Association analysis between the A118G polymorphism in the OPRM1 gene and treatment response to venlafaxine XR in generalized anxiety disorder
In this study, we examined whether the OPRM1 gene, which has been implicated in antidepressant treatment response in major depressive disorder, also has an effect in GAD. In our study, 156 patients diagnosed with GAD received venlafaxine XR treatment as part of an 18‐month relapse prevention study. Genotypes were obtained for the OPRM1 functional variant A118G for the entire sample (n = 151); however, only the European American population was considered (n = 108) for pharmacogenetic analysis. We found no significant association between A118G and antidepressant treatment response in our GAD pop...
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2013 Category: Psychiatry Authors: Alissa J. Cooper, Karl Rickels, Falk W. Lohoff Tags: Research Article Source Type: research

Attention control in mood and anxiety disorders: evidence from the antisaccade task
The antisaccade task (in which participants must suppress a reflexive saccade towards a sudden, peripheral stimulus and generate a volitional saccade in the opposite direction) is considered a measure of cognitive inhibition. The task has been used to examine cognitive control deficits in several neuropsychiatric conditions, most notably schizophrenia. This commentary summarizes recent evidence from antisaccade tasks in mood and anxiety disorders, with reference to neuropsychological models and psychopharmacological mechanisms. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2013 Category: Psychiatry Authors: Ben Ainsworth, Matthew Garner Tags: Short Communication Source Type: research

Prospective associations between benzodiazepine use and later life satisfaction, somatic pain and psychological health among the elderly
This study aimed to investigate prospective associations between benzodiazepine use and later life satisfaction, sleep difficulties, perceived general health, anxiety symptoms and somatic pain among the elderly. MethodsA 13‐year prospective cohort study was conducted in a Norwegian population‐based sample of 15 830 elderly individuals. Baseline control measures of the investigated psychological constructs and a wide range of demographic and health‐relevant covariates were obtained from the Nord‐Trøndelag Health Study (HUNT 2, 1995–1997). Follow‐up data were obtained from the third wave (HUNT 3...
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2013 Category: Psychiatry Authors: Trond Nordfjærn Tags: Research Article Source Type: research

A double‐blind trial of the effect of docosahexaenoic acid and vitamin and mineral supplementation on aggression, impulsivity, and stress
ConclusionsThe influence of supplementation on aggression and impulsivity can be conveniently studied in a sample without a history of antisocial behavior, using laboratory‐based measures. No evidence was found of a synergistic interaction between vitamins/minerals and DHA. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2013 Category: Psychiatry Authors: Sara‐Jayne Long, David Benton Tags: Research Article Source Type: research

Effects of oral 5‐hydroxytryptophan on a standardized planning task: insight into possible dopamine/serotonin interactions in the forebrain
ConclusionsOral exogenous 5‐HTP disrupts dopaminergic function in the human forebrain. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2013 Category: Psychiatry Authors: Mathew H. Gendle, Erica L. Young, Alexandra C. Romano Tags: Short Communication Source Type: research

Association of the dopamine β‐hydroxylase 19 bp insertion/deletion polymorphism with positive symptoms but not tardive dyskinesia in schizophrenia
This study examined whether the functional DBH 5'‐Ins/Del polymorphism was associated with TD severity in Chinese patients with schizophrenia. MethodsWe compared the rate of this polymorphism in patients with (n = 312) and without TD (n = 435), and healthy controls (n = 625). The severity of TD was assessed using the Abnormal Involuntary Movement Scale (AIMS) and psychopathology using the Positive and Negative Syndrome Scale (PANSS). ResultsThere were no significant differences in the distribution of the allele and genotype frequencies between the patients and controls, or betwee...
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2013 Category: Psychiatry Authors: Na Zhou, Qiong Yu, Xiaokun Li, Yaqin Yu, Changgui Kou, Wenjun Li, Hongqin Xu, Xingguang Luo, Lingjun Zuo, Thomas R. Kosten, Xiang Yang Zhang Tags: Research Article Source Type: research

Relationship between nicotine dependence and the endophenotype‐related trait of cognitive function but not acoustic startle reponses in Japanese patients with schizophrenia
ConclusionsNicotine dependence might influence the level of verbal memory and executive function in schizophrenia patients. In addition, rs755203 and rs1044397 in CHRNA4 might play a role in the pathophysiology of nicotine dependence in healthy controls in the Japanese population. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2013 Category: Psychiatry Authors: Taro Kishi, Yasuhisa Fukuo, Tomo Okochi, Kunihiro Kawashima, Masatsugu Moriwaki, Osamu Furukawa, Giovanna M. Musso, Kiyoshi Fujita, Christoph U. Correll, Nakao Iwata Tags: Research Article Source Type: research

Sex differences in the effect of four second‐generation antipsychotics on QTc interval in patients with schizophrenia
ConclusionTo our knowledge, this is the first study to demonstrate sex differences in the effect of four SGAs on the QTc interval. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2013 Category: Psychiatry Authors: Yutaro Suzuki, Takuro Sugai, Naoki Fukui, Junzo Watanabe, Shin Ono, Nobuto Tsuneyama, Mami Saito, Toshiyuki Someya Tags: Research Article Source Type: research

Issue Information
No abstract is available for this article. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2013 Category: Psychiatry Tags: Issue Information Source Type: research

