Discovery in Orthostatic HypotensionNovelty and Significance [Proteomic Profiling in Orthostatic Hypotension]
Orthostatic hypotension (OH) has been linked with higher incidence of cardiovascular disease, but little is known about the mechanisms behind this association. We aimed to identify cardiovascular disease biomarkers associated with OH through a proteomic profiling approach. Seven hundred seventy-eight patients with unexplained syncope or orthostatic intolerance underwent head-up tilt test and supine blood samples. Of these, 220 met diagnostic criteria of OH, and 179 demonstrated normal hemodynamic response during head-up tilt test. Blood samples were analyzed by antibody-based Proximity Extension Assay technique simultaneou...
Source: Hypertension - February 7, 2018 Category: Cardiology Authors: Madeleine Johansson, Fabrizio Ricci, Nay Aung, Richard Sutton, Olle Melander, Artur Fedorowski Tags: Autonomic Nervous System, Biomarkers, Vascular Biology Original Articles Source Type: research
Genetic and Environmental Effects on Gene Expression Signatures of Blood PressureNovelty and Significance [Genetics]
In this study of 391 twins (193 twin pairs and 5 singletons; age 55–69 years; 40% male; 57% monozygous) recruited from the Finnish Twin Cohort, transcriptome-wide data on peripheral leukocytes were obtained using the Illumina HT12 V4 array. Our transcriptome-wide analysis identified 1 gene (MOK [MAPK/MAK/MRK overlapping kinase], P=7.16×10−8) with its expression levels associated with systolic BP at the cutoff of false-discovery rate (Source: Hypertension)
Source: Hypertension - February 7, 2018 Category: Cardiology Authors: Yisong Huang, Miina Ollikainen, Pyry Sipila, Linda Mustelin, Xin Wang, Shaoyong Su, Tianxiao Huan, Daniel Levy, James Wilson, Harold Snieder, Jaakko Kaprio, Xiaoling Wang Tags: Genetics Original Articles Source Type: research
Pulse Wave Velocity Predicts the Progression of Blood Pressure and Development of Hypertension in Young AdultsNovelty and Significance [Predicting Hypertension in Young Adults]
The aim of the present study was to examine whether pulse wave velocity (PWV) predicts the progression of blood pressure and the development of hypertension in young adults. In addition, we studied whether PWV improves the risk prediction of incident hypertension beyond traditional cardiovascular risk factors. Systolic and diastolic blood pressures were measured in 2007 and 2011 for 1449 Finnish adults (aged 30–45 years). In addition, PWV and other cardiovascular risk factors were measured in 2007. The association between PWV (in 2007) and blood pressure (in 2011) was studied in the whole population (n=1449) and in a nor...
Source: Hypertension - February 7, 2018 Category: Cardiology Authors: Teemu Koivistoinen, Leo–Pekka Lyytikainen, Heikki Aatola, Tiina Luukkaala, Markus Juonala, Jorma Viikari, Terho Lehtimaki, Olli T. Raitakari, Mika Kahonen, Nina Hutri–Kahonen Tags: Hypertension Original Articles Source Type: research
Is Blood Pressure Improving in Children With Chronic Kidney Disease?Novelty and Significance [Hypertension in Children With Kidney Disease]
Uncontrolled hypertension in children with chronic kidney disease (CKD) has been identified as one of the main factors contributing to progression of CKD and increased risk for cardiovascular disease. Recent efforts to achieve better blood pressure (BP) control have been recommended. The primary objective of this analysis was to compare BP control over 2 time periods among participants enrolled in the CKiD study (Chronic Kidney Disease in Children). Casual BP and 24-hour ambulatory BP monitor data were compared among 851 participants during 2 time periods: January 1, 2005, through July 1, 2008 (period 1, n=345), and July 1...
