Sympathetic Nervous System Regulation in Human Normotensive and Hypertensive Pregnancies [Brief Review]
(Source: Hypertension)
Source: Hypertension - April 11, 2018 Category: Cardiology Authors: Laura M. Reyes, Charlotte W. Usselman, Margie H. Davenport, Craig D. Steinback Tags: Autonomic Nervous System, High Blood Pressure, Hypertension, Preeclampsia Brief Reviews Source Type: research
Should Hypertension Be Treated in Late Life to Preserve Cognitive Function?Response to Should Hypertension Be Treated in Late Life to Preserve Cognitive Function?: Con Side of the Argument [Controversies in Hypertension]
(Source: Hypertension)
Source: Hypertension - April 11, 2018 Category: Cardiology Authors: Rebecca F. Gottesman Tags: Aging, Epidemiology, Cognitive Impairment Controversies in Hypertension Source Type: research
Should Hypertension Be Treated in Late Life to Preserve Cognitive Function?Response to Should Hypertension Be Treated in Late Life to Preserve Cognitive Function?: Pro Side of the Argument [Controversies in Hypertension]
(Source: Hypertension)
Source: Hypertension - April 11, 2018 Category: Cardiology Authors: Clinton B. Wright Tags: Primary Prevention, Secondary Prevention, High Blood Pressure, Hypertension, Cognitive Impairment Controversies in Hypertension Source Type: research
Resistant Hypertension [Clinical-Pathological Conference]
(Source: Hypertension)
Source: Hypertension - April 11, 2018 Category: Cardiology Authors: Marc J. George, Daniel J.B. Marks, Tamer Rezk, Ross Breckenridge, Reecha Sofat, John Martin, Raymond MacAllister, Rhian M. Touyz, Jan A. Staessen, Michael Bursztyn, David Lappin, Mohammed Barigou, Aroon Hingorani Tags: Clinical – Pathological Conference Source Type: research
Clinical Implications [Clinical Implications]
(Source: Hypertension)
Source: Hypertension - April 11, 2018 Category: Cardiology Tags: Clinical Implications Source Type: research
Correction to: Cellular FLICE-Inhibitory Protein Protects Against Cardiac Remodeling Induced by Angiotensin II in Mice [Corrections]
(Source: Hypertension)
Source: Hypertension - April 11, 2018 Category: Cardiology Tags: Correction Source Type: research
Mechanistic Role of the Calcium-Dependent Protease Calpain in the Endothelial Dysfunction Induced by MPO (Myeloperoxidase)Novelty and Significance [Calpain and Endothelial Dysfunction]
MPO (myeloperoxidase) is a peroxidase enzyme secreted by activated leukocytes that plays a pathogenic role in cardiovascular disease, mainly by initiating endothelial dysfunction. The molecular mechanisms of the endothelial damaging action of MPO remain though largely elusive. Calpain is a calcium-dependent protease expressed in the vascular wall. Activation of calpains has been implicated in inflammatory disorders of the vasculature. Using endothelial cells and genetically modified mice, this study identifies the µ-calpain isoform as novel downstream signaling target of MPO in endothelial dysfunction. Mouse lung microvas...
Source: Hypertension - March 7, 2018 Category: Cardiology Authors: Zienab Etwebi, Gavin Landesberg, Kyle Preston, Satoru Eguchi, Rosario Scalia Tags: Endothelium/Vascular Type/Nitric Oxide, High Blood Pressure, Hypertension, Vascular Disease Original Articles Source Type: research
Cocaine Exposure Increases Blood Pressure and Aortic Stiffness via the miR-30c-5p-Malic Enzyme 1-Reactive Oxygen Species PathwayNovelty and Significance [Cocaine Exposure and Blood Pressure]
Cocaine abuse increases the risk of cardiovascular mortality and morbidity; however, the underlying molecular mechanisms remain elusive. By using a mouse model for cocaine abuse/use, we found that repeated cocaine injection led to increased blood pressure and aortic stiffness in mice associated with elevated levels of reactive oxygen species (ROS) in the aortas, a phenomenon similar to that observed in hypertensive humans. This ROS elevation was correlated with downregulation of Me1 (malic enzyme 1), an important redox molecule that counteracts ROS generation, and upregulation of microRNA (miR)-30c-5p that targets Me1 expr...