Effectiveness of paliperidone extended‐release for patients with schizophrenia: focus on subjective improvement
ConclusionOur results suggest that switching to paliperidone extended‐release was associated with improvements in various subjective symptoms, decreased overall symptom severity, and increased social functioning. The results also suggest that early detection and reduction of subjective symptoms are important for treatment outcome. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - February 18, 2013 Category: Psychiatry Authors: Kyoung‐Sae Na, Chul‐Eung Kim, Yong‐Sik Kim, Jong‐Il Lee, Wou Sang Han, Ung Gu Kang, Doo‐Heum Park, Bongseog Kim, Han‐Yong Jung, Jin‐Sang Yoon, Se‐Won Lim Tags: Research Article Source Type: research

The BTBD9 gene may be associated with antipsychotic‐induced restless legs syndrome in schizophrenia
ConclusionsThese data suggest that the BTBD9 gene is associated with antipsychotic‐induced RLS symptoms in schizophrenic patients. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 30, 2013 Category: Psychiatry Authors: Seung‐Gul Kang, Heon‐Jeong Lee, Young‐Min Park, Hee Jung Yang, Hyun Mi Song, Yu Jin Lee, Seong‐Jin Cho, Sung Nam Cho, Leen Kim Tags: Research Article Source Type: research

Yokukansan in the treatment of behavioral and psychological symptoms of dementia: a systematic review and meta‐analysis of randomized controlled trials
ObjectivesThere is currently no meta‐analysis of the efficacy and tolerability of Yokukansan in the treatment of behavioral and psychological symptoms of dementia. MethodWe used information obtained from the PubMed and Cochrane Library databases until October 2012. We conducted a systematic review and meta‐analysis of individual patient data from randomized controlled trials comparing Yokukansan with usual care (UC, i.e., controls). Standardized mean difference and weighted mean difference were calculated. All studies used the Neuropsychiatric Inventory (NPI) for the evaluation of behavioral and psychological symptoms ...
Source: Human Psychopharmacology: Clinical and Experimental - January 28, 2013 Category: Psychiatry Authors: Yuki Matsuda, Taro Kishi, Hiroto Shibayama, Nakao Iwata Tags: Research Article Source Type: research

BIS impulsivity and acute nicotine exposure are associated with discounting global consequences in the Harvard game
ConclusionsBIS impulsivity and acute nicotine exposure reflect a bias in the governance of choice by immediate reward contingencies over global consequences, consistent with contemporary dual‐process instrumental learning theories. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 28, 2013 Category: Psychiatry Authors: Lee Hogarth, David J. Stillwell, Richard J. Tunney Tags: Research Article Source Type: research

The effects of acute tryptophan depletion on impulsivity and mood in adolescents engaging in non‐suicidal self‐injury
ConclusionsAcute tryptophan depletion caused an impulsive response style and increased attentional capacity. Importantly, the findings suggest that low serotonin function is a vulnerability among female adolescents for engaging in NSSI when in emotional distress. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 28, 2013 Category: Psychiatry Authors: Linn T. Fikke, Annika Melinder, Nils I. Landrø Tags: Research Article Source Type: research

Low prevalence of metabolic syndrome and its prediction in Japanese inpatients with schizophrenia
ObjectivesThere have so far been few papers studying the metabolic syndrome (MetS) prevalence rate in Japanese patients with schizophrenia. We studied the MetS prevalence rate in Japanese controls and inpatients with schizophrenia and compared the prediction factors for the occurrence of MetS. MethodsThe subjects were 319 inpatients with schizophrenia and 154 controls. The predictive utilities of body mass index (BMI) and the individual components of MetS for MetS diagnosis were evaluated. ResultsThe prevalence of MetS did not differ between schizophrenia and control subjects. Subjects with schizophrenia showed higher prev...
Source: Human Psychopharmacology: Clinical and Experimental - January 1, 2013 Category: Psychiatry Authors: Yutaro Suzuki, Takuro Sugai, Naoki Fukui, Junzo Watanabe, Shin Ono, Nobuto Tsuneyama, Mami Saito, Toshiyuki Someya Tags: Short Communication Source Type: research

Population pharmacokinetics of blonanserin in Chinese healthy volunteers and the effect of the food intake
ConclusionThis is the first study assessing the PK profile of blonanserin with population PKs method. The results can be used for simulation in further clinical trial and optimize individual dosage regimens using a Bayesian methodology in patients. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 1, 2013 Category: Psychiatry Authors: Yu‐Guan Wen, De‐Wei Shang, He‐Zhi Xie, Xi‐Pei Wang, Xiao‐Jia Ni, Ming Zhang, Wei Lu, Chang Qiu, Xia Liu, Fang‐Fang Li, Xuan Li, Fu‐Tian Luo Tags: Research Article Source Type: research

Exploratory study on association of genetic variation in TBC1D1 with antipsychotic‐induced weight gain
ConclusionsThis is the first study examining the association between TBC1D1 and AIWG. The moderate association of rs9852, located in the 3′UTR near a miRNA binding site, indicates an influence of TBC1D1 on AIWG. Further investigations remain necessary to elucidate the role of this gene in AIWG. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 1, 2013 Category: Psychiatry Authors: Eva J. Brandl, Arun K. Tiwari, Tristram A. Lett, Sajid A. Shaikh, Jeffrey A. Lieberman, Herbert Y. Meltzer, James L. Kennedy, Daniel J. Müller Tags: Short Communication Source Type: research

Issue Information
No abstract is available for this article. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - January 1, 2013 Category: Psychiatry Tags: Issue Information Source Type: research