Source: Hypertension - February 7, 2018 Category: Cardiology Authors: Gina-Marie Barletta, Christopher Pierce, Mark Mitsnefes, Joshua Samuels, Bradley A. Warady, Susan Furth, Joseph Flynn Tags: High Blood Pressure, Hypertension Original Articles Source Type: research
Determinants of Cardiometabolic Risk Factors in the First Decade of LifeNovelty and Significance [Childhood Cardiometabolic Risk Factors]
In conclusion, although BW was a proxy of the events during fetal life and projected its influence later, the influence of gaining weight was a key determinant in the risk to develop obesity and metabolic abnormalities. (Source: Hypertension)
Source: Hypertension - February 7, 2018 Category: Cardiology Authors: Empar Lurbe, Francisco Aguilar, Julio Alvarez, Pau Redon, Maria Isabel Torro, Josep Redon Tags: Obesity, Pediatrics, Risk Factors Original Articles Source Type: research
Left Ventricular Hypertrophy and Remodeling and Risk of Cognitive Impairment and DementiaNovelty and Significance [Epidemiology/Population]
In conclusion, in a multiethnic cohort of participants without clinically detected cardiovascular disease and dementia at baseline, LV hypertrophy and concentric remodeling were independently associated with incident dementia and cognitive impairment. (Source: Hypertension)
Source: Hypertension - February 7, 2018 Category: Cardiology Authors: Kasra Moazzami, Mohammad Reza Ostovaneh, Bharath Ambale Venkatesh, Mohammadali Habibi, Kihei Yoneyama, Colin Wu, Kiang Liu, Isabel Pimenta, Annette Fitzpatrick, Steven Shea, Robyn L. McClelland, Susan Heckbert, Rebecca F. Gottesman, David A. Bluemke, Timo Tags: Magnetic Resonance Imaging (MRI) Original Articles Source Type: research
Hypertension and Diabetes MellitusNovelty and Significance [Epidemiology/Population]
Type 2 diabetes mellitus and hypertension overlap in the population. In many subjects, development of diabetes mellitus is characterized by a relatively rapid increase in plasma glucose values. Whether a similar phenomenon occurs during the development of hypertension is not known. We analyzed the pattern of blood pressure (BP) changes during the development of hypertension in patients with or without diabetes mellitus using data from the MCDS (Mexico City Diabetes Study; a population-based study of diabetes mellitus in Hispanic whites) and in the FOS (Framingham Offspring Study, a community-based study in non-Hispanic whi...
Source: Hypertension - February 7, 2018 Category: Cardiology Authors: Vasilis Tsimihodimos, Clicerio Gonzalez-Villalpando, James B. Meigs, Ele Ferrannini Tags: Hypertension Original Articles Source Type: research
Central and Brachial Blood Pressures, Statins, and Low-Density Lipoprotein CholesterolNovelty and Significance [Epidemiology/Population]
This study aims to characterize the association of statins and LDL-c with central and brachial blood pressures and to quantify their respective effects. Of the 20 004 CARTaGENE participants, 16 507 had available central blood pressure, LDL-c, and Framingham risk score. Multivariate analyses were used to evaluate the association between central pressure and LDL-c in subjects with or without statins. The impact of LDL-c on the association between statin and pressure parameters was determined through mediation analyses. LDL-c was positively associated with systolic and diastolic central pressure in nonusers (β=0.077 and ...
Source: Hypertension - February 7, 2018 Category: Cardiology Authors: Florence Lamarche, Mohsen Agharazii, Annie–Claire Nadeau–Fredette, Francois Madore, Remi Goupil Tags: Lipids and Cholesterol Original Articles Source Type: research
Primary Aldosteronism and Cardiovascular Events [Editorial Commentary]
(Source: Hypertension)
Source: Hypertension - February 7, 2018 Category: Cardiology Authors: Martin Reincke Tags: High Blood Pressure, Cerebrovascular Disease/Stroke Editorial Commentaries Source Type: research
Parameters of Left Ventricular Mass and Dementia [Editorial Commentary]
(Source: Hypertension)
Source: Hypertension - February 7, 2018 Category: Cardiology Authors: Merrill F. Elias, Rachael V. Torres, Adam Davey Tags: Hypertrophy Editorial Commentaries Source Type: research
Does Chronic Obstructive Pulmonary Disease Cause Cardiovascular Disease? [Editorial Commentary]
(Source: Hypertension)
Source: Hypertension - February 7, 2018 Category: Cardiology Authors: G.B. John Mancini, John A. Fleetham Tags: Cardiovascular Disease, Risk Factors, Prognosis Editorial Commentaries Source Type: research
Transcriptomics in Twins Separates Genetic From Environmental Effects on Gene Expression and Blood Pressure [Editorial Commentary]
(Source: Hypertension)
Source: Hypertension - February 7, 2018 Category: Cardiology Authors: Brian J. Morris Tags: Gene Expression & Regulation, Genetic, Association Studies, Functional Genomics Editorial Commentaries Source Type: research
Atherosclerosis and Blood Pressure Variability [Editorial Commentary]
(Source: Hypertension)
Source: Hypertension - February 7, 2018 Category: Cardiology Authors: Michael G. Ziegler Tags: Peripheral Vascular Disease Editorial Commentaries Source Type: research