Source: Hypertension - March 7, 2018 Category: Cardiology Authors: Wei Zhu, Huilan Wang, Jianqin Wei, Gregory C. Sartor, Michelle Meiqi Bao, Clay T. Pierce, Claes R. Wahlestedt, Derek M. Dykxhoorn, Chunming Dong Tags: Animal Models of Human Disease, Basic Science Research, Mechanisms, Oxidant Stress, High Blood Pressure Original Articles Source Type: research
Prognostic Value of Echocardiography in Hypertensive Versus Nonhypertensive Participants From the General PopulationNovelty and Significance [Echocardiography in Hypertension]
This study examines the incremental prognostic value of adding echocardiographic parameters to established risk factors in individuals from the general population with and without hypertension. A total of 1294 individuals from the general population underwent a health examination and an echocardiogram including 2-dimensional speckle tracking. Outcome was a composite of ischemic heart disease and heart failure. The prevalence of hypertension was 38.3%. During a median follow-up of 12.5 years (interquartile range, 9.4–12.8 years), 222 participants (17.2%) developed the outcome. Out of these 222 events, 145 (65%) occurred i...
Source: Hypertension - March 7, 2018 Category: Cardiology Authors: Daniel Modin, Sofie Reumert Biering–Sorensen, Rasmus Mogelvang, Nino Landler, Jan Skov Jensen, Tor Biering–Sorensen Tags: High Blood Pressure, Hypertension, Echocardiography, Prognosis, Ultrasound Original Articles Source Type: research
Growth Differentiation Factor 11 Promotes Abnormal Proliferation and Angiogenesis of Pulmonary Artery Endothelial CellsNovelty and Significance [Pulmonary Hypertension]
This study identified a novel growth and differentiation factor signaling pathway involved in the zinc finger protein 740/GDF11/transforming growth factor-β receptor I/Smad signaling axis and involved in pulmonary artery endothelial cells proliferation and angiogenesis. These results provide critical insights for the development of novel therapeutic strategies for pulmonary arterial hypertension involving components of the GDF11 signaling system. (Source: Hypertension)
Source: Hypertension - March 7, 2018 Category: Cardiology Authors: Xiufeng Yu, Xinxin Chen, Xiao Dong Zheng, Junting Zhang, Xijuan Zhao, Ying Liu, Hongyue Zhang, Lixin Zhang, Hao Yu, Min Zhang, Cui Ma, Xuewei Hao, Daling Zhu Tags: Pulmonary Hypertension Original Articles Source Type: research
Plasma Cell Depletion Attenuates Hypertension in an Experimental Model of Autoimmune DiseaseNovelty and Significance [Immune System and Hypertension]
Numerous studies show a direct relation between circulating autoantibodies, characteristic of systemic autoimmune disorders, and primary hypertension in humans. Whether these autoantibodies mechanistically contribute to the development of hypertension remains unclear. Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by aberrant immunoglobulin production, notably pathogenic autoantibodies, and is associated with prevalent hypertension, renal injury, and cardiovascular disease. Because plasma cells produce the majority of serum immunoglobulins and are the primary source of autoantibodies in S...
Source: Hypertension - March 7, 2018 Category: Cardiology Authors: Erin B. Taylor, Michelle T. Barati, David W. Powell, Hannah R. Turbeville, Michael J. Ryan Tags: Hypertension Original Articles Source Type: research
Myeloid CD11c+ Antigen-Presenting Cells Ablation Prevents Hypertension in Response to Angiotensin II Plus High-Salt DietNovelty and Significance [Immune System and Hypertension]
Increasing evidence shows that antigen-presenting cells (APCs) are involved in the development of inflammation associated to hypertension. However, the potential role of APCs in the modulation of renal sodium transport has not been addressed. We hypothesized that APCs participate in renal sodium transport and, thus, development of high blood pressure in response to angiotensin II plus a high-salt diet. Using transgenic mice that allow the ablation of CD11chigh APCs, we studied renal sodium transport, the intrarenal renin–angiotensin system components, blood pressure, and cardiac/renal tissue damage in response to angiote...
Source: Hypertension - March 7, 2018 Category: Cardiology Authors: Daniel Hevia, Patricio Araos, Carolina Prado, Eugenia Fuentes Luppichini, Macarena Rojas, Rodrigo Alzamora, Flavia Cifuentes-Araneda, Alexis A. Gonzalez, Cristian A. Amador, Rodrigo Pacheco, Luis Michea Tags: High Blood Pressure, Hypertension Original Articles Source Type: research
Susceptibility to Hypertensive Renal Disease in the Spontaneously Hypertensive Rat Is Influenced by 2 Loci Affecting Blood Pressure and Immunoglobulin RepertoireNovelty and Significance [Genomics]
High blood pressure exerts its deleterious effects on health largely through acceleration of end-organ diseases. Among these, progressive loss of renal function is particularly important, not only for the direct consequences of kidney damage but also because loss of renal function is associated with amplification of other adverse cardiovascular outcomes. Genetic susceptibility to hypertension and associated end-organ disease is non-Mendelian in both humans and in a rodent model, the spontaneously hypertensive rat (SHR). Here, we report that hypertensive end-organ disease in the inbred SHR-A3 line is attributable to genetic...
Source: Hypertension - March 7, 2018 Category: Cardiology Authors: Isha S. Dhande, Stacy M. Cranford, Yaming Zhu, Sterling C. Kneedler, M. John Hicks, Scott E. Wenderfer, Michael C. Braun, Peter A. Doris Tags: Genetics, Hypertension Original Articles Source Type: research
Whole Exome Sequencing Reveals a Monogenic Cause of Disease in ≈43% of 35 Families With Midaortic SyndromeNovelty and Significance [Genomics]
Midaortic syndrome (MAS) is a rare cause of severe childhood hypertension characterized by narrowing of the abdominal aorta in children and is associated with extensive vascular disease. It may occur as part of a genetic syndrome, such as neurofibromatosis, or as consequence of a pathological inflammatory disease. However, most cases are considered idiopathic. We hypothesized that in a high percentage of these patients, a monogenic cause of disease may be detected by evaluating whole exome sequencing data for mutations in 1 of 38 candidate genes previously described to cause vasculopathy. We studied a cohort of 36 individu...
Source: Hypertension - March 7, 2018 Category: Cardiology Authors: Jillian K. Warejko, Markus Schueler, Asaf Vivante, Weizhen Tan, Ankana Daga, Jennifer A. Lawson, Daniela A. Braun, Shirlee Shril, Kassaundra Amann, Michael J.G. Somers, Nancy M. Rodig, Michelle A. Baum, Ghaleb Daouk, Avram Z. Traum, Heung Bae Kim, Khashay Tags: Genetics Original Articles Source Type: research
Spironolactone Versus Clonidine as a Fourth-Drug Therapy for Resistant HypertensionNovelty and Significance [Clinical Study: Resistant Hypertension Optimal Treatment Trial (ReHOT)]
The aim of this study is to compare spironolactone versus clonidine as the fourth drug in patients with resistant hypertension in a multicenter, randomized trial. Medical therapy adherence was checked by pill counting. Patients with resistant hypertension (no office and ambulatory blood pressure [BP] monitoring control, despite treatment with 3 drugs, including a diuretic, for 12 weeks) were randomized to an additional 12-week treatment with spironolactone (12.5–50 mg QD) or clonidine (0.1–0.3 mg BID). The primary end point was BP control during office ( (Source: Hypertension)
Source: Hypertension - March 7, 2018 Category: Cardiology Authors: Eduardo M. Krieger, Luciano F. Drager, Dante M.A. Giorgi, Alexandre C. Pereira, Jose Augusto Soares Barreto–Filho, Armando R. Nogueira, Jose Geraldo Mill, Paulo A. Lotufo, Celso Amodeo, Marcelo C. Batista, Luiz C. Bodanese, Antonio C.C. Carvalho, Ir Tags: Clinical Studies, Hypertension Original Articles Source Type: research